Formulation of Wound Healing Transdermal Patch from Tubers Extract of Momordica Cymbalaria and its In-vitro Evaluation
P. Saundharya, Jerrine Joseph, G. Rajalakshmi, Mary Shamya
Page Numbers : 224-233
DOI : 10.36348/sjls.2022.v07i07.004
Developing wound infection in type Ⅰ or Ⅱ diabetic people had risk complications like gangrene. Although there are enough antibiotic ointments or creams, still it needs physician dressing and continuous monitoring of wound. So, to make it simple and more effective, a combination of transdermal drug delivery route with herbal usage contribute in controlled release of medication with minimum undesirable side effects. And also help to treat wound infections by self-medication. This work is focused, to formulate wound healing transdermal patch for diabetics with Momordica cymbalaria tuber extract. A sequence of techniques was performed to analyse antioxidant content then Starch assay was performed In vitro to evaluate its healing efficacy, determine cytotoxicity using zebra fish embryos and artemia salina using hexane extract of tuber. Optimized combination is used to prepare Patch by solvent evaporation method then evaluated the patch by organoleptic and physico-chemical properties. The result proofs, the tuber extract had Strong Antioxidant activity whereas weak cytotoxicity showed in two concentration (25 and 50µg/ml) towards brine shrimp lethality assay and fish embryo toxicity. High migration rate found in 25µg/ml and 50µg/ml in scratch assay using Human Epidermal Keratinocytes. Evaluated the patch for its organoleptic and physico-chemical properties, it shows good result. As a final observation of the study, bio compounds present in tuber extract proved to enhance wound healing and could pave way as alternate to the synthetic wound healing patches owing to its ecofriendly, economical and herbal nature be natural replacement to hasten wound healing especially in diabetic patients.
Original Research Article
July 8, 2022
Cardiac Function Assessment By Echocardiography In Ischemic Stroke/Non Hemorrhagic Cerebral Infarction
Mahadi Hassan, Md. Tariqul Islam Khan, Mahmood Hasan Khan, Dilbanu Trishna, Md. Asifudduza, Sakit Mahmud
Page Numbers : 220-223
DOI : 10.36348/sjls.2022.v07i07.003
Background: Every year, more than half a million people in the world suffer from acute cerebrovascular events, including ischemic stroke, intracerebral and subarachnoid hemorrhage, giving a mortality of nearly 20%. Acute strokes, especially subarachnoid hemorrhage is frequently accompanied by a variety of electrocardiographic (ECG) abnormalities. Objective: To find out the cardiac function assessment by echocardiography in ischemic stroke/non hemorrhagic cerebral infarction. Material and Methods: An observational study was conducted in Department of Medicine and Cardiology, Sher-E-Bangla Medical College Hospital, Bangladesh from July to December-2019. 51 patients of ischemic stroke were taken and 2D transthoracic echocardiography was done to find potential cardioembolic abnormalities. Results: 74.5% of patients had echocardiographic abnormalities and 41.1% had potential cardioembolic abnormalities, out of which most common were ventricular wall hypokinesia, calcific aortic valve, rheumatic heart disease and dilated cardiomyopathy. The prevalence was almost similar in different age groups and both the sexes. Conclusion: Prevalence of potential cardioembolic abnormalities is high (41.1%) in ischemic stroke patients and 2D echocardiography is therefore recommended in the management and secondary prevention of cardioembolicstroke, which has a higher mortality and more chances of recurrence than atherothrombotic type of ischemicstroke.
Original Research Article
July 5, 2022
Impact of Conservation Agriculture System on Combating Water Erosion Hazards at Wadi El-Raml, Northwestern Coast of Egypt
S. F. T. Sharkawy, A. A. Ali, Omnia, M. Wassif, A. A. Meselhy
Page Numbers : 210-219
DOI : 10.36348/sjls.2022.v07i07.002
Conservation agriculture practices (CA) is a management for available organic matter resources and considered important measures to enable farming in accordance with the principles of sustainable agriculture. The two-years experiment were performed on the soil under wheat crop. CA practices can help to decrease the area and duration for exposed soil to water erosion by increased soil aggregate size distribution, soil porosity, soil moisture and soil organic matter. Soil organic matter (SOM) is an important indicator of soil fertility and productivity because of its crucial role in soil chemical, physical and biological properties. CA leaves a soil organic mulch at the soil surface, which decreases runoff and soil loss. On other hand, soil mulch with plant residue as a component of CA is increased soil content of SOM. The least total cost for cultivation wheat crops under rainfed agriculture of Egypt achieved at conservation agriculture with No-tillage treatment (CANT) while the highest cost achieved at traditional agriculture (TA) treatment. The best results of decreased soil loss, increased SOM and wheat crop yield obtained when continue to apply conservation practices for more than one season. Indeed, our results showed the soil loss decreased about (56%) while wheat grain yield and SOM increased about (7% and 45%) respectively when using CA at the second season compared to TA. Conservation agriculture signifies environmentally friendly technologies reduce of climate related risks.
