Stroke is one of the main causes of mortality and disability in developed countries. In acute ischemic stroke, the standard treatment is recombinant tissue plasminogen activator (rt-PA). The benefits of the treatment depend on the time of administration, the earlier it is administered, the greater its benefit. There are limited studies on the retrospective outcome of thrombolytic therapy in patients with acute ischemic stroke outside of clinical trials. The present retrospective study aimed to analyze the clinical data of 40 patients over 7 years who were hospitalized with acute ischemic stroke at the AHEPA University Hospital in Greece. From January 2013 to December 2020, 40 patients with acute ischemic stroke were admitted and treated. Computed tomography (CT) was performed at 24 h after thrombolytic treatment or earlier in case of neurological worsening. The hospital had 3 months follow-up at the stroke clinic and data consisting of the National Institute of Health Stroke Scale (NIHSS), functional outcome assessed by modified Rankin Scale (mRS) and mortality were reviewed in the medical records from the stroke clinic. The clinical outcome of functional independence defined by the modified Rankin Scale (mRS) ≤ 2 at 3 months was evaluated. Safety outcomes were in-hospital mortality, mortality at 3 months, and symptomatic intracerebral hemorrhage (sICH) defined by the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) criteria. The main finding of the present study, that there was an overall reduction in the NIHSS scale after thrombolysis, proves that the patients showed improvement after performing thrombolysis. Consequently, from the total of 40 thrombolysis performed at the clinic, it can be concluded that most patients had a good outcome.

Cosmetology is a rapidly growing field, resulting in increasing numbers of beauty centers and beauticians. Ear piercing is a common practice in Nigeria and, in recent years piercing of other body parts has greatly increased in popularity. Beauty treatments, such as piercing, tattooing, manicuring, and barbing are used by many people. Individuals working in barber shops, hairdressing and beauty centers are likely to have contact with blood through applications such as shaving, manicure, pedicure and skin care. The aim of this study was to determine hepatitis B virus (HBV) seroprevalence in a sample of beauticians in Yenagoa local government area, Bayelsa State (Nigeria) and to assess the level of knowledge of these professionals regarding viral hepatitis. This was a descriptive cross-sectional study involving a total of 120 beauticians (hairdressers and manicurists/pedicurists) that were selected by a multistage sampling method. Data was collected by an interviewer-administered questionnaire for knowledge assessment and serum samples were tested for HBsAg positivity using commercial enzyme-linked immunoassay (ELISA) kits. Data collected were analyzed using the statistical package for social science (SPSS), version 25 software. Of the total 120 participants 16 (13.3%) were males and 104 (86.7%) were females. The prevalence of HBV infections among the respondents was 7.5%. The knowledge of beauticians on awareness of viral hepatitis B was 5.8%, and their knowledge on ways of transmission was 61.7%. Conclusions: the findings indicate that, due to their low level of awareness of viral hepatitis B existence, beauticians working in Yenagoa Local Government Area are in a risk of HBV infection even though the seroprevalence of HBV was low.

Introduction: Grave’s Disease (GD) and Hashimoto's Thyroiditis (HT) are two autoimmune diseases whose coexistence is rare. We report a case of a patient in whom both diseases manifested simultaneously. Case report: A 36- year-old woman presented with thyrotoxicosis. She had tachycardia with WHO grade 2 homogeneously non-pulsatile goiter, without exophthalmos. The evaluation revealed peripheral hyperthyroidism with positive anti-thyroid peroxidase (anti-TPO) antibodies and anti-thyroid-stimulating hormone receptor (anti-TSHR) antibodies. Cervical ultrasound revealed a goiter affecting the right lobe in the context of thyroiditis. Thyroid scintigraphy indicated a picture suggestive of Graves' disease in the left lobe and hypocaptating thyroiditis in the right lobe. The patient was treated with propranolol and Carbimazole, with alternating phases of hyperthyroidism and hypothyroidism. Discussion and Conclusion: Autoimmune thyroid diseases, GD and HT, are specific to the thyroid gland and are common in women. They share pathogenic features that could explain their association, including genetic and environmental factors leading to thyroid cell damage, T-cell-mediated autoimmunity, human leukocyte antigen binding, and the presence of autoantibodies such as anti-thyroid peroxidase antibodies in GD. Rare cases have demonstrated that HT can manifest after GD, and vice versa, leading to an alternation of hyperthyroidism and hypothyroidism in certain patients due to changes in the balance between various categories of antibodies. In the present case, the patient simultaneously presented both diseases.

