Biclonal Gammopathies: A Retrospective Study in Hassan II University Hospital Center, Fez, Morocco
Ghammad W, Berrada S, Aissaoui M, Slaoui A, Iraqui FZ, Benbella I, Mustapha M, El Boukhrissi F
Page Numbers : 226-231
DOI : 10.36348/sijb.2020.v03i11.001
Biclonal gammopathies manifestations (BGMs) are defined as a clonal proliferation of plasma cells or B-lymphoid progenitors that produces 2 different monoclonal proteins known as M-proteins or paraproteins. The aim of our study is to report and analyses the epidemiological, biological and clinical features of the cases of biclonal gammopathies diagnosed at the Hassan II University Hospital Center (HUHC), Fez during a period of 10 years (2010-2020). Among the 782 cases of gammopathies diagnosed by immunofixation (IF), 28 were shows biclonal gammopathies (3.5%), the sex ratio M/F was 1 and the median age was 63 years. The most frequent isotype was IgG/IgM with a slight predominance of the Kappa light chain. The most common diagnosis was biclonal gammopathy of undetermined significance (BGUS) in 12 patients (42%), followed by 10 cases of multiple myeloma (MM) (35%) and 6 cases of lymphoproliferative syndrome (21%). Although the clinical features are similar to monoclonal gammopathy, dentification of BGMs increases diagnostic precision in our region, in particular