Annickia affinis is a medicinal plant traditionally used in Africa against several diseases including peptic ulcers. We conducted this study to evaluate the antiulcer and gastroprotective activities of the ethanolic extract of the stem bark of this plant. The antiulcer activity was evaluated on Wistar rats using 95% ethanol and then administering to them as treatment solutions, the ethanolic extract of the stem bark of the plant and other referenced anti-ulcer drugs over periods of 7 and 14 days. The gastroprotective activity was carried out following the opposite path, the different batches of rats first received one of the treating solutions and an hour later, the ulcer was induced on them and they were finally sacrificed an hour after administring the ulcerogenic solution for the macroscopic and microscopic analysis of their stomachs. Phytochemical screening revealed the presence of alkaloids, saponins, reducing sugars, coumarins, anthocyanins, anthraquinones. UPLC-MS analysis revealed the presence of 16 compounds, notably berberine, berberrubine, canadine, palmatine, jatrorrhizine, columbamine, pseudocolumbamine, 7,8-dihydro-8-hydroxypalmatine, atherosperminine, argentinine, 7-hydroxydehydronuciferine, 7-hydroxydehydronornucierine, Caryophyllene oxide, 1,5-epoxysalvial-4(14)-ene, humulene epoxide II and spathalenol. The administration of the ethanolic extract of the stem bark of Annickia affinis at doses of 2000 mg/kg and 5000 mg/kg showed no acute toxicity. The results obtained from the evaluation of pharmacological activities revealed that the ethanolic extract of the stem bark of Annickia affinis would have antiulcer and gastroprotective properties comparable to omeprazole and sucralfate at the dose of 150 mg/kg. It appears from this study that the stem bark Annickia affinis could be used both in the prevention and in the treatment of gastric ulcers which would justify its use in the traditional pharmacopoeia.

During the period between 1933 and 1945 the racial theory of National Socialism underwent enormous variations. It is possible to observe four different phases, some of which overlap in time. The first of these is based on the existence of a superior 'Aryan' race and defined by Hitler in Mein Kampf. This second stage, which ended around 1934, was characterized by the uncritical acceptance of Hans Günther's theses. Günther idea is centered on the Nordic breed: a tall, long-legged, thin, with average height, among males, about 1.74 m. Hair color is blonde. The stream of thought emanating from Hans Günther is known as Nordicism. The fact that about 95% of the German population, as well as almost the entire top leadership of the NSDAP, qualified as 'bastards-à-la-Günther', the Party was unable to accept such a conclusion. This was the generator of the third stage of NS racial theory. This phase is defined by an entire rejection of Günther's Nordicism. In Nuremberg, on the Day of the Party of 1933, Hitler declared: 'We do not conclude from the physical type of a man his ability, but from his achievements his race’. The fourth stage of the NS racial theory is fully demonstrated when the Waffen SS begins to welcome non-Nordic elements into its ranks. Since this fourth stage of National Socialist Racial Theory was interrupted in 1945, it is very difficult to predict what its end would have been.

Introduction: Clinical trials are essential in the advancement of global scientific knowledge. The role of nurses at SQCCCRC-UMC has become more significant because of their direct role in caring for clinical trial participants. This necessitated building their capacity through training to care for trial participants as per the International Council of Harmonization- Good Clinical Practice (ICH- GCP). Objectives: This study aims to investigate the effect of a capacity-building initiative that includes conducting Clinical Trial Workshops (CTW) and getting nurses certified in online ICH-GCP. Method: 21 CTW were conducted. Pretest and posttest scores to check knowledge were collected from 2022 to 2024 and analyzed using paired t-tests to compare averages. Nurses were also asked to submit ICH-GCP certification to the clinical trials department (CTD) for record keeping. Results: CTW had a total of 171 participants composing of 96% of nurses (n=165). Those nurses accounted for 50.6% of the total nursing workforce (n=326). 88.5% (n=146) of those nurses completed both the pretest and posttest. The mean posttest score (87.2%) was compared with the mean pretest score (68.5%) showing an average increase of 19 %, which indicated statistical significance. (CI=95%, t=0.05). 86 nurses have completed ICH-GCP certification during the same period. (26.4 % of all nurses, n=326). Conclusion: The capacity building approach significantly improved nurses’ knowledge about clinical trials which can potentially aid in caring for patients in clinical trials. Additional research is needed to assess the long-term impact of this approach on nurses’ attitude in caring for those patients.

