Abstract: Education is nationally and internationally recognized as one of the most important ways and means for promoting economic development. Here arises a question on what type of education to be imparted for the national development in terms of primary, secondary and tertiary education. Knowledge-based challenge within a globalized economy is accelerating a fresh consideration of the role of higher education in economic development and its expansion. In the past, it was seen that the higher education was very much costly and at the same time, it was really inefficient public service which could only benefit the wealthy and privileged class. Importance of education has now been realized to be successful in the field of economic development. A short look upon some recent research findings indicates that higher education is a determinant of increasing income. Additionally, the higher education may create awareness about how to increase tax revenue, boosts savings and investment, improve a nation’s health, contribute to reducing the rate of population growth and enhance the adoption of technology in order to strengthen the governance. Colleges and Universities have an important role to play in regional and national economic development efforts through producing quality graduates. Undoubtedly, the higher education and economic development complement to each other. To gain national economic development, colleges and universities must be the key partners throughout the development process of the country.

Abstract: In this paper, we propose a non-monotone adaptive trust region algorithm based on conic model for solving unconstrained optimization problems. Unlike the traditional non-monotone trust-region method, our proposed algorithm avoids resolving the sub-problem whenever a trial step is rejected. Instead, it performs a non-monotone Armijo-type line search in direction of the rejected trial step to construct a new point. The algorithm can be regarded as a combination of non-monotone, line search and conic trust region method. Theoretical analysis indicates that the new approach preserves the global convergence to the first-order critical points under classical assumptions.

Estimating a company’s sustainable profitability is a big challenge to investors. A profitable company yielding a steady revenue stream with modest capital expenditure has the ability to compound shareholder wealth at an attractive rate over time. Even though many studies have been conducted, most companies strive to provide competitive returns. The golden path of being profitable has not yet been revealed. Selected 15 Sensex Companies standing as leading players are expected to provide considerable support to empower the efforts of the Indian Government. On this backdrop, the present study aims at focussing and assessing the efficacy of the performance of the selected Sensex Companies with the help of the most appropriate accounting-based measure of profitability i.e. Return On Capital Employed (ROCE) from 2012 to 2017. The empirical study reveals that companies have not been able to increase revenue and ROCE simultaneously and they are not also compatible in comparison with the global capital market.

Abstract: Medicinal herbs are moving from fringe to mainstream use with a greater number of people seeking for remedies and health approaches from side effects caused by synthetic chemicals. This has aggravated the search for antimicrobials from plants sources. Therefore, this study was aimed at investigating the efficacy of aqueous extract of Moringa oleifera leaves against some clinical isolates (Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa). The study was carried out between January and June, 2014. The Moringa oleifera leaves sample were collected from the Kebbi State University of Science and Technology Aliero Orchard and screened for antimicrobial activity against the isolates using agar well diffusion assay, and preliminary phytochemical analysis were also conducted using standard procedures. Concentrations of the extract used were 30mg, 60mg, 90mg and120mg. The extract demonstrated the highest activity at 120mg, with the zone of inhibition of 28.5mm, 25.5mm and 24.0mm on Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa respectively. The results of preliminary phytochemical screening revealed the presence of Saponins, Tannins, Flavonoids, Glycosides and Alkaloids. The antibacterial assay results portrayed broad spectrum activity of Moringa oleifera leaf extract against the test organisms with the comparable inhibitory zones by standard antibiotic (Ciprofloxacin). In conclusion the results from these findings have shown the antibacterial potentials of Moringa oleifera leaf extract implying that the extract could help as a chemotherapeutic agent or might be a lead compound for the development of new potent antibacterial agents.

L-ornithine (L-Orn), is an intermediate metabolite in the urea cycle that plays an important role in the human beings and is used for the treatment of the liver diseases etc. Based on these versatile advantages, L-Orn is widely applied in the health care and pharmaceutical industries. In this study, l-arginase from Idiomarina sediminium was immobilized onto chitosan-hydroxyapatite. Effects of immobilization parameters including medium temperature and pH, enzyme concentration and coupling time was evaluated to obtain the best reaction conditions. The optimal immobilization pH was determined as pH 7.5 with the highest enzyme activity of 101.24 U chitosan-HAP beads and highest immobilization efficiency of 81.4%. Furthermore, the immobilized protein amount showed an increase with increasing enzyme concentration as expected. Characterization of immobilized enzyme was evaluated using l-arginine as a substrate. Immobilized enzyme exhibited better thermostability and higher stability at lower and higher pH values. Immobilization also resulted in a shift of 0.5 units in pH optimum for maximum enzyme activity. In contrast to optimum pH value, after immobilization no shift occurred in optimum temperature. Furthermore enzyme retained 81.8% of its initial activity during consecutive eight cycles. The results suggests that chitosan-HAP immobilized l-arginase can be employed on the large scale for industrial production of l-ornithine

Every Society has her value system they cherish and these systems of norms and behavioural regulation must be strictly adhere and transmitted for the purpose of progressive and continuity of the society. Socialization is a complex process by which everybody or individual come together to learn and perform an attitude expected of them by the society. As societies become more sophisticated and diversified, some certain societal roles are assigned for a specialized body. The school system is one of such specialized body assign for a specific function which she carries through various subject areas of which Physical Education is one of them. The school must therefore be encouraged and supported to perform this task of socialization.

