Background: Male sexual dysfunction is a group of disorders that affect sexual function, most notably erectile dysfunction (ED), Peyronie's disease (PD), and premature ejaculation (PE). More than 50% of men between the ages of 40 and 70 report having some form of erectile dysfunction, which is a rather high prevalence that rises with age. Age, diabetes mellitus (DM), cancer, stroke, hypertension, penile trauma, depression, anxiety, and disturbances in central serotonin neurotransmission and 5-HT postsynaptic receptor function are risk factors for male sexual dysfunction. The International Index of Erectile Dysfunction, the Sexual Health Inventory for Men, and the Premature Ejaculation Diagnostic Tool are three sexual questionnaires that can be used to screen for these illnesses. Fenugreek, or Trigonella foenum-graecum L., also known as methi (in Hindi), has been used as a culinary spice, flavouring ingredient, and medicinal plant for a long time. Despite being more well-known for its seeds, fenugreek leaves and stems have also been claimed to offer medical benefits, including laxative, lactation stimulant, and labour assist properties. Method: The purpose of the current study was to assess the efficiency of flavonoids and steroid saponin found in Trigonella foenum-graecum seed for their inhibitory influence on PDE-5 enzyme to elicit the aphrodisiac potency. The Auto Dock software used a grid-based docking algorithm to determine the bond. Result: Fenugreek found to be effective aphrodisiac agent and effectively binds to be target protein PDE-5 with binding energy -9.8, -10.6, -7.88 & -6.61 kcalmol-1for Diosgenin, gitogenin, Naringenin and Vitexin respectively. Conclusion: The outcome of findings revealed that steroidal saponin(diosgenin) and flavonoid(vitexin) showed potent inhibitory effect on PDE-5 enzyme which reflects the efficacy of fenugreek seed as potent aphrodisiac agent via synergetic effect of steroidal saponin and flavonoid.

With the accelerating speed of artificial intelligence and mobile technology so many companies have fully replaced the traditional services with technology-based self-services. However sometimes fully replacing the traditional service with self-service technologies develops negative attitude among users and they resist and inhibit that technology. For understanding that resistance behavior we draw inferences from psychological reactance theory. Grounded on this theory present study examines the role of some paradoxes (technology anxiety, insecurity) within the context of self-service technology environment. This research develops conceptual model to investigate the impact of two paradoxes such as: technology anxiety and insecurity on adoption attitude. We tested the model and relevant research hypotheses with survey data collected from 152 users of self-service technology in India. The results of the study recommend the service providers that instead of replacing whole service options some choices during the process develops positive attitude among users of technology.

Background: Androgenic alopecia (AGA), commonly referred to as male pattern baldness, represents a prevalent condition characterized by hair loss in men worldwide. While genetic factors primarily influence AGA, hormonal imbalances, particularly involving androgens, play a significant role in its pathogenesis. Platelet-Rich Plasma (PRP) therapy has emerged as a promising treatment option for AGA in males, offering hope for effective solutions for hair loss. Objective: To evaluate the effectiveness of PRP injections in the treatment of androgenic alopecia in males. Methodology: In this prospective study spanning January 2023 to January 2024, 30 male patients with androgenic alopecia (AGA) were enrolled. Diagnosis relied on clinical evaluation, with AGA staging based on the Norwood-Hamilton scale. Patients underwent baseline blood workup and received four PRP injection sessions every three weeks. Visual assessments, digital photography, and a hair pull test were conducted at specified intervals. PRP was prepared from peripheral blood using centrifugation and activated with calcium chloride before injection into affected scalp areas using the nappage technique. Data analysis employed SPSS software, with continuous variables expressed as mean ± SD and categorical variables as numbers and percentages. Fisher’s exact test was used for qualitative data analysis, with significance set at p < 0.05. The study aimed to evaluate the effectiveness of PRP injections in treating AGA in males. Results: The study population's age distribution showcases a varied demographic, with the majority falling within the 28 to 47-year-old range, particularly dominant in the 38-47 years group (50%), followed by 28-37 years (36.67%), while individuals aged 18-27 years represent 13.33% of the total participants. In terms of male pattern baldness, the Modified Norwood Hamilton classification reveals a predominant presence of moderate to slightly advanced stages, with Grade III being the most prevalent (23.30%), followed by IIIa (16.67%) and IIa (16.67%). Additionally, Grade II accounts for 10% of the population, while the more severe stages, IV and IVa, collectively make up 18.50%. At baseline assessment, the majority of patients exhibited moderate hair loss (75%), with mild hair fall noted in 20% and severe hair fall in 5% of the cohort. Over the course of the study, visual assessment on a 7-point scale demonstrated a progressive improvement, with initially all participants showing no change, which decreased to 26% by the 4th month, accompanied by increasing percentages of mild (40.6% at 4th month), moderate (29.6% at 4th month), and excellent (3.7% at 4th month) improvements. Analysis of improvement in the fronto-temporal region compared to the vertex region indicated differences in distribution but lacked statistical significance across categories of improvement (p-values ranging from 0.15 to 1.00), with moderate improvement being more prevalent in the vertex region (50%) compared to the fronto-temporal region (23.8%). Conclusion: PRP therapy offers a straightforward and cost-effective approach to treating AGA in males. With high patient satisfaction rates and minimal adverse effects, PRP presents itself as a viable option for individuals who have not responded satisfactorily to conventional treatments.

