EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important in managing the patient and giving correct treatment. We here by discuss about a case of, A 21 year old male admitted for fever for evaluation showed severe thrombocytopenia by automated 5 part Mindray analyser. Manual count and peripheral smear done revealed higher count and small platelet aggregates. Following which citrated sample was collected and manual counting done both showed similar values, low count in singles without aggregation when compared to EDTA sample. EDTA induced platelet aggregation was thus conformed.

Implantable cardiac devices, including defibrillators and pacemakers, may be the cause of tricuspid regurgitation (TR) or may worsen existing TR. Diagnosis by clinical exam and 2-dimensional echocardiography may be augmented by 3-dimensional echocardiography and/or computed tomography or cardiac magnetic resonance. The mechanism may be mechanical perforation or laceration of leaflets, scarring and restriction of leaflets, or asynchronized activation of the right ventricle. Pacemaker-related TR might cause severe right-sided heart failure. Percutaneous removal of PM and ICD leads is often performed in large specialty centers with significant experience, but carries with it significant and sometimes fatal risk. TR is usually treated by either surgical repair (usually consisting of ring annuloplasty) or by tricuspid replacement in some patients with advanced valvular disease

Chalk board talk lecture is the oldest and most commonly used teaching method. After introduction of digitalized teaching in medical colleges Power point presentation Lecture method is commonly used. To evaluate the feedback from first MBBS students regarding opinion and preferences of chalk board and PPT lecture delivery aids. A cross sectional questionnaire based study was conducted in medical college in Telangana State .150 first MBBS students participated in this study. Students were divided into 2 groups .In one group Lecture was delivered by using chalk board, for second group same topic was delivered using PPT presentation, two such lecture were delivered. Multiple choice questions paper was used for assessing the knowledge gained on next day. A questionnaire containing 10 questions was used to study students opinion for blackboard and power point teaching method. The differences in marks obtained in the 2 groups were analysed by independant student t test. Students who attended the lecture using chalk board obtained higher score in MCQ test as compared to those who attended the same lecture using PPT. The chalk board teaching method was preferred by 65% of the students. The blackboard teaching remains the best preferred teaching method, which can be supplemented by PPT presentation for better understanding.

Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus. Most women have no symptoms while others may have painful or heavy periods. If large enough, they may push on the bladder causing a frequent need to urinate. Dermatoglyphics is referred to as study of the friction ridge formation that appears on the palms of the hands and soles of the feet. There have been works done by different researchers on dermatoglyphics in the field of medicine which has helped in the detection of diseases like breast cancer, anemia etc. But not much has been done at level 2 dermatoglyphics which has created a gap in literatures on those areas especially uterine leiomyoma. This study was aimed at determining the level 2 dermatoglyphic digital patterns in Uterine Leiomyoma. The study was non-experimental and analytical. One hundred subjects selected by simple random sampling. Chi-square test was done using SPSS twenty version. The result of the study has shown clearly that the most distributed level-2 pattern in both categories is the bifurcation and ridge crossing the least distributed pattern in both categories. In uterine leiomyoma the distribution of bifurcation was higher than in the control group. The higher distribution of bifurcations in the uterine leiomyoma could be attributed to the genetic difference in both categories. The difference between the uterine leiomyoma subjects and the control subjects (normal) was not significant statistically (p>0.05) in there pattern distribution, but there was a marked difference that can be used as a guide in the diagnosis of uterine leiomyoma condition

Friction is the vital aspect of Orthodontics which requires attention during all the phases of treatment, especially during the phase of space closure. In Orthodontics, space closure can be achieved by the sliding mechanics and/or the segmented arch mechanics. Though sliding mechanics is the most commonly used space closure mechanics, it has the disadvantage of generating the friction at the bracket-archwire interface which indirectly affects the desired tooth movement. Due to the universal acceptance of this type of mechanics, the role of friction in orthodontics has become the topic of interest. Thus, this article enlightens the role of friction in orthodontic tooth movement, with an approach to its clinical implication, the importance of frictional resistance, and the recent advances in orthodontics to reduce the friction.

Allopurinol is a drug indicated for the treatment of hyperuricemia. Its hepatic toxicity is rare. This is a case report about acute cytolytic hepatitis caused by allopurinol in a 62-year-old.

