The aim of orthodontic treatment in a bimaxillary protrusion case is to obtain an esthetically pleasing face with harmonious soft tissue profile, stable occlusion and pleasant smile. The etiology of bimaxillary protrusion is multifactorial involving both genetic and environmental causes like mouth breathing, tongue and lip habits and tongue volume. The following case report is management of class I bimaxillary protrusion malocclusion in a hyperdivergent case with extraction of all first premolars. The effective management of space without losing anchorage is itself a big challenge. the results produced a pleasant facial profile with attainment of good occlusion. The case required extraction of 1st premolars for correction of the proclined, forwardly placed and crowded upper and lower anterior teeth. Clinical and cephalometric evaluation revealed skeletal Class I pattern and clinical examination revealed presence of an orthognathic facial profile, a vertical growth pattern, increased overjet and average overbite, crowding in maxillary and mandibular anterior region, potentially incompetent lips, increased lip fullness and lip strain, a gummy smile with an unaesthetic smile arc and a decreased nasolabial angle. Following fixed orthodontic treatment by removal of all 1st premolars and with retraction of anterior segment, a marked improvement in patient's smile, facial profile and occlusion was achieved and there was a remarkable increase in the patient's confidence and quality of life. The profile changes and treatment results were demonstrated with proper case selection and good patient cooperation with fixed appliance therapy.

Background and Objectives: There is increasing evidence that mitochondrial dysfunction and oxidative stress may be central to both chronic periodontitis and type 2 diabetes mellitus pathogenesis. HSP 60 is a mitochondrial stress protein believed to be caused by mitochondrial dysfunction. The aim of this research was therefore to test the salivary and circulatory expression of HSP 60 in periodontitis patients. Methods: A total of 30 patients aged 35-50 were chosen and classified into two groups; (1) Healthy controls; (2) Chronic periodontitis and systemically healthy. HSP 60 in serum and saliva was estimated using a specific ELISA kit and correlated with periodontal parameters using statistical tests. Results: The serum and salivary levels of heat shock proteins were significantly higher in chronic periodontitis patients compared to healthy controls. Conclusion: Salivary levels of HSP 60 can be used as a biomarker to determine periodontitis severity. Patients with chronic periodontitis had higher salivary HSP 60 levels.

Background: Clomiphene citrate is an orally active nonsteroidal triphenylethylene derivative, commonly used for ovarian stimulation; it is an ovulation inductor, an important tool in various assisted reproduction treatments. The side effects are unusual however they are listed in the OHSS ovarian hyperstimulation syndrome, which is an exaggerated response to excess hormones that can lead to significant complications. Case presentation: This is a case is about a unilateral adnexal torsion secondary to clomiphene citrate’s stimulation, without associated pregnancy which was managed in our department of gynecology in the maternity of Rabat. Conclusion: The ovarian hyperstimulation syndrome is becoming more common as the number of women undergoing in vitro fertilization increases. A worsening of the symptoms of OHS can still normally be managed in outpatient form, but can also have serious complications resulting from are much less common and can involve risk to life.

Rugae patterns are used in forensic investigations, owing to its uniqueness. In severely deceased burn victims, palatal rugae aid in identification process due to the resistance of hard palate. However changes in rugae form seen in diseases or trauma are intense in nature to alter identification process. Studies focusing on the effects of growth, tooth loss, or its combination are very few. Hence, the present study was carried out to determine the influence of tooth loss following extraction on rugae pattern in dentulous maxillary arch. A total of 25 patients with completely or partially dentulous maxillary arch indicated for extraction were selected based on inclusion and exclusion criteria. Following consent, Impressions of maxillary arch of patients were made using irreversible hydrocolloid material, and a cast was poured. The procedure was repeated over a period of 6 months after extraction and the rugae patterns traced every month were compared with the previous cast. All the observations were subjected to statistical evaluation. Based on the rugae pattern it was observed that line (mean 1.0 ± S.D 1.22), curved (1.3 ± 1.37) and sinnous (1.9 ± 1.56) patterns were predominant while circular, interrupted and trifurcated rugae patterns were less common. Though the frequency of circular rugae was low; conversely, it showed a high statistically significant difference between post-extraction follow up (P<0.001*) in their mean followed by Line and bi-furcated rugae pattern. We conclude that rugae patterns are not always consistent, as they are susceptible to changes during extractions that can alter substantial identification process.