Background: The study of free radical chemistry has received a considerable lot of attention recently. Our bodies produce reactive oxygen and nitrogen species and free radicals as a result of a variety of endogenous processes, exposure to various physiochemical situations, or pathological conditions. For optimum physiological function, free radicals and antioxidants must coexist in balance. Oxidative stress results when the body's defences against free radicals are overpowered. As a result, free radicals damage lipids, proteins, and DNA and cause a variety of human disorders. Therefore, using antioxidants from an external source can help to manage this oxidative damage. In contrast to synthetic antioxidants, which are either added to food to increase its shelf-life or are synthesised by plants and found in the foods we consume, natural antioxidants are produced by plants (for example, vitamins and other naturally-occurring substances in our food) (e.g. BHT). Annona squamosa. (Annonaceae, Family). Hindi-speaking locals refer to it as "Sitaphal." Insecticidal, purgative, laxative, astringent, anti-inflammatory, antidiabetic, anti-ulcer, anti-oxidant, antimalarial, and antibacterial are only a few of the pharmacological effects of the plant. Method: In current study HO-1 protein selected as target protein. The Auto Dock software used a grid-based docking algorithm to determine the bond. Using the Merck Molecular Force Field, 2D structures of compounds were created, transformed to 3D, and then energetically decreased up to an arms gradient of 0.01. (MMFF). Result: Flavonoids of A.squamosa found to be effective antioxidant component and effectively binds to be target protein HO-1 with binding energy -6.18 & -5.26 kcalmol-1for quercetin and rutin respectively. Conclusion: The finding of the in-silico molecular docking showed that both lead compound is effective binds & inhibitory action on target protein. The molecular docking of ligands like quercetin and rutin with human HO-1 receptor revealed that it has exhibited the chemical interaction with the amino acids in the active pockets.

Plasmodium berghei infections which usually kill mice in 7-14 days can be terminated in most cases by administration of leaf and stem extracts of Phyllanthus amarus, in doses of 325-108.3mg/kg after inoculation of the animals with 6.2x103 parasitized red blood corpuscles. The methods employed in the course of the study were evaluation of the blood schizontocidal activity on early evaluation of the blood schizontocidal activity during established infection using mice as a case study. The 3-test showed a merozoiticidal action on Plasmodium berghei after taking 4-5µ1 of blood and preparing a thick smear and viewing with x 100 magnification. From the result obtained, blood schizontocidal activity during established infection showed a more promising result from 82.72-93.64%. Thus from all indications of my result it shows that the aqueous extract of P. amarus is therapeutically efficacious in the treatment of P. berghei in all the three test carried out in this study, and this tally closely to the claims by Nigeria Traditional healers of its effectiveness in human P. falciparum infection.

The integration of artificial intelligence (AI) in healthcare has revolutionized the way medical data and information are managed. While AI offers unprecedented opportunities for improving patient care and outcomes, it also raises concerns about patient privacy and data security. This literature review examines the implications of AI on healthcare data and information management, exploring the benefits, challenges, and potential solutions to ensure patient privacy and data security. By analyzing relevant articles and research, this review provides insights into the current state, future directions, and ethical considerations of AI in healthcare. The review finds that while AI has immense potential, there are critical aspects that need to be addressed to strike a balance between innovation and patient data protection. This study contributes to the growing body of knowledge by offering recommendations and best practices to mitigate risks and harness the full potential of AI in healthcare while upholding patient privacy and data security.

