The chemical compounds extracted from medicinal plants have potential to evoke mental and social sensations in addition to maintain physical health. . Species of Asteraceae and Liliaceae play significant cardiovascular roles irrespective of exploring their toxicological aspects. Carbohydrates, proteins, lipids, nucleotides, fats, and steroids are the primary organic compounds which are involved in metabolism of essential developmental and growth functions of plants. The detrimental effects of environmental stress factors are suppressed by the gene expressions of ion transporters and water channel proteins present in the cell membranes incorporated with the up or downregulation of osmo-proctant osmolytes and essential proteins such as HSP and chaperones. Sunflower (Helianthus annuus L.) is an important crop known for its food, forage, and silage constituents. It is a prominent specie in Asteraceae family. Its seeds are enriched with edible oil-world’s fourth largest oil source. The mineral elements, dietary fibers, and secondary metabolites such as carotenoids, flavonoids, tocopherols, saponins, tannins, alkaloids, chlorogenic acid, caffeic acid, peptides, phytosterols, triterpene glycosides, and vitamins contribute towards nutraceutical roles. Pot marigold (Calendula officinalis) possesses antibiotic, anti-inflammatory, and antifungal properties which allow its applications in preventing muscle spasms, treating sore throat and ulcers of duodenum and stomach, soothing eczema, healing wounds, and relieving rashes.

Intersectins (INSTNs) have been defined as scaffold proteins that have several biochemical functions. Initially INSTNs are described as endocytic regulators and function in different signalling pathways including Ras and Ras-like GTPases, PI3Ks and RTKs in several diseases. Recently, INSTNs have been reported in viral endocytosis. INSTNs was found to be upregulated in transcriptomic analysis of differentially expressed protein from Dengue virus serotype four from our recent data. Hence, this review summarises the role of INSTNs in viral endocytosis by interaction with signalling pathways. INSTN-2 interact with K15 protein of Kaposi’s Sarcoma-Associated Herpesvirus by selective SH3 domain, INSTN-1 interaction with Epstein-Barr virus Latent Membrane Protein 2 (LMP2A), while direct interaction of NPF motifs at C-terminus of A36 with INSTN-1 and Epsin15 homology domains recruiting AP-2 and clathrin mediate viral release was reported in Vaccinia virus. Most recent, INSTN-2 was shown to regulate adaptive immune response during viral infectivity. This was discovered when mice deficient in INSTN-2 exhibited high mortality rate, impaired antibody responses to vaccination and reduced germinal centre formation in Influenza A virus. This review revealed INSTNs as essential viral endocytic proteins. The review also highlights INSTNs role in other diseases and the regulation of signalling pathways. Targeting INSTNs could be important for the development of pharmaceuticals against viruses and diseases. More study is required to establish the mechanistic role of INSTNs for viral endocytosis.

Physical activity and exercise on a regular basis can help you stay healthy, energetic, and independent as you age. Exercise is essential in preventing health problems such as heart disease and stroke. Many studies have demonstrated the health benefits of regular exercise. This report examines the evidence regarding the health benefits of exercise across the board. Physical activity and exercise can help to lower stress and anxiety, enhance happy neurotransmitters, promote self-confidence, boost brain function, improve memory, and strengthen our muscles and bones. It also aids in the prevention and treatment of heart disease, obesity, blood sugar swings, cardiovascular disease, and cancer. It also aids in the prevention and treatment of heart disease, obesity, blood sugar swings, cardiovascular disease, and cancer. Regular physical activity has been shown the useful in the primary and secondary prevention of a variety of chronic diseases (e.g., cardiovascular disease, diabetes, cancer, hypertension, obesity, depression, and osteoporosis) as well as premature death.

This study aims to determine and analyze the effects of leadership and organizational culture on employee performance and customer satisfaction variables as an intervening at PT. Sukaputra Graha Cemerlang Sentul City. Quantitative descriptive method with a causal relationship approach is the method used in this study. The population selected in this study were all employees of PT. Sukaputra Graha Cemerlang in Sentul City with a population of 217 people. Of all the population samples taken based on the Slovin formula are 141 samples. Data analysis using Structural Equation Model (SEM) with SmartPLS (Partial Least Square) 3.0. The results showed that leadership style had a positive and significant effect on customer satisfaction, organizational culture had a positive and significant influence on customer satisfaction, leadership style and organizational culture had a positive and significant influence on customer satisfaction, and customer satisfaction had a positive and significant effect on performance. employees of PT. Sukaputra Graha Cemerlang in Sentul City. Customer satisfaction can mediate the influence between leadership style and organizational culture with the performance of employees of PT. Sukaputra Graha Cemerlang in Sentul City.

