A series of novel substituted 2-((3-chloro-2-methylphenyl) ((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)amino) benzoic acid (5a-l) derivatives were synthesized using a multi-step synthetic route involving the click chemistry approach. The structures of the synthesized compounds were confirmed using various spectroscopic techniques, including NMR, IR, Mass and elemental analysis. The antibacterial and antifungal activities of the synthesized compounds were evaluated against a panel of bacterial strains (including B. Subtilis, B. Sphaericus, and S. Aureus, P. Aeruginosa, K. Aerogenes and C. violaceum) and fungal species (such as C. albicans, A. Fumigatus, T. Rubrum and T. mentagrophytes). The results revealed significant inhibitory effects, with some derivatives showing superior activity compared to standard drugs. Additionally, the cytotoxicity of these compounds was assessed against human cancer cell lines (MCF-7, PC-3, and HeLa) using MTT assays. Several derivatives exhibited potent cytotoxic effects, indicating their potential as anticancer agents. Molecular docking studies of newly synthesized derivatives 5a-l, along with Doxorubicin and Tamoxifen, against enoyl reductase (PDB ID: 1QSG) indicate potential inhibitors for lipid biosynthesis in cancer therapy.

Wearable cardiovascular devices have emerged as essential tools for continuous heart rate monitoring. Especially for the early detection and management of heart related conditions. This article explores the advancements and functionalities of four categories of the wearable heart monitoring products like, smart patches, in – ear heart monitoring devices, smartwatches and smart rings. The smart patches offer clinical grade heart rhythm data with mobility, allowing real- time analysis without hospital equipment. In- ear monitors, utilizing photoplethysmography (PPG) sensors, provide accurate readings from the ear canal due to its rich blood supply. Smartwatches combine multi sensor capabilities, including heart rate, blood oxygen levels, and ECG, with smartphone integration for user friendly health tracking. Smart rings, the most discreet among them, prioritize minimalism while offering essential metrics like heart rate variability (HRV), sleep, and activity data. These technologies collectively push the boundaries of personalized healthcare, providing accessible, real time cardiovascular monitoring.

This narrative review comprehensively evaluates the clinical applications and effectiveness of oral irrigators (water flossers) compared to traditional interdental aids in the management of periodontal and peri-implant diseases. Drawing from an extensive literature search across databases including PubMed, Embase, MEDLINE, and Google Scholar (1971–2025), the review covers historical evolution, current usage patterns, device classification, and future technological advancements in water flossing. Oral irrigators, which utilize pulsating and pressurized water streams, have demonstrated efficacy in plaque removal, reduction of gingival inflammation, and improved access to subgingival and interproximal areas—particularly beneficial for patients with implants, orthodontic appliances, or compromised manual dexterity. Clinical evidence indicates that water flossers are often superior or at least equivalent to dental floss and interdental brushes in reducing bleeding on probing, plaque indices, and inflammatory markers. Furthermore, their synergistic use with antimicrobial agents such as chlorhexidine enhances their therapeutic impact. While water flossers show promise in improving patient compliance and oral hygiene outcomes, certain limitations—such as the risk of transient bacteremia and microbial colonization—warrant further investigation. Innovations like app-controlled devices, biofeedback mechanisms, and AI-driven water flow adjustments represent the future of personalized oral hygiene. Overall, water flossers emerge as effective, patient-friendly tools with broad utility in modern dental care. Continued research and innovation will further solidify their role in promoting periodontal and peri-implant health.

Fifteen coal samples were collected from Dangote, Zouma. and Omelewu coal sites, Kogi, State. Five samples from each site were subjected to laboratory tests which include proximate analysis, ultimate analysis, calorific value and total Sulphur content determination to determine their suitability for power generation. ASTM D3173, ASTM D5142, ASTM D3175, and ASTM D5865 standards were used respectively. Tests were carried out at FUTA laboratories and Sheda Science and Technology laboratory, Abuja, Nigeria. Dangote coal is a sub-bituminous B, low Sulphur and medium ash coal; Zouma sub-bituminous C, low Sulphur, medium ash coal, while Omelewu coal is a sub-bituminous C, low Sulphur, low ash coal. The coal samples analyzed are suitable for power generation (Heating value: 8,300 - 9,500 Btu/lb; Moisture content: 16.52% - 17.49%; Low Sulphur content <1.0); low to medium Ash contents 8.0-15.0%) and is in agreement with requirements published by coal-fired power plant operators. Gross calorific values, inherent moisture and contents of Zouma sub-bituminous coal make it more largely suitable for pulverized coal combustion when compared with the coal fuel used for the Genessee Phase 3 power station in Canada.

