Alternative therapies for the alleviation of chemical/xenobiotic-induced metabolic aberrations and risk factors for cardiovascular disease have been inadequately explored, despite their rich cardiovascular protective bioactive constituents. The aim of the present study was to accurately evaluate the effect of Cymbopogon citratus extract on gasoline-induced oxidative stress, hyperglycaemia, hyperuricemia, dyslipidaemia, and atherogenic index of plasma (AIP) in rats. Seventy-two female Wistar albino rats were segregated into six groups (n = 12 per group). The rats in group 1 served as controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Rats in groups 3, 4, and 5 were exposed to GV and co-administered 500 mg/kg, 1000 mg/kg, and 1500 mg/kg C. citratus leaf extract, respectively, once daily for 14 days. Rats in group 6 were exposed to GV and co-administered 200 mg/kg vitamin C for the same time period. The results showed that group 2 had significantly higher glycaemic levels, lipid parameters (TG, T-chol, and LDL-C), uric acid (UA), MDA, and AIP and significantly lower (p < 0.05) HDL-C than group 1. Co-administration of C. citratus leaf extracts in groups 3, 4, and 5 and vitamin C to group 6 significantly lowered blood glucose levels, UA, lipid parameters MDA and AIP and simultaneously increased serum HDL-C in a dose-dependent manner. C. citratus leaf extract has an ameliorative effect against GV-induced oxidative stress, hyperglycaemia, hyperuricaemia, dyslipidaemia, and AIP, probably mediated through its varied bio – constituents and their activities

Management of a case of internal root resorption is a challenge to the endodontists.Internal resorption of teeth is an insidious process and is generally found in teeth with previous history of trauma.It may occur in cases with chronic pulpal inflammation, following caries or due to trauma in the form of an accidental blow. Internal resorption is very often noticed in anterior teeth, due to their susceptibility to trauma. However, it may be seen in posterior teeth, most likely because of carious involvement of the pulp. Early diagnosis, removal of the cause, proper treatment of the resorbed root is mandatory for successful treatment outcome. This case report describes the management of theresorptive defect in the apical 1/3rd whichwas treated nonsurgically with thermoplastized guttapercha technique. A six-month follow up demonstratedclinically asymptomatic and adequately functional tooth, with radiographic signs of healing

Urinary schistosomiasis though a neglected disease is endemic in many rural communities in Nigeria and is second only to malaria. The present study was carried out to determine the current status of urinary schistosomiasis in Ilie, a rural community in Southwestern Nigeria. Urine samples were collected from 320 school pupils (4-15 years old) and examined for ova of Schistosoma haematobium. Out of the 320 urine samples examined, 131 (40.9%) had ova of S. haematobium. The prevalence of urinary schistosomiasis between the male (42.8%) and female (39.0%) participants was not significantly different (p = 0.49) but prevalence increased significantly with increase in age (p = 0.002). The overall geometric mean intensity of infection was 38.2 eggs/10 ml urine. The intensity of infection was not dependent on sex (p = 0.79) or age (p = 0.69). The overall prevalence of haematuria in this study was 26.3%. The prevalence of haematuria was independent on sex (p = 0.72) but varied significantly with age (p = 0.01). Haematuria was significantly associated with urinary schistosomiasis (p < 0.001, OR 37.1, 95% CI 19.4 - 71.0). This study shows that urinary schistosomiasis is quite endemic and still actively transmitted in Ilie and appropriate control measures are highlighted