Cancer is re-unowned by production of neoplastic cells. In cancer, un-developed cells are produced by bone marrow. After their entry into the blood normal cells are un-able to produce and cause anemia. Several oncogenes, including the p53, c-fms and Ras genes, can be activated by point mutations that change the amino acid sequence in the critical portion of protein. L-asparaginase is an enzyme which, by hydrolysis, produces aspartic acid and ammonia. It is used as medicine and in the food industry. It acts as a chemo-therapeutic agent to diagnose the ALL and lymphoproliferative syndrome. The level of Asparagine reduced in plasma decreases the formation of Deoxy ribonucleic acid and Ribonucleic acid. In ALL, asparaginase used in chemotherapy medicines for dealing the patients. it donates the important development in therapy results and helps achieve reform sullener approximately 90% of patients.

Transverse deficiencies should be a priority in orthodontic treatment, and should be corrected as soon as diagnosed, to restore the correct transverse relationship between maxilla and mandible and, consequently, normal maxillary growth. Corrections may be performed at the skeletal level, by opening the midpalatal suture, or by dentoalveolar expansion. The choice of a treatment alternative depends on certain factors, such as age, sex, degree of maxillary hypoplasia and maturation of the midpalatal suture. Thus, the present case report discusses rapid palatal expansion to correct maxillary hypoplasia in a female patient with advanced skeletal maturation and bilateral cross-bite with constricted maxilla.

Hidradenitis suppurativa (HS) is a chronic and painful skin disease. In addition, HS lesions may be associated with pus and odor, potentially leading to significant stigma. Our patient is a 33 year old single man with previous diagnosis of hidradenitis suppurativa since childhood and now is suffering from depression and anxiety. The patient mention follow clonazepam and cigarette use his discharge are declined. As role of stress and anxiety in inflammation, it is possible that benzodiazepine drug and cigarette smoking reduce inflammation and related secretion.

Job satisfaction is an essential element for the maintenance of the workforce numbers of any organization. Lack of job satisfaction for employees not only leads to high turnover rates but could also have detrimental effects on the individual, like burnout. Turnover provides the organization with new ideas and is a normal process. However, it does not need to be unnecessary and excessive. A high turnover rate leads to the inability of an organization to provide quality care and job satisfaction to employees. Turnover has a cyclic nature and remains a challenging issue. An organization should identify whether turnover is voluntary or involuntary. If the organization has high rates of involuntary turnover, then careful examination of recruitment, selection, training and motivation strategies are important. If turnover is voluntary, then the organization needs to look at factors that influence nurses to leave namely: intrinsic and extrinsic factors according to Herzberg’s theory. The extrinsic factors are conditions surrounding the job and intrinsic factors are relating directly to the job. A study in Jordan, which studied private hospitals’ nurses’ levels of job satisfaction, concluded that nurses in private hospitals reported higher levels of job satisfaction and higher intentions to stay at their jobs than nurses who did not work in private hospitals. This probably indicates that nurses’ levels of job satisfaction are directly related to nurse turnover rates. Nurses in the private hospitals who had intrinsic job satisfaction, had lower turnover rates.

