Bisphosphonate-related osteonecrosis of the jaws represents a widely studied pathology. Moreover, some cases of ONJ related to the use of Denosumab have also been described recently. Denosumab is a human monoclonal antibody. It is bound with high affinity and specificity to nuclear factor kappa beta activating factor ligand (RANKL) and prevents Rank activation with reduction bone reabsorption. However, medium and long term effects of this drug are not unknown yet. The main goal of the present report is twofold. First, we point out the serious complications that these drugs might provoke. Second, we describe four cases of Denosumab related ONJ in order to expand the knowledge about the proper management of this rare complication.

The world of implant ology is continuously expanding. The application of computer-aided design and computer-aided manufacturing (CAD/CAM) to advanced dental rehabilitation programs is one of the most interesting innovations in this area. In fact, this technique offers high precision and simpler fabrication protocol. This paper describe three cases of advanced dental rehabilitation carried out using CAD-CAM technology associated with immediate functional loading protocols for reducing to the minimum the surgical times. Extremely positive results were evidenced in our patients. Aesthetic and functional outcomes, as well as prostheses stability, were satisfactory. The main aim of the present report is to show the brilliant outcomes that we obtained with the use of this procedure. We highlight that this method may guarantees numerous advantages such as shorter treatment time, elimination of human error in the manufacturing process and positive aesthetic and functional outcomes. Furthermore, it facilitates the performance of surgery.

Oral Verrucous Carcinoma is a premalignant lesion which has a potential to transform into oral squamous cell carcinoma. It is also called as Ackerman’s tumor, Buschke Loewenstein tumor, florid oral papillomatosis, epithelioma cuniculatum, and carcinoma cuniculatum. The commonest site is oral cavity followed by pharynx. It is difficult to differentiate the lesion from verrucous leukoplakia and verrucous hyperplasia. In this case report we are reporting such a case of verrucous carcinoma which is involving the lower lip.

Dental caries is a complex disease affecting the teeth, which is mainly caused by imbalance between demineralization and remineralization process around the tooth surface. It is a major cause of tooth loss and pain around the world. Today it is one of the most common diseases of world which if left untreated lead to infection, pain and tooth loss. Therefore there is need for early assessment of dental caries to lower its prevalence and to assess efficiency in the provision of preventive and therapeutic dental services, to know the selective use of dental caries preventives and targeting of services toward persons at greatest risk. For early assessment of dental caries, indices can be used to know its prevalence and the population which is at higher risk. There are some limitations in the previously developed dental caries index regarding the quantification and severity of diseases. To solve these problems later new indices are developed like ICDAS, PUFA, CAST index. Dental caries index helpful in detection of oral diseases on large scale in field survey. Provide data regarding prevalence of a particular condition occurring within a given population and use of this data for the implementation of the dental caries prevention program.

A supernumerary tooth is an extra tooth in any region of dental arch with predilection for premaxilla and are associated with various developmental disorders and syndromes. Here we present a case of supernumerary tooth present in left maxilla region and its surgical procedure for its removal along with brief overview on its associated complications and their management.

A thorough knowledge of the root canal configuration including the morphology of teeth involved in root canal treatment is fundamental for effective endodontic treatment. This case report discusses successful management of five cases of c-shaped canal configuration.

Oral cancer is a public health problem. Despite all the efforts and improvements in the field of oncology, the mortality rate had not significantly declined in the course of recent years. This may be due to the fact that diagnosis of oral cancer is frequently delayed. The main goal of this study is to analyze the factors responsible of this delay. We analyzed the clinical history of 76 patients with oral cancer diagnosed in our center from 2013 to 2016. We divided the diagnostic delay into 3 major groups: delay attributable to patient, delay attributable to public health system and delay attributable to professionals. According with our results, the major delay is attributable to patient. However, we find that the waiting time to get an appointment with Maxillofacial Unit is too long for patient referred by family doctors and dentists (α <0,01). Moreover, we could observe that other hospital professionals such as emergency physicians and ENT specialists take less time to suspect oral cancer than family doctors or dentists (α <0,01). However, dentists suspected oral cancer earlier than family doctors (α <0,01).the major diagnostic delay is due to patient and this could depends on several variables. However, the waiting time to obtain a specialist consultation after the request of family doctors or dentists is too long. The creation of special derivation protocols is essential in cases of suspicious lesions.