The Present study was carried out to analyse the prescribing pattern of drugs and appropriateness of antimicrobials use in gastroenteritis in hospitalized children. It was a prospective, observational, single centre study undertaken in gastroenteritis inpatients of paediatric department, aged one month to seventeen years, over a period of six months. Modified Kunin's criteria along with the guidelines set by the World Gastroenterology Organization were followed for assessing the appropriateness of the antimicrobials prescribed and prescribing patterns respectively. A total of 120 patients were enrolled, of whom 61% were in the age group below 5 years. Diarrhoea with mild dehydration was diagnosed in 53% patients followed by no dehydration (28%) and severe dehydration (19%). IV fluids (90.8%) and antimicrobials (86.6%) were the commonest drugs prescribed. 89% of antimicrobials were given in parenteral dosage form. 27.9% of antimicrobials were given for 3 days duration. Among the antimicrobials, ceftriaxone was frequently prescribed. Inappropriate antimicrobial therapy was given in 9.6% of the cases. Precise use of antimicrobials was preferred in 10.5% of cases. Microbiology report was missing in 79.9% of cases. No ADRs were observed during the study. Inappropriate use of antimicrobials was seen in the study. Emphasis on proper diagnosis, treatment, education and availability of effective guidelines may help in a judicious use of drugs in children.

We describe the first case report of an Adult Onset Still’s Disease (AOSD) in a previously healthy young man from Jazan, Saudi Arabia in the summer of 2017. The patient symptoms, signs and investigations fulfilled Yamaguchi’s criteria for the diagnosis of Adult Onset Still’s disease [1]. The patient experienced a sore throat, high grade fever, right knee arthralgia, left knee arthritis, a generalized salmon colored rash, leukocytosis, elevation of liver transaminases, high LDH, high ferritin, absence of ANA, RF, AMA, ASMA and DNA and reactive bone marrow aspiration and biopsy without any evidence of infectious diseases etiologies or malignancies that were satisfactory to confirm the diagnosis of AOSD. We have observed an evidence of two different bacterial sources simultaneously as triggering etiologies; positive ASO titer and positive blood culture for E. Coli where the clinical features and laboratories investigations derangement post antibiotics treatment have remained. The patient has responded to the pulse methylprednisolone and tapering doses of prednisolone. Our successful clinical experience in the case is that the prednisolone lower doses combined with NSAID (voltaren) to minimizing the steroid adverse effects was sufficiently effective to maintaining remission.

The article analyzes that properly managed complaints can provide a strong link between users and the organization. So, if companies are seeking consumer loyalty, they must look at complaints as a strategic tool, not as the proof of their mistakes. Complaints are a feedback system that can help organizations quickly and easily run away, which is currently relevant to each business, change its product, service style, and marketing goals. If a user is successfully addressed after the problem is addressed, it is usually not possible to make formal complaints. So, one of the best ways to find out what the user wants is what his expectations are to hear his complaints, and one of the most reliable ways to improve personal relationships is to draw attention when someone feels depressed for us and responds accordingly in order to resolve the conflict. However, most customers are dissatisfied with how companies react and deal with customer complaints, although they are well aware that this is very important.

Marine organisms are potential sources of unique natural products with pharmacological and biological activities. In mariculture, diseases of microbial origin can cause huge economic losses worldwide. The evolution of microorganism resistance to antibiotics has resulted in a growing need for new antibacterial compounds that are effective in veterinary medicine and characterized by limited undesirable side effects. Increased attention has recently been turned to plants as a promising source for metabolites with antimicrobial activity. Achyranthes aspera is one such important plant with various established pharmacological properties. The aim of the present study was to assess the antibacterial activity of the Achyranthes aspera extract against Vibrio alginolyticus 1374. Aqueous extract of Achyranthes aspera was prepared. Different concentrations of the root and stem extracts of Achyranthes aspera were transferred to the agar plates, which had been streaked with the bacterium Vibrio alginolyticus; 1374. The plates were incubated aerobically at 37°C for 24 h and the zones of inhibition were measured using well diffusion method. Achyranthes aspera extract showed significant zones of inhibition. Achyranthes aspera showed marked antibacterial activity against Vibrio alginolyticus 1374.

