Oestrogenic Activity of the Methanolic Extract of the Stem Bark of Cylicodiscus gabunensis Harms (Fabaceae)
Ngoule Christian, Ngene Jean Pierre, Ladoh-Yemeda Christelle Flora, Essome Henri, Ngongodi Bagnak Anne Syntyche, Etame-Loe Gisèle, Mpondo Mpondo Emmanuel
Page Numbers : 170-174
DOI : 10.36348/sijtcm.2022.v05i08.003
The aim of this study is to evaluate the estrogenic effects of the methanolic extract of the stem bark of Cylicodiscus gabunensis in the female rat. The evaluation focused on the effect of the extract on the oestrous cycle, the evolution of the fresh weight of the uterus and ovaries, the total cholesterol level, and the total protein and oestradiol levels. The doses of extract administered to the female rats were 100, 200 and 400 mg/kg for 28 days. Administration of C. gabunensis extract at 400 mg/kg induced an increase in total protein levels. The administration of the extract at doses of 100 and 200 mg/kg gives the same results as the negative control which is distilled water. No significant variation of the C. gabunensis extract on the other parameters studied was observed compared to the negative control. This study shows that C. gabunensis would have anti-estrogenic effects, additional work should be carried out in order to validate the use of this extract in the treatment of female infertility.
Original Research Article
Sept. 2, 2022
Study on the Knowledge, Attitude and Practices during the COVID-19 Pandemic in the Rural Community in Aligarh
Uzma Eram, Zakia Sultan
Page Numbers : 159-163
DOI : 10.36348/sijtcm.2022.v05i08.001
Research into individuals’ risk perception is essential to understanding their behaviour, and adoption of individual-level preventive measures (e.g. wearing masks, washing hands etc) in case of pandemic. Various perceptions and practices have been associated with the COVID-19 pandemic. In this study, we assessed the knowledge, attitude and practices regarding COVID-19 among rural population in Jawan in Aligarh. A descriptive cross-sectional study design was used. Data was collected using an interviewer-administered questionnaire. Data collection took place from August - October,2021.We conducted a door to door survey and interviewed 300 persons, aged ≥18 years, who gave consent for the study .The questionnaire was developed using the risk communication and community engagement tool, which was modified according to local settings. Majority of the study population thought Covid 19 to be a disease while few thought it to be a biological weapon used by China or to be due to radiation caused by 5 G network testing. Majority of the study population washed their hands with soap and water and avoided crowded places. Majority of the respondents perceived fever, cough and sore throat as the main symptom, followed by breathlessness and running nose .Very less respondent’s perceived loss of taste and loss of smell. Majority of the population adopted some homemade remedies as a precautionary measure in the form of tea or Kaadha. Most of them had knowledge about mode of spread through cough and sneeze but no one know about the spread of disease through asymptomatic patient. Health care workers also need to use strategies for identifying and communicating with at-risk populations (specifically the elderly) through field visits. They also need to prioritize research in areas of elderly COVID-19 perceptions, particularly around barriers and facilitators to adherence to preventive measures.
Original Research Article
Sept. 2, 2022
Prevalence of Psychosocial Problems among Female Employees (A Study in Aligarh)
Dr. Pawan Kumar Patric, Uzma Eram, Dr. Najam Khalique, Dr. Anees Ahmad
Page Numbers : 164-169
DOI : 10.36348/sijtcm.2022.v05i08.002
Occupational mental health not only creates an impact on the professional life and performance given by an employee but it is also responsible for affecting the quality of personal life lead by the employees.Depression and anxiety are the most common psychosocial crisis that the female employees undergo while trying to give their best performance both at home and at the workplace. Recent studies have proved that married woman with young children show more anxiety and depression. This study aimed at analyzing the impact of the Psychosocial problems faced by female employees. In this regard, the objective of this study was set to assess the prevalence of psychosocial problems among female employees. A cross-sectional study was conducted from July 2019 to June 2020. Stratified random sampling was done in female employees in Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh. A pre-tested semi-structured proforma was used. The study was being done on 378 participants. All the data were entered and analysed in SPSS-20.0 To find out the association between certain variables Chi-square/Fisher Test was used. Among the study participants, 26.7% of working female employees falls below 25th percentile of psychological well-being. This indicates that majority (73.3%) of the female employees have higher psychological well-being. 24.6% of working female employees falls below 25th percentile of Social Well-being. This indicates that majority (75.4%) of the female employees have higher SWB. Only 40% of the doctors scored above 25th percentile of Social Well-being which is the least in terms of the percentage among all the occupational categories of the working women. Among the nursing officer, more than three-fourth (n=166; 78.7%) scored above 25th percentile on PWB scores whereas, 21.3% (n=45) of nursing officer scored below 25th percentile. The Psychological Well-Being is significantly associated to the occupation of the women. The Social Well-Being is significantly associated with Occupation of the women.