July 3, 2022
Tuberculosis, Challenges and Status with Special Reference to Jammu and Kashmir: A Way Forward
Ajaz Ahmed Wani, Ashwani Kumar
Page Numbers : 206-209
DOI : 10.36348/sjls.2022.v07i07.001
Tuberculosis (TB) is one of the most ancient disease of mankind and is one the ten major cause of mortality worldwide particularly in developing countries. It is an infectious disease caused by bacteria Mycobacterium tuberculosis. It usually affect the lungs but can also affect other organs of body. Inspite of various measures taken to eliminate the TB by Govt .of India by 2025. The trend of TB cases and drug resistant cases in India is very disturbing .The article is compiled with the objective to study the present status and challenges in India with special reference to Jammu and Kashmir.
Original Research Article
June 18, 2022
Anti-diabetic Effects of Aqueous plant (Citrullus colocynthis) Extract in Streptozotocin Induced Diabetic Mice
I. Shahzadi, R. M. Fazal, Z. Hussain, R. Yasin, M. K. Aziz, K. Samiullah, I. U. Malik, M. Waseem, A. Yar, S. H. Khan, M. Ilyas
Page Numbers : 199-205
DOI : 10.36348/sjls.2022.v07i06.004
The aim of this study was to find out anti-diabetic effects of Citrullus colocynthis commonly known as bitter apple. Random blood glucose levels were measured before and after plant extract administration. Powdered form of plant extract was used as an oral treatment. Diabetes was induced in mice using artificial diabetes inducer named- Streptozotocin. Maximum anti-hyperglycemic effect and reduction in glucose level was observed with individual treatment of extract of C. colocynthis @400mg/kg, which was 75%±1.3. This treatment was more effective than amaryl @3mg/kg, which shows effectiveness of 52%±2.4 and Glucophage @500mg/kg, which shows effectiveness of 29%±2.1. Results showed that bitter apple have insulin tropic activity which helps in regeneration of beta cells of pancreas which turn normalize blood glucose levels without any significant side effects such as hypoglycemia. Further research is still required before implementation of this plant to treat diabetic patients.
June 14, 2022
Effects of Air Pollution on Respiratory System (Lungs) and Modern Techniques to Control Pollution
Air pollution is a significant health risk factor all over the world. A global study of diseases showed that air pollution is one of the top ten global health risk factors. Approximately 7 million people in the world and 40, 0000 people experience early death due to air pollution. The most common pollutants include particulate matter, carbon monoxide, ozone, nitrogen oxide, and sulfur dioxide. The two types of air pollution, indoor and ambient, both contribute to a host of cardiac and respiratory illnesses. General ambient air pollution, chiefly due to the incomplete combustion of fossil fuels, may be responsible for increased rates of lung cancer. Exposure to excess levels of air pollution is significantly associated with a variety of acute and chronic respiratory illnesses, such as chronic obstructive pulmonary disease, asthma, respiratory allergies, and lung cancer. The effects of air pollution disproportionately impact the extremes of the age distribution, perhaps due to altered immune responses. The presence of one or more contaminants in the atmosphere, such as dust, fumes, gases, gas, ‘fog’, odour or vapour in quantities or with characteristics, and of a duration that may be detrimental to human, animal or plant. Combustion-source air pollution contributes to the occurrence of lung cancer among the general population. By using modern techniques to control pollution Multi-vortex wet air scrubber’s technology, nano technology, recycle reuse techniques is very helpful to control pollution.
June 9, 2022
Agriculture Insights for Improving the Soil Conservation through Optimizing of Water Storage and Advanced Agricultural Methods
Asia Bibi, Zoha Malik, Um E Habibah, Muhammad Atif, Malaika Zaheer, Samra Naz, Muhammad Faraz Ali, Abdul Basit, Amjad Ali
Page Numbers : 186-190
DOI : 10.36348/sjls.2022.v07i06.002
Soil damage has been increased the in the few last decades due to human activities, urbanization and other erotic factors. Absorption of water through soil and aerial parts of plants and resource management strategies allow for the conservation of water. While, organic matter playing important role in good soil structure and water holding capacity, promotes water infiltration, and protects the soil from erosion and compaction. The best water conservation practices to be made in order to optimize the water usage as quantity of water reflected to the crops cultivations. Soil restoration increases the chances to minimize the risk of climatic conditions that ultimately helpful for making the soil fertility. In soil, water from different sources absorbed including the rain sources, surface water, ground water and external water sources. Agricultural groundwater sources are also maintained for irrigation and storage of water needed for survival of climatic conditions. Water storage through solar panels also another way for marinating the water balance and also helpful for storage system. Vertical flow CWs (VFs) are more efficient for marinating the water balance in the agricultural land as compared to the horizontal flow.