Indigenous knowledge, a multidimensional framework of know¬ledge system passed down from genera¬tion to generation, provides a valuable but often neglected tool in addressing global challenges. Such understanding, rooted in millennia of cultural, environmental, and spiritual traditions, fosters sustainable livelihoods, resilient communities, and social harmony. In an era of ecological crises, climate change, and growing divisions between rich and poor amidst the promise of rapid technological advancement, incorporating indigenous wisdom into innovation processes offer an opportunity for deep system change that can create effective, impactful, sustainable solutions. However, the place of indigenous knowledge within global systems of entrepreneurship and innovation presents both opportunities and challenges worthy of engagement. This paper explores how indigenous knowledge can be integrated in a manner beyond a Western paradigm; something that would be valuable to global innovation in sustainable development, biodiversity strategies, and social entrepreneurship. Through archival documents and specific case studies of indigenous knowledge applications in environmental management and community-driven business models, the paper illustrates a mutualistic relationship between traditional practices at local levels and modern science and technology. Agroforestry and crop diversification, for instance, are indigenous agricultural practices that provide sustainable methods of producing food as alternative models to industrial agriculture. Traditional medicinal knowledge has also played a complementary role in the progress of pharmaceutical products by introducing novel natural agents that can potentially be used as therapeutic agents. Indigenous governance systems, with their emphasis on communal well-being and sustainability for future generations, offer ethical frameworks for social entrepreneurship that can engender more equitable models of doing business around the world. Despite the potential benefits, there are challenges. For instance, incorporating indigenous knowledge raises the concern in intellectual property of whether indigenous communities would be acknowledged as legitimate source of innovation. The paper advocates a holistic approach in collaboration and promotion of indigenous knowledge towards a more inclusive innovation and sustainable development for the overall benefit of the global population.

The viral Monumental Labs Instagram post showing robotic reproduction of Michelangelo's David sparked global debate about artificial intelligence (AI)'s role in art creation, garnering 2.9 million views and revealing deep cultural tensions around technological intervention in creative practices. Building upon the aforementioned discourse, and approaching this unique opportunity, this paper aims to examine how artistic expertise shapes public reception of automated art production. This research uses a mixed-methods analysis of 1,437 organic social media comments, combining automated sentiment analysis with human-coded thematic categorization across six professional artist categories. Comments were systematically filtered from 2,913 initial responses and analyzed using two-way ANOVA, chi-square tests, and qualitative discourse analysis to examine relationships between artistic identity and technological reception. Results illustrate that while both artists (-0.289) and non-artists (-0.272) showed negative sentiment on average, Fine Arts & Traditional Media practitioners expressed significantly more negative attitudes than Digital & Multimedia Arts professionals (p=0.041). Professional background significantly predicted comment themes (χ²=69.07, p=0.038, Cramér's V=0.155), with traditional artists emphasizing authenticity concerns and skill preservation, while digital artists focused on technical innovation and collaboration advocacy. In conclusion, artistic identity influences both the emotional depth and the conceptual structures used to assess technological integration in arts. Traditional artists express their concerns using philosophical concepts like ‘soul’ and ‘authenticity’ while non-artists emphasize concrete attributes such as ‘handmade’ features. These results are significant for cultural organizations and technology firms involved in the incorporation of artificial intelligence into creative processes.

Mercuric chloride is highly toxic and known to cause significant liver and kidney damage through degeneration and inflammation of the tissues. Sarcocephalus latifolius is a medicinal plant traditionally used for its antioxidant and therapeutic properties. This study investigates the protective effects of Sarcocephalus latifolius on mercuric chloride-induced hepatorenal toxicity in albino Wistar rats. The animals were divided into six groups (A-F); A. control group, B. mercuric chloride-induced group, three treatment groups (C, D, E) with two receiving Sarcocephalus latifolius extract and one vitamin C, in addition to mercuric Chloride. The last group (F) received Sarcocephalus latifolius extract only. The result showed that mercuric chloride caused disruption and degeneration of hepatocytes around the central vein while the groups that received Sarcocephalus latifolius showed structural organization relative to that of the control group. Significant improvement was observed in kidney function test (urea and creatinine) when compared to the mercuric chloride treated group. AST and ALT activity showed significant increase but the group (s) treatment with Sarcocephalus latifolius and vitamin C showed significant reduction AST and ALT activity when compared with the mercuric chloride treated group. Histological examination revealed hepatic and glomerular degeneration and disruption in the mercuric chloride treatment group while Sarcocephalus latifolius exhibits potent hepatorenal effects against mercuric chloride-induced hepatorenal damages which could be due to its anti-inflammatory and anti-oxidant properties