Background: Head and neck squamous cell cancer” (HNSCC) is a term collectively describes the malignant tumours of oral cavity, pharynx and larynx. Globally, the total burden of HNSCC is estimated to be around 22 millions and males outnumber females by 4.1 to 2. Folate Metabolic pathway is complex and crucial process that contributes to folate levels and DNA methylation. The genes behind the enzymes in the pathway are polymorphic in nature and a specific combination of genetic variants may implicates differential susceptibility to different cancers. Methylenetetrahydrofolate reductase (MTHFR), a key enzyme for intracellular folate homeostasis and metabolism provides methyl groups for the methylation of homocysteine to methionine. Aim: The present study aimed to identify genetic variants of MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) among HNSCC patients and controls, gene – environment interactions in North Coastal Andhra Pradesh. Methods: A total of 220 samples (110 HNSCC patients and 110 controls) were included in the study and genotyping was accomplished by using PCR - RFLP technique and analyzed by SPSS. Results: The chi square p values revealed that MTHFR (C677T) polymorphism has association with HNSCC and MTHFR (A1298C) polymorphism does not shows association with HNSCC. For MTHFR (C677T) polymorphism, the odds ratio p value of TT genotype and CC genotype of MTHFR (A1298C) was found to be statistically significant. Conclusions: In conclusion, the MTHFR C677T (rs1801133) polymorphism shows association and A1298C (rs1801131) polymorphism does not shows association with HNSCC.

Introduction: Pleural effusion, that is commonly encountered clinical problem by the Pulmonologists and physicians.The gold standard for diagnosis of tuberculous pleuritis is detection of Mycobacterium tuberculosis bacilli in pleural fluid, either by microscopy/ molecular methods (CB-NAAT) and culture, or the histological demonstration of the caseating granulomas in biopsy specimen. Aims & objectives are to assess Significance of ADA level in the diagnosis of pleural effusion. Materials and method: The study was done in microbiology laboratory at Sir-T Hospital, Bhavnagar, Gujarat from January, 2020 to December, 2020 to Analysis of pleural fluid adenosine deaminase in diagnosis of tubercular pleural effusion. Adenosine Deaminase levels are evaluated by Adenosine Deaminase Assay Kit (DIAZYME). Observation & results: In our study, Total 48 pleural fluid samples were tested for ADA. Out of total 48 samples 34 were males and 14 were females in our study. However out of 48 samples, n20 samples positive for CB-NAAT. Out of the total 48 pleural fluid samples, 20 pleural fluid samples were positive (value >60 U/L) for ADA in our study. Conclusion: From this study, its concluded that Pleural Fluid Adenosine deaminase is important biomarker in diagnosing the Tubercular pleural effusion and can be useful aid in the day to day clinical practice.

The translation of legal terms is one of the most difficult problems in legal translation. It involves legal cultures and specific legal concepts as well as source and target language. Therefore it is of great significance to study the translation of legal terms to improve the translation quality of legal English. Criminal charges are typical legal terms. This article selects some charges from the American criminal law, and then compares them with some of the crimes in Criminal Law of People's Republic of China. Based on the comparison of different legal cultures between the two countries and under the guidance of Sarcevic's translation theory, this article summarizes some translation strategies for criminal charges.

Introduction: Phospho-calcium balance disorders are very common in chronic hemodialysis. They are accompanied by a high risk of mortality, mainly due to cardiovascular complications. In this context, the KDIGO finalized recommendations updated to improve the quality of life of chronic hemodialysis and warn the complications which can engage the prognosis for survival. The objective of our study was to analyze the phosphocalcic status in Morocco chronic hemodialysis patients and to estimate the conformity of the results with the recommendations KDIGO. Materials and methods: This is a retrospective study over a period of 8 months from January to August 2018 which includes chronic hemodialysis patients followed at the laboratory of Biochemistry-Toxicology of the Moulay Ismail military hospital and the nephrology-hemodialysis clinic from Meknes. The biochemical parameters evaluated were determined on Cobas®6000 from Roche Diagnostics and then compared to the targets of the KDIGO recommendations. Results: A total of 86 patients were enrolled in the study. The average age of our patients was 44.86 ±12.65 years, with a sex ratio of 1.38. The percentages of patients with phosphocalcic data consistent with the KDIGO recommended targets for calcemia, phosphoremia and PTH1-84 were 75.5%, 50% and 43% respectively. Finally, 17.4% of patients met the KDIGO 2009 recommendations by combining all three criteria. Conclusion: The results obtained during this study should encourage clinicians to improve management of chronic hemodialysis patients.

