Sexual violence are escalating not only in Malaysia but all over the world. Most often the perpetrator have close contact with the victim. Sexual violence against children and women brings with it long-term complications. The victims suffer in silence. Effective and organised preventive measures are necessary to safe guard the vulnerable innocent people.

Background: Adolescent and young adults with cancer are a unique population, but not much is known about their endof-life sexual preferences and trajectories. Limited information is available on the sexual need of terminally adolescent cancer patients. Objective: Follow-up of 3 young unmarried female terminal cancer patients; all of them had a wish of losing their virginity before dying. Results: Two of the patients were in their late teens and one 22, all had advanced disease. One patient received only alternative herbal treatment for her osteogenic sarcoma; the other patient received conventional plus alternative homeopathy therapy after relapse of her brain tumour (Glioblastoma multiforme) and the last patient had only conventional treatment for her chronic lymphoid leukaemia. Two patients could fulfil their wish of losing virginity, in one it was possible after her marriage. One patient committed suicide after she became pregnant, and the other two died because of the disease. Conclusion: Adolescents and young adults with life-limiting illnesses have a tendency to indulge in some crazy activities before dying. Sex can be one such activity they may want to attempt. It is therefore important to counsel adolescent cancer patients about high-risk sexual behaviours. Special space could be created after obtaining necessary permission from the concerned authorities where open minded volunteer (boy/girl) can spend some intimate time with the terminal cancer patients under the supervision of health care providers.

In order to achieve success in the fabrication of fixed prostheses, an appropriate marginal fit is mandatory. Despite the technological advancements in terms of the improvement of casting techniques, die fabrication, waxing pattern and coping fabrication, a discrepancy remains between the restoration’s margin and the cervical edge of the prepared tooth. The purpose of the study was to evaluate the casting accuracy by axial coverage of the die spacer 1.00 mm short from the finish line. Efforts were made to select and utilize standard method. Increased casting accuracy with die spacer application short by 1.00 mm from finish line could be due to the reason that unpainted area will ensure an area of close adaptation at the margin. Irrespective of the method of the die spacer application, all the castings showed deficiency in the marginal fit. application of die spacer 1.00 mm short from finish line on the die is beneficial to reduce the discrepancy in marginal fit and also to reduce the exposure of the cement at the margins.

Aim: To know the seroprevalence of clinical pattern of dermatophytosis (superficial mycosis) with most common fungal pathogen and association with the occupation in P.D.U. Hospital, Rajkot Gujarat region of the India. Methods: A clinical and mycological study of superficial mycosis was conducted on 250 cases (135 male and 115 female). Direct microscopy by KOH mount and culture was undertaken to isolate the fungal pathogen in each case. Results: 225 out of 250 cases (xxx) were positive by direct microscopy in which 130 (xxx) were positive by culture. The commonest age group involved was 21-30 years.Ladourer were affected in115 case out of 250(47.6%) Tinea corporis was the most common clinical presentation and Trichopyton rubrum was the most commonfungal pathogen isolated followed by Trichopyton mentagrophyte. Conclusion: It was concluded that dermatophytes, are the most common fungal causes of superficial mycosis.

The aim of this review is to highlight the awareness and utilization of mouthguards and reasons for not wearing it. A literature search was performed using the PubMed, Web of Science, Scopus and Google scholar data base for all the articles between 2000 and 2018 and was not restricted to specific languages. The search terms used were mouth guard, mouth piece, mouth protector, awareness and use. The results revealed that the awareness of mouthguards is high but the usage is low. In most of the studies the given reason for not using mouthguards is not necessary to wear it followed by discomfort.