Review Article
Aug. 29, 2022
Mechanistic Insights an Anthelmintic Potential of Cleome viscose Seeds: “Molecular Docking”
Rizwan Ahmad, Jitender K Malik
Page Numbers : 152-158
DOI : 10.36348/sijtcm.2022.v05i07.004
Herbal remedies used traditionally to cure different types of human disease. The research in herbal drugs, to discover single compound used a lead for developing new therapeutically active products. Cleome viscosa Linn. (wild or dog mustard), belongs to family(Capparaceae). Cleome viscosa well known plant for their antimicrobial, anti-diarrheal, hepatoprotective, analgesic and anti-fibrolytic potential. In living beings, infection caused by helminths (helminthiasis) is a severe problem to health that results in hardship and stunted growth. In the developing world, helminthiasis (in human intestine) is the most common infectious disease. The seed contained salicylic acid and Lupeol. This study has been carried out to evaluate anthelmintic potential of Cleome viscose seed by molecular docking via drug-tubulin interaction. The molecular docking result revealed that salicylic acid and Lupeol showed encouraging docking score. The docking score found to be -1.98 and -3.82 kcal mol–1 respectively.
Original Research Article
Aug. 13, 2022
Prognostic Value of Inflammatory Biomarkers in COVID-19
Background: Coronavirus disease 2019 (COVID-19) is characterized by a variable clinical picture ranging from asymptomatic to severe or even critical forms that can be life-threatening. The biological assessment can also be within the limits of normality, even little disturbed or outright witness of an excessive inflammatory response or a real cytokine storm which would follow the virological phase of the disease. The objective of our study is to evaluate the contribution of inflammatory biomarkers: LDH, procalcitonin (PCT), ferritin, C-reactive protein (CRP) and the level of lymphocytes, in the prediction of mortality in COVID-19 patients. Methods: We collected 79 patients diagnosed with COVID-19 on the basis of a set of clinical, radiological and / or biological arguments, which we divided into two groups: Survivors (N = 45) and deceased (N = 34). All these patients had all the biomarkers measured upon admission. Results: In our study, we found that the levels of the four inflammatory biomarkers studied in our series were elevated in both groups of patients (survivors and decedents), however, the decedents did not have significantly higher levels than the survivors (P >0.05).
Original Research Article
Aug. 11, 2022
Toxicological Profile of the Stem Bark Extract of Cylicodiscus gabunensis Harms (Fabaceae)
Ngoule Christian, Essome Henri, Ngene Jean Pierre, Ladoh-Yemeda Christelle Flora, Ngongodi Bagnak Anne Syntyche, Etame-Loe Gisèle, Mpondo Mpondo Emmanuel
Page Numbers : 140-146
DOI : 10.36348/sijtcm.2022.v05i07.002
This study aimed at evaluating the toxicity of the methanolic extract of Cylicodiscus gabunensis stem bark, a plant traditionally used against female fertility problems. Acute toxicity was evaluated in rats by sequential administration of a single dose of 2000 mg/kg and 5000 mg/kg of body weight of extract according to the method described by protocol 425 of the Organization for Cooperation and economic development. Subacute toxicity was assessed by daily administration of the extract at 100, 200 and 400 mg/kg for 28 days. The weight evolution and the signs of toxicity were observed, the biochemical and haematological parameters of the blood of the animals were collected and analysed. The administration of the extract at 2000 and 5000 mg/kg caused no death and no toxic signs. The weight evolution, the biochemical and haematological parameters of the surviving rats were analysed and compared with those of the controls. Acute oral toxicity data determined that the LD50 of the extract is greater than 5000 mg/kg. Repeated dose administration did not cause any deaths or significant changes in haematological parameters. Some signs of intoxication were however noted and certain biochemical parameters analysed in the rats showed statistically significant differences compared to the controls. A decrease in creatinine was observed on the renal level, an increase in transaminases and a decrease in alkaline phosphatase on the hepatic level. An increase in total proteins at 100 and 200 mg/kg and triglycerides at 100 mg/kg were observed and also a significant drop in LDL-cholesterol at 100, 200 and 400 mg/kg. This study shows that the stem barks of C. gabunensis would be moderately toxic in repeated oral administration, additional studies should be carried out to determine the effect of the extract on the tissues of the different organs.
Short Communication
Aug. 3, 2022
Virtual Reality Complementary Therapy and Breast Cancer Recovery: A Brief Update
Dr. A. M. Tacon
Page Numbers : 137-139
DOI : 10.36348/sijtcm.2022.v05i07.001
This update reviewed the effects of VR complementary therapy in breast cancer patients regarding physical symptoms such as the common triad of pain, lymphedema and upper limb impairment following treatment. The results revealed weak but consistently positive, significant effect in physical symptoms. Findings, however, were limited by poor methodological quality, small sample sizes and low statistical power in studies. Future recommendations include better designed studies with large sample sizes and acceptable power to investigate the effects of VR interventions in women with breast cancer, during and after cancer treatment.