The global burden of diabetes is becoming alarming; this has been aggravated by the change in lifestyle patterns which has encouraged the high prevalence of diabetes noticed today. The oil and gas company workers over the years have been predicted to have an increased prevalence of diabetes which has been attributed to the affluence of this population. The aim of this study is to determine the prevalence of diabetes and its associated factors among oil and gas company workers in Port Harcourt. The present study aim was to determine the prevalence of diabetes and its associated factors among oil and gas company workers in Port Harcourt. The study was carried out using a descriptive cross-sectional study and data’s were collected using a questionnaire. A total of 376 questionnaires were administered and 318 questionnaires were retrieved from three oil and gas companies in Port Harcourt. Majority (51.9%) of the workers were above 40years of age. (72.01%) were married and Christianity (94.03%) was the main form of religion as recorded in the study. The study revealed that (56.1%) of the workers have poor dietary habit as against (43.9%) that have good dietary habit. The mean BMI of the workers (26.5) shows that majority (40.9%) of the workers are overweight, which depicts the nutritional status of the workers. The overall prevalence of diabetes in this study is (19.8%) and of all the risk factors predicted to be associated with the occurrence of diabetes, only women who have given birth to babies weighing more than 4kg at birth showed an association with an adjusted odd ratio of 4.79(1.34-17.11) 0.016. Therefore, there is a significant association between women who have given birth to babies weighing more than 4kg at birth and the occurrence of diabetes. Management of the oil companies, through the health education department should encourage exercise and diabetes management education to curtail the growing prevalence of diabetes.

Background: Substance Use Disorders (SUDs) impose significant challenges not only on individuals grappling with addiction but also on the caregivers who provide support and care. The caregiving role is associated with multifaceted burdens that require understanding and targeted interventions. Recognizing the diverse dimensions of caregiver burden is crucial for offering effective support. Objective: The study aimed to find out the caregiver burden in substance use disorder patients, examining severity and socio-demographic correlations, contributing insights into effective support strategies. Methodology: The cross-sectional observational study took place at Sylhet MAG Osmani Medical College's Psychiatry Department and a private psychiatric and drug rehabilitation center in Sylhet from September 1, 2018, to August 31, 2020. The research focused on substance use disorder patients and their caregivers, involving 50 eligible patients selected through inclusion and exclusions criteria. Diagnoses followed DSM IV criteria. Socio-demographics were gathered via semi-structured questionnaires. Caregiver burden was assessed using the Bengali Zarit Burden Interview (ZBI) scale through approximately hour-long interviews, with 1-2 daily. Ethical procedures encompassed informed consent and confidentiality assurance. Result: The study included 50 male participants. Patients mean age was 31.92 (±8.21) and caregivers mean age was 41.68 (±12.89). Mainly, caregivers were mothers (40%) and wives (34%). Caregivers experiencing moderate to severe burden were 58%, mild to moderate burden were 26%, and severe burden were 16%. Mean ZBI score was 48.22±13.55. Higher burden correlated with illiteracy, low family income, excessive drug spending, prolonged substance use, and multiple drug usage. Alcohol users faced more burden than other substance users. Female caregivers, younger age, and housewives experienced heightened burden. No burden links were found with marital status, habitat, religion, family type, or drug administration method. Conclusion: This study concluded that Substance use heightens caregiver burden, notably among female, young, and housewife caregivers. Addressing these trends is vital for effective care of substance use disorder patients.