This paper focuses on an African pluralistic conception of human nature with specific reference to a Cameroonian Philosopher and Theologian Pierre Meinrad Hebga (1928-2008), whose thesis was developed as an attempt to resolve the problems raised by dualism. It should be recalled that the question on human nature since the 17th century had been dominated by Western dualism, in its diverse forms, and it was based on the dichotomy between two substances; a perishable material body; and the immortal soul. The dualist conception of human nature combines both materialist and immaterialist perspectives of human nature. However, it suffered from the dilemma of the dualist problem precisely to know which of the two substances controls the other and how two completely different substances can interact. From this dualistic conception, a question arises to know whether the human body is pure matter. It in this light that Hebga rejects the Western dualism and hence proposes a pluralistic and unified interpretation of human nature from an African perspective based on a tripartite division (a three in one conception); body, breath and shadow which co-exists with each instance representing an entire person viewed from a particular perspective. Likewise, the three instances are relational and cohabit as a composite. This implies that both the body and the soul that form a composite both subsist at death and are hence transcendental. The basic thrust to Hebga’s thesis of this paper is that the human body is not just simple material entity, but material entity informed by breath (spirit), which subsists at death and goes beyond. Human beings are to be thought as beings distinct in kind from purely physical objects. Hebga’s transcendental view of the body in particular and the other non-corporeal instances enable us to understand paranormal phenomena. Hence, throughout this paper our position shall be that of a pluralistic conception of the human being as a composite of the material body, the immaterial breath and shadow. I will further employ Hebga’s tripartite division of human instances to explain paranormal activities as another dimension of human nature. A historical and critical analysis of various secondary sources including Hebga’s philosophical works will help to bring to limelight that his philosophical approach on human nature falls within the armpit of the philosophy of postmodernism, and particularly, deconstruction, for it attempts to disclose the contradictions of classical philosophical concepts; and also tries to open up new and innovative human thinking.

A case is presented of falsely low serum bicarbonate levels with normal arterial blood gas bicarbonate levels in a patient with high triglyceride (TG) levels. This false phenomenon is explained by the presence of high triglyceride levels. Most laboratories use an enzymatic/photometric or indirect ion-selective electrode method to measure bicarbonate. Hyperlipidemia interferes with photometric analysis due to its light scattering effect. An ABG analyser employs a direct ion-selective electrode method that is free from the errors of a photometric analyser. Currently, several methods are available to eliminate the interference of lipemia and allow accurate measurement of biological quantities. The clinical laboratory must establish a protocol for handling lipemic samples according to the biological quantity to be tested.

Objective: The aim of this study was to evaluate the effectiveness and tolerability of biological treatments administered after an initial treatment with Rituximab. Methods: A cross-sectional study was conducted using the baseline data of the Moroccan biotherapy registry for RBSMR. Demographics and disease features were compared using descriptive statistics. The study evaluated the effectiveness of switching to a new biological by measuring DAS28 and ΔDAS28 at baseline, 6 months, and 12 months of follow-up. Adverse effects were also assessed. The study compared the switcher and non-switcher groups, with a significance level set at p < 0.05. Results: A total of 165 patients diagnosed with rheumatoid arthritis were treated with Rituximab as their first biologic. The mean age of patients was 51.79 ± 11.27 years with a majority of females (87.9%). The mean duration of the disease was 13.84 ± 9.07 years. In 21.81% of cases, 36 patients required at least one switch due to ineffectiveness. After 1 year of follow-up, switchers had a greater ΔDAS 28-ESR (-0.31 ± 2.22) compared to non-switchers (-0.17 ± 1.72). At 1-year follow-up, 53.6% of switchers were in remission/LDA compared to 43.8% of non-switchers. Adverse effects to biotherapy were more common in switchers (44.4%) than non-switchers (31%), with infections being the most common adverse effect in both groups (22.2% and 13.2%, respectively). Conclusion: Switching after Rituximab in RA patients may be as effective and tolerable as switching after TNF inhibitors.

This study analyses the impact of the Comprehensive Economic Partnership Agreement (CEPA) between the United Arab Emirates (UAE) and India on their trade and investment connections. The CEPA is a bilateral trade agreement that encompasses discussions on the exchange of services and investments, as well as other aspects of economic collaboration. This trade deal is India’s inaugural bilateral trade pact in the Middle East and North Africa (MENA) area. The article employs several data sources and analytical techniques, including trade statistics, economic indicators, qualitative data, and econometric models, to examine and differentiate the trade and investment trends between India and the UAE prior to and following the CEPA agreement. The article also examines the potential variables that impacted the changes, including the tariff and non-tariff obstacles, market access and possibilities, political and diplomatic connections, and the regional and global context. The study reveals that the CEPA agreement has notably augmented the two-way trade and investment between India and the UAE, particularly in crucial industries such as mineral fuels, electrical machinery, gems and jewellery, vehicles, essential oils, cereals, and chemical products. The study also offers policy suggestions for strengthening their bilateral collaboration in the post-pandemic period.