Background: Non-ST Segment elevation myocardial infarction is heterogeneous in its presentation. Like ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction is life-threatening of a major cause of emergency medical care and hospitalization. Patients with non-ST segment elevation myocardial infarction are at risk for adverse cardiac events, so the initial treatment is very important. Increasing age is a strong predictor of adverse events in non-ST segment elevation myocardial infarction patients. Objective: To determine the in-hospital outcome and severity of coronary artery disease of older patients with Non-ST Segment elevation myocardial infarction. Methods: This was a descriptive cross-sectional study. The study was carried out in the cardiology department, National Heart Foundation Hospital, and Research Institute from June 2011 to May 2012. Patients of Non-ST Segment elevation myocardial infarction admitted at National Heart Foundation & Research Institute who fulfill the inclusion criteria were the study population. Patients were recruited by nonrandom sampling. One hundred and thirty-four patients were recruited in this study. Data were prospectively collected in a pre-designed data collection form and analyzed using SPSS - 16 software. Results: In this study, patients had a greater prevalence of hypertension diabetes mellitus. Chest pain and shortness of breath were common presentations observed in study patients during admission. They had a lower left ventricular ejection fraction than their younger counterparts. The older group was associated with an increased risk of triple vessel disease. In-hospital complications were significantly higher in older patients. Duration of hospital stay was longer in older patients. Conclusion: Older patients with Non-ST Segment myocardial infarction strongly predict adverse in-hospital outcomes and severe coronary artery disease profiles. Older patients should alert physicians to an increased risk of morbidity and mortality, which may, in turn, support more judicious treatment, including appropriate utilization of cardiovascular diagnostic tests and therapeutics used in current cardiovascular care to optimize outcomes in these high- risk patients.

Different factors involved in increasing the risk of infectious diseases caused by genetic and environmental changes. Due to high risk of infectious diseases such as chronic kidney disease, osteoarthritis, osteoporosis, Alzheimer's disease, cataracts, advances have been made in the fields of molecular sciences and engineering technology for highly effective tools and high-throughput omics technologies. Ebola virus is the most contagious as compared to the other viruses colds, influenza, or measles. Pathogenic bacteria are involved in causing of infectious diseases. Hib disease is the serious public health concern disease caused by Haemophilus influenza. Norwalk virus also causes serious abnormalities in the digestive system that ultimately leads to muscle cramp. Antimicrobial resistance have been challenging in the fields of biomedical sciences. Sequencing of bacterial genomes helpful for track the different status of fates of mutations that rise and fall through indication of multiple replicates. Genetic engineering based biomedical therapies needed to understand the target microbial cell, protein factory that secreted the variety of products.

Legal education has changed very little over the last century. At the same time, there have been significant advances in the field of education leading to several theories. The following will examine the five leading theories of education: connectivism, humanism, constructivism, cognitivism, and behaviorism. Each of these will be evaluated next to the Socratic Method, which is the primary method employed by law school instructors. Specific examples of how some of these theories have surfaced in law school and how the Socratic Method embodies other theories will be noted. The effect of technology on law school instruction will also be addressed. The overall goal of this article is to reveal how these theories can be utilized in the law school setting to produce highly competent graduates who will improve the efficacy of the field as a whole. Anecdotal example from North American and African law schools will underscore the notions put forth in this article.

The background of this research is to find the weaknesses of the current Criminal Policy for Police Personnel Who Abused Drugs and how to Reconstruct the Criminal Policy For Police Personnel Who Abused Drugs Based On Justice Value. This research is a normative-legal type of research that is used to examine the function of a norm that lays the law as an instrument that regulates and controls society. The approach used in this research is conceptual, a statute approach, a philosophical approach, and a comparative approach. The analysis used in this research is descriptive-qualitative. The results show that Police officers who are suspected of using narcotics and subjected to the investigation must still be considered innocent until proven through a court decision that has permanent legal force (the principle of presumption of innocence) as stipulated in Article 8 paragraph (1) of Law no. 48 of 2009 concerning Judicial Power. However, in reality, the enforcement of the police professional code of ethics against members of the police who are entangled in criminal cases of narcotics abuse has not been carried out properly as the police still do not immediately take firm action against members who are entangled in criminal cases of narcotics abuse, it is impressed that the police are still protecting their members and are considered after the members have been tried in general court and were found guilty of committing a narcotic crime. The police should be able to monitor their members more and instill a higher law-abiding attitude so that their members can avoid criminal acts of drug abuse, such as urine tests. For those who have the authority to prosecute violations of the code of ethics committed by members of the police, they should be more strict in taking action against police who are caught in narcotics use cases and should be rehabilitated as soon as possible, not fired or imprisoned.

