The hemorrhagic syndrome in its clinical, cutaneous and ocular diversity most often constitutes the circumstances in which acute leukemia is discovered. Digestive mucosal involvement is rarely indicative of serious bone marrow failure, thus posing a problem of etiological diagnosis in a gastroenterological medical setting [1]. In the literature, it varies from 2 to 10-15% depending on the study and is considered a sign of poor prognosis requiring early diagnosis for better management [2]. We report a case of a 59-year-old woman admitted for rectal bleeding associated with an anemic syndrome. The initial clinical examination showed a finger cot stained with bright red blood. The blood count had shown anemia at 6.4g/dl microcytic, normochromic, neutropenia at 1.8x103, thrombocytopenia at 36.103. Colonoscopy and esogastroduodenoscopy were normal. Blood smear and myelogram were in favor of Acute Myeloid Leukemia. Karyotype and immunophenotyping were not performed. Symptomatic treatment was offered. The evolution is marked by the improvement of the clinical signs. This association, acute myeloid leukemia and rectal bleeding is rarely described in the literature.

Background: Acne vulgaris is a common dermatological problem. Acne is most commonly found in adolescents, caused by increased androgens in both sexes. It is usually caused due to Propionibacterium acnes. Minocycline is a newly introduced drug in treating acne vulgaris. On the other hand, it is assumed that azithromycin having a long half-life like can be very effective with better compliance in treating acne vulgaris. But we have not enough research-based comparative data regarding this issue. Objective: The objective of this study was to compare the efficacy and safety of azithromycin pulse therapy with minocycline in treating acne vulgaris. Methods: This was a prospective, comparative study and was conducted in Department of Dermatology, Naogaon Medical College, Naogaon, Bangladesh, during the period from January 2021 to December 2021. In total 80 patients with moderate-to-moderately severe (Grade II and III), acne vulgaris were included in the study population. Patients were randomly assigned to two treatment groups of group A & group B respectively. In group A, there were 25 patients received 500 mg azithromycin once a day for 3 days per week as pulse therapy along with 0.05% topical tretinoin for 3 months whereas in group B, there were another 25 patients received 50 mg minocycline twice a day along with 0.05% topical tretinoin for 3 months. All data were processed, analyzed, and disseminated by SPSS version 23.0 and MS Office program. Results: In this study, group A (Azithromycin) between baseline and final score distribution we found a significant correlation (P=0.023). On the other hand, in group B we did not find any significant correlation (P=0.073). In analyzing the changes in severity score of acne from baseline to the final assessment of both groups we observed, in group A at baseline 15%, 38%, and 48% of participants had the score points 2, 3, and 4 respectively whereas in the final stage 63%, 30%, and 8% participants had the score point 1, 2 and 3 respectively. So, in group A between baseline and final score distribution, we found a significant correlation (P=0.023). On the other hand, in group B at baseline 10%, 40%, and 50% of participants had the scored points 2, 3, and 4 respectively whereas in the final stage 65%, 28%, and 8% of participants had the score point 1, 2 and 3 respectively. In group B between baseline and final score distribution we found P value 0.073. Conclusion: In this study, the efficacy of both azithromycin pulse therapy and minocycline was found satisfactory. But as per the findings regarding the safety profiles, we can conclude that minocycline is safer than azithromycin pulse therapy in treating acne vulgaris.

Introduction: The incidence of rheumatic fever is decreasing day by day in Bangladesh. Recent advances in the diagnosis and management of Rheumatic fever are demanding a review of the cause of Rheumatic fever. The illness may present itself in several ways, such as carditis, arthritis, chorea, subcutaneous nodules, and the recognizable erythema marginatum rash [2]. Aim of the Study: The aim of the study was to observe the rate of sore throat in patients with rheumatic fever. Methods: This retrospective study was carried out at the National Centre for control of Rheumatic fever and heart disease, Sher-c-Bangla Nagar, Dhaka. The study period was 11 months, starting from January 2019 to November 2019. The study was performed on recorded data of 300 patients with Rheumatic fever. Result: The present study showed that 30 (10%) patients out of 300 came with an acute sore throat, 216 (72%) patients with a history of sore throat, and 54 (18%) patients with no history of sore throat either acute or past. Rheumatic fever is undoubtedly a morbid one but can be prevented at its beginning by primary prophylactic measures. Conclusion: Rheumatic fever is a disease, which usually follows streptococcal infection of the throat. The study's underlying presumptions appear to overstate rather than understate the dangers of non-antibiotic sore throat treatment. Low socio-economic status, poverty, illiteracy; overcrowding, low levels of nutrition and non-immunization status were the predisposing factors in the causation of rheumatic fever.

Background: Helicobacter Pylori (H. pylori) infection is a major gastric infection worldwide and has been associated with many hematologic disorders. Objective: The purpose of this study was to determine the effect of H. pylori infection on Sudanese people. Method: Blood samples are collected from 60 persons; 30 patient (as sample) and 30 patients (as control sample). Vitamin B12 and complete blood count (CBC) tests are performed. Results: The results revealed that Vitamin B 12 level mean was significantly lower among H. pylori patients than the controls (p-value 0.013). The results also revealed that there are no significant differences between gander in vitamin B12 level among patients. The correlation between vitamin B12 and age was found to be negative (R=0.444 & P=0.014). Conclusion & Recommendations: Vitamin B12 level, HB and RBC are lower in H. pylori infected Sudanese individuals compared to the normal people. Thus, we highly recommend for further research and case-control studies in discovering the causal factors related to reduction of vitamin B12 among H. pylori infected Sudanese individuals.

