Endodontic pharmacology constitutes a fundamental pillar in modern dental practice, integrating pharmacological principles with clinical endodontics to achieve optimal patient outcomes. The primary objectives include pain control, elimination of microbial infection, and facilitation of periapical healing. Advances in pharmacology, microbiology, and biomaterials have significantly improved treatment success; however, challenges such as antibiotic resistance, opioid misuse, and management of medically compromised patients demand a rational and evidence-based approach. This review comprehensively discusses pharmacological agents used in endodontics, their mechanisms, clinical applications, and recent trends, while emphasizing safe prescribing practices and patient-centered care.[1]

Managerial pricing decisions are central to organizational profitability but are often compromised by systematic cognitive biases. This study investigates how anchoring, loss aversion, and overconfidence distort managerial pricing judgments and identifies the psychological mechanisms through which these effects occur. The study pursues four objectives: first, to quantify the individual effects of anchoring, loss aversion, and overconfidence on pricing accuracy; second, to examine their joint and interactive influence on pricing distortions; third, to develop and empirically test a bias-corrected managerial pricing framework integrating behavioral factors; and fourth, to generate robust empirical evidence that advances the fragmented behavioral pricing literature and informs debiased pricing practices. Using a between-subjects experimental design, 240 experienced managers were randomly assigned to anchoring, loss-aversion, overconfidence, or control conditions and completed a realistic pricing simulation. Pricing error was measured as deviation from optimal benchmarks, alongside assessments of cognitive distortion and confidence bias. Results show that all three biases significantly increased pricing errors, with anchoring and loss aversion exerting the strongest direct effects. Mediation and structural equation modeling reveal that cognitive distortion is the primary pathway through which bias-inducing conditions translate into pricing errors, while confidence bias plays a secondary but reinforcing role, particularly under overconfidence. When multiple biases co-occur, their effects compound, producing larger deviations from optimal prices. The findings make a theoretical contribution by providing an integrated, pricing-specific account of multiple managerial biases and empirically validating a dual-mediation framework linking bias, cognition, and pricing outcomes. Practically, the results highlight the value of structured decision protocols, calibration training, and decision-support systems as effective interventions for improving pricing accuracy and managerial decision quality.

The present study examined the impact of treadmill and resistance training packages on selected motor fitness components and skill performance variables among hockey players. A pre-test and post-test randomized group design was employed. Forty-five male hockey players (aged group 19–25 years) were selected from affiliated colleges of Bharathidasan University, Tiruchirappalli, Tamilnadu, India. They were randomly assigned into three groups: group I Treadmill Training Group (TTG), group II Resistance Training Group (RTG) and group III Control Group (CG), with fifteen participants in each group. The TTG and RTG underwent their respective training interventions on alternate days for twelve weeks, while the control group followed their regular academic routine without additional training. Motor fitness variables such as cardiovascular endurance and agility, along with performance variables including stick control and passing accuracy, were assessed. Statistical analysis was conducted by using paired sample t-tests and analysis of covariance (ANCOVA) at a 0.05 level of significance. The results revealed significant improvements (p ≤ .05) in all selected motor fitness and performance variables for both experimental groups compared to the control group. The findings indicate that treadmill training and resistance training packages are effective methods for enhancing physical fitness and skill performance among university hockey players.

This study examines the evolution of the center–periphery structure in Japanese intellectual history through the thought of Motoori Norinaga and Yanagita Kunio. It explores how Japan sought self-identity and independence under external cultural and academic pressures. During the Edo period, under the influence of Chinese civilization, Motoori Norinaga reinterpreted the Huayi distinction, emphasizing indigenous tradition and Shinto thought while rejecting China’s absolute centrality and repositioning Japan as a cultural center. In the modern era, facing a Western-dominated academic system, Yanagita Kunio proposed “national folklore studies” to secure the autonomy of Japanese scholarship through a strategy of relative centralization. By comparing their approaches, this study reveals both continuity and transformation in Japan’s center–periphery structure. It argues that despite differences in historical context and disciplinary focus, both thinkers retained the hierarchical logic of the center–periphery framework while redefining Japan’s position within it.

Laser dentistry has emerged as a significant advancement in modern dental practice, offering a minimally invasive alternative to conventional instruments such as scalpels and rotary devices. Its growing popularity is driven by improved precision, enhanced patient comfort, reduced postoperative complications, and expanding clinical applications across multiple dental specialties. This narrative review aims to explore the expanding role of lasers in dentistry, focusing on their fundamental principles, clinical applications, advantages, limitations, and future directions. The literature consistently highlights benefits such as reduced bleeding, decreased pain, faster healing, and improved patient acceptance. However, challenges including high cost, operator dependency, learning curve, and variability in clinical evidence continue to limit universal adoption. Overall, laser dentistry represents a transformative tool in contemporary dental care, with strong potential for further integration into routine practice as technology advances and evidence continues to grow.

The lack of process standardization and formal management tools in animal feed plants can lead to operational variability, negatively affecting production efficiency and final product quality. This study aims to optimize the performance of the operational system of an animal feed plant through the implementation of process standardization, quality assurance, and lean manufacturing tools. The study was conducted under an applied approach using a case study at the “El Aire” animal feed plant, located in the state of Jalisco, Mexico. The methodology was structured in three phases: process standardization through procedure manuals, flowcharts, and Standard Operating Sheets; strengthening of the quality system through technical specifications and a quality control plan; and implementation of the 5S methodology to improve operational environment conditions. The results show a significant improvement in the control of the production system, reflected in an increase in the level of process documentation, improvements in critical product quality parameters, and an increase in the level of order and cleanliness in operational areas, which rose from an average of 16% to 85%. These actions contributed to greater efficiency in operational execution and improved compliance with production schedules. It is concluded that the structured and progressive application of standardization and lean manufacturing tools strengthens operational management in animal feed plants, even in highly automated environments, providing a solid foundation for continuous improvement and the sustainability of the production system.

This study investigates the effects of Cucumis sativus (cucumber) leaf extract on hormonal levels, semen quality, and sperm cell morphology in male Wistar rats. Thirty rats were randomized into three groups: control, 400 mg/kg, and 800 mg/kg extract-treated groups, and administered for 28 days. Hormonal assays revealed significant dose-dependent reductions in follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels in treated groups (p < 0.05). Semen quality analysis showed a significant decline in semen color, consistency, pH, sperm motility, and live proportion, alongside increased abnormal sperm morphology and non-motile spermatozoa, especially in the 800 mg/kg group. Furthermore, differential sperm abnormalities, including head deformities, twisted tails, and bent mid-pieces, were significantly elevated in treated groups, indicating structural and functional damage to sperm cells. The results suggest that Cucumis sativus leaf extract, at higher doses, impairs male reproductive hormones, semen quality, and sperm morphology, potentially due to oxidative stress or phytochemical-induced toxicity. This aligns with prior studies on phytotoxic effects of plant extracts, where flavonoids, alkaloids, and other bioactive compounds were implicated in reproductive toxicity. However, the exact mechanism underlying these effects remains unclear and warrants further exploration. This study provides a foundation for understanding the reproductive toxicity of Cucumis sativus leaf extract, emphasizing the need for cautious use of herbal preparations containing this plant.