Background: Sleep is vital, but issues are mounting. Sleep deprivation is dangerous for hospital nurses. This reduces nurse productivity and increases patient-harming medical mistakes. Shift work affects sleep and circadian rhythms; therefore, night shift female nurses' sleep is important. Nurses and patients lose sleep amid disturbances. Objectives: The study examined night-shift female nurses' sleep quality. Methods: A cross-sectional study was conducted in Dhaka Medical College's Physiology Department from January to December 2019 among 160 female nurses aged 24-50 who work night shifts from 8 p.m. to 8 a.m. in In-patient department of Medicine, Surgery, Obstetrics, and Gynecology. Pittsburg Sleep Quality Index and nurse demographics were obtained. After informed consent was signed, the individual was thoroughly questioned and recorded in the predesigned data form. Statistics were done with Excel and SPSS-26. Results: Mean BMI was 23.91 ± 1.64 kg/m², and systolic and diastolic blood pressures were 105.63 ± 11.10 and 69.94 ± 6.68 mmHg, respectively, without statistical significance (p > 0.05). The Pittsburgh Sleep Quality Index (PSQI) components showed significant results (p < 0.001), with mean scores for subjective sleep quality (1.09 ± 0.35), latency (1.95 ± 0.84), duration (1.77 ± 0.72), and additional parameters resulting in a mean global PSQI score of 7.94 ± 1.76. Highest number of respondents were belonging to age group 31–40 and 68.75% were married and in medical wards (42.50%). The lowest sleep quality was seen in Obstetrics & Gynecological wards, with 54 nurses scoring over 5 on the global PSQI (p < 0.001). About 69% of nurses had a PSQI score > 5, suggesting poor sleep quality, associated with age, marital status, and ward type (p < 0.001). Conclusion: Female nurses need sleep hygiene instruction, shift schedule adjustments, and stress management to sleep better. These obstacles affect nurses' well-being and care quality.

Japanese encephalitis (JE) is the leading form of mosquito borne viral encephalitis in Asia, with about 100,000 annual cases in which children are more dominant. The causative agent of JE is Japanese encephalitis virus (JEV) which is transmitted by Culex mosquitoes particularly Culex Tritaeniorhynchus. Mostly JE infections in humans are asymptomatic while severe JEV infection occurred in only few cases characterized by high grade fever, headache, seizures and unusual behavior, lesion and paralysis. The specific treatment of JEV is not available so far but the supportive care is effective. Many antiviral drugs have been investigated, but none of these have shown to improve the effect of JE except minocycline. The objective of gathering information and performing review is to asses JEV emergence possibility in Pakistan and to define some mitigation measure. In this review, the current knowledge of the prevalence and the pathogenesis of the JEV have been summarized. Furthermore, the current scenario of JEV, challenges and possible way forward in Pakistan has been discussed.

Oil revenue is still one of the most relevant sources of foreign earner in contemporary Nigeria despite the systematic and the numerous challenges bedeviling the management of oil revenue. The study therefore, examined the relevance of oil revenue in economic growth in contemporary Nigeria using annual time series data from 1981-2020. The data were sourced from the Central Bank of Nigeria (CBN) Statistical Bulletin, Volume 31, 2020. The data obtained were modelled using the Ordinary least square (OLS) method; three control variables “non-oil revenue, government expenditure and exchange rate” were included to moderate for the effect of crude oil revenue, while economic growth was proxied by real GDP. The OLS estimate suggests that a significant (0.0000) and negative (-2.083536) relationship exists between oil revenue and Real GDP in Nigeria; while non-oil revenue have a positive and significant relationship with real GDP. The negative relationship as shown between oil revenue and real GDP in Nigeria in this study is buttressed by the Resource Curse Theory. We therefore recommend amongst others that government should rehabilitate and upgrade our refineries to increase efficiency, capacity and product quality to burst economic growth that will lead to the reduction in poverty, inequality and unemployment.

Technologies such as Artificial Intelligence and Automation are shifting the human workforce to new roles, creating the need for new skills. This research aimed to understand the expectations of companies in Chihuahua, Mexico, regarding the skills required for the future of work and compare them with the results presented by the World Economic Forum in its 2018 Future of Jobs Report. A survey was conducted among 359 companies on this topic. The main findings reveal a 60% match between the top 10 skill groups prioritized globally and locally. However, skills such as "Technology Design and Programming," "Emotional Intelligence," "Reasoning, Problem-Solving, and Ideation," and "System Analysis and Evaluation" are considered crucial globally but not locally.