Background: Perinatal and maternal morbidity and mortality is decreasing in most countries with effective antenatal care and safe child delivery facilities, but it is rising in underdeveloped nations with low resources and dangerous home birth practices. The present study sought to determine the factors that influence home birth in western Sudan. Methodology: This is a descriptive longitudinal study that took place at the Obstetrics and Gynecology teaching hospital in Al-Obeid, North Kordofan State, Sudan, from January to December of 2023. This study has enrolled around 224 individuals. Results: Financial problems were the most common reason for choosing home birth (23.6%). The majority of cases (22.3%) occurred among individuals under the age of 20. The majority of cases were from rural areas, accounting for 62.1%. The majority of the study population (29.9%) were illiterates. The majority of the patients (22.7%) were from Shikan, while the remaining were from other war-affected locations. Conclusion: The preference for home childbirth is growing in western Sudan states, particularly among illiterates, rural residents, teenagers, and low-income patients. The most apparent factors include financial and community beliefs.

Hodgkin’s lymphoma (HL) is a lymphoid malignancy of mature B lymphocytes. Based on morphology and immunophenotype, HL is classified into two types: classical HL (cHL), and nodular lymphocyte-predominant HL (NLPHL). cHL usually present with asymptomatic lymphadenopathy and Constitutional symptoms ("B" symptoms, i.e., fever, night sweats, or unintended weight loss). In a minority of cases the clinical presentation of cHL is atypical. Here, we report a rare case of Hodgkin’s lymphoma (HL) presenting as combined of multiple unusual manifestations of autoimmune haemolytic anaemia, polymyositis, celiac disease, and venous thromboembolism before the diagnosis.

This research investigation centers on assessing the mechanical properties of hybrid composites formed by integrating composite fibers in woven mat form into a matrix element, employing diverse stacking sequences of symmetrical laminates. Specifically, the objective of this research is to experimentally evaluate the mechanical characteristics, including density, hardness, impact resistance, flexural strength, tensile strength, and interlaminar shear strength (ILSS) of S-glass and Basalt fiber epoxy hybrid composites, followed the procedures outlined as per ASTM standards. The laminates were manufactured using a combination of hand lay-up and compression molding techniques, employing four distinct stacking sequences. The mechanical characteristics of these hybrid composites were subsequently compared to those of pure composite counterparts. The mechanical robustness of the resultant composites was systematically evaluated. Experimental findings revealed that the hybrid composite with a stacking sequence of 2/2 B-S-E-C exhibited the highest tensile strength and flexural strength, measuring 330.5 MPa and 367.53 MPa, respectively. Furthermore, this composite demonstrated elevated density and Shore hardness, registering a value of 90. However, it is noteworthy that the impact properties and ILSS of the pure B-E-C composite were superior, boasting a Charpy impact strength of 98.85 KJ/m2, Izod impact strength of 1225.80 J/m, and ILSS of 38.10 MPa. To gain insights into the fracture morphology of the hybrid composites during testing, Scanning Electron Microscope (SEM) analysis was conducted. SEM images revealed that the hybrid composite with a 2/2 B-S-E-C stacking sequence exhibited fiber/matrix and its interfacial interactions upon their failure, mainly focusing its fractured surface in comparison to other hybrid composite configurations. Overall, the results underscore a significant enhancement in mechanical properties when hybrid composites are configured optimally.

Talents in the public sector are considered an elite force of the Vietnamese Party cadres; the contingent of civil servants, state employees and the intellectuals of our country. Consequently, attracting and appreciating talented people in the public sector is a strategic matter for national construction and development, especially in the context of the Fourth Industrial Revolution (Industry 4.0), trends in globalization and transition to a knowledge economy. In this article, by clarifying the connotation of attracting and appreciating talents, especially attracting and appreciating talents in the public sector, the author analyzes the necessity of attracting and appreciating talents in Vietnam public sector in the context of digital transformation in Vietnam; raise some concerns about this issue and thereby making proposals to improve the efficiency of attracting and appreciating talents in Vietnam public sector to meet the requirements of the new context.

Bacillus spp. and related bacteria such as Lysinibacillus spp. are commonly regarded as contaminants if isolated in the laboratory primarily due to their ubiquitous nature and perceived lack of pathogenicity. There are no reports of ocular infection by this agent in the literature. This article describes an unusual case of corneal abscess caused by Lysinibacillus sphaericus, which developed after corneal trauma.