Scoliosis, also known as lateral curvature of the spine or spinal lateral deviation, is a three-dimensional spinal deformity characterized by the bending of one or multiple segments of the spine to the side accompanied by vertebral rotation. It appears in the shape of an "S" or "C" and can cause pain during standing, walking, or lifting heavy objects, leading to a reduction in physical activity. Scoliosis is the most common spinal disorder among children and adolescents. Adolescent Idiopathic Scoliosis (AIS) refers to scoliosis that occurs during the teenage years and its etiology remains unclear. AIS is a spinal condition characterized by a three-dimensional deformity in the coronal, sagittal, and axial planes, with a Cobb angle of 10 degrees or more. The global prevalence of AIS ranges from 0.47% to 5.2% (Erwin et al., 2020; Konieczny et al., 2013). According to a study by Qiu Guixing et al., the prevalence of scoliosis in China is estimated to be approximately 0.6% to 2.0%, with 90% of cases being AIS. Jia Juanjuan et al., conducted a scoliosis screening of 8,026 students in Jiaxing City in 2019, with initial screening identifying 218 positive cases. Among them, 132 cases were confirmed through X-ray examination, estimating a scoliosis prevalence rate of 5.46% among primary and secondary school students in Jiaxing City. Chen Xiaosheng, Ru Shouhang et al., conducted a scoliosis survey among students from the fourth grade of primary school to the second grade of high school in various districts of Shenzhen City from January to December 2020, with the results showing a scoliosis prevalence rate of 5.01% among primary and secondary school students in Shenzhen City. The prevalence rate was higher in females than males and increased with age. If scoliosis in adolescents is not promptly and effectively treated during their growth process, the spinal deformity can rapidly progress and lead to various complications. For example, scoliosis can cause changes in the shape of the ribs, resulting in unequal thoracic cavity volume and breathing difficulties. Prolonged restricted breathing can lead to complications such as chest tightness and shortness of breath. Additionally, scoliosis can affect the functioning of abdominal organs, leading to pulmonary dysfunction and hypoxia, and in severe cases, it can cause cardiorespiratory failure. Furthermore, scoliosis not only affects the physical health of patients but also their mental well-being. The physical appearance changes caused by scoliosis deformity can potentially lead to psychological disorders.

Lipids are indispensable in the SARS-CoV-2 infection process and studies have focused on investigating the clinical significance of plasma lipid profile on COVID-19 patients. There are studies in patients with COVID-19 that document that blood lipid levels change in individuals who have been infected by SARS-CoV-2 and that their increase is consistent with the degree of morbidity and mortality. At the same time, it has been measured that during the complete recovery of the patients there is also a complete normalization of the lipid profiles. Furthermore, it has been reported that a large proportion of COVID-19 patients continue to receive lipid-lowering therapy after recovery. Lipid-lowering medication is generally continued throughout the period of active infection and beyond. The present review focuses on investigating the relationship between low-density lipoproteins (LDL) and SARS-CoV-2 infection and how lipid levels can predict prognosis or mortality in patients with COVID-19.

