Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous group of malignancies arising from the mucosal linings of the oral cavity, pharynx, and larynx. Locally advanced HNSCC (LA-HNSCC), encompassing stages III and IV, involves large tumors and regional lymph node metastases without distant spread, contributing to high morbidity and mortality. Understanding the clinical features of LA-HNSCC is crucial for improving treatment strategies and patient outcomes. Objective: To evaluate the clinical characteristics of patients with LA-HNSCC and their impact on treatment outcomes, specifically comparing the TPLF and LFP regimens. Methods: An experimental study was conducted at Khwaja Yunus Ali Medical College & Hospital from January to December 2015, involving 60 patients with LA-HNSCC. Patients were treated with neoadjuvant chemotherapy (TPLF or LFP regimens) followed by concurrent chemoradiation. Data was collected through patient interviews, clinical evaluations, and laboratory tests. The primary outcome measures were tumor regression, clinical response, and acute toxicities. Statistical analysis was performed using SPSS, with significance set at p < 0.05. Results: The majority of patients were male (80% in Arm A and 77% in Arm B) and over 50 years old. Smoking prevalence was high (83.3% in Arm A and 80% in Arm B). The most common primary tumor sites were the oral cavity (Arm A: 30%, Arm B: 33.3%) and oropharynx (Arm A: 23.3%, Arm B: 26.7%). Neck node swelling, pain, dysphagia, and weight loss were the most frequent clinical complaints. No statistically significant differences were found between the two treatment arms in terms of age, smoking, occupation, ECOG performance status, or histological grading. Conclusion: Both TPLF and LFP regimens provided similar outcomes in terms of clinical characteristics and treatment response in patients with LA-HNSCC. These results suggest that the choice between TPLF and LFP regimens may not significantly influence treatment outcomes. Further research is needed to explore additional factors affecting treatment efficacy and refine therapeutic strategies for LA-HNSCC.

This study aims to analyse the effect of intrinsic motivation and work discipline on employee performance with organisational commitment as an intervening variable at Puskesmas Siwalan, Pekalongan Regency. The research sample consisted of 58 employees, and the data were analysed using the Structural Equation Modeling (SEM) method with the Smart PLS tool. The results showed that intrinsic motivation and work discipline had a positive and significant effect on employee performance. Organisational commitment also proved to be a variable that mediates the relationship significantly. The findings underscore the importance of strengthening intrinsic motivation and work discipline as key factors for improving performance in the healthcare work environment. This study provides practical implications for health centre management to develop performance improvement strategies through strengthening employee motivation and commitment.

Bangladesh is a Muslim dominated country. Many of the Muslims are practicing Muslims. Islam has influence on the life of Muslims and many aspects of women human rights are influenced by Islam. Marriages, divorce, maintenance of wife, inheritance are regulated by Islamic laws. Some other aspects are regulated by secular laws. Bangladesh is signatory to many International conventions and declarations regarding women human rights. So Bangladesh women human rights are emanated from Islamic sharia laws, Bangladesh constitution, policies of the government and international declarations and conventions. In many respects women human rights in Islam and the rights emanate from secular sources are consistent with minor inconsistency where Bangladesh has made reservation. But the problem is that these rights are not observed properly. Local cultures have significant influence on the non-observance of women human rights in Bangladesh. As many of us are Muslims and we observe women human rights in Islam, it will uphold women rights in Bangladesh.

This thesis's motive is to recognize the challenges that university students face while trying to speak English because of the effect of their educational background and it aims to uphold the role of teachers to assist students in overcoming those challenges using motivation and teaching strategies according to social-psychological aspects of Applied Linguistics. The data are collected from Army-governed universities, Schools, and Colleges from a sub-district and a renowned education consultant center in Bangladesh. There were 100 participants, and it used a mixed method. The failure of students to speak English at the tertiary level, this research identifies the possible barriers and suggests some solutions that will be effective for all English speakers. In most cases, the highest obstacles are anxiety, inferiority, lack of self-motivation, and dependency on the native language in academics. It also finds that the focus is mostly given to writing skills in the mentioned institutions as well as motivation, co-curricular activities, building a friendly and interactive environment in the classroom, improving the assessment policy, and equal facilities in educational institutions can overcome these challenges. It indicates the social, economic, and psychological obstacles that may block students from Speaking English in a public place and offers some methods to build student-friendly classrooms where students' both extrinsic and intrinsic motivation can be boosted.

The purpose of this study was to analyze the effect of competency development and compensation through motivation on the performance of health workers at the Karanganyar and Kajen District Health Centers. The sample of this study was midwives and nurses at each health center in Karanganyar and Kajen Districts totaling 84 respondents. With SEM PLS analysis tools. The findings of this study are that there is a positive and significant influence between competency and performance; there is a positive and significant influence between compensation and performance and there is a significant positive influence between motivation and performance.

The aim of this research is to analyze efforts to improve employee performance by using IT, work discipline with organizational commitment as an intervening case study at the Central Java Province BKKBN office. The sample for this research is the Pekalongan Residency Family Planning Counselor with a total of 90 respondents, using the SEM PLS analysis tool. The findings of this research are that there is a positive and significant influence between the use of IT on employee performance; There is a positive and significant influence between work discipline on employee performance and there is a significant positive influence between organizational commitment on employee performance.

The present study investigates the teaching of the English language in some Chadian educational institutions of science and technology, with the aim of bringing out the specificities in the teaching and learning processes in the concerned institutions. The study is thus informed by Morley’s (2000) perspective on Halliday’s (1985) Systemic Functional Linguistics, and makes use of a quali-quantitative method. Informants randomly sampled from a population constituted of teachers, students and government officials were subjected to questionnaires as main research tool. The findings reveal that common teaching and learning practices in the institutions under inquiry rather fall under general English instead of ESP. Thus, need is to revisit syllabuses and teaching methods so as to meet the communicative needs of the learners.