Streptococcus constellatus is a microorganism that lives commensally in the oropharyngeal region, urogenital region, and intestinal tract. However, it can cause infection in patients with certain predisposing factors. We present a rare case of a right-sided frontal abscess caused by Streptococcus constellatus in a 47-year-old male with well-controlled type 2 diabetes mellitus patient who was injured by shrapnel pieces in the head and who was malnourished. The patient was successfully treated by surgical evacuation and antibiotherapy. Very few cases of brain abscesses caused by S. Constellatus have been reported in the literature. Only four cases in an immunocompetent patient have been reported to date.

Squamous Cell Carcinoma (SCC) is an epithelial neoplasm arising from the malignant proliferation of keratinocytes and it is the second most common type of skin cancer behind basal cell carcinoma (BCC). SCC presents with a wide variety of clinical manifestations including erythematous patches and nodules although its most usual presentation includes indurated well demarcated ulcerative lesions. We present historical case of SCC of the scalp who made the extension and invasion the brain after eroding the vault.

Background: The effects of cholesterol and statin therapy on serum uric acid (SUA) concentration are poorly known, and the latter's effects are even less clear. A mean atorvastatin dosage of 24 mg/dl satisfies the American Cardiovascular Assessment Campaign management objectives and dramatically lowers prevalence of chronic in individuals with cardiovascular events, according to the Greek Drug and Cardiovascular Evaluation research. We compare the temporal evolution of SUA levels in patients receiving standard treatment who received insufficient statin therapy (12 percent received statins) to patients receiving formalised care who received atorvastatin therapy almost exclusively (98 percent). Methods: In this study 160 individuals with abnormal lipid profiles in their blood were enrolled to investigate the connection between lipid profile and uric acid in dyslipidemic patients (dyslipidemia). It was a 5-month cross-sectional study conducted at Dr Abdul Sattar Lab Sialkot using a convenient sampling method. The uric acid, total cholesterol, triglycerides, LDL, and HDL cholesterol levels of enrolled participants were measured. In short, we performed uric acid and lipid profile tests on under-observation samples to investigate the association between uric acid and lipid profile parameters in the enrolled (dyslipidemic) individuals. Result: This research looks at people between the ages of 20 and 60. The Graph shows that (15) patients are between the ages of 20 and 30, (46) patients are between the ages of 31 and 40, (74) patients are between the ages of 41 and 50, and (25) patients are between the ages of 51 and 60.Patients of both sexes are covered. It was found that there exist significant positive relationship between uric acid and lipid profile in dyslipidemic patients. This study shows a positive correlation between LDL, triglycerides, total cholesterol and uric acid whereas a negative correlation was observed between HDL and uric acid. According to the current results, when uric acid rises, Total Cholesterol, Triglycerides, and Low Density Lipoproteins (LDL) rise as well. But High Density Lipoproteins (HDL) falls with the increase in uric acid levels. As a result, this study may be useful in reducing the incidence of related cardiovascular morbidities, and we will be able to predict dyslipidemia more accurately, which may further leads to CVDs. As the rate of CVDs rises in Pakistan, it is becoming increasingly necessary to investigate the factors that are directly linked to the disease. Conclusion: This article's objective was to investigate any connections between Uric Acid and Lipid Profile. Because dyslipidemia predicts the risk of coronary artery disease, so uric acid levels should be considered in these individuals for more complete risk factor prediction and treatment. Increased levels of lipid profile parameters can lead to serious heart diseases, and the only way to avoid this is to get a quick diagnosis of the disease.