Klebsiella pneumoniae, Gram Negative, capsulated rod shaped Bacilli is responsible for causing life threatening infections in humans and also opportunistic bacterial pathogen of clinical relevance for its association with both nosocomial infections and community acquired infections.Moreover, increased resistance to these antibiotics complicates and limits the available therapeutic drug options for the clinicians. Hence this study was taken to investigate the antimicrobial drug resistance and Prevalence of ESBL producing Klebsiella pneumoniae. This is a Retrospective study conducted at from JANUARY 2018 to DECEMBER 2018 at Saveetha Medical College and Hospital included Sputum sample of 3125 in patients from various Department, out of which 2154 had growth, from which 1320 Klebsiella pneumoniae isolates were collected. Patient’s demographic details, co-morbid conditions other associated risk factors were also collected. Antibiotic susceptibility testing (AST) was done on Muller Hinton agar by Kirby bauer method as described by the Clinical Laboratory Standard Institute (CLSI). The result shows 1320 Isolates, resistance to antibiotics like (Amoxicillin intrinsically resistance), Cefepime (70.8%),Ceftriaxone (67.5%), Cefuroxime (58.3%), Gentamycin (43.3%) and 726 ESBL producers (55%) which clearly point towards the multi-drug resistance of Klebsiella pneumoniae isolates and ESBL producers were significantly more resistant compared to ESBL nonproducers. Hence, Routine ESBL testing should be done along with antibiogram for the proper treatment of patients and also to prevent the development of multi drug resistance.

The forensic odontology is the study making use of the human dentition throughout each stage of dental evaluation. The key element for identification includes their radiographic morphology and filling materials. The knowledge of detecting this is a valuable tool mark in the presumptive identification of the dentition of a burned victim. Dental identification of a deceased individual is a core task in forensic odontology. The accurate recording of clinical dental procedures has become more important over time due to the increasing trend of medicolegal issues worldwide. Previous reports have discussed the practical usefulness of endodontic evidence for human identification. Advances in endodontic imaging, root and root canal anatomy, and biomaterials have been consistently emerging in endodontic research and practice. This paper throws light on the clinician’s role & perspectives in forensic odontology & endodontics.

This paper examined the long run relationship between FDI inflows and oil exports in Nigeria which most previous studies have not fully explored in recent times. Data were collected from CBN Statistical Bulletin and UNCTAD investment report from 1990 to 2016, and various diagnostic tests such as Unit Roots and Johansen co-integration were conducted. Thereafter, Dynamic Ordinary Least Square (DOLS) and Granger Causality Test were adopted to address the objective of this study. It was established that a significant positive relationship exists between FDI inflows and oil exports in Nigeria. This shows that what drives foreign investors in Nigeria is crude oil which constitutes the major share of the nation`s exports. In the same vein, there is an existence of a unidirectional causality which runs from FDI inflows to oil exports in Nigeria. This further shows that FDI inflows motivate oil exports in the country. Due to the significant findings that emerged from this study, it could be recommended that when attraction of FDI inflows are the target of the policy makers in Nigeria, improving variables like oil exports and inflation rate will induce the inflows of cross border investment accordingly in the long run. Also, the Nigerian government should be committed to effective exchange rate management which is sensitive to FDI inflows in the country.

A new reversed phase simple, economic and specific validated high performance liquid chromatography method for estimation of moxifloxacin in human plasma. Mobile phase used is acetonitrile: trisodium phosphate (5:95% v/v). UV detection at 294nm. The bioanalytical procedure involves de proteination of plasma with liquid-liquid extraction. The percentage of relative recovery and coefficient of variation of accuracy and precision were within acceptable limits. The method proved in simple, cost effective and sensitive for estimation of moxifloxicin in human plasma

The aim of present work is to develop simple, economic, precise and cost-effective UV spectrophotometric method for determination of Nevirapine, an anti-retro viral drug, in bulk and pharmaceutical dosage form. Forced degradation is a degradation of new drug substance and drug product at conditions more severe than accelerated conditions. Forced degradation studies show the chemical behaviour of the molecule which in turn helps in the development of formulation and package. The method for Nevirapine was developed using methanol and water and absorbance maxima was found to be at 282nm with a correlation coefficient of 0.9978. Forced degradation studies of Nevirapine like Acid degradation, Base degradation, Thermal, Photolytic, and Peroxide was conducted in UV Spectrophotometer using methanol and water and percentage degradation was calculated.