Kinetic properties and stability studies of pepper chitosanase immobilized on chitin by covalent bond for production of chitooligosaccharides was the main objective of this work. A comparison with the properties that shown by the free one was also carried out. Maximum enzyme activity was observed at 2.825 and 0.576 mg chitosan /reaction mixture for free chitosanase (FC) and immobilized chitosanase (IC), respectively. They followed Michaelis-Menten Kinetics. The values of the Michaelis-Menten constant indicated that IC exhibited higher affinity toward chitosan than that of the free one. Km value was 35.71 mg/reaction mixture for the IC and 17.86 mg/reaction mixture for the free one. The maximum velocities (Vmax) were 12.5 and 47.62 U/mg for IC and FC, respectively. The optimum pH of IC was slightly shifted to acidic range (pH 5.6) from 5.8, which is the optimum for free one. IC exhibited high activity at wide range of temperature from 40 to 60ºC with optimum at 55ºC, while high activity of FC was found at range from 40 to 55ºC with optimum at 45ºC. The thermal and operational stabilities of both free and immobilized chitosanase were also evaluated. Results showed that the immobilization enhanced the enzyme stability. IC showed better thermal stability than the free one. It lost 5-10 % of its original activity after heating at 50oC for 1h, while FC lost 35 % after the same treatment. IC also lost 58% of its original activity after heating at 60oC for 1h, while free one lost 80 % after the same treatment. Results showed 22% rate of hydrolysis after 1 h and reached about 24 and 30 % after 2 and 24 h of hydrolysis. The end product of chitosan hydrolysis by the IC showed N-acetyl glucosamine and mixture of DP 2-6 oligomers. This improvement of the IC properties made it a potential candidate for future use in industrial application especially in chitooligosaccharides production

Antimicrobial resistance became a growing public health problem in the world and sexually transmitted infections (STIs) are one of the five types of pathologies which special care should be given. Staphylococcus aureus appear the most prevalent bacteria encountered causing infections in male urethral discharge (MUD) at Cotonou in Benin. It prevalence and it resistance to antibiotics were evaluated. This paper aims to describe the bacterial profile and antimicrobial susceptibility of S aureus strains isolated from MUD specimens at the National Laboratory (NL) of Heath Ministry. A retrospective study included 81 men at Cotonou suspected MUD during 1st January 2004 and 31st December 2015. MUD swabs were collected and analyzed to identify the bacteria by standard biochemical reactions, screening of trichomonads and detection of intracellular Gram-negative diplococci within phagocytes. The three main pathogens encountered among 81 MUD were Staphylococcus aureus (30/81; 37.04%), Staphylococcus spp (19/81; 23.46%) and Staphylococcus dore (12/81; 14.81%). S aureus susceptibility ranged from 60- 80% for minocyclin, lincomycin, chloramphenicol and gentamycin. But resistance was observed to ofloxacin, kanamycin, amoxicillin, amoxicillin-clavulanic acid, oxacillin, ceftriaxon, tetracyclin, trimethoprim+Sulfonamides and ampicillin between 59-100%. Conclusion: This study highlights the importance of routine susceptibility tests to antibiotics in the treatment of S aureus responsible of MUD in Benin.

This study was designed to examine the relationship between organisation design and organisational effectiveness in the Nigerian construction industry. The population of this study was the entire managerial staff population of Julius Berger Nigeria Plc and Setraco Nigeria Limited, both construction companies in Nigeria. The study adopted the survey research design and copies of structured questionnaire were administered to a sample of 341 respondents. Proxies for organisation design were drawn from Kates and Galbriath “Star Model” of organisation design. Descriptive statistics were used to analyse the data, while simple linear regression analysis was used to test the hypotheses formulated for the study. The findings of this study indicate that the five elements under study have strong positive relationship with organisational performance. Consequently, it is recommended that management of organisations in the Nigerian construction industry should consider all five elements when designing or re-designing their organisation.

Primary Squamous cell carcinoma of the gallbladder is extremely rare and constitutes 0.5- 3% of all gall bladder malignancies. We report a 50-year-old female who presented with vague symptom of right upper quadrant pain. She was operated on a presumptive diagnosis of chronic cholecystitis according to clinical and ultrasonography findings. Histopathological examination showed an infiltrating mass of the gallbladder which revealed well differentiated keratinized squamous cell carcinoma invading full wall thickness. Thorough evaluation revealed no other primary site for the tumor. Pure primary squamous cell carcinoma of the gallbladder is very rarely reported. Clinicians must be aware of its vague clinical presentations.

According to the report of Institute of Medicine (IOM) that about 7,000 of death are occur annual because of the medication error which is going worse day by day. The effect of medication error is not good for patient health. It reduces the efficiency of health care system. It is also evident from the report of IOM that about 1.5 million of people are injured because of the medication administration error and annual expense for treating those patient take more than 3.5 billion Dollars annually which is a great expense. This all happen just because of the medication administration error. To assess the barriers to which minimize reporting medication administration error among nurses in Services hospital Lahore. This study was carried out by using a cross sectional descriptive study design in Services Hospital Lahore. Data was taken from the staff nurses and the total sample size was 222. Response from the participants was taken through simple random sampling techniques.Spss21 version used for descriptive analysis and applied chi square and one sample t-test. The results after study show 35% of the staff nurses were agree that they didn’t recognize an error occurred properly while 16% were disagree. 41% of staff nurses were agree that while reporting an medication error then the colleagues will be think that they are incompetent while 38% of the nurses were disagree to this statement. 68% of staff nurses were agree that it is very important for a Hospital to have proper medication error reporting system while 20% were disagree, 62% of staff Nurses were agree that the response of hospital administration doesn’t match with the severity of case while 24% disagree. The barriers which play a vital role in underreporting of medication error is the fear of staff nurses form the hospital management and the response of hospital administration