“Specular Microscopy Analysis of Donor Corneal Tissue in a Tertiary Care Hospital- A 4-Year Review”
R S Chauhan, Chetan Chhikara, Ashok Rathi, Apoorva Goel, Chinging Sumpi, Harshvardhan Chilkoti, Nidhi Sharma
Page Numbers : 214-218
DOI : 10.36348/sjmps.2021.v07i05.003
Aim: The aim of this study was to detailed analysis of the donor corneal tissue using Eye Bank Specular Microscope (EBSM). Materials and Methods: Retrospective analysis was done for 408 donor corneas procured and processed between April 2016 and March 2020, at an Eye Bank in a Tertiary Care Hospital for Endothelial cell density (ECD), coefficient of variance (CV), and percentage of hexagonality (6A) and were compared across different age groups & gender of the donor tissue. Results: The mean age of the donors was 66.78 ± 17.27 (range 12–95 years). The mean ECD of the donor cornea was 1400.65 ± 627.01 cells/mm2; the average CV was 37.5 ± 18.2; and the average percentages of hexagonal cells were 44.9%. The cell count was significantly greater in the donor corneas in age groups of <20, 21-30 & 41-50 years when compared to rest of the age groups. There were no significant differences between the age groups on basis of CV and 6A. The ECD of the male donors (65%) was more than that of female donors (35%). Conclusion: ECD is significantly greater in younger age group as compared to older age groups; however, there were no significant differences in CV and 6A. Endothelial cell analysis by Eye Bank Specular Microscopy is a great tool for the grading of donor tissues, its subsequent utilization for corneal transplantation & prognostic value of the graft survival.
Original Research Article
May 10, 2021
“Study of Psychiatric Co-morbidity in Autism Spectrum Disorder”
Lt. Col. Anwar Parvez Bhuiyan, Brig. Gen. (Rtd) Md. Azizul Islam, Mohammad SI Mullick, Lt. Col. Salah Uddin Ahmmed, Maj. Mohammad Saifur Bayzid, Atiyah Hasin
Page Numbers : 205-213
DOI : 10.36348/sjmps.2021.v07i05.002
Background: Autism is one of the pervasive developmental disorders throughout the world that is causing serious familial, social and economic burden to the different nations. The prevalence of autism is probably about 20 per 10000 children. Autism is four times common in boys as in girls. Objective: To find out the psychiatric co-morbidity in Autism spectrum disorder. Methods: This was a descriptive and cross sectional study among the patient attending in Department of Psychiatry, Combined Military Hospital, Dhaka, Proyash School (Special Child Special Right), Dhaka Cantonment, National Institute of Mental Health (NIMH), Dhaka and Institute of Pediatric Neurodisorder & Autism (IPNA) in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. The study was carried out 6 months from April, 2016 to September, 2016. Sample size n=100 patients. Informed written consent was taken from patent’s parent/caregiver. During data collection, a semi-structured questionnaire designed by the researcher containing socio-demographic and other variables was used. Then Developments and Well-Being Assessment (DAWBA) was applied on the ASD children. The DAWBA has three versions-parent versions, self-version and teacher version. In this study parent version was used. Data was analyses by software program me statistical package for Social Sciences (SPSS) version 16 for windows using appropriate statistical test- chi square test. Results: Among the respondents (n=100) 79% Autism spectrum disorder (ASD) children had comorbid psychiatric illness and 21% children had no comorbid psychiatric illness. Most frequent 72.15% was ADHD followed by Specific phobia 11.39%, Social phobia 6.33% and Major Depressive disorder 1.27%. Two comorbid psychiatric illnesses were present in 8.86% ASD children. Chi-square test was done to measure the level of significance. But there were no significant association (significant when p value ≤0.05) found between socio-demographic factors and comorbid psychiatric disorder. Conclusion: Although there were many limitations, the present study provides important information. High number of co-morbidities found in this study. It could be necessary to increase the sample size and to collect the largest number of clinical information, for studying etiopathogenesis and risk factors for the occurrence of co-morbidity. Knowing the burden and extent of disease could be help design screening tools that are applicable, culturally acceptable and cost-effective for early diagnosis and intervention. Furthermore, raising ASD awareness among parents, preschool/elementary school teachers are invaluable in helping autistic children cope with different challenge and improve their quality of life.
Original Research Article
May 4, 2021
Assessment of Prunus amygdalus Gum for Functionality of Tablet Excipient
Sivakumar R, Komala M, Athira C, Fathima A. F, Rinseena M. G, Reshma Fathima K
Page Numbers : 200-204
DOI : 10.36348/sjmps.2021.v07i05.001
The aim of the research work is to assess the Purnus amygdalus gum for the potentiality of tablets binder / disintegrant excipient and potato starch was used as standard excipients. The gum was assessed for various tests. Ibuprofen was used as a model drug for the preparation of tablets. Totally eight batches were developed using various compositions. Pre-formulation and post formulation study were performed for the tablets. Also the tablets qualities were compared with innovator tablet. FTIR studies ruled out the drug excipient interaction. The hardness of the tablets were in the acceptable range. Disintegration time was ~4 minutes. Dissolution were between 70 – 89%. The results of the study describe that the Purnus amygdalus gum (PA ) could be alternative tablet excipients for potato starch.
