Ezrin, podocalyxin and paxillin are cytoskeleton-associated proteins, implicated in several malignancies, but their role in Urothelial carcinoma of the bladder (UCB) is still controversy. We investigated the expression of those markersin UCB and the association of their expression pattern with clinicopathological parameters.Quantitative rt-PCR analyses used to examine mRNA level of ezrin and paxillinin23 fresh specimens of UCB and adjacent normal mucosal tissues from patients undergoing cystoscopy.Also, immunohistochemical evaluation of ezrin, podocalyxin and paxillin was performed on 123 paraffin blocks of UCB. Ezrin mRNA levelwas significantly high in normal mucosa than in UCB (p=0.012) while paxillinmRNA level wasn'tsignificant (p=0.34). Significant negative correlation was found between membranous ezrin immunoexpression and prognostic parameters as grade,T-stage and recurrence(p=0.001, p<0.0001and p= 0.002 respectively). Regarding paxillin immunoexpression,significant negative correlation was detected with grade andT-stage (p<0.0001). Membranous expression of podocalyxin was significantly correlated with grade, T-stage and recurrence (p=0.016, p= 0.003 and p<0.0001respectively). A significant correlation was found between three markers.These results suggest that ezrin, podocalyxin and paxillin could be valuable prognostic molecules in evaluation of UCB and this might lead to establishment ofnew molecular therapeutic strategy and prognostic biomarkers in UCB.

Several procedures, methods, and techniques aiming at generating higher quality foodstuffs with minimal sensory and nutritive qualities have been developed and adapted over the past several decades. Pasteurization is a heat treatment procedure that kills harmful micro-organisms in foods and drinks. Pasteurized juices have been warmed to great temperatures for limited period of time to destroy any germs or bacteria which may still present. Double-pasteurization, that contains a subordinate heating procedure, can increase the shelf-life by killing the spores which have developed. Drying is indeed a natural method of prevent spoiling because most of the disease-causing microorganisms needed a humid environment to exist and grow. Chemical and physical methods of preserving food are used to destroy or hinder the development of germs. Modified atmosphere packaging, different conditions dehydration, controlled atmospheric storage, freezing, refrigeration, vacuum- packing, different forms of thermal treatment, ultraviolet-radiation, ionizing radiation, and extreme hydrostatic pressure are all physical ways of preserving food. canning heat methods are meant to eliminate the spores of a bacteria C. botulinum.

Introduction: Hand hygiene is most important measure to minimize the ratio of transmission of health care associated infections (HCAIs) as this is one of the major problem especially in developing countries and most of the time caused behind it is poor hand hygiene of health care providers especially nurses as they have maximum interaction to the patients .This study was conducted to assess the knowledge and practices regarding hand hygiene among the nurses of DHQ hospital Okara. Methodology: A self-structured questionnaire with the help of WHO guidelines base cross sectional study was done on the sample of 100 nurses among the nurses of DHQ hospital Okara. Likert scale was used to assess their knowledge and they knowledge were scored as good (13-15), average (9-12) and poor (0-8) according to their responses. Practices were also assessed by questionnaire. Results: Most of the participants showed having good (51%) and average (39%) knowledge and there are only some nurses (4%) who showed poor results. But despite of having sufficient knowledge there was no implementation of hand hygiene because of lacking of facilities, over burden of patients, shortage of time. Conclusion: To improve the practices of hand hygiene continues training sessions, sufficient nurses, and provision of all facilities needed for the hand hygiene are most important things.

Corruption is an act that can not only harm the state's finances but can also cause losses to the people's economy. Corruption is a very despicable act, condemned and very hated by most people, not only by the Indonesian people and nation but also by the people of the nations of the world. The problem in this study is to find weaknesses in the application of the criminal sanction system in eradicating corruption and how to reconstruct it based on justice value. This research is using the constructivism paradigm and sociological-Juridical approach. The results of the study are that the weaknesses in the aspect of legal substance are the Law on the Eradication of Criminal Acts of Corruption does not regulate the number of minimum sanctions based on the classification of the amount of money that is corrupted, both for cases of embezzlement, bribery or gratification, and sanctions are also considered less firm. Weaknesses from the aspect of the legal structure are the weak coordination between law enforcement officers that causes the handling of corruption crimes to be hampered by time and bureaucracy. Weaknesses from the aspect of legal culture are the emergence of corruption itself is strongly influenced by the demands of individual and group needs and is supported by a socio-cultural environment that inherits a corrupt tradition. Accordingly, it is necessary to reconstruct Law Number 31 of 1999 concerning the Eradication of Corruption Crimes by adding paragraphs in the article up to Article 3 and Article 5.

Among the many contributions of Professor Rasidi Akinade Salawu to nursing profession in Nigeria, is his introduction into nursing of a model about the prevailing administrative and managerial environment in nursing. Although not formally documented all these years, many nurse managers, his colleagues as well as students (like us) who have encountered him have informally experienced and applied the tenets of this model in their day-to-day running of their wards and units. Drawing from Management and Nursing Science philosophies, Rasidi Akinade Salawu developed the Vice Syndrome Theory which has led to a better understanding of the intrigues and patterns in the working relationships between heads of units/departments/organisations and their deputies within the nursing circles. This presentation aims at sensitising the nursing (and general) scientific world to increase the awareness of this model, and increase its acceptance as an explanation for administrative processes and its application in a variety of research settings. This model has a great potential to make nursing administration more robust with sound scientific explanation. It will be an alternative paradigm for describing, explaining and predicting and therefore control issues of leader-deputy (“boss-vice”) engagements.

Introduction: Hypertension is one of the important causes of coronary heart disease and cerebrovascular disease. The autonomic nervous system has a significant role in the circulatory system and blood pressure regulation. Analysis of heart rate variability (HRV) is a non-invasive tool that is widely used to assess autonomic nervous function. Aims & Objectives: The study aimed to analyze HRV in Hypertensive individuals. Materials & Methods: An analytical study was conducted on 50 normotensives and 50 hypertensives in the age group of 40–60 years. Blood pressure was measured by using a sphygmomanometer in sitting position. According to JNC VII criteria, normotensives are those with SBP ≤ 120 mmHg and DBP ≤ 80 mmHg. Hypertensives are those with SBP ≥ 140 mmHg and DBP ≥ 90 mmHg. HRV is measured for 2min using Polar H10 chest strap and data is analyzed using Elite HRV software. In Time-domain methods Mean RR, SDNN, RMSSD, and PNN50 were assessed. In Frequency domain methods LF, HF, and LF/HF were assessed. The data was entered into Excel 2016 and SPSS version 21 was used for analysis. An unpaired “t” test was used to compare the HRV values between normotensive and hypertensive groups. Results: Mean HR, SDNN, RMSSD, PNN50, and HF were found to be decreased and LF, LF/HF were increased in hypertensives suggesting increased sympathetic activity and reduced parasympathetic activity in hypertensives. All the values were statistically significant (p<0.01). Conclusion: There is increased sympathetic activity and a decreased vagal tone associated with hypertension. Thus HRV can be used as a routine screening test to predict the future risk of hypertension at an earlier stage and also for a better prognosis during treatment.

Climate change affects the plant growth by inhibiting the genes involved for promoting the roots, shoots, leaves and reproduction. Toxic gases that accumulated in the air due to heavy chimneys can cause serious environmental and health hazards. Wastewater released from industries can increase the risk of environmental pollution that can be treated through highly effective treatments plants. Soil conservation helps to mitigate these threats of climate change and traditional farming practices by replacing the traditional farming methods employed for agriculture land. Soil conversation through green manure practices required less labor and lower costs that increase farmers profits. Microbial biomass also increases the soil fertility relative to conventional agricultural systems by marinating the nutritional balance between crops and microorganisms. CRISPR is the latest technology for controlling the different microorganisms that causes soil salinity and abnormal growth of seed developments. Nitrogenous fertilizers contribute substantially to the greenhouse gas emissions that promote climate change.

The composition and therapeutic values of the essential oils obtained from the leaves of O. gratissimum and L. martinicensis was investigated. The GC-MS results reveals the presence of bioactive compound such as eucalyptol (10.99%), estragole (48.52%) and linalool (24.49%) in O. gratissimum while for the Leucas martinicensis its reveals the presence of diazoprogesterone (0.15%), Isoaromadendrene epoxide (0.10%) and beta.-copaene (4.37%). Oxalic acid, oleic acid, p-Menth-8(10)-en-9-ol, and Caryophyllene was detected in the essential oils of both plants. The IR-spectroscopy results confirmed the functional group of most of the compound identified. Test for tannins, flavonoids, steroids, cardiac glycoside, alkaloids terpenoid, and anthraquinone were positive in methanolic and aqueous extracts of both plants. The in vitro antimicrobial screening of the essential oils against S. aureous, E.coli, S. pneumonia, K. pneumonia, A. niger and C. albicans showed that they are potential antimicrobial agents. The DPPH scavenging activity of essential oils showed that L. martinicensis with an IC50 of (145.7ug/ml) have higher antioxidant activity than essential oil obtained from the leaves of O. gratissimum with the IC50 of (158.3ug/ml) but their activities is lower than the standard with IC50 of (134.3ug/ml) and (145.7ug/ml) respectively.

The problem in this study is to find weaknesses in Corporate Social Responsibility in Realizing Sustainable Development that is not valued with Justice and how to reconstruct it based on the values of justice. The approach method used in this study is qualitative research, with a sociological juridical approach, and analyzed using descriptive analysis. The conclusion of this study is the weakness of the construction of Article 74 of Law Number 40 of 2007 concerning Limited Liability Companies from the aspect of legal substance, legal structure, and legal culture has implications for the value of justice which cannot be realized in carrying out corporate social responsibility in realizing sustainable development in the form of CSR. Because of that Article, 74 of Law Number 40 of 2007 concerning Limited Liability Companies must be reconstructed so that Corporate Social Responsibility Values Justice which is appropriate and in line with the values of Pancasila justice.

Companies in digital era face a host of challenges in order to satisfy the need for more and more customized growth and production. However, this development gives both businesses and consumers enormous opportunities. This article presents Industry 4.0's concept based on recent research and practice developments, then analyses the perceptive 4.0 perceptions of Moroccan companies, and then examines whether companies focusing on Industry 4.0 tools are more efficient in terms of productivity by building a quantitative analysis template. The results link innovation to business performance through the use of advanced 4.0 tools.

The purpose of the study was to investigate “Effects Of Roasted Garlic With And Without Moringa On Mean Atrial Pressure, Thyroid Stimulating Hormone And Testosterone Among Sedentary Men”. Selection Of Variables: The following variables were selected for this study. I. Dependent Varibles: Mean Atrial Pressure, Thyroid Stimulating Hormone And Testosterone. II. Independent Variables: 1. Roasted Garlic With Moringa Oleifera 2. Roasted Garlic 3.Control Group. Experimental Design: forty five The subject were selected for this study through the random group design consisting of pre and post test, forty five men randomly divided into three groups, the group was assigned as an Experimental Group I Experimental Group II and control group. The groups are 1. Roasted Garlic with Moringa Oleifera 2. Roasted Garlic 3.Control Group. Training Schedules: During the training period, the experimental group underwent their training program period of eight weeks for all days. The experimental groups underwent training for forty five minutes of duration in evening hours between 4:30 to 5:30 p.m for seven days per week. Statistical Technique: Analysis of Covariance statistical technique was used, to test the significant difference among the treatment groups. If the adjusted post-test results were significant, the scheffe’s post hoc test was used to determine the paired mean significant difference. Thirumalaisamy R. (2004). Result: After Incorporate Statistical Technique, It Was Found That A Significant Decrease Mean Atrial Pressure And Thyroid Stimulating Hormone And Testosterone In Experimental Group I (Roasted Garlic With Moringa Oleifera), when compared with experimental II and This Change Due To Eight Weeks Of training Among sedentary Men.

This Article deals with the issue of independence struggle in Africa. Our goal is to show how African freedom-fighters struggled against the colonial system in Africa for independence reasons. Despite the independence they got, they are always confronting the negative impacts of that struggle, not only in political fields but also in economic and social ones. So, from 1960 to the present day, African nationalists are confronting arrestations, imprisonments, accusations, tortures, murders, coups d’états, and so on. Through socio historical approach, we have noticed that the colonial system is always gaining ground in Africa through some strategies.

Development of high temperature dense refractory bricks using clay minerals and grog has been carried out with a view to determining the consequence of variation in percentages of Al2O3.2SiO2.2H2O and grog on the properties of locally produced dense bricks. The raw materials were used to compose five batches (of five samples each) from all the clay minerals and their blends (ED1–EN5). The clay bodies were hydraulically shaped and oven dried at 1100C. The properties of the produced bricks investigated after sintering at 13500C indicated that samples ED1–EN5 had shrinkage ranging from 8.4%-11.5% with corresponding bulk density of 1.57g/cm3–2.26g/cm3 respectively. The investigation revealed that samples ED1–EN5 of the bricks as stated above had compressive strength ranging from 13.5MPa–23.1MPa with corresponding porosity ranging from 12.84% -23.39% respectively. The estimated refractoriness using shuen’s formula shows that samples ED–EN5 had 16660c-17680c, while the result of the refractoriness using pyrometric cone equivalent indicated that samples ED1–EN5 had cone 30(16600C)– <34(<17500C) respectively. The spalling-count test result revealed that samples as stated above had number of cycles ranging from 19-35 respectively. It was discovered that the higher the grog content, the lower the shrinkage, bulk density and compressive strength while the higher the porosity, spalling-count-cycle with refractoriness, and vice versa when considering blended samples with increase in Al2O3.2SiO2.2H2O content. However, sample EN4 gave the most apposite result when considering the properties stated above. Therefore sample EN4 is recommended for mass production of dense refractory bricks for high temperature applications.

Modern handball is still evaluated by the criteria of 50 years ago. They are full of the report on the work and preparation of the national women team of Russia in handball for the World Cup 2017 in Germany. A lot of unrelated secondary parameters (height, age, accuracy of shots) can be replaced by a computer version of the upcoming match based on innovative PIRS technology. The basis of the PIRS model is the difference created by the player in the score which is added to the final score of the team. Since you have to play both with your superior opponents (negative difference) and downstream ones (positive difference), then a rating scale is created to display this difference. The rating stability allows you to simulate the upcoming match. The difference in the ratings in one action is converted into the difference of goals scored and conceded in a personal meeting and can be checked for compliance with the actual results obtained. The game consists of a sequence of diverse single combats (> 50 components) that end with a shot. Read more at www.ra-first.com. The balance of the won and lost single combats in each component in each pair of players is converted to the player's rating for this component. The fact of winning single combat isn’t used in the calculation, but its cost does that means the expected change in the score in the case of winning single combat. The player's rating for the game component exponentially falls from the number of single combats in this component in the course of the game. This allows you to pre-allocate the number of single combats in each component so as to win their largest number. Due to the stability of the rating estimation player's ratings for all components can be obtained from the previous match. It is possible to calculate the most favorable arrangement for the team which the greatest number of single combats will be won in based on the distribution of the opponent's activity according to the positions of the players and the components of the game and placement during the match. From the DB the algorithm generates the most advanced combinations in the attack and the most dangerous attacks of the opponent in the defense. The result of the work is the expected maximum possible score of the game which must be on the scoreboard when the players fulfill all the conditions. Existing Instat, Basket-stats, ICEBERG, LONGO Match PRO, FUTSALSTAT, etc. form the headache of a trainer from the statistics of past games. PIRS technology provides already calculated solutions for the best result of the upcoming match. The trainer will not be able to compete with PIRS, since the information pool called handball is too large for one person. Therefore, the resource of the game in matches of different levels is used only by two thirds. Provided 50% of the recommendations are fulfilled, the team will receive 20 - 30% of the points collected additionally. An example of the work is shown at the match of Russia and Poland women teams on the World Cup on February 25, 2017.

Background: Over last decade progressive increase in the rate of deliveries by cesarean section, is a cause of major public health concern due to potential maternal and perinatal morbidity. The driving factor leading to steady increase in cesarean delivery is not completely understood and there is lack of consensus on the appropriate cesarean section rate. This study will present the cesarean section rate in primigravida at our institute, indications of cesarean section and associated maternal and fetal morbidity. Methods: This was a retrospective study done on primigravida who delivered by cesarean section in the department of Obstetrics and Gynecology, SMBT institute of medical sciences & research center during one-year period. Result: The incidence of cesarean section in primigravida in our study was 29.09%. Most common indication of cesarean section in primigravida was fetal distress 39.81%. Amongst 41 cases of cesarean sections done for fetal distress, 33 cases had spontaneous onset of labor, 5 cases were induced with pgE1. Other common indication of cesarean section was cephalopelvic disproportion in 12.62% of cases, oligohydramnios in 11.65% of cases and breech presentation in 9.71% of cases. Most common antenatal high-risk factor was hypertensive disorder of pregnancy in 18.44% of cases. Blood transfusion and postpartum hemorrhage were the maternal morbidities noted in our study. Common cause for NICU admission was respiratory distress syndrome. Conclusion: Standardization of indications of primary cesarean section at tertiary center level is required. So that sequential annual audit of cesarean sections can help to strategize improvement of antenatal care for the reduction of primary cesarean section rate.