Background: Numerous obligatory intracellular bacteria from the Alphaproteobacteria genus Rickettsia can cause rickettsial infection. The most prevalent newly emerging and reemerging diseases are rickettsial infections. Objectives: The aim of the study was diagnosis and management of rickettsial infections among febrile patients attending in inpatient and outpatient department in a district hospital in Bangladesh. Methods: This cross-section observational study was carried out in the 250 Beded District Hospital, Joypurhat. The duration of the period from March 2022 to February 2023. A total of 250 patients participated in the study. Both male and female with any age, patients with elevated body temperature, headache, malaise, rash, nausea, and vomiting and gave consent to be included in the study. Severely ill patients, not willing to participate were excluded from the study. Weil Felix test was used in this study and a titre of 1:80 was considered to be positive. Statistical evaluation of the results used to be obtained via the use of a window-based computer software program devised with Statistical Packages for Social Sciences (SPSS-24). Results: The mean age of the patients was 39 ± 1.9. 8% of the patients had ≤18 years of age. 16% were within the age group of 19-29 years, 28% were within the age group of 30-39 years, 24% were within the age group of 40-49 years, 14.4% were within the age group of 50-59 years and 9.6% were ≥60 years and 52% of the patients were male. 100% of the respondents had fever, 20% had generalized weakness, 15.2% had headache, 16% had cough and cold, 24% had body ache, 8% had vomiting and abdominal pain respectively, 4% had per nasal watery discharge, 36% had rash, 16% had nausea, 24% had anorexia and 4% had other symptoms. CBC & ESR and Weil Felix test were the most common (100%) investigation among the patients, Urine R/M/E in 68%, serum creatinine in 18%, USG of W/A in 15%, CRP in 18%, PBF in 7, Urine C/S in 10%, S. Electrolytes in 4% cases. We found 90 Rickettsial Infection positive patients. Doxycycline and Paracetamol and Esomeprazole were prescribed to all patients 90(100%) and followed by Linagliptin+Metformin to 20(22.22%), Glimipiride to 19(21.11%), Azithromycin to 18(20%) and Domperidon to 10(1.11%), Montelukast 9 (10%), Pantoprazole to 8(8.89%), Rupatadine to 7(7.77%), Ondansetron to 6(6.67%), Tiemonium to 5 5.57%), Fexofenadin to4(4.44%) and other treatment along with the prescribed medicines was given to 40(44.44%) patients. Authors studied the response of Doxycycline which showed 85(94.44%) cases improved within 48 hours of start of treatment. Remaining 5(5.55%) cases showed delayed response due to late presentation. Conclusion: Rickettsial illness is inextricably linked to the sociocultural life of the majority of metropolitan residents. However, a lack of medical facilities and qualified doctors makes it challenging to identify rickettsial disease in febrile patients. It's important to make an early diagnosis when treating rickettsial illness.

Today, it is common practice to employ computational software tools for investigating the structure, dynamics, surface characteristics, and thermodynamics of inorganic, biological, and polymeric systems. Computational software tools are a vital part of the guide for drug discovery. It is frequently employed in approaches for rational drug design and structure-based drug design. The process of drug design and discovery is essential in the invention of a new chemical entity. For this process, plenty of computational tools are available globally, Those computational software tools are fast, free, open online excess paid. Pharmaceutical software decreases human efforts, error, and time utilization in a particular task without compromising the quality of work with great accuracy and efficiency. This software is utilized by various institutes globally related to science and medicine. A computer program that transforms an input structure according toa library of medicinal chemical transformation rules before allowing evaluation of the output structures. High throughput screening is now widely accepted as a viable option that CADD supports. The development of top-notch datasets and design libraries that may be optimized for molecular diversity or similarity has resulted from the quest for novel molecular entities. On the other hand, breakthroughs in computing infrastructure and molecular docking methods are allowing screening throughput to increase quickly.

A pharmacist in general and community pharmacist in specific is a key member of the “healthcare team” involved in achieving a common objective of better healthcare provision. The emergence of “community pharmacy” during post-world war-II era, with a known motto of “drug control” and “patient oriented practice” (POP) came in to existence. The modern pharmacy practices, are not devoid of obstacles and challenges specifically for “Newbie Community Pharmacist (NCP)”, who comes in to direct patient contact at root level, thus necessitates to strict to standards which will help not only in quality care provision but will enhance the abilities of the pharmacist to cope challenges facing at community level. Herein, we will discuss some of the concerns for NCP and their considerations to deal with.