Background: One of the most effective instances of readily detected biomarkers diagnosing a very big health concern is the measuring of proteins in blood to represent heart damage. The idea of utilizing a blood test to reflect organ or cell harm necessitates a chemical that is plentiful in the target cell, can reach blood, has a suitable half-life in blood, and is preferably in a particular form that only reflects the target cell in tissue. Because contraction is the primary function of the myocyte, proteins involved in contraction or the energy required to sustain it should be suitable potential indicators. The work on diagnostic tests for myofibrillar proteins begins in 1978. Different key pieces of evidence fueled in the research. In Ist-year outcomes were identical in chest pain patients whose acute myocardial infarction (AMI) was ruled out by electrocardiography and cardiac enzymes, demonstrating that the existing diagnostic tools were not beneficial for risk prediction and treatment recommendations. Second, CK and lactate dehydrogenase isoenzymes were brought into clinical practice and demonstrated to have higher specificity and sensitivity than traditional tests. All of the biomarkers used to diagnose cardiac injury are involved in contraction or energy metabolism, but the markers evolved via trial and error, beginning with transaminases in the 1950s and ending with troponins in the 1990s. This background is discussed, along with observations on my experiences establishing CK-MB and Troponin I assays. Methods: 140 individuals with AMI are included who are diagnosed using WHO criteria. A cross-sectional study with purposive sampling technique is conducted in wazirabad institute of Cardiology. This research is last around 6 months. Before the examinations, blood samples are obtained from patients by vein puncture using syringes and preserved in clot tubes. The research includes patients experiencing chest pressure, tightness, or discomfort, shortness of breath, and irregular cardiac rhythms on ECG. Patients having a normal ECG are not included in the study. Different equipments are utilized to assess appropriate heart function and to obtain serum for the identification of various cardiac biomarkers. Result: The sensitivities of all biochemical markers change depending on the time of infarction, as previously demonstrated and expected from a patho-physiologic standpoint, the blood sample of all the patients was collected and used for further investigation in the Lab. In the current study, 140 patients are enrolled, and all of the patients who had a single episode of AMI had their ECGs taken. All of the patients' ECGs are abnormal. In compared to other Bio-Cardiac Markers, the Troponin –I has a higher ratio of patients, according to the present findings. When a person undergoes AMI, the first protein that is released is troponin-I. When these tests are conducted over a period of time, they provide us with a quick assessment of the severity of AMI. As a result of the current findings, patients have a higher level of Trop-I in their blood when they experience their first episode of AMI. In this situation, the patient should go to the nearest health care center's emergency room as quickly as feasible. Conclusion: The traditional enzymatic assays of creatine kinase (CK), CK-MB (activity), and lactate dehydrogenase are rapidly being replaced by mass measurements of myoglobin, CKMB, and troponin T and troponin I (Tnl) 1 " to achieve high diagnostic sensitivity and specificity within a few hours from the onset of tissue necrosis; the ultimate goal is the early and appropriate management of patients' conditions. We compared the diagnostic sensitivity and specificity obtained by measuring various biochemical markers, some of which are widely used, and concluded that Troponin I is the first cardiac marker that releases simultaneously after the first episode of AMI when performed as single tests and in parallel and serial modes.

Chorangioma is a placental lesion consisting of capillary proliferation in chorionic villi and typically presents as a nodule or as multiple nodules on the placenta. It is a rare abnormality of placental vascular development and its clinical characteristics depend on size of the lesion. Giant chorangioma is chorangioma with an average diameter greater than 5cm. It is associated with both maternal and foetal complications. This report documents our findings in a hysterectomy specimen removed from a 40-year old female, following emergency hysterectomy for intractable postpartum haemorrhage after an elective caesarean section for three previous sections. A giant chorangioma was discovered in association with both placenta praevia and placenta increta. The outcomes for both mother and child were good.

Reportedly, SARS-CoV-2 infection impairs glucose homeostasis and metabolism. Moreover, hyperglycaemia has emerged as an important risk factor for COVID-19 mortality. A cross-sectional study involving hospitalized patients in Sidi-Bel-Abbes with COVID-19 critical infection regardless of diabetes status was conducted. Data was collected from COVID-19 Registry, including age, sex, and blood sugar level at admission. Out of 800 patients admitted for SARS-CoV-2 with, 332 patients (206 males, 126 females) exhibited hyperglycaemia, which equates to a prevalence of 41,5%. Patients had a median age of 64 years and a median blood sugar of 1,59. Admission hyperglycaemia was not statically associated with age and sex. Blood glucose status is paramount for ensuring safe and effective treatment of inpatients COVID-19. Additional studies are forthcoming to address the study's limitations and to better understand the impact of hyperglycaemia on COVID-19 patients.