Background: Healthcare workers face high levels of stress, long hours and demanding workloads, which can impair sleep, mental health and job performance. Aerobic exercise has been shown to improve these outcomes by enhancing mood, reducing stress and promoting better sleep. Exploring the effects of aerobic exercise on sleep quality, mental health, and job performance among healthcare professionals is necessary. Aim of the Study: To determine the effects of aerobic exercises on job performance, mental health and sleep quality among interns in Federal Medical Centre, Owo. Material and Methods: This pretest-protest study design involved 40 physically fit healthcare interns at Federal Medical Centre, Owo selected through consecutive sampling. Participants engaged in supervised aerobic exercise sessions; three times weekly for six week, each lasting 40 minutes. Pre and post intervention data were collected using the Werwick-Edinbugh Mental well-being Scale (WEMWBS), Pittsburgh sleep quality index (PSQI), and the Minnesota Job Satisfaction Questionnaire (MJSQ). Data were analyzed using Statistical Package for Social Sciences (SPSS) version 26 with Wilcoxon signed-rank test applied to assess pre-and post- intervention differences at a 0.05 significance level. Results: A total of 37 interns (mean age= 25.54 ± 2.40 years) completed this study. Pre and post intervention comparison of results showed no significant difference in mental well-being (p=0.219) and job satisfaction (p=0.158). However, a significant difference was observed in sleep quality of participants (p=0.001), indicating better sleep quality. Conclusion: Aerobic exercise significantly improved sleep quality, with positive trends (though not significant) in mental well-being and job satisfaction.

Background: The integration of allied health roles is crucial for enhancing the efficiency and effectiveness of healthcare delivery. Objectives: This review examines the roles of radiology, laboratory services, pharmacy, dental health, and medical secretaries in the context of a multidisciplinary healthcare team. Findings: By analyzing the contributions of these allied health professionals, we highlight the importance of collaboration in improving patient outcomes, streamlining processes, and fostering a holistic approach to healthcare. The review also addresses the challenges faced in integrating these roles and offers recommendations for future practice. Ultimately, the successful integration of allied health roles can lead to improved patient satisfaction, reduced healthcare costs, and better health outcomes. This review underscores the necessity of a cohesive healthcare framework that values the contributions of all allied health professionals, ensuring that patients receive comprehensive and coordinated care. The integration of allied health roles is essential for delivering comprehensive and effective healthcare. By examining the contributions of radiology, laboratory services, pharmacy, dental health, and medical secretaries, we can appreciate the importance of collaboration in improving patient outcomes. Addressing the challenges faced in integrating these roles and fostering a culture of teamwork will be crucial for the future of healthcare delivery. As the healthcare landscape continues to evolve, the integration of allied health professionals will play a vital role in enhancing the quality of care and ensuring positive health outcomes for patients. In conclusion, the successful integration of allied health roles not only improves patient care but also enhances the overall efficiency of the healthcare system. By fostering collaboration, embracing technological advancements, and prioritizing interprofessional education, we can create a healthcare environment that is responsive to the needs of patients and equipped to meet the challenges of the future. The ongoing commitment to integrating allied health roles will ultimately lead to a more effective and patient-centered healthcare system.

Background: Female sexual health is often underexplored in the context of chronic liver diseases, despite its key role in overall quality of life. Sexual dysfunction in this population is rarely addressed during hepatology consultations, even though it may be aggravated by clinical complications such as cirrhosis. Methods: This was a cross-sectional, descriptive, and analytical study conducted between January and December 2024, including 106 female patients (53 with chronic liver disease, 53 controls). All completed the FSFI questionnaire. A score < 26 indicated sexual dysfunction. Data were analyzed using Jamovi version 2.2.5. Results: Sexual dysfunction (FSFI score < 26) was observed in 60.4% of patients with chronic liver disease, versus 28.3% in the control group (p < 0.001). The most affected domains were lubrication (84.4%), satisfaction (75%), and desire (65.6%). Cirrhosis was significantly associated with dysfunction (OR = 6.8; p = 0.046). Conclusion: Sexual dysfunction is frequent in women with chronic liver disease, especially in those with cirrhosis. Despite its high prevalence, it remains neglected in routine hepatology practice, underscoring the need for integrated sexual health assessment.