Interest rate is an important economic factor that can determine the level of investment in any economy, hence, the need for any organization or economy that wishes to grow to pay attention to it dynamism. This study was conducted to examine the effect of interest rate on the growth of insurance industry in Nigeria. Total insurance investment, and gross premium income which represents the insurance industry growth constitute the dependent variables while interest rate was the independent variable. The researcher employed a pooled ordinary least square (OLS) regression using secondary data drawn from audited annual financial statements of insurance industry in Nigeria from 2003-2023, a period of twenty-one years. The results show that interest rate (INTR) has significant effect on Total Insurance Investment (TII), while it has no significant effect on Gross Premium Income (GPI). It was concluded that there is a statistically significant of interest rate on total insurance investment, indicating that interest rate is very important in determining the growth of insurance companies in Nigeria. The second hypothesis shows insignificant effect of interest rate on the gross premium income of insurance, this could be attributed to low patronage of the insurance business, or by factors that enhanced premium collection such as compulsory insurances, among others. Therefore, it was recommended that premium income generated should be put into viable investment as it is not significantly influence by interest rate, this will help in increasing total insurance investment. Also, the government through the insurance regulatory authority should implement the compulsory insurance mechanism, to enables more patronage, while also mandating the insurance companies to follow the doctrine of interest rate set by the Central Bank of Nigeria (CBN) when pricing their products so as to avoid unfair, deceptive and abusive practices of overpriced policies which consequently affect the industry growth.

This study examines how knowledge management affects Akwa Ibom State SMEs' work quality. The knowledge management aspects included in the study were knowledge creation and knowledge acquisition. Cross-sectional survey research was used for this study. The study's population included 9,483 SMEs registered in Akwa Ibom State. The sample size was 384 using the Krecjie and Morgan (1970) table. Data was collected with a standardized Likert scale questionnaire. Data was analyzed using descriptive and inferential statistics. The inferential statistics used a simple linear regression procedure. The study's results indicate that knowledge creation had an R-value of 0.571, but knowledge acquisition had an R-value of 0.406 concerning work quality. Thus, it was concluded that knowledge management significantly improves the quality of work produced by SMEs in Akwa Ibom State. Since knowledge creation is necessary to guarantee the promotion of competitive advantage in their operations, it was suggested at the conclusion that managers of SMEs should make sure that knowledge is created inside the company in order to improve performance. SMEs should also create policies that support knowledge management techniques. Through staff learning and training, their companies will be able to enhance their performance.

Background: Sickle Cell Disease and Thalassemia are inherited hemoglobinopathies that produce systemic metabolic derangements chronic hemolysis, iron misdistribution, oxidative stress, mitochondrial dysfunction, endothelial activation, and nutrient depletion. Conventional hematologic therapies reduce acute morbidity but often leave biochemical vulnerabilities unaddressed. Objective: To present a systems biology, evidence based clinical review of Nephesh Dam™, a multi nutrient integrative formulation designed to support erythropoiesis, redox balance, mitochondrial function, membrane integrity, endothelial health, and iron regulation in SCD and Thalassemia, and to align clinical recommendations with Edenic Hebrew Pastoral Medicine principles. Methods: A structured synthesis of randomized controlled trials, systematic reviews, mechanistic biochemical studies, and clinical guidelines was performed for each ingredient. Evidence was graded by study design and relevance to hemoglobinopathy pathophysiology. Pastoral Medicine statutes supplied by the author were used to frame ethical and implementation guidance. Results: Individual components show varying evidence strength: L glutamine (phase 3 RCT) reduces vaso occlusive crises in SCD; silymarin demonstrates hepatoprotective and iron modulating effects in adjunctive thalassemia studies; lactoferrin improves iron handling and gut barrier function in pediatric anemia trials; ferrous bisglycinate offers improved tolerability and absorption in iron deficient populations. Antioxidant and mitochondrial cofactors (ALA, riboflavin, thiamine, ribose) provide mechanistic support for redox and energetic recovery. Synergistic networks address methylation, glutathione cycling, mitochondrial energetics, membrane phospholipid repair, endothelial NO bioavailability, and iron buffering. Safety priorities include iron stewardship, hepatic monitoring, and herb–drug interaction vigilance. Conclusion: Nephesh Dam™ is a mechanistically coherent, clinically grounded integrative formulation that addresses the biochemical drivers of hemoglobinopathies. Controlled adjunctive clinical trials are warranted to evaluate clinical endpoints (pain crises, transfusion frequency, organ biomarkers)

Traumatic dental injuries involving the anterior teeth frequently present as complicated crown fractures, posing challenges in achieving functional and esthetic rehabilitation. Conservative fragment reattachment techniques, reinforced with fiber posts or polyethylene fibers, provide an ultraconservative approach while preserving tooth structure. In this report, two male patients (25 and 42 years old) presented with complicated crown fractures of the maxillary anterior teeth following trauma. Both cases were managed with nonsurgical root canal therapy followed by conservative fragment reattachment. Fiber reinforcement was employed using prefabricated fiber posts in one case and Ribbond polyethylene fiber in the other. Clinical and radiographic evaluation demonstrated stable fragment reattachment, satisfactory esthetic results, and restored occlusal function. Both patients remained asymptomatic on follow-up. These findings suggest that conservative reattachment of fractured tooth fragments using adhesive techniques, combined with fiber reinforcement, is a predictable and effective treatment for complicated crown fractures, ensuring functional stability and optimal esthetic outcomes while preserving natural tooth structure.