The objectives of this research are to study the problematic rights of advocates for immunity in the perspective of Law No. 18 of 2003, and how to reconstruct the right to immunity. An advocate with dignity in Catur Wangsa based on the value of justice. This research uses sociological juridical methods. Informants as sources of research data are advocates who are members of the Indonesian Advocate Union (Peradi), prosecutors, judges and police. Data collection techniques are done by interview and documentation. Data analysis through the stages of data collection, data reduction, data display and verification. The results of the study found that The Problematic rights of advocates for immunity in the perspective of Law No.18 of 2003 are: Legal substance, legal structure, legal culture. Therefore, the Reconstruction of the immunity rights of advocates with dignity in Catur Wangsa based on the value of justice is a reconstruction of values, and legal reconstruction is needed, in the form of Reconstruction of Article 14, 15, and 16 of Law no. 18 of 2003, which contains the value of the immunity rights of advocates to realize legal protection for advocates and maintain dignity and integrity as advocates is to enforce administrative sanctions and until the dismissal of an advocate who violates the code of ethics and commits a criminal act, law enforcers are permitted to be examined with the approval of the Advocate Honorary Council.

The objective of this study was to assess the chemical safety awareness for undergraduate analytical chemistry students. Data were collected from years one (First year) and four (final year) students in February 2018 using structured questionnaires (Multiple choices) designed for this purpose with chemical safety in mind, e.g. hazard warning symbols (signs), first aid, Material Safety Data Sheets (MSDS), waste handling and the use of safety equipment. The results of the study revealed that year four students have an average grade of below average (%51.1) which is significantly low and not encouraging compare to year one students who have an average grade of good (%79.2). Results of this study also showed that there isn’t much noticeable difference between female students' average grades than their male colleagues. Based on the results of this study, researchers recommend that year four student should get some sort of chemical safety training or asked to complete a chemical safety course prior to their graduation in order to avoid the possible happening of chemical accidents on them, their future work colleagues' and the environment.

The ultimate goal of this paper is to provide an in-depth analysis of the frequency of do you have and have you got within the Corpus of Contemporary American English (COCA), the British National Corpus (BNC), and the Corpus of Historical American English (COHA). The COCA clearly indicates that do you have is preferred over have you got by Americans. With respect to the genre frequency of the COCA, it is worth pointing out that in the TV/movie genre, the type do you have is the most widely used one. Likewise, in the TV/movie genre, the type have you got is the most commonly used one. The BNC shows, on the other hand, that have you got is preferred over do you have by British people. This clearly indicates that the type have you got is the most preferable one for British people in the spoken genre. Additionally, the COCA clearly shows that the collocation do you have children is the most preferred by Americans, followed by do you have time, do you have kids, do you have plans, do you have evidence, do you have family, do you have trouble, and do you have access, in that order. The COCA also shows that the collocation have you got time is the most preferable one for Americans, followed by have you got money, have you got room, and have you got plans, in that order. With regard to the collocation of nouns along with do you have in the BNC, it is important to note that do you have children is the most preferable one for British people, followed by do you have sugar (do you have milk, do you have problems), and do you have faith, in that order. In addition, it is significant to note that the collocation do you have children is the most preferable one for both Americans and British people. With respect to the collocation of have you got and nouns in the BNC, it is noteworthy that have you got time is the most preferred by British people, followed by have you got proof (have you got money), and have you got daddy (have you got potatoes, have you got news). Accordingly, the collocation have you got time is the most preferable one for both Americans and British people. When it comes to the COHA, it is worthwhile noting that do you have reached a peak (1,332 tokens) in 2010. This indicates that it was the most preferable type for Americans. It is significant to note, on the other hand, that have you got had the highest frequency (462 tokens) in 1930. From this, it is clear that have you got was the most preferred by Americans.