Original Research Article
April 29, 2021
Pattern of Ocular Toxicity in Patients on Long-term Antipsychotic Drug
Dr. Tasnim Khanom, Prof. Dr. Md. Sanwar Hossain, Dr. Mohammad Solaiman Tanveer, Dr. Mohammad Mazaharul Islam, Dr. ASM Morshed
Page Numbers : 195-199
DOI : 10.36348/sjmps.2021.v07i04.006
Background: The eye is supported to be the second organ to manifest drug toxicity following liver. Systemic drugs are frequently administered in persons of all age group ranging from children to the elderly for various disorders. There has been increased reporting of ocular side effects of various antipsychotic drugs in the past two decades. Psychiatrists, ophthalmologists and patients need to be aware of and prepared for any medication-induced toxic effect. Early prevention and intervention can avoid most of the serious and potentially irreversible ocular toxicities. Objective: The aims of the present study were to evaluate the occurrence of toxic ocular effects of antipsychotic drugs, evaluate intraocular pressure of chronic psychotic patients treated with psychiatric medications, correlate toxic ocular effects in patients treated with a variety of antipsychotics to duration of treatment. Methods: The present study was conducted on 100 chronic psychotic patients attending the Dr. Sirajul Islam Medical College and Hospital Ltd, Dhaka, Bangladesh who on treatment of antipsychotic drugs for a period more than six months period with age group between20 - 60 years. Data was entered in MS Excel and Statistical analysis was done using SPSS trial version 22. Results: 14% of those patients were on typical therapy alone, 16% on atypical antipsychotic alone while 70% were on combined therapy. As regard lens opacity, 7% was suffered from lens opacity, six cases due to typical therapy while one cases due to atypical therapy. Intraocular pressure was manifested in 11% of all cases. Optic disc examination revealed two cases had increased cup disc ratio who on typical therapy alone. Conclusion: It can be concluded that many systematic drugs can produce ocular and visual side effect which range from mild to severe and can be even vision threatening.
April 27, 2021
Malaria and COVID 19 Interactions: The Effects of the Collision of Two Giants
COVID-19 and malaria share similar pathogenic pathways with the angiotensin converting enzyme 2 as a central initiator of signals to stimulate host cellular responses which in some instances result in multi-organ affectation. These signaling proteins are either upregulated or downregulated with the consequences of provoking immune responses with varying tissue damages. The similarities in clinical presentations, associated complications and therapeutic responses to the repurposed medications (anti-malarial drugs being used as anti-viral molecules) for the treatment of the novel disease COVID-19 have stimulated enormous interest in the recent past. The major objectives in this regard are to define the association between these two disease entities and possibly unveil options for interventions. This paper therefore aims at reviewing the molecular interactions which these diseases possibly share in their pathogenesis and phenotypic expressions and make projections for future interventions.
April 8, 2021
Thyroid Diffuse Large B cell Lymphoma: A Case Report
Ait Taleb Oum’hand Hajar, Belhaj Najoua, Mahiou Noureddine, Benyahia Zainab, Nitassi Sophia, Oujilal Abdelilah and Essakalli Leila
Page Numbers : 191-194
DOI : 10.36348/sjmps.2021.v07i04.005
Thyroid diffuse large B cell lymphoma (DLBCL) presents typically as a rapidly growing neck mass that is sometimes accompanied by respiratory compression symptoms. It is more predominant in women and has a peak onset age of 50 to 70 years . DLBCL should be treated with chemotherapy and radiotherapy after diagnosis through biopsy, and extensive surgery should be avoided. Here we describe a rare case of 63-year-old woman who was admitted in our ENT department due to rapidly growing (2 months), painful thyroid enlargement with compressive cervical symptoms.
April 6, 2021
Lifestyle Diseases: The Link between Modern Lifestyle and Threat to Public Health
Wahied Khawar Balwan, Sachdeep Kour
Page Numbers : 179-184
DOI : 10.36348/sjmps.2021.v07i04.003
Globalization and economic progress have been accompanied with an increase in the incidence of lifestyle diseases worldwide. Lifestyle Diseases are a major public health problem globally. According to World Health Organization (WHO), nearly 71% of all deaths globally were attributed to Lifestyle Diseases, a subset of non-communicable diseases (NCDs). A lifestyle disease is linked to the way a person lives. Lifestyle diseases are ailments that are primarily based on the day to day habits of people. Habits that detract people from activity and push them towards a sedentary routine can cause several health issues that lead to chronic non-communicable diseases with life threatening consequences. A primary intent of this article is to educate readers about the risk factors associated with Lifestyle diseases as well as to encourage them to follow a healthy lifestyle in order to reduce the chances of developing a Lifestyle related disease later in their lives.