Introduction: The lipid profile of a Bangladesh population, which has a lower prevalence of coronary heart disease, compared with others nations, is studied to determine whether lipid-modifying disease prevention programs are necessary. Aim of the Study: The aim of the study was find out the Lipid Profile and Its Association with Risk Factors for Coronary Heart Disease. Methods: This is a cross-sectional study; a total of 172 patients were enrolled and analyzed. The study conducted during January 2020 to December 2020 at the Department of Cardiology in Department of Cardiology, Shaheed M. Monsur Ali Medical College, Sirajganj, Bangladesh. Result: The study population is shown in more than 30% of patients had hypercholesterolemia, 41(23.84%) patients were at the high borderline (5.17-6.19), and 38(22.09%) patients had high-density lipoprotein. Under low-density lipoprotein, 7(4.07%) patients had high LDL-C, and only 2(1.16%) patients had very high LDL-C. The age distribution of the study; 33.72% of patients were from the age group 40-49 years, and 17.44% of patients were aged more than sixty years. Conclusion: WHR is associated with an increase in TG, TC, and LDL-C and supports the view that abdominal obesity may be an important cardiovascular risk factor. This study emphasizes the role of HDL-C, which may avert the CHD risk in females. Further studies with longitudinal data are needed to assess the risk factors for CHD in high-altitude populations.

Background: Pulmonary stenosis (PS) is one of the common congenital heart diseases (CHD) with the incidence of 8-10% of all CHD. Percutaneous balloon pulmonary valvuloplasty (PBPV) is considered as the treatment of choice for these purposes. It is a safe, effective and less time-consuming procedure. But in Bangladesh, we have very limited research-based data regarding the effectiveness of percutaneous balloon pulmonary valvuloplasty in treating pulmonary stenosis. Aim of the Study: The aim of this study was to evaluate the immediate and intermediate term outcome of percutaneous balloon pulmonary valvuloplasty in treating pulmonary stenosis. Methods: This was a hospital based prospective observational study conducted from January 2021 to December 2021 at Combined Military Hospital (CMH) Dhaka, Bangladesh. Interventional work was completed during the first 06 months and follow up was completed during the remaining 06months. A total of 50 patients were evaluated who had undergone PBPV by detailed clinical history, thorough physical examination and relevant investigations, like- CXR, ECG and Echocardiography. All data were processed, analyzed and disseminated by using MS Excel and SPSS version 24 program as per necessity. Results: In this study, two cases were undergone double intervention. During the procedure all cases developed bradycardia and 5(10%) developed cardiac arrest. Immediately after the procedure RV pressure was reduced and PA pressure was increased and PS gradient was reduced dramatically. The peak-to-peak pressure gradient across pulmonary valve reduced from pre-procedure value of 76.8± 5.41mmHg to post procedure value of 18.14±6.88 mmHg which is statistically significant (P<.00001). On D1 Echocardiographic follow up, 13 cases developed trivial pulmonary regurgitation (PR) and after that at D30 follow up, 1 patient developed mild PR out of these 13. In our study 46(92%) cases were successful and 4(8%) and procedure failed; out of these 04 procedures failed cases 3(6%) cases developed restenosis, one patient on D30 Echo and two cases on D90 Echo, D180 Echo do not develop any complications. Other than 3 restenosed cases all 47(94%) cases were leading healthy life without any unwanted events. All the restenosed cases had dysplastic pulmonary valve (PV). RV function of 50(100%) cases was good both in pre and post procedure as evidenced by normal TAPSE ranges from 15-22. Chest X- Ray (CXR) and Electrocardiography was found normal in 180 days follow up. Conclusion: Percutaneous balloon pulmonary valvuloplasty (PBPV) is already considered as the gold standard in the treatment of valvular pulmonary stenosis. This patient friendly procedure should be taken as a first line interventional treatment for congenital as well as post-operative valvular pulmonary stenosis. This study showed excellent outcome among study population without major complications and mortality and recommend PBPV as the first-choice therapy in our setup.

Background: The chest radiograph provides excellent contrast between the air-filled, cardiac, and aortic outlines. Deviations from normal measurements suggest pathology. This study was aimed at measuring the selected normal chest morphometry of Nigerians residing in Port Harcourt to establish a baseline for people in a normal condition. Materials and Methods: This was a retrospective descriptive study carried out in the Radiology Department of the University of Port Harcourt Teaching Hospital, Rivers State. The study duration was 8 months (January–September, 2021), which involved four hundred and forty-eight (216 males and 232 females) normal chest radiographs of adult Rivers aged between 18 and above. The radiographs were found to be normal by a qualified radiologist in the department. Random sampling was used to determine the sample size for the study. Results and Discussions: For adult males aged 18 and up, the mean values of all measured parameters were: TAD (cm): 4.15 ±21.54; TCD (cm): 10.88 ±1.55; WITD (cm): 26.06 ±3.25; and mean age (yrs): 44.15 ±21.54. TAD (cm) was 5.11±0.69 in females, TCD (cm) was 10.8±21.50, WITD (cm) was 26.05±2.98 and the mean age (yrs) was 40.93±20.22. In the two variables (TCD and WITD), the males had slightly higher values than the females, although not significantly higher, while the females had a higher TAD, also not significantly higher. Conclusions: The correlation between the transverse aortic diameter and the transverse cardiac diameter for female subjects; the correlation between the transverse aortic diameter and the transverse cardiac diameter for male subjects; and the correlation between the transverse cardiac diameter and the widest internal thoracic diameter were all positively correlated (r = 0.611, r = 0.566, r = 0.822, P 0.05).