Abstract: Large numbers of drugs are used in the treatment of hypertension and Calcium Channel Blockers are an important group among them. Cilnidipine is a new calcium channel blocking drug distinguished from other L-type calcium channel blockers with additional N-type of calcium channel blocking property. Cardioprotective, renoprotective and neuroprotective action of cilnidipine can provide additional benefit in form of reduced morbidity in the management of hypertension by controlling sympathetic over activity.

Abstract: The oil shale of the down area ES4 in the center Damingtun Depression which is wide distribution and large thickness. The ES4 depression is the most important source oil rocks and has a good tight oil reservoir, what is the key area of tight oil exploration and development in Liaohe Depression. The key factors affect the fracture extent of tight oil reservoir rock and mining effectiveness is the brittleness of rock. By transverse and longitudinal wave sonic logging data to calculate the object of the study area tight oil reservoir horizon dynamic style modulus and Poisson's ratio dynamic, application Rickman rock brittleness index calculation formula to calculate the tight oil reservoirs brittleness. On this basis, Damintun Depression ES4 tight oil reservoirs in the oil shale carbonate quality oil shale, silty shale, siltstone and shale lithology dolomites five kinds of brittleness analyzed establish superiority brittleness index lithologic sequences. The results show that the best index of brittleness shale dolomite, the brittleness index greater than 40 accounted for 92.43%. It is advantageous purpose layers of dense oil Hirai fracturing.

Abstract: In this paper, we propose and analyze a new non-monotone pattern search method for unconstrained optimization problems. Actually, we combined a new strategy of non-monotone technique with the traditional pattern search method. Then some properties of the new algorithm are analyzed. Theoretical analysis shows that the new proposed method has a global convergence under some mild conditions.

Abstract: In this paper, we propose a non-monotone trust region algorithm based on conic model for unconstrained optimization problems. The method combines a non-monotone technique and a trust region method. Different from the usual trust region methods, the sub-problem of our new algorithm is the conic minimization sub-problem. The theoretical analysis indicates that the new method has the global convergence under some reasonable conditions.

Abstract: Self-directed learning is increasingly used in higher education and has special importance in the context of healthcare education. In this single-center cross-sectional study, we aimed to study self-directed learning readiness among medical students at Umm Al-Qura University. Eight hundred medical students from the Faculty of Medicine at Umm Al-Qura University in Makkah, Saudi Arabia, participated in the study. Participants were from all academic years (1st year to 6th year) and included both genders. They completed a self-administered questionnaire that identified demographic characteristics and also contained Fisher’s Self-Directed Learning Readiness Scale (SDLRS). Among these students, 99 (12.4%) scored below average on the SDLRS, 293 (36.6%) obtained an average score, and 408 (51%) scored above average. The highest SDLRS mean score was 4.41 for the item “I want to learn new information,” and the lowest SDLRS mean score was 2.94 for the item “I set strict time frames.”About half of the medical students scored above average (i.e., were high achievers), which is encouraging. Implementing time management skills into different teaching modules might improve the teaching outcomes.

Abstract: Women’s health status is affected by complex biological, social and cultural factors, which are interrelated and only can be addressed in a comprehensive manner. Reproductive health is determined not only by the quality and availability of health care, but also by socio-economic development levels, lifestyles and women’s position in society. Women health is compromised not by lack of medical knowledge, but by infringement on women’s human rights including reproductive health rights. Poor women, who lack adequate food, basic health care, or modern contraception, suffer grave consequences for reproductive health. A woman who is malnourished and in poor health runs much greater risks in reproductive health issues and usually suffers without proper treatment and dies in most of cases. The aim of the present study to find out the factors affecting women’s reproductive health in Punjab. Multistage sampling techniques were used for data collection. At the first stage two Districts i.e. Faisalabad and Multan of Punjab province were selected randomly. At the second stage four tehsils, two from each district (Tehsil Faisalabad and Tehsil Jaranwala from District Faisalabad and Tehsil Multan and Tehsil Shujabad from District Multan) were selected randomly from the selected districts, than 12 localities, three from each tehsil (Chak No. 59/JB, 30/JB & 31/JB from Tehsil Faisalabad, Chak No. 60/GB, 55/GB & 54/GB from Tehsil Jaranwala and Khokhran, Mithal Shah and Gondian from Tehsil Shujabad and Ghalu, Sanhbai and Hasnabad from Tehsil Multan) were selected randomly. A sample of 300 respondents (25 from each locality) selected purposively. It was found that majority of the respondents were eating vegetables and less than a half of them were drinking milk on daily basis. It is clear from the findings that the respondents had many health problems i.e. headache (61.7%), high blood pressure (60.3%), back pain (54.7%), swelling on different body parts (41.3%), irregular menses (33.0%), hand, facial swelling (32.7%), urinary complications (28.3%), cramps and abdominal pain (26.7%), vaginal bleeding (25.0%) and some of them had anemia and heavy bleeding. Less than a half of the respondents (45.0%) used any contraceptive method and one-fourth of them were observed its side effects. Bi-variate analysis shows that education, income and age at marriage were positively associated with reproductive health status and age and total no. of pregnancies were negatively associated with reproductive health status. There is a dire need to improve the health facilities available at government Health Centers especially at BHUs to address the reproductive health problems that will surely improve women’s health status.

Abstract: Interlayers commonly found in the river sand inside, by studying how it is formed, for the restoration of river sand deposition process，reservoir genetic mechanism has an irreplaceable role. Based on the principle of sedimentology analysis, interlayers and sand body is the product of a certain deposition, both closely integrated into a unified whole, by studying the causes interlayers can be assisted genesis of reservoir sand bodies. Different types of channel sand bodies have different internal configuration, the underground reservoir sands internal structure is difficult to directly study, such as changes in its occurrence is difficult to identify, and interlayer is relatively easy to study. Thus, the sand can be studied by studying the interior configuration thin interlayer. Because of its low permeability or permeable, interlayer flooding on oil displacement agent has a certain shielding effect, interlayer internal fluid reservoir seepage can play spoiler, limiting the role. Channel sand reservoir characteristics can be changed according to their internal Interlayer displacement path, influence displacement efficiency, thereby affecting the inner layer of remaining oil distribution, especially for high water cut stage remaining oil distribution in complicated situations, interlayer study can effectively guide field development.

Abstract: Depositional system analysis is an important part of basin analysis,also, it is the foundation of sequence stratigraphic research, and of important significance for understanding the evolution of the basin. It plays an important role in studying distribution of sedimentary facies, reservoir evaluation and hydrocarbon accumulation. According to the well logging data and core data analysis, the sedimentary system is a complete and typical contraction system domain, the sedmentary microfacies it mainly develops are underwater distributary channel, debouch bar and sheet sand. Combined with the north provenance, the northern sedimentary system decided that the sand bodies in the north region of the study area are more developing. Also, the area that river flowed has a great scale.

Abstract: Retail environment in Malaysia was changed especially in food and grocery segment when hypermarket format was introduced by foreign retailer in 1993. In this paper we tried to understand consumer decision during shopping food and grocery either hypermarket is a main location or not. An empirical study, which was carried out in Shah Alam with 400 grocery shopper as respondent showed no significant relationship between shopping decisions and demographic characteristic except marital status. On the other hand, only two out of five trips characteristic showed significant relationship namely trip frequency and companion during shopping in hypermarket.

Abstract: The Junggar basin in Jimsar depression X group’s lithology give priority to fine siltstone, micritic dolomite and transition rocks, the average porosity is 9.17%, the average permeability is 0.15 mD, belongs to low porosity, low permeability reservoir. With the method of conventional high pressure mercury injection experiment we find out that, Reservoir microscopic pore structure change is poor; with the method of Constant velocity mercury injection experiment learned that, Reservoir percolation ability is mainly composed of throat radius distribution and pore throat radius ratio distribution.