A Comparative Study on Animal Colostrums Probiotics as Emerging Neutraleuticles
Page Numbers : 207-212
DOI : 10.36348/sjbr.2021.v06i07.004
In spite of promising outcomes, significance of colostrum probiotics in human wellbeing, just as assurance of their utilization ought to be studied as our comprehension of attributes needed for their usefulness in the gut is deficient. The goal of this study is to create awareness about the nutraceutical properties of colostrum and to examine the different source of colostrum and its dynamic ingredients just as to address colostrums nutraceutical and therapeutic ramifications. Nutraceutical, a term consolidating the words nourishment and drugs, is a food item that gives medical advantages as an adjuvant or elective treatment, remembering the therapy and anticipation of irresistible illnesses for youngsters and grown-ups. Since colostrum is a rich source of fundamental supplements, their utilization in useful food sources has considerably expanded lately. BC is wealthy in immunity, growth and antimicrobial elements, which advance tissue development and the development of stomach related tract and immune function in neonatal creatures and people. In spite of the fact that bovine milk is ordinarily thought to have insignificantly higher dietary benefit, goat milk has been portrayed as fair nutritious font with better allergenic properties.
Original Research Article
July 12, 2021
Association of Vitamin D Receptor Gene Polymorphisms in Rheumatoid Arthritis Patients from North Coastal Andhra Pradesh
H. Uma Bharathi, V. Lakshmi Kalpana, A. Ramakrishnam Naidu, B. Papa Kusuma, A. Anuradha
Page Numbers : 199-206
DOI : 10.36348/sjbr.2021.v06i07.003
Background: Rheumatoid Arthritis (RA) is a chronic, symmetrical, inflammatory autoimmune disorder that primarily affects small joints, progression to large joints. About 1% of the world's population is affected by rheumatoid arthritis, women three times more frequent than men. The onset is more common between the ages of 40 and 50 years. Other than genetic, environmental factors have been associated with the development of rheumatoid arthritis. Vitamin D deficiency has been associated with several autoimmune disorders especially with RA. One of the candidate gene of RA is vitamin D receptor (VDR). The role of VDR has been well-known in variety of metabolic disorders and in regulation of inflammation. Aim: The aim of the present study was to investigate the association of VDR Fok1 (rs10735810) and VDR Bsm1 (rs1544410) gene polymorphisms in RA patients and controls from North Coastal Andhra Pradesh. Methods: A total of 300 samples (150 RA patients and 150 controls) were included in the present study and genotyping was accomplished by using PCR – RFLP technique. Results: Data was analyzed by SPSS 19 software. Chi square ‘p’ value revealed that VDR Fok1 (rs10735810) polymorphism has association with RA and VDR Bsm1 (rs1544410) polymorphism does not shows association with RA. Conclusions: In conclusion, the present study revealed that the VDR FokI (rs10735810) gene polymorphism is associated with RA and VDR Bsm1 (rs1544410) gene polymorphism does not shows association with RA.
Original Research Article
July 9, 2021
Proportion and Associated Factors of Primary Rifampicin Resistance among New Pulmonary TB Patients in Public Hospitals of Gen-Xpert Testing Sites, East Amhara–Ethiopia, 2019
Introduction: The emergence and spreading of Rifampicin-resistance strains of mycobacterium tuberculosis pose significant challenges to tuberculosis control programs in resource-limited countries like Ethiopia. This study aimed to assess the proportion and factors associated with primary rifampicin resistance. Methods: A facility-based cross-sectional study was conducted from April to November 2019 among 570 new pulmonary tuberculosis patients. A systematic random sampling technique was used to select the study participants from 8 Gene-Xpert testing hospitals. Rifampicin resistance was detected by Gene-Xpert assay from sputum specimens. Data were collected by face-to-face interviews, document review, and laboratory results using a pre-tested structured questionnaire. We developed the questionnaire from different kinds of literature and the World Health Organization resources. Variables with P-value <0.2 in simple binary logistic regression were included in the multiple binary logistic regressions. A statistical test was reported as significant when p-value < 0.05 in multiple variable logistic regressions. Fitness of goodness was checked by using the Hosmer Lemeshow model fitness test. Results: A total of 570 individuals have participated in this study. Of those, 43 (7.50%) 95% CI: 5-10) were resistant to rifampicin. Persons, have a contact history with known tuberculosis Patients (AOR 2.5 [95% CI: 1.21-5.11]), with human immune virus infection (AOR 2.3 [95% CI: 1.11-4.73]) and being diabetic Mellitus cases (AOR 4.2[95% CI: 1.51-8.78]) were factors significantly associated with rifampicin resistance. Conclusions and recommendations: The proportion of rifampicin resistance was high. Identified factors significantly associated with rifampicin resistance were persons having contact history with known tuberculosis patients, human immune virus infection, and being diabetic Mellitus cases. Strengthen the prevention of rifampicin resistance tuberculosis transmission, strengthening contact tracing, improve TB/HIV coinfection health care services, and screening tuberculosis patients for diabetic Mellitus is crucial.
