Mobile phone usage has become an essential component of daily life. Several studies have raised concerns about the possible deleterious effects on the nervous system due to exposure of electromagnetic radiations. We aimed to study the effect of radiofrequency electromagnetic radiation (RF-EMR) on the spinal cord of albino rats. In the present study twenty-four adult albino rats of either sex weighing 180-200 grams each were divided into four groups: 1 control and 3 experimental and were exposed to RF-EMR via complete missed calls of 45 seconds duration each. Both the experimental and control groups were then sacrificed and spinal cord was isolated for tissue processing. The processed tissue was then stained (hematoxylin and eosin) and observed under light microscope. Light microscopy of the spinal cord showed the cellular size of the neuronal cells was reduced in dorsal and ventral horn interneurons, their nucleus was heterochromatic. Neurons were irregular, loosely arranged, darkly stained and decreased in size. Ventral horn cells of the spinal cord showed absent cytoplasm, heterochromatic nucleus with invisible nucleoli. Dose dependency with more radiation exhibit more changes in comparison to less exposed rats. From our findings, it is suggestive to protect the population living around base stations and users of mobile handsets. For this the government and regulatory bodies adopt safety standards which minimizes the hazardous effects of mobile radiation

Post-operative hearing loss is a very poorly understood complication in the medical field in general and in the Anesthesiology practice more specifically. This has been observed past three decades and yet, it still is a mystery and unresolved medical condition. Senso-neural hearing loss (SNHL) results in temporary deafness as a side-effect of a puncture during spinal (subarachnoid) anesthesia. Although it is also observed after general anesthesia, but the numbers are much less. In the present study, we report a case of 48 year old man who underwent a surgery for anal fistula incision with spinal anesthesia and complained about the hearing inability in both the ears (bilateral SNHL) started few hours after the surgery. His symptoms improved over a few days’ time with a conservative approach (rest, hydration and increased caffeine intake). There have been other reports on permanent type of hearing loss. Even though in a majority of cases, the patients recover, considering the threats from the minority, we believe that it is the responsibility of the medical staff to be aware of the patients’ condition before undertaking such surgeries and anesthesia

Heart failure is the end stage of all diseases of the heart and is a major morbidity and mortality. Unfortunately, heart failure may be difficult to diagnose clinically, as many features of the condition are nonspecific. The overall incidence is likely to increase in the future because of both an aging population and therapeutic advances in the management of acute myocardial infarction leading to improved survival in patients with impaired cardiac function. Aim: the various clinical manifestations of Chronic Heart Failure and to identify the major etiological and risk factors of Chronic Heart Failure. Methods: This study was conducted in the Department of General Medicine and Cardiology, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. Institutional Ethical committee Permission was obtained for the study. A total of 50 patients with symptoms of heart failure were included in the study. All patients selected were subjected to detailed history, clinical examination and investigations. Complete Hemogram, Serum electrolytes - Sodium, Potassium, Calcium, and Magnesium, Blood glucose levels, Renal function tests, Chest X-Ray, ECG, 2D ECHO, Serum fasting lipid profile, BUN, serum uric acid, Liver function tests, and complete urine analysis. Results: The most common sign on examination was pulmonary rales in 34(68%). Next was S3on auscultation in 31patients (62%), B/L ankle edema was noticed in 29 patients (58%), raised JVP in 24 (48%), tachycardia HR >120 bpm was noticed in 16 (32%), tachypnea RR >30 was seen in 19 patients (38%). Diabetes was noticed in 9 patients, five of them had and two were having previous h/o of IHD. Broad QRS complexes >120 msec was noticed in 12 patients (24%) had complete LBBB with very broad QRS complexes >140 msec. ...