Introduction: Prosthetic joint infection (PJI) is a serious complication of arthroplasty, associated with significant morbidity and therapeutic challenges, particularly due to biofilm formation and the emergence of multidrug-resistant (MDR) bacteria. In Morocco, where osteoarticular trauma and resistant nosocomial pathogens are frequent, a local assessment of PJIs is warranted. The objectives of our study are to determine the frequency of infections in prostheses, specify the epidemiology and resistance profile of isolated strains to antibiotics. Methods: This is a retrospective study conducted in the bacteriology laboratory of the Mohammed V Military Teaching Hospital in Rabat over a 4-year period (2015–2018), involving 572 arthroplasties. Samples were processed using standard microbiological techniques, and antimicrobial susceptibility testing was performed by the disk diffusion method and interpreted according to CA-SFM/EUCAST guidelines. Results: Out of 53 samples received, 37 (69.8%) were culture-positive. Twenty-four cases of PJIs were confirmed, representing an infection rate of 4.19%, predominantly affecting hip prostheses (3.49%). Delayed infections (3–24 months post-surgery) were the most frequent (87.5%). Gram-positive cocci accounted for 59.5% of isolates, followed by Enterobacterales at 31.7%. Staphylococcus aureus was 100% methicillin-susceptible, while 26% of coagulase-negative staphylococci were methicillin-resistant. Resistance rates among Enterobacterales were 32% for cefotaxime and 4% for imipenem. Conclusion: PJIs represent a major issue in our setting, with a predominance of staphylococci and an alarming emergence of multidrug-resistant Gram-negative bacilli. These findings highlight the need for rigorous diagnostic protocols, strengthened preventive measures, and antibiotic policies tailored to the local microbiological ecology.

Prosthetic joint infection caused by Mycobacterium tuberculosis is extremely rare. It can mimic aseptic loosening or chronic infection with common bacteria, delaying diagnosis. We report a case of tuberculous infection in a total hip arthroplasty in a 55-year-old immunocompetent patient, revealed by prosthetic loosening. The diagnosis was confirmed by histology, culture, and molecular biology (GeneXpert). This case highlights the need to consider tuberculosis in the differential diagnosis of chronic prosthetic infections, particularly in endemic areas.

Species of Corynebacterium are Gram-positive bacilli, often considered contaminants, but some non-diphtheritic species are now recognized as opportunistic pathogens. We report a case of infective endocarditis caused by Corynebacterium argentoratense, an extremely rare species, in a 59-year-old patient with a history of severe pneumonia. This case highlights the potential emergence of this species in severe human infections and the importance of cautious interpretation of positive blood cultures involving corynebacteria.

Bartholinitis is a common infection of the vulvar region, often polymicrobial in origin. While Escherichia coli and sexually transmitted pathogens are usually implicated, Haemophilus influenzae is rarely identified. We report a case of bartholinitis caused by H. influenzae in a young woman with no notable medical history. This case highlights the need to consider unusual pathogens in bartholinitis and the importance of an appropriate protocol for sample collection and culture.

The global imperative to decarbonize energy systems and mitigate climate change has catalyzed intense research and development into alternative energy carriers. Hydrogen, the most abundant element in preconceived universe, is emerging as a pivotal vector in this transition, offering a versatile, high-energy-density fuel that can be produced from various sources. This paper explores the burgeoning "Hydrogen Horizon," focusing on the technical innovations driving its advancement, particularly within the renewable energy paradigm. It critically compares blue hydrogen (produced from fossil fuels with carbon capture) and green hydrogen (produced from renewable electricity via electrolysis), examining their respective production processes, economic viabilities, and environmental implications using relevant data. The pros and cons of different hydrogen production pathways are discussed, alongside a comparative analysis with the incumbent oil and gas industry. The paper concludes that while blue hydrogen may serve as a transitional technology, green hydrogen, propelled by continuous technical innovation, holds the ultimate promise for a truly sustainable energy future.

