Most nanoparticles have diameters that lie within 1 to 100 nm. A variety of metal oxide nanoparticles can be synthesised chemically as well as biologically. NiO nanoparticles, which are synthesised chemically, tend to be highly toxic in their effects. In contrast, synthesis by the route of biogenesis or biomimetics is much more favourable than chemical synthesis. The pre-existing properties of purple cabbage are remarkably enhanced by NiO nanoparticles. Nickel oxide (NiO) nanoparticles were synthesised from the leaves of Brassica oleracea var. capitata. f. rubra (purple cabbage) by reducing Nickel nitrate hexahydrate solution for the formation of NiO nanoparticles. The analysis done using a Particle size analyser reveals the spherical morphology and the size of the NiO nanoparticles. The size and shape were studied under a Scanning Electron Microscope, which shows that the nanoparticle ranges from 34.5 nm to 89.6 nm. The formation of NiO nanoparticles was confirmed by the peaks obtained in Raman spectroscopy and UV-DRS analyser. The peaks that ensure the formation of NiO nanoparticles in Raman spectroscopy are 568.40 cm-1, 1129.46 cm-1 and 1379.07 cm-1 and UV-DRS are 265.60 nm and 339.69 nm. Preliminary phytochemical analysis of the aqueous extract of purple cabbage leaves shows that there is an abundance of phytochemical content present in purple cabbage. From the preliminary phytochemical analysis of purple cabbage, it was observed that the aqueous purple cabbage leaf extract contains alkaloids, sterols, flavonoids, coumarin, tannins, cardiac glycosides, anthraquinones, saponins, quinones, and carbohydrates.

This paper aims to determine how Digital Transformation Maturity and Digital Change Management affect Work-Life Integration through Digital Work Adaptation as an intervention variable among Government Civil Servants of Central Java's Capital Municipality, which has implemented a digital work system. Quantitative methodology is used in this study, and 200 State Civil Apparatus (ASN) of the Semarang City Government are involved. The data will be analyzed using a quantitative approach through statistical analysis using variance-based structural modeling with PLS-SEM and SPSS, which aims to conduct path analysis with latent variables and coefficients. The findings reveal that Digital Transformation Maturity and Digital Change Management significantly enhance Digital Work Adaptation. Digital Work Adaptation is proven to mediate the relationship between the two independent variables of Work-Life Integration. Digital Change Management has a more decisive influence than Digital Transformation Maturity in forming Work-Life Integration through Digital Work Adaptation. These findings indicate the importance of digital change management and transformation maturity in supporting ASN work and life balance adaptation in the digital era. The study provides theoretical and practical contributions to developing public sector HR management in digital transformation.

Background: Lumbosacral radicular pain, commonly known as sciatica, is a prevalent and challenging condition arising from nerve root compression in the lumbar spine due to various underlying pathologies. Epidural steroid injections (ESIs) are often employed for symptomatic relief when conservative treatments fail. While ESIs are minimally invasive and provide localized pain relief, their safety, especially concerning neurological complications, remains a critical concern. Objective: This article reviews the neurological complications associated with ESIs and compares the safety and effectiveness of various corticosteroid formulations administered via transforaminal, interlaminar, or caudal injection techniques. Method: A comprehensive literature search was conducted using PubMed, Scopus, and the Cochrane Library, focusing on studies published within the last ten years. Inclusion criteria encompassed studies addressing lumbosacral radicular pain, the safety and efficacy of ESIs with different corticosteroid formulations, and comparative effectiveness analyses of injection routes. Data on corticosteroid types, formulation characteristics, adverse effects, efficacy measures, and patient demographics were extracted and analyzed both qualitatively and quantitatively. Results: Findings indicate significant variation in safety profiles and effectiveness among different corticosteroid formulations used in ESIs. Dexamethasone, often favored for its efficacy, has been linked to potential neurological complications, particularly concerning preservatives like benzyl alcohol. Comparative studies suggest that while dexamethasone may provide adequate pain relief, it may lead to higher rates of repeat injections compared to particulate steroids like triamcinolone. Conclusion: The review underscores the need for a personalized approach to ESI administration, balancing the benefits of pain relief against potential long-term complications. The data highlights a pressing need for ongoing research into optimizing corticosteroid use and ensuring patient safety in the management of lumbosacral radicular pain.