Background: Gbogbonise Epa Ijebu is a commercially sold native concoction in South-West, Nigeria, with the potential of curing many ailments as claimed by the manufacturer and vendors. This study investigated the antimicrobial quality and efficacy of Gbogbonise Epa Ijebu. Materials and Methods: A total of 20 samples of the herbal remedy were purchased from local vendors in Ilishan-Remo Community of Ogun State, Nigeria and were assessed for their microbiological quality using standard microbiological methods. Also, the efficacy of the herbal remedy was tested against some selected uropathogens using the Punch-hole agar diffusion method. Data generated were analyzed using the Instant GraphPad software package and P value <0.05 was considered statistically significant. Results: The outcome of the study shows that half (50%) of the herbal remedy samples examined were sterile, while the other half (50%) were contaminated with a microbial count of <10 CFU/mL. The microbial isolates recovered from the herbal remedy include: Staphylococcus aureus (8.3%), Coagulase negative Staphylococcus (75%) and Microsporium spp (16.7%). Assessment of the antimicrobial potential of the herbal remedy show that the test herbal remedy had strong inhibitory activity against Staphylococcus aureus (17±0.6 mm), Escherichia coli (16.3±0.3 mm), Pseudomonas aeruginosa (16.3±0.3 mm), Klebsiella pneumoniae (15±0.6 mm) and Proteus mirabilis (14±0.8 mm), except Candida albican, at a concentration of 200 mg/mL. The combined herbal solution and standard drug gave higher zone diameter of inhibition: Klebsiella pneumoniae (25±0.6 mm), Pseudomonas aeruginosa (24±0.6 mm), Staphylococcus aureus (23.7±0.3 mm), Escherichia coli (23.3±0.3 mm) and Candida albican (15±0.6mm), except Proteus mirabilis. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) of the herbal remedy for all the test isolates (except Candida albican) was 100mg/mL and 200mg/mL, respectively. The result of the phytochemical screening showed the presence of alkaloids, anthraquinones, cardiac glycosides, flavonoids, saponins and tannins, while steroids and resins were absent. Conclusion: The outcome of this study further strengthens the claim of efficacy made by the manufacturer and vendors of the herbal remedy. However, more attention should be given to quality preparations, packaging and storage in view of the general safety of the consumers.

Background: Pregnancy is associated with anatomic, physiological and metabolic adaptations to accommodate the fetus and prepare the mother for delivery. These adjustments are mediated by the hormonal influences of the placenta. The study is aimed at evaluating the pattern of changes of serum growth hormone and cortisol in normal pregnancy to access the possible effect of gestational age and parity on these parameters. Methods: A cross sectional study involving a total of 300 apparently healthy females (21-50yrs) with 200 and 100 pregnant females and non-pregnant controls respectively. The age of the subjects, last menstrual period, gestational age and parity were obtained using a simple questionnaire while the weight and height were obtained following standard protocols. Blood samples were obtained from the subjects and serum growth hormone and cortisol were analyzed using standard laboratory methods. Results: Serum growth hormone was found to reduce in pregnant subjects compared to the non-pregnant control with the lowest decrease observed in the second trimester (p<0.05). Conversely, serum cortisol increased among pregnant subjects compared to the non-pregnant control, showing a gestational age-dependent increase (p<0.05). Conclusion: Our findings suggest that serum growth hormone and cortisol vary with gestational age with growth hormone decreasing while cortisol increases. The present study also highlights that parity appears not to have any influence on serum growth hormone and cortisol during normal pregnancy.

The outbreak of the unconventional coronavirus (SARS-CoV-2) on account that December 2019 has created an extraordinary state. Senna is a type of plant in the tropics. Senna, the sienna’s, is a huge variety of blossoming plants in the vegetable family (Fabaceae, subfamily Caesalpinioideae, clan Cassia). As It is a brand new variation of a deadly disease remedy alternatives aren't simplest confined however require painstaking trials to verify theireffectiveness. Due to the lack of information in lots of growing international locations, humans have begun out the usage of herbalmedications, used for numerous different diseases, to fight COVID-19. Misleading data on social mediaregarding “Senna Makki” has gone microorganism in the Asian nation. However, consumption of bush Makki isn't suggested as atreatment possibility for COVID-19 thanks to its several harmful associated side-effects. Though its use in different diseases isevident, trials to verify its effectiveness against COVID-19 got to be prioritized because the public has startedconsuming bush Makki in high doses and while not monitoring prescript.