Despite the fact that the World Health Organization (WHO) had provided an average global reference data of Coagulation Properties (CP) of blood in the world, available statistics still suggest a significant discrepancy in CPs of blood among various age groups, socioeconomic classes and races in different locations of the world. Here in Port Harcourt Nigeria, absence of such local reference data had continued to pose over-reliance on the WHO global standards without recourse to our distinctive geospatial and socioeconomic peculiarities. As a result, this study therefore investigated coagulation properties of blood in healthy university students in Port Harcourt. A total of 157 participants were recruited into the study using Stratified Random Sampling techniques. They were administered well-structured questionnaires for an on-the-spot data collections. Thereafter, 5ml of venous blood were aspirated for various coagulation properties (Bleeding, clotting and Prothrombin times and Platelets Counts) investigation. Clotting and bleeding times were measured instantly using capillary and Ivy’s methods respectively. Results from the study revealed a significant (ρ≤0.05) coagulation difference between the WHO standards and both gender (male, 311032 ± 17300* and female, 293600 ± 12800*) for platelets counts. In the age groups, only ≥40 group were significant to all CP (10.30 ± 0.00* for BT, 10.00 ± 1.30* for CT, 10.22 ± 2.88* for PT and 190320.73 ± 1886.45* for PC). Similar significant result was also noted for Obese Class 2, morbid obesity and protein diet groups as compared with the Control. This study therefore concluded that CP significantly vary with the WHO standards, age, gender, BMI and nutritional background and recommended similar study be conducted in other locations in Nigeria and Africa.

Background: One of the most serious complications of diabetes that places an enormous strain on the patient, the healthcare system, and the world economy is diabetic retinopathy (DR). It includes long-term exposure to the metabolic changes linked to diabetes, which cause damage to the retina's microvasculature. Objectives: The aim of the study was to assess the prevalence of diabetic retinopathy and associated risk factors among diabetic patients in a tertiary care hospital. Methods: This cross-section observational study was carried out in the Department of Ophthalmology, North Bengal medical College. Convenience sampling technique was followed. Face to face interview was done to collect data with a semi-structured questionnaire. After collection, the data were checked and cleaned, followed by editing, compiling, coding and categorizing according to the objectives and variable to detect errors and to maintain consistency, relevancy and quality control. Statistical evaluation of the results used to be obtained via the use of a window-based computer software program devised with Statistical Packages for Social Sciences (SPSS-24). The duration of the period from July 2018 to July 2022. A total of 120 patients were participate in the study. Results: About 58.33% respondents were male and 41.67% were female. Majority (33.33%) of the respondents were within the age group of 50-59. 33.33% were service holder, 41.67% were businessman, 12.5 were day labor, 6.67% were farmer. 75% were from urban area and 25% from rural area. The prevalence of DR in this study was 41.1%. About 90% had DM of <5 years, 55% had 6-10 years, 40% had 15-20 Years, 30% had 16-20 years and only 7% had >21 years. About 50% had normal grade of diabetic retinopathy in the worse eye, 15% had Mild NPDR, 8.33% had Moderate NPDR, 6.67% had Mild to moderate NPDR with non-CSME, 2.5% Moderate NPDR with CSME, Severe NPDR with non-CSME Severe NPDR with CSME and Advanced PDR respectively. Mean FBS (mg/dl) was 160.86±70.6, Total cholesterol (mg/dl) was 183.2 ± 2.1, Triglycerides (mg/dl) was 161.2 ± 2.6, Systolic BP was 130.56±15.7 and Diastolic BP was 80.86±13.4. Patients with baseline age of <60 years were three times (AOR = 3.2:95% CI: 1.19–8.63) more likely to develop DR. The odds of DR is about 3 times (AOR = 2.91:95% CI: 1.01–8.35) higher for patients with disease duration of ≥6 years as compared to disease duration of <6 years. Systolic blood pressure also had statistically significant association with patients having blood pressure of <140 mmHg being about 3.6 times (AOR = 0.28:95% CI: 0.09–0.82) less likely to have DR as compared to hypertensive patients with systolic blood pressure of ≥140 mmHg. The other cofactors, history of hypertension, and total cholesterol level were not independent significant factors for the development of DR in our study. Conclusion: Systolic hypertension, being on insulin alone or in combination with OHA, and having diabetes for a longer period of time were all independently linked to the occurrence of DR. The significant DR prevalence our study suggests that routine patient care, including treatment facilities, has to be improved. Healthcare practitioners must make a consistent effort to educate diabetic patients about the importance of blood sugar control and hypertension management in lowering the risk of the start and progression of DR. It is advised that diabetic patients get health education regarding the importance of routine eye exams for the early detection and treatment of diabetes-related eye problems.