HIV/AIDS is a viral malady which is causing havoc with the lives of the people in the Punjab Province of Pakistan. It has become notorious in taking away the lives of the people due to the lack of awareness on the part of the victims. The chief sources of the mass prevalence of this disease are: contaminated water, reuse of needles and syringes, carelessness about blood transfusion, lack of awareness about the use of contraceptives while having sex, and non-sterilized shaving and surgical instruments. District Faisalabad, from the central Punjab (Pakistan) was the place where this present research study was conducted. Throughout the course of this research study, multistage sampling technique was widely employed. At first stage, out of four tehsils of district Faisalabad, one tehsil (tehsil Faisalabad) was selected randomly. At second stage, out of eight towns of tehsil Faisalabad, two towns (Jinnah Town and Iqbal Town) were selected randomly. At third stage, two union councils were randomly selected from each town. At fourth stage, a sample of 25 young people was drawn from each selected union council to make an overall sample of 200 respondents. An interview schedule was developed for data collection which was divided into two parts. Individual characteristics i.e. gender, age, conjugal status was included in the preliminary part of the questionnaire. The questions related to the awareness regarding HIV/AIDS were the part and parcel of the remaining part of the questionnaire. The major findings of this study are: majority of the respondents 68.0 % were males, 56.0 % of the informants were intermediate, 48.5% were disclosed during interview that they had adequate knowledge about the preventive methods of HIV/AIDS after blood test or blood transfusion, 30% respondents had no knowledge about the preventive methods of HIV/AIDS after blood test or blood transfusion, 76.0 % were un-married, and 42.5 % were of the view that their source of sexual health information was their friends. HIV/AIDS, no doubt, is a fatal malady but can be controlled by launching awareness campaigns via mass media informing people about the preventive measures such as insisting on new syringe during inoculation, secure and safe blood transfusion, abstaining from extra-marital activities, avoiding contaminated water, and refraining from using the razor, tooth brush, and towel of an infected person.

Sickle cell disease is a chronic, inherited disorder. Complications from SCD place patients at risk for poor psychosocial adaptation, including symptoms of depression anxiety and stress. To measure the prevalence of depression, anxiety and stress in adults with sickle cell anemia in the Kingdom of Bahrain, and to study the factors related to the development of depression, anxiety and stress in these patients, we did a cross-sectional study that involved administering Depression Anxiety Stress Scales (DASS-21). A total number of 343 patients above 18 years, with sickle cell disease were recruited by convenient sampling from Salmaniya medical complex, health centers and sickle cell disease society. Participants also completed a survey of demographic data with specific inquiries about common sickle cell anemia risk factors and complications. From 343 participants (199 males &144 females) 53.9% were depressed, 70.8% had anxiety and 51.6% were stressed. A significant association was seen for depression and female gender(p-value 0.041), lower educational level (p-value 0.005), unemployment (p-value 0.01), number of emergency visits (p-value 0.008), hospital admissions (p-value 0.005) and medications like anti-depressants (p-value <0.001). Similarly, anxiety was significantly associated with female gender (p-value 0.031), unemployment (p-value 0.017), hospital admissions (p-value 0.047) and medications (like MST, codalgin and anxiolytics). Stress, however, was not found to be associated with any of the socio-demographic factors but was significantly associated with number of emergency visits (p-value 0.001), hospital admissions (p-value 0.008) and medications (like MST, codalgin and anxiolytics). We found the prevalence of depression to be (53.9%), anxiety (70.8%) and stress (51.6 %) among the studied population. Screening of sickle cell anemia patients for depression, anxiety and stress symptoms is recommended at regular intervals

The prosthetic considerations for treatment of partially edentulous patients involve evaluation of important aspects such as presence of certain functional or skeletal deficits, orientation of the occlusal plane, free-way space, size and location of edentulous areas, number, strategic location and quality of the likely abutment teeth, vertical dimension, and the type of occlusion. A comprehensive evaluation, multidisciplinary approach and a sequential treatment plan, worked out in harmony with the patient’s perceptions are important factors to ensure a successful outcome. One of the major conditions faced for full mouth rehabilitation is the severely worn dentition. In the present era with increased life expectancy, improved dental care, increased retention of teeth and increased awareness about oral health number of patients with generalized worn dentition have increased. This case report presents a case of partially edentulous bilateral jaws in which full mouth rehabilitation was done using implants and tooth supported prosthesis.

Infertility has remained a major health problem among couples and sexually active individuals who seek to procreate, and the search for therapeutic solutions have remained endless. This led to the consumption of moringa oleifera as fertility aid. Therefore, this study investigated the effects of ethanolic extract of moringa oleifera seeds and leaves on pregnancy. Eighty-four (84) albino rats comparing of 56 females and 28 males, which acclimatised for two weeks and mated in ratio of 2 females to 1 male, the pregnant female rats were then divided into 7 Groups of 7; All rats were weighed on a daily basis throughout the research period. Group 1- Control (10ml/kg body weight/day of vehicle [Tween 80] orally). Groups 2-4 (Seed extract at dose level of 100, 200 and 400mg/kg body weight/day respectively), Groups 5-7 (Seed extract at dose level of 100, 200 and 400mg/kg body weight/day respectively). Administration was carried out throughout the gestation period. The blood samples were collected for hormonal assay and under standard aesthetic conditions. From the results it was observed that the moringa oleifera leave and seed extract caused resorption of the foetus with decrease in weight in a dose dependent manner; however, there was no disruption of the normal gestation. The levels of FSH and LH for animals treated with 400mg/kg were significantly lower than those of 200mg/kg, 100mg/kg and the control group. In conclusion, the ethanol extract of both the leaf and seed of moringa oleifera has shown abortifacient effect and therefore not advise for consumption during pregnancy.

