With the newly emerging concepts and advancements in genetic/genomic technologies, information on causative or candidate gene(s), transcription factors or growth factors responsible for orthodontic cases such as craniofacial dysmorphologies, morphogenesis and differentiation of craniofacial tissues, midfacial defects, crowding of teeth, prognathism, genetic variations associated with susceptibility of developing and/or heterogeneity in treatment response of malocclusions are emerging. Promising results have been accrued on utilization of genetic testing for management of monogenic traits such as primary failure of eruption (PFE), and Class III malocclusion. As the impact of genetic/genomic factors on orthodontic treatment outcome is emerging, gene therapy as a novel approach is being explored for effective and precise orthodontic treatment. Despite certain challenges and biosafety issues, the emergence of some promising success stories and ongoing research in gene therapy provides an optimistic future in the field of precision orthodontics. However, in order for precision orthodontics to be implemented in daily practice, more exquisite research is warranted. This review encompasses a conspectus on the potentials of genomics and gene therapy in achieving precision orthodontics.

Through this study we aim firstly, to understand the correlation between pain, intensity of pain and different clinical Data. Secondly, to highlight the accurate etiological diagnosis and be able to take the adequate decison for pain managment. This study was carried out on 200 edentulous patients who came to the departement of complete denture of dental clinic at Monastir Tunisia from february to june2019.All the patients were examined and assessed by one prosthodontist under the supervision of a professor. A questionnaire was used to record information wich was taken directly from the patient when they attend the dental clinic. The patient consent were taken verbally. The questionnaire included 19 questions divided in 3 heading: Medical history, exploration of pain and its intensity and Management strategies. The statiscal analysis were done with an SPSS's logiciel version 22.0. The results are presented in form of tables and graphics. Moreover, in this study the most common chief complaint was pain 63% of the sample. This result corroborate with other studies in litterature. Besides, a statistically significant relationship was observed between pain and patient’s satisfaction with their prosthesis (P=0.044<0,05). However, no significant difference was found between pain and other differents clinical Data (age, gender, general condition ….) (P>0.05). Neither between intensity of pain and different clinical data (P<0.05). This result came in argument with results of other worldwide researches. Finally, we came to the conclusion that management strategy of pain must follow a comprehensive, multidisciplinary and systemic approach.