Background: Dilated cardiomyopathy (DCM) poses a significant health risk in pediatric populations, yet its pathophysiological mechanisms remain unclear. This study aims to explore new biomarkers as potential predictors in pDCM. Methods: A total of 84 pediatric patients diagnosed with dilated cardiomyopathy (DCM) and 34 age-matched healthy controls were prospectively recruited. Inclusion criteria were based on clinical diagnosis, echocardiographic findings, and relevant exclusion criteria for other cardiac or systemic conditions. Serum levels of total carnitine, procollagen type III N-terminal propeptide (PIIINP), cystatin C (Cys-C), β2-microglobulin (β2M), and haptoglobin (Hp) were quantitatively assessed using enzyme-linked immunosorbent assay (ELISA). Expression of acylcarnitine was assessed via qRT-PCR. Results: There were significantly higher plasma levels of total carnitine (p=0.001), PIIINP (p=0.016), Cys-C (p=0.001), β2M (p=0.009), and haptoglobin (p=0.001) in pDCM compared to matched controls. Total carnitine, PIIINP and β2M at cut-off points 65 umol/ml &3 & 2 mg/L showed 73&79% & 75% sensitivity and 91& 56% & 81% specificity respectively for predicting risk of pDCM. Haptoglobin at cutoff point 164 mg/L has highest specificity (100%) but with low sensitivity 56%). Combined β2M, PIIINP, and total carnitine demonstrated the best accuracy (83.5%) with 75% sensitivity, 92% specificity, 90% PPV, and 79% NPV for the presence of pDCM. A significant upregulation of the acylcarnitine expression gene was also observed in the DCM group compared to controls. Conclusion: Acylcarnitine, PIIINP, Cys-C, β2M and heptoglobin are potential emerging predictors for pDCM and might have a pathogenic role in pDCM with mechanistic associations.

Barriers to effective mental health problems management by family doctors in primary health care settings often stem from systemic and structural issues. One significant barrier is the lack of time during patient consultations. Family doctors frequently have heavy caseloads, which limits their ability to conduct thorough assessments and engage in meaningful discussions about mental health. Additionally, many practitioners may feel ill-equipped to handle mental health issues due to insufficient training during their education. Despite the high prevalence of mental health conditions, primary care training programs have historically emphasized physical health, leaving physicians underprepared to identify and treat psychological disorders. Furthermore, stigma surrounding mental health can further complicate patient interactions in primary care settings. Family doctors may experience their own latent biases about mental health, which can influence the quality of care they provide. Patients, too, may be hesitant to disclose mental health concerns due to fear of being judged or misunderstood, leading to underreporting of symptoms. Financial and resource limitations also play a role; many family practices lack access to mental health specialists for referrals or collaborative care, constraining doctors' ability to offer comprehensive treatment plans. As a result, these barriers can lead to inadequate management of mental health issues, potentially exacerbating the overall health outcomes for patients in primary care environments.

A key global concern that relates to Intellectual Capital and Financial Performance of Listed Manufacturing Companies is that the measurement and disclosure models relating to intellectual capital are not standardized in various international markets. This paper has looked at the influence of intellectual capital on financial performance of publicly traded manufacturing firms in Nigeria. In particular, it examined the impact of structural capital, human capital and capital used on financial performance of these firms. The research utilized ex-post facto research design, which made it possible to analyze secondary financial data in detail. The subject of the research included thirty-three (33) listed manufacturing firms in Nigeria that were selected to include both industrial and consumer goods firms, as of December 31, 2024, listed on the Nigerian Exchange Group (NGX). Descriptive statistics and Random-effects Generalized Least Squares (GLS) regression were applied to analyze data. Results showed that both the components of intellectual capital are not statistically significant predictors of financial performance at a significant level, as the value of the Wald chi-square was insignificant. The regression results showed poor explanatory ability with a negligible contribution to financial performance variance. The findings imply that firm-specific heterogeneity, as opposed to intellectual capital revaluations across time, are the significant sources of financial performance variation. Though the intellectual capital has theoretical significance, its output as far as the financial performance of the Nigerian manufacturing sector is concerned, seems minimal. The research advocates that manufacturing firms ought to do a better job of recognizing and reporting on the components of intellectual capital; and policymakers need to come up with uniform reporting regimes to enhance financial transparency, comparability and strategic thinking in emerging markets.