Subsidized LPG products are only intended for the poor. While non-poor people are encouraged to use non-subsidized LPG. In the midst of increasing the number of poor people in Medan City, the realization of non-subsidized LPG sales has decreased. The purpose of this study is to find factors that affect non-poor household customers switching using non-subsidized LPG and drafting alternative strategies and policies that can be implemented by Pertamina's management to make switching of non-poor household LPG customers who have been using LPG subsidies to non-subsidized LPG. This type of research is correlational research. The questionnaire was distributed accidentally to 100 non-poor household LPG customers in Kota Medan who have switched to non-subsidized LPG. From the results of the analysis, it was found that 52.2% of non-subsidized LPG purchases were influenced by Advertising, Sales Promotion, Public Relations, Personal Selling, and Interactive Marketing, while 47.8% were influenced by other variables outside the variables used in this study. Advertising variables, Sales Promotion, Public Relations, Personal Selling, and Interactive Marketing have a significant effect on the decision of purchase of non-subsidized LPG. However, based on partial testing, Personal Selling variables have no significant effect on non-subsidized LPG purchases. On the contrary, the variables of Advertising, Sales Promotion, Public Relations, and Interactive Marketing significantly affect the purchasing decisions

Metal Injection moulding (MIM) is an advanced near net shape forming process for high quality of complex shapes combined with high properties of materials. The concept of the MIM is based on mixing of the fine powders with a small proportion of polymer to form a feedstock that can be moulded. The granulated feedstock is then giving shape using injection moulding machine. After shaping, the polymer binder is then removed from the moulded part without significant disturbing the powder particles. Then, the powder is sintered at high temperatures. This paper discussed the mechanical properties and in-vitro evaluations of injection moulded cobalt based alloy for potential orthopedic

Chalcones comprise of a three carbon enone system. These are the products of condensation between aromatic aldehydes and acetophenones in the presence of a strong base. They represent a main skeletal in the plenty of organically dynamic molecules including synthesized and natural products. Synthesized chalcones or their disengagement from normal sources are being explored worldwide for the improvement of progressively powerful and proficient medications for the treatment of a few loathsome sicknesses, for example, malignant growth, diabetes, HIV, tuberculosis and so on. In this review, we will be focusing on the synthetic methods including gree methods for synthesis of chalcones and an overview of anticancer and anti-HIV activities of chalcones.

Background: Rickettsial infections are attributed as one of the important cause of pyrexia of unknown origin and there is a need to be differentiated from other common febrile illness. This study was conducted to know the prevalence of rickettsial disease among febrile patients since scrub typhus is endemic in our district in monsoon season the prevalence of scrub typhus is also studied. Materials & Methods: Clinical data and history collected from all PUO patients. A careful search of eschar was performed in all patients, peripheral smear, rapid test for Malaria, widal, Dengue NS1 done accordingly based on the clinical data. Serum samples collected from all the cases and weil felix test was done. Most of the samples were reactive to OX-K antigen, they were subjected to scrub typhus investigation. IgM ELISA was done for scrub typhus. Results: Out of 180 patients 58 (32.22%) were positive for weil felix test. Among the 58 positives 28 (48.27%) were positive for OXK antigen suggestive of scrub typhus. Out of 28 patients 27 (96.45%) were positive in both ELISA & ICT. Only 1 (3.57%) was negative by ICT but positive in ELISA. Seropositivity of scrub typhus is higher in Males in the age group 30 – 45yrs .Fever with chills was present in all cases & headache followed by rashes was the next common finding in all patients with scrub typhus. Conclusion: In our study the Seroprevalence of scrub typhus throws a light that, this has to be included in the fever panel in differential diagnosis, which will help in timely diagnosis and adequate treatment can be given and avoid complications.

The implementation of General Principles of Good Governance as a behavior political corruption village administration is very urgent, because over General Principles of Good Governance philosophy had a role in showing furnish and the lack of clarity and uncompleteness a norm. This type of research is non doctrinal research. The method of applying General Principles of Good Governance as a test stone for corruption in village funds is carried out with 2 (two) methods, namely: (1) legal changes and renewal. This legal amendment and renewal can only be done through national legislation carried out by the DPR, but this legislation path is very difficult to do unless there is a common logic of political equality, so that legal changes and reforms can be carried out. (2) the method of construction by the judge. This method is carried out by the judge in order to find the law because the law is vague in regulating or occurring a vacuum of norm. This path is commonly known as the Jurisprudence pathway where the law can also be born from a judicial institution.