Background: Endometrial cancer (EC) is a leading gynecological malignancy worldwide, with rising incidence in developing countries. Prognostic factors play a critical role in guiding management, especially in resource-limited settings where molecular testing is not routinely available. Aim of the study: To evaluate clinicopathological prognostic factors influencing recurrence in patients with endometrial cancer treated at a tertiary care hospital in Bangladesh. Methods: A retrospective observational study was conducted on 45 histologically confirmed EC patients who underwent hysterectomy-based surgery. Demographic, clinical, pathological, and treatment-related data were analyzed using SPSS version 26.0. Univariate analysis was performed with Chi-square or Fisher’s exact test, and multivariate Cox regression was used to determine independent predictors of recurrence. Hazard ratios (HR) with 95% confidence intervals (CI) were reported, and a p-value <0.05 was considered statistically significant. Result: The mean age was 54.9±12.4 years; 55.6% were postmenopausal. Most patients presented with stage I disease (77.8%). Significant independent predictors of recurrence included tumor grade 3 (HR 2.75; p=0.039), myometrial invasion ≥50% (HR 3.80; p=0.023), LVSI presence (HR 4.25; p=0.007), advanced FIGO stage III–IV (HR 5.67; p=0.004), and lymph node positivity (HR 3.92; p=0.032). Surgical approach and adjuvant therapy were not significantly associated with recurrence. Conclusion: Advanced stage, high tumor grade, deep myometrial invasion, LVSI, and lymph node involvement are key prognostic factors for recurrence in EC. In low-resource settings, reliance on these clinicopathological predictors is essential for risk stratification and optimizing treatment strategies.

Abū Bakr Moḥammad Ibn Zakriyā Al-Rāzī, a distinguished physician of the 9th–10th centuries, made ground-breaking contributions that significantly shaped the discipline of paediatrics and advanced the knowledge and treatment of infectious diseases. His scholarly works, which include the renowned texts Kitāb al-Hāwi and Kitāb al-Judri wa al-Hasbā, underscore the critical importance of preventive health measures, stringent hygiene practices, and the necessity of implementing age-appropriate treatments tailored specifically for children. Al-Rāzī made a significant distinction between the illnesses that affect children and those that are prevalent in adults, advocating for a therapeutic approach that is uniquely tailored to the specific health needs of the younger population. His ground-breaking monograph, titled Kitāb al-Tibb al-Atfāl, systematically addressed the various aspects of paediatric care, offering insights that were revolutionary for his time. Furthermore, Al-Rāzī's meticulous and detailed descriptions of diseases such as smallpox and measles enhanced the precision of diagnostics, thereby improving the understanding of these conditions and their management. His insightful contributions laid the essential foundations for the evolution of modern paediatrics as well as for the contemporary approach to infectious disease management, influencing several generations of medical practitioners and researchers in subsequent eras.

Wheat is a critical staple crop in Pakistan, contributing significantly to food security and the national economy. However, the adoption of modern sustainable wheat production practices (SWPP) remains low, leading to suboptimal yields and persistent food insecurity. Therefore, this study is conducted to investigate the socio-economic factors influencing the adoption of sustainable wheat production practices among smallholder farmers in Khyber-Pakhtunkhwa, Pakistan. Using a multistage sampling technique, data were collected from 268 farm households in the Charsadda district. Descriptive statistics and econometric models were employed to analyze the data, with an adoption index constructed to measure the extent of SWPP. The results reveal that education, farm size, farming experience, income, and access to extension services are significant determinants of SWPP adoption. Older farmers and those with larger families also showed a propensity to adopt SWPP, though to a lesser extent. The regression model explained 65.1% of the variation in adoption, highlighting the importance of these factors in enhancing wheat productivity. Barriers to adoption include limited access to credit, inadequate extension services, and low education levels. The study concludes that targeted interventions are needed to promote the adoption of SWPP. Recommendations include enhancing farmer education and training, strengthening extension services, improving access to credit, and implementing policies that support SWPP.

This research investigates the empirical linkage between trade openness and poverty in India through a comprehensive three-stage model approach. In first stage descriptive statistics, correlation matrix analysis and unit root tests are used to analyse the characteristics, nature and stationarity of the selected variables. Further, in the study Autoregressive Distributed Lag (ARDL) co-integration model to explore both long-run and short-run relationships between trade openness and poverty. Some post estimation test including the Breusch-Godfrey LM test, White heteroskedasticity test, and the Ramsey RESET test in the last stage. The empirical findings of the study show that there is positive correlation between trade openness and poverty (HDI). In the long run, trade openness, foreign direct investment (FDI), and exchange rate have significant impacts on poverty reduction, while inflation rate and GDP per capita exhibit mixed effects. Impact of FDI and Trade Openness (TO) is positive on poverty reduction, while exchange rate, inflation rate, and GDP per capita show varying impact on poverty. The study suggests that policymakers should consider fostering trade openness and addressing other economic factors to effectively reduce poverty in the country.