Original Research Article
July 6, 2021
Relationship between Vascular Endothelial Growth Factor Polymorphism (Rs699947) and the Development of Hepatocellular Carcinoma
Sobhy Hassab El-Nabi, Islam M. El-Garawani, Eman Abdelsameea, Salama M. Elshennawy, Sabah S. Elashmawy, Amany E. Elashkar
Page Numbers : 181-187
DOI : 10.36348/sjbr.2021.v06i07.001
Background: Angiogenesis is defined as the expansion and remodeling process affecting the vascular network and it occurs in many pathological conditions including cancer. Hepatocellular carcinoma (HCC) is one of the hyper-vascular cancers. Understanding the process of angiogenesis and its regulatory mechanisms are crucial in HCC treatment. Almost all approved systemic therapies used in HCC target the angiogenesis process especially the vascular endothelial growth factor (VEGF) pathway. Studying genetic variations and other factors that affect angiogenesis could allow tailoring systemic therapy with the most benefits to patients. Aim: Investigating the association between the VEGF variant (rs699947) and the progression of HCC was the main target of this study. Methods: A total of 122 subjects were enrolled in this study (64 patients with HCC, 24 patients with cirrhosis and 34 subjects served as a control group). Genotyping of the VEGF gene (rs699947) was performed by tetra primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Results: The AA genotype and the A-allele were found to be lower in patients with HCC compared with other groups. In HCC patients, the AA genotype was associated with higher serum albumin and lower total bilirubin level. Conclusion: The variant allele (rs699947) could be considered as a predictive factor for HCC development.
Original Research Article
June 22, 2021
Outcomes and Evaluation of Patelloplasty using Delayed Absorbable Suture Materials of Displaced Patella Fracture
Dr. Ataul Haque, Dr. Md. Munzur Rahman, Dr. Mohammad Rajib Mahmud, Dr. Md. Zafar Imam
Page Numbers : 174-180
DOI : 10.36348/sjbr.2021.v06i06.004
Introduction: Surgical attachment of displaced patella fractures is now the international standard treatment. The non-absorbed braided suture fixation group's study goal is to measure clinical, radiological, and functional findings as well as to detect complications of patellar fractures. As a control group, these patients were compared to those who had mid-substance fractures and were treated with K-wire or canceled tension strip wiring. Methods: From January 2018 to December 2020, a multicenter nonrandomized quasi-experimental prospective study was conducted in Rajshahi Medical College Hospital and Sador Hospitals in Rajshahi Division (Joypurhat & Sirajganj) Bangladesh. The total number of patients was n=108 The mean age was 36.28 years ranging from 20 to 60 years. All patients are treated with delayed absorbable suture wiring without using hardwiring of the fractured patella. The outcome was assessed by the Böstman scoring system. All demographic data including injury and surgical data were also documented. In all of the patients, non-absorbable sutures were twisted through the patellar tender and drilled to decrease and fracture the patella. Results: A total of 108 individual patients with patella fracture were treated prospectively over 2 years. 78 patients were male. The male-female ratio was 2.6: 1. Their mean age was 36.28 years ranging from 20 to 60 years. 57 (52.78%) patients were injured at right and 51 (47.22%) affected on the left side. The mean injury surgery interval was 2.0 days ranging from 2-8 days and their mean hospital stay was 4 days. We have found all patients in our schedule follow-up system and most of the patient's 103 (96.14%) knee ROM were 120 degree. Only 5 (3.86%) patients' Knee ROM found 90-120 degree. Most of the Patient 103 (96.14%) had come back to their daily works. Our assessment was done with the Böstman scoring system and we have found satisfactory results (Excellent and good) 103 (96.14%) patients and unsatisfactory (fair and poor) results 5 (3.86%). Only 2 (1.85%) patients had SSI out of them one patient was needed revision surgery and their result was unsatisfactory. Conclusions: In individuals who sustain lower polar patella fractures, fraction fixation options are limited. Suture repair that is clinically acceptable and produces results that are comparable to metal implant patella fractures. Suture repair patients appear to have fewer postoperative hardware-related problems than those who have midsole fracture wire fixation.