Sacrum is a triangular bone formed by fusion of five sacral vertebrae. It is wedged between two hip bones. Its base articulates with 5th lumbar vertebra and apex with coccyx. Complete agenesis of the dorsal wall of sacrum was observed during one routine osteology tutorial. The same is presented. The sacral canal was completely open posteriorly due to non fusion of the laminae from S1 to S5. The sacral canal is formed by sacral vertebral foramina. The anterior wall of the canal is formed by fusion of the sacral vertebral bodies. The fused laminae, spines and ossified ligamenta flava form the dorsal wall. The sacral canal is triangular in cross section and contains cauda equina, filum terminale and spinal meninges. Duramater and arachnoid mater end at middle of sacrum (generally at the level of S2) while filum terminale is continuation of piamater till coccyx. Knowledge of variations in the dorsal wall of sacrum due to congenital factors is essential for anesthesiologists, surgeons and physicians to treat the related disorders. Study of the variation in anatomical features of sacral hiatus and dorsal wall of sacral canal is important with regards to its clinical application in caudal epidural anesthesia. Sacral approach to epidural space is reliable and effective means of blocking sacral nerves.

Graphene, a carbon, displays unique 2-D structures with preternatural physical, chemical and electronics properties that necessitated its applications in different fields of engineering systems. Among these applications, bioelectronics application of graphene has attracted an increasing interest over the last years. The advantages conferred by the physical, optical and electrochemical properties of graphene-based nanomaterial have contributed to the current variety of ultra-sensitive and selective biosensor and sensors devices, Nano electronics, super-capacitors, solar cells, batteries, flexible displays, hydrogen storage in electronics. This paper provides a review on graphene variant properties and their applications especially in bioelectronics

This case report concerns a patient, presented unusually with an ulcero proliferative parotid tumor; diagnosed histologically as polymorphous low-grade adenocarcinoma. (PLGA) Its rare association with a collision tumor of squamoid sebaceous carcinoma; arising from overlying adnexal elements is previously unreported. Controversies in the histological diagnosis of this entity; particularly in relation to its prognosis are emphasized and discussed, drawing comparison of similar tumors occurring elsewhere.

Phyllanthus muellerianus is a large genus of the Euphobiaceae, is popularly known as ‘nvo nkwo’in Oghe traditional medicine. This species is used in the folk medicine for the treatment of sexually transmitted desieases. The aim of this study was to isolate and identify and spectroscopic characterize of sample GH3 from leaves of P. muellerianus. Sample GH3 from leaves of P. muellerianus was analyzed for their absorption, functional groups (CH, H, OH and NH) and 1H NMR resonance peaks (7.2 ppm and 6.7 ppm), resulting in the identification of benzopyran’s groups, suggesting 2H-1-benzopyran (chromene). The identification of benzopyran’s groups is here reported for the first time in P. muellerianus.

Bone is the host to many diseases. Diagnostic biopsies of bone lesions are generally done in two forms i.e. Percutaneous core needle biopsy or open surgical biopsy. Core needle biopsy is initial method of tissue diagnosis in bone tumours. To study the adequacy and accuracy of core needle biopsy in diagnosing bone lesions. To establish definitive diagnosis of bone pathology. The study was conducted in department of pathology, MNJ Cancer Institute and TB & Chest hospital, Osmania Medical College, Hyderabad. A total of 53 cases were analyzed prospectively for a period of two years from October 2015 to September 2017. Female to Male ratio was 1.1:1, Average age 3 to 70 years. Out of 53, 26 cases were primary malignant bone tumors, 12 were metastatic deposits, 10 were benign tumours (9 -Giant cell tumors,1- osteo chondroma) 2 were chronic osteomyelitis,3 were not adequate. In 26 cases of primary malignant tumours 10 - osteosarcoma, 6 - ewings sarcoma, 4 - chondrosarcoma, 2 - plasma cell neoplasm, 1 case was high grade NHL, 1 - chordoma, 1 synovial sarcoma,1 germ cell tumour. Adequacy rate (94.6%) in our study is in concordance with the similar study of Amit Joshi et al., (2013) where adequacy rate was 92%.present study is also in concordance with study of Logon et al with adequacy rate of 97.8%. It has demonstrated that the Core needle biopsy is a safe, easy, and effective technique for the evaluation bone tumours, with a high rate of diagnostic yield and accuracy.