Background: The risk factor for knee osteoarthritis (knee OA) is multifactorial. Socioeconomic status is a risk factor that is commonly underreported. The study aims to find the relationship between socio-economic factors and knee OA, and the influence of these on gender. Methods: This is a case-control study conducted at Orthopaedic Hospital Wamakko, Sokoto, North-Western Nigeria between January 2022 and December 2022. Adult patients aged >40 years with knee OA were included in the study. The data was collected via participants’ interviews through a self-administered questionnaire. The risk factors for knee OA under consideration were occupation, educational level, and monthly income. Data were analysed using the SPSS version 23. The significant level was set at less than 5%. Results: There were a total of 372 patients in the study, with 124 cases and 248 controls in a ratio of 1:2. The average age was 53.7±10.8 (range 40 to 88 years). There were 165(44.4%) males and 207(55.6%) females. For occupation, 201(53.7%) were unemployed, 60(16%) on business, 61(16.3%) were civil servants and 50(13.4%) worked as farmers. For education, 250(66.8%) had non-formal education, and 122(32.6%) had formal education. Most patients (237/57.8%) were high-income earners and 135 (41.7%) were low-income earners. The knee OA prevalence was 13.17% for males and 20.16% for females. In the case group, the majority were unemployed with 63 (50.8%) patients and the least were farmers with only 16 (12.9%). Non-formal education was the most common educational level among the cases with 89(71.8%), and low-income earners are also more common with 74(59.7%) compared with high-income earners with 61 (40.3%). There was a statistically significance result between socioeconomic status and knee OA (OR=0.334, CI=0.214-0.521, and P<0.0001). The odd ratio (OR) for low-income earners among females is 2.238 (CI=1.878-2.666) and p value<0.0001. The OR for non-formal education in low-income earners is 2.332 (CI=1.466-3.709) and p value<0.0001. Conclusion: Low-income level was the most important predictor of knee OA in the study, and the female gender has the lowest income with higher knee OA risk and ....

Oil and gas pollution poses significant environmental and health risks to communities in Nigeria, particularly in the Niger Delta region. Despite the devastating impacts of pollution, Nigeria's legal framework for controlling oil and gas pollution has been criticized for being inadequate and ineffective. This article undertook a critical appraisal of the legal measures for the control of oil and gas pollution in Nigeria. The article examined the relevant international, regional, and national laws and policies governing oil and gas pollution in Nigeria, including the International Convention on Oil Pollution Preparedness, Response and Cooperation, the African Convention on the Conservation of Nature and Natural Resources, and the Nigerian Oil and Gas Industry Content Development Act. The article critiques the strengths and weaknesses of these laws and policies, highlighting gaps and inconsistencies that hinder effective pollution control. The article also analyzed the institutional framework for pollution control in Nigeria, including the roles and responsibilities of regulatory agencies such as the National Oil Spill Detection and Response Agency and the Department of Petroleum Resources. The article argued that while these agencies have made efforts to control pollution, they are often hindered by inadequate funding, lack of capacity, and conflicting mandates. Furthermore, the article examined the impact of oil and gas pollution on local communities in Nigeria, highlighting the human rights implications of pollution and the need for effective remedies and compensation. The article concluded by proposing recommendations for strengthening the legal framework for pollution control in Nigeria, including the adoption of more stringent regulations, the enhancement of institutional capacity, and the provision of effective remedies for affected communities.

Background: Type 2 diabetes mellitus (T2DM) is a growing public health concern in Bangladesh, driven by urbanization, lifestyle changes, and dietary habits. Poor glycemic control contributes to complications and imposes a financial burden on the healthcare system. Understanding the clinical factors influencing glycemic control is essential for developing targeted interventions. Objective: To assess the clinical status of T2DM patients with a focus on glycemic control and its association with demographic and clinical variables. Methods: This cross-sectional study was conducted at Bangabandhu Sheikh Mujib Medical University, Dhaka, from March 2022 to February 2023. Eighty T2DM patients were recruited based on ADA diagnostic criteria. Glycemic control was classified using HbA1c levels (<7% for adequately controlled, ≥7% for inadequately controlled). Data collection included anthropometric measurements, saliva and blood sampling, and laboratory analyses for HbA1c and salivary A2MG. Statistical analyses were performed using SPSS version 26.0, with significance set at p<0.05. Results: The mean age of participants was 44.1 ± 9.97 years, with no significant age-related difference in glycemic control (p=0.513). Gender (p=0.194), residence (p=0.900), and family history of diabetes (p=0.637) showed no significant association with glycemic control. However, BMI was significantly higher in the inadequately controlled group (27.6 ± 3.44 kg/m²) compared to the adequately controlled group (25.2 ± 2.76 kg/m²) (p=0.002), highlighting the influence of obesity on glycemic outcomes. Conclusion: Glycemic control in T2DM patients in Bangladesh is influenced more by clinical factors like BMI than demographic variables. Targeted interventions focusing on weight management and lifestyle modifications are critical for improving glycemic outcomes and reducing diabetes-related complications.

Food security means all people at all times have economic and physical access to food for dietary needs and healthy life. Ensuring food security for all is a challenge at the global level. Developing nations need help with food security. Developing countries like India are facing a severe challenge in ensuring food security. Various international and national factors contribute to food security. Global factors such as climate change affect agriculture production and productivity. Rising temperatures, increasing greenhouse gas emissions, erratic rainfall, and increasing flood and drought events affect food security adversely. The declining proportion of millet in total food production is another severe issue for physical and economic access to healthy food. Millet's crop is a consumer, environment, and farmer's friend. Several factors, such as increasing population, urbanization, food waste, reducing land for cultivation, and unhealthy change in crop patterns, are making the problem of food security more difficult. The increasing population and resulting anthropogenic activities are putting pressure on natural resources. This article discusses the food security problem and the factors contributing to this problem in the Indian case. We need to work on several fronts to ensure physical and economic access to healthy food security for the increasing population.