Everyone is stressed to some extent. The way you respond to stress, on the other hand, has a significant impact on your overall well-being. Stress is defined as any type of change that causes physical, emotional, or psychological strain. Stress is your body's reaction to anything that requires your attention or action. Students are exposed to a wide range of potentially stressful situations in their daily academic lives, which can have a negative impact on both their academic achievement and their health. Among the factors that may be weakened by academic stress are self-efficacy expectations, which are regarded as one of the most important determinants of student engagement, persistence, and academic success. Sometimes the best way to deal with stress is to change your situation. Other times, changing your response to a situation is the best strategy. Short-term and long-term stress are both possible. Both can cause a variety of symptoms, but chronic stress can take a serious toll on the body and have long-term health consequences. As a result, they must be educated on healthy coping strategies. Counselling sessions and other student support systems must be better organized to address issues such as career guidance, healthy coping behaviors, time management, and improving self-esteem among those affected. It is also important to pay attention to making the study environment in the classroom less stressful and free of excessive academic load (Joseph, 2021). This would accomplish the aim of reducing academic stress, improving academic performance, and minimizing anxiety. This review article aims to discuss the causes and coping strategies for adolescents dealing with academic stress.

To integrate with the jawbone and gum tissues, a prosthetic dental material must be appealing, long-lasting, repairable, cleanable, and bio-compatible. In terms of new prosthetic materials, prosthodontics is rapidly evolving. Despite the fact that all artificial materials emit compounds into the oral environment, side effects and unpleasant responses are possible. We utilized Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to conduct an automated and manual search to find clinical studies that looked at the relationship between prosthetic materials and biohazards. A 'ideal' material will have properties that are equal to or very close to those of the material being replaced. One of the most important properties for any material used in the human body is biocompatibility, or more specifically bioactivity. Unlike other implanted materials, the biocompatibility of dental materials varies depending on their structure and state.

Intimate Partner Violence (IPV) has been identified as a global public health problem of human rights concern. It is a global issue with far reaching consequences for the physical, reproductive, and mental health of women, regardless of social, economic, religious or cultural group. Most of the times, IPV is usually perpetrated by a husband or an intimate male partner of a woman or girl and this is often due to the emotional attachment with or economic dependency of the women on the perpetrators of violence. The outbreak of the COVID-19 pandemic and the lockdown measure, although effective in reducing the disease spread has led to unintended negative consequences. The social, economic and financial distress experienced during the COVID-19 lockdown period has increased the prevalence of Intimate Partner Violence. The financial difficulty associated with the lock-down period has been known to precipitate stress and frustration, and subsequent negative coping mechanisms such as substance abuse and depression; all of which are baseline triggers for intimate partner violence. This has been labelled the silent pandemic. This article examines the rise in incidences of Intimate Partner violence in Nigeria during the COVID-19 Pandemic and contends that Individual Risk Factors, Financial Dependence on the Abuser, Poor Implementation of the rights of women, Cultural Perception of Women, Poor Governance and Resource Management, Lack of Adequate Social Welfare Palliative Schemes, in addition to the complications arising from dealing with COVID-19 pandemic are major factors that have resulted in the surge of Intimate Partner Violence in Nigeria. This work underscores recommendations to curb Intimate Partner violence in Nigeria during and beyond the COVID-19 pandemic, and ensure better realization of the rights and welfare of women and girls such as Legal Framework Reform, Socio Economic Empowerment of Women and girls, Community Mobilization and Behaviour Change Communication, Awareness Creation, and establishment of Sexual Assault Referral and Counselling Centres.

Short clinical crowns are more prone to crown dislodgment. Therefore, extra retentive features may be warranted. Though, classic retentive techniques are not always possible to apply in fixed prosthodontics. Hence, it may be beneficial to utilize non-conventional methods to enhance retention in situations where retention cannot be obtained from primary and secondary retentive factors. This article describes a modified technique to increase cast metal and porcelain fused to metal crowns’ retention to cast post and core by using a horizontal retentive pin and hole to lock the crown to the cast post and core.