Phenytoin is an Anticonvulsant mainly acts by promoting Na+ efflux or decreases Na+ influx from membranes in motor cortex neurons; stabilizes the neuronal membrane. Slows conduction velocity.Indicated in Seizures. A child of 12 years old of female patient came to pediatrics department with chief complaints of seizures not associated with fever. Generalised tonic clonic activity with loss of consciousness for 10 min and admitted in pediatrics department-II and his treatment chart was phenytoin 100mg PO OD and valproic acid 200mg – 200 mg – 200 mg Po 2tablets TID. During his second day of treatment child developed fever of 1020F and cough and to reduce the condition physician prescribed paracetamol 500mg Po BD and syrup chlorpheneramine maleate 5ml Po BD and increased the phenytoin dose 100 mg 2 tablets OD. On the 12th day of treatment child was irritable with hyperactive behaviour. Better vigilance is necessary for implementation of safe and effective treatment for each individual patient.in order to prevent serious adverse drug reactions of this drug, close monitoring drug treatment course, creating awareness, recognition of the problem and careful management of all the patients who receive medication are essential, because use of phenytoin causes Drowsiness, Fatigue, Ataxia, Irritability, Headache, Restlessness, Slurred speech, Nervousness, Nystagmus, Dizziness, Vertigo, Dysarthria, Paresthesia, Rash, Pruritus, Gingival hyperplasia (pediatric patients), Ataxia, Paradoxical seizure, Drug withdrawal seizure, Diplopia, Psychosis (high dose), Toxic amblyopia, Encephalopathy, AV conduction disorder, Ventricular fibrillation, Nausea, Vomiting, Constipation, Diarrhea, Megaloblastic (folate-deficiency) anemia, Hypocalcemia, Hepatotoxicity, Hypertrichosis, Lymphadenopathy, Purple glove syndrome, Rash, Allergic reactions in the form of rash or, rarely, more serious forms (drug reaction with eosinophilia and systemic symptoms, or DRESS) or anaphylaxis, Purpuric rash, Toxic epidermal necrolysis, Bullous dermatosis, Coarsening of facial features,Periarteritis nodosa,Immunoglobulin abnormalities, Altered taste sensation, including metallic taste, Peyronie disease

This study was designed to investigate the levels of blood glucose and hemoglobin among malaria infected students in Nnamdi Azikiwe University, Nnewi, Anambra State, Southeast Nigeria. A total of 100 participants (75 malaria infected and 25 control subjects) aged between 18 and 30 years were randomly recruited for the study. Thereafter, 5mls of blood sample each was collected from the subjects and dispensed in unit quantity into fluoride oxalate and EDTA bottles respectively for the determination of malaria parasites, hemoglobin (Hb) and fasting blood glucose levels respectively using standard laboratory methods. The results revealed no significant difference in the mean fasting blood glucose level (p>0.05), but there was a significant decrease in the mean hemoglobin level in malaria infected students than in control (p=0.000) respectively. Also, there was no significant difference in the mean values of fasting blood glucose level obtained between students with heavy malaria infection and those with moderate malaria parasitemia (p>0.05), while the mean hemoglobin level observed in the students with heavy malaria parasitemia was significantly lower compared with students with moderate malaria parasitemia (p=0.000). The implication of this finding is that malaria infection depletes the hemoglobin level in infected persons, thus predisposing them to the risk of anaemia

Chronic myeloid leukemia is a malignant clonal expansion of hemato¬poietic progenitor cells causally linked to a specific chromosomal abnormality, the Philadelphia chromosome. It occurs uncommonly in childhood, accounting for only 2 to 5% of all pediatric leukaemias with an annual incidence of about 1 per million in this age range. We describe one such case of chronic myeloid leukemia in an 11 year old boy, who presented with massive splenomegaly and hyperleukocytosis. The diagnosis was made from peripheral blood smear examination, supported by karyotypic study. Because of the infrequency of its occurrence, it was thought of interest to report this case of CML and to review certain interesting features of this entity in the pediatric population

In order to understand cerebral vascular disease better in stroke, we collect the reasons of prevention and control so as to find the methods. Complex network is a new tool to find the inner factors of a real system that it can be used to cerebral vascular disease to improve the prevention and control. The custom methods provide active role for prevention and control of cerebral vascular disease, which can work together with complex network to get better. The design method of stroke based on complex network will provide the novel window for Cerebral vascular disease

In order to make full use of data of stroke and find the potential characters, we use computer algorithm to model the stroke so as to comply with the evolution of stroke disease. In order to visual express the complex reason of stroke, we use complex network to model the stroke so as to express the complex reason and describe the relation of stroke structure and function. Computer model and complex network model should be combined with stroke standard method and custom index, which are more direct for clinical index and practice. Hybrid methods for research of stroke are a test to model, prevention, control and serve for stroke and other clinical disease