Diabetic foot ulcers (DFUs) are a significant global health burden, exacerbated by the rise in multidrug-resistant (MDR) bacterial infections. This study evaluated the antibacterial effects of Sansevieria zeylanica (S. zeylanica) leaf and root extracts against MDR Proteus mirabilis isolated from diabetic patients with DFUs at a teaching hospital in Nigeria. Antimicrobial susceptibility testing of clinical isolates of MDR P. mirabilis was conducted using the Kirby-Bauer disc diffusion method. The antibacterial activity of S. zeylanica extracts was evaluated using the agar well diffusion method. Additionally, the synergistic/antagonistic effect of the extracts with Ofloxacin was assessed. Antimicrobial susceptibility testing revealed high resistance to conventional antibiotics, with 61.5% of isolates identified as MDR. Methanolic extracts of S. zeylanica demonstrated moderate antibacterial activity, with root extracts exhibiting greater inhibition zones (10-17 mm) compared to leaf extracts (8-13 mm). However, co-administration with Ofloxacin revealed an antagonistic effect. These findings suggest that S. zeylanica root extracts hold promise as an alternative therapeutic agent for DFU management. Further research is needed to optimize extract formulations and explore their clinical applications.

This narrative review synthesizes the existing literature to define and optimize the distinct and coordinated roles of allied health technologists during the critical initial phase of trauma care. The analysis is framed within the modern interpretation of the "Golden Hour" not as a literal 60-minute timeframe, but as a guiding principle of urgency that demands rapid, parallel, and protocol-driven actions to save life and limb. Through a narrative review of peer-reviewed literature, clinical guidelines, and professional standards focusing on adult trauma care in Level I and II trauma centers, this paper examines the contributions of a spectrum of specialists: Emergency Medical Technicians (EMTs), Medical Laboratory Technicians, Radiology Technologists, Anesthesia Technologists, Pharmacy Technicians, and Dental Assistants. The key finding of this review is the identification of a complex system of interdependent, time-sensitive tasks performed by these technologists, which collectively form the diagnostic and preparatory foundation for all definitive surgical and medical interventions. A central theme emerges wherein the efficiency and success of the entire trauma response are contingent on the seamless communication and coordination between these technologist specialties. The review concludes that the "Golden Hour" is saved not only by the visible leadership of physicians and nurses but by the rapid, highly coordinated, and often unseen efforts of this multidisciplinary technologist team. Consequently, this paper advocates for greater institutional recognition of these essential roles, the development of integrated, technologist-inclusive trauma protocols, and the mandatory inclusion of all relevant technologist specialties in high-fidelity interdisciplinary trauma simulations to enhance system-wide performance and improve patient outcomes.

Lung cancer is leading cause of mortality worldwide. About 80-85% of lung cancers are nonsmall cell lung carcinomas (NSCLC). The main subtypes of NSCLC are adenocarcinoma, squamous cell carcinoma and large cell carcinomas. These NSCLC are grouped together as their treatment and prognosis is often similar. Diagnosis depends on symptoms, histopathology and molecular biomarkers. Even treatment in late stages of NSCLC requires appropriate testing with predictive molecular biomarkers as it provides information that is essential for establishing appropriate treatment options for each patient. This review paper provides current molecular biomarkers in NSCLC which are useful in diagnosing as well predicting treatment.

Healthcare technicians play a pivotal role in the modern healthcare system, serving as the backbone of various medical disciplines. This review article explores the multifaceted roles of healthcare technicians across five key areas: radiology, nursing, laboratory services, medical records, and pharmacy. Each section delves into the specific responsibilities, skills, and contributions of technicians in these fields, highlighting their importance in enhancing patient care, ensuring safety, and improving healthcare outcomes. By examining the evolving landscape of healthcare technology and the increasing complexity of patient needs, this article underscores the necessity for ongoing education and collaboration among healthcare technicians and other professionals. Ultimately, the integration of healthcare technicians into multidisciplinary teams is essential for delivering comprehensive and effective patient care.