Original Research Article
June 20, 2021
Comparison of the Effectiveness of 4% Articaine Hydrochloride and 2% Lignocaine Hydrochloride in Impacted Mandibular Third Molar Surgery- A Prospective, Parallel Arm, Randomized Controlled Trial
Objectives: This study aimed to compare the effectiveness of 4% articaine hydrochloride and 2% lignocaine hydrochloride in impacted mandibular third molar surgery. Materials and Methods: Sixty subjects randomly received either the 4% articaine injection (Group 1) or 2% lignocaine injection (Group 2) with 1: 200000 adrenaline via a pterygomandibular nerve block. The onset of the action of anesthesia, pulpal anaesthesia and its quality during the surgery, duration of anesthesia, duration of the surgery, the total volume of the anesthetic solution, hemodynamic statistics and pain levels were recorded. Results: The mean onset of anesthesia was significantly shorter in Group 1 (4.243 minutes) as compared to Group 2 (4.398 minutes). Onset of pulpal anesthesia was significantly shorter, with values as 4.287 ± 0.335 mins (Group 1) and 5.215 ± 0.3157 mins (Group 2). The duration of anesthetic effect in Group 1 was 3 hours (14.60 ± 9.76 mins), significantly higher than lignocaine -2 hours 43.33 mins (163.33 +-11.97 minutes). The duration of the procedure was marginally higher in Group 1- 41.67 ± 20.14mins; Group 2- 39.30 ±18.54mins. There was a statistically significant difference (P < 0.05) between qualities of anesthesia with pain scores lower in Group 1 as compared to Group 2. Articaine was found to have better cardiovascular stability than lignocaine. Conclusion: 4% articaine hydrochloride with 1:200000 adrenaline is more effective than 2% lignocaine hydrochloride with 1:200000 adrenalines in impacted mandibular third molar surgery in terms of onset, quality of anesthesia and hemodynamic parameters.
Original Research Article
June 9, 2021
Medicinal Potency of Lime (Citrus aurantifolia) Juice and Ogogoro (Local gin) Mixture on Ascariasis and its Assessment on Hepato-Renal and Inflammatory Biomarkers in Ikotun Egbe Lagos State Nigeria
Egoro Emmanuel. Tonbra, Ikhide Godwin Ilegbedion, Ogiogwa Joseph Iruobe
Page Numbers : 163-167
DOI : 10.36348/sjbr.2021.v06i06.002
Ascariasis is an infection of the small intestine caused by Ascaris lumbricoides. The aim of this study was to evaluate the medicinal potency of lime (Citrus aurantifolia) juice and ogogoro (Local gin) mixture on ascariasis as well as assessing its effects on hepato-renal and inflammatory biomarkers. Thirty primary school children whose stool samples upon microscopical examination at x40 were found to have 2+ ova of Ascaris lumbricoides (experimental group) and another thirty whose stool samples had no ova of Ascaris lumbricoides (control group) were recruited for this study. Each of the subjects in the experimental group was administered orally with ten milliliters of the mixture twice daily for five consecutive days. Two weeks after the completion of this oral administration, their stool samples were re-examined microscopically using x40 objective and it revealed 70% significant therapeutic response to Ascaris lumbricoides i.e. zero ova. Thereafter, five milliliters of blood specimens were collected into lithium heparin anti-coagulated bottles from each subject in the control and experimental groups respectively. These specimens were spun and the obtained plasma used for the quantitative measurement of hepato-renal and inflammatory biomarkers which revealed no statistically significant differences (p>0.05) when compared. In conclusion, this study has given an insight on the medicinal potency of this mixture in the treatment of ascariasis and its use is therefore recommended.