Background and Objective: Staphylococcus aureus is a major human pathogen responsible for a wide range of clinical infections. While aminoglycoside antibiotics are vital for treating staphylococcal infections, resistance to these agents is an increasing global concern. This study aimed to determine the prevalence of aminoglycoside-modifying enzyme genes [aph-3 and armA] in clinical isolates of S. aureus from various hospitals in Khartoum State. Materials and Methods: A cross-sectional study was conducted between May and August 2022. Seventy-two [72] S. aureus isolates were obtained from clinical specimens, including wound swabs, blood, and aspirated fluids. The isolates were identified using standard biochemical tests. Antimicrobial susceptibility testing for amikacin and gentamicin was performed using the disk diffusion method. All 72 isolates were analyzed via multiplex polymerase chain reaction [PCR] to detect the presence of the aph-3 and armA resistance genes. Results: Of the 72 S. aureus isolates, 35 [48.6%] were positive for at least one resistance gene. Specifically, the aph-3 gene was detected in 34 [47.2%] isolates [including one isolate carrying both genes], while the armA gene was detected in 2 [2.8%] isolates. Phenotypic resistance was found to be higher for amikacin than for gentamicin. Statistical analysis showed no significant association between the presence of these genes and patient gender, age, or specimen type [p > 0.05]. Conclusion: This study concludes that the aph-3 gene is the predominant aminoglycoside resistance marker among S. aureus isolates in Khartoum State. The low prevalence of the armA gene suggests it is currently a less common mechanism in this region. The high frequency of resistance to amikacin underscores the need for continuous molecular surveillance to guide effective antimicrobial therapy.

Antibiotic contamination in aquatic ecosystems drives the dissemination of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs). While heterogeneous photocatalysis using metal-free porous organic polymers (POPs) and covalent organic frameworks (COFs) offers a sustainable remediation strategy, current literature predominantly focuses on parent pollutant disappearance rather than fundamental degradation bottlenecks. This review critically addresses this gap by evaluating the inherent molecular trade-offs governing COF/POP design, the mechanistic pathways of real-water matrix interference, and the ecotoxicity of transformation products. Furthermore, we provide a critical Life Cycle Assessment (LCA) and Techno-Economic Analysis (TEA) perspective on synthesis versus performance, concluding with a standardized reporting checklist to guide future research toward practical, pilot-scale implementation.

Leaks and misuse of banking customer personal data in Indonesia are increasingly common along with the acceleration of digital transformation. Although Law Number 27 of 2022 concerning Personal Data Protection (PDP Law) has been passed, the burden of proving fault still often presents a challenge for customers as the injured party. This study aims to analyze the urgency of implementing the principle of strict liability as a legal protection instrument for customers in cases of personal data misuse by banking institutions. The research method used is a normative juridical approach with a statutory approach and a conceptual approach. The results show that the application of the principle of fault liability in the highly regulated banking industry is no longer relevant due to information asymmetry and the complexity of information technology systems. Adopting the principle of strict liability holds banks accountable for any failure to protect data without requiring customers to prove fault on their part. The implementation of this principle is expected to encourage banking institutions to maximize cybersecurity standards while providing legal certainty and redress for customers more effectively and efficiently.

Desertion, a novel by Abdulrazak Gurnah, has been widely noted for its insightful examination of colonial history and its impact on individual lives. Within this novel, the central female character, Rehana, has a destiny that is very closely connected to space. Using Rehana as its focus, this study seeks to explore the memory predicament and reconstruction pathways of marginalized women within a postcolonial context. Utilizing a close reading methodology and drawing on Gabriel Zoran’s spatial narrative theory, this research undertakes an analysis structured around three key dimensions: topographical space, textual space, and chronotopic space. The findings reveal that Rehana’s spatial mobility enables her to transition from being “abandoned” to actively “abandoning,” thereby achieving memory reconstruction. This transformation underscores the subjectivity of marginalized women and provides a significant framework for comprehending individual memory predicaments and identity reconciliation within a postcolonial context.

Introduction: Central Serous Chorioretinopathy (CSCR) is an eye condition in which fluid builds up under the retina, the light-sensitive layer at the back of the eye. This fluid accumulation causes a small detachment of the retina, leading to blurred or distorted vision. Many individuals with CSCR recover their vision completely, but some may experience persistent or recurrent problems depending on the type and duration of the condition. This paper presents a case of CSCR treated successfully using Yoga Prana Vidya healing protocols. Method: A 44-year-old male who is a US resident came with a history of blurred vision which became a distorted vision within 2 days underwent Yoga Prana Vidya (YPV) distant healing sessions by an Associate Certified YPV Healer for 12 days continuously and once in 3 days for next 15 days and once in a week till date. Results: The patient reported noticeable improvement in his vision after the healing sessions, which was subsequently confirmed by ophthalmological evaluation. Conclusion: Yoga Prana Vidya (YPV) healing may be a helpful complementary approach for managing central serous chorioretinopathy by reducing stress and supporting natural healing.

There is concrete evidence of cults that continued to be practiced despite their official prohibition. If human sacrifices were known in Jewish antiquity and if practices can persist in marginal groups, then the blood libels may be explained as the occasional detection, on the part of Christian communities, of a practice that had survived in certain marginal or heretical Jewish groups, or that had been transformed into an esoteric ritual. The veracity or falsity of this hypothesis cannot be determined with certainty, and therefore, the assertion that all blood libels are false is as unproven as the assertion that some are true. In Gaza there occurs a slow and almost daily sacrifice of the population: continuous immolation of civilians, structurally analogous to the herem of ancient Israel. Here we present the full text of the third edition of Jewish Morality and the Blood Mystery written by Theodor Fritsch (Athanasius Fern). It is enlarged with many additions.

Industrial production systems face disruptions caused by machine failures, material delays, workforce shortages, and changing production requirements. Conventional scheduling and maintenance practices often operate separately, limiting coordinated responses to changing operational conditions. This study proposes a Digital Twin enabled adaptive production and asset coordination framework that integrates machine degradation, Remaining Useful Life (RUL), workforce capacity, material availability, and disruption states within a virtual production environment. A co-simulation layer represents machine workforce interactions, while an adaptive multi-objective scheduling layer considers makespan, schedule deviation, energy consumption, material waste, recovery time, and operating cost. An Adaptive Twin-Reinforcement Learning (ATRL) layer incorporates carbon and waste considerations into disruption recovery decisions. A hierarchical edge cloud architecture supports local schedule repair and cloud-based policy updates. The framework is evaluated through synthetic simulation scenarios involving machine failures, demand surges, supply delays, workforce shortages, and simultaneous resource disruptions. Results show that the proposed framework reduces makespan from 120 h to 94 h and recovery time from 34 h to 17 h compared with static scheduling. Lower energy consumption and material waste are also observed across the evaluated scenarios. The findings indicate that Digital Twin-based adaptive coordination can support resilient production planning, asset management, sustainability-aware recovery, and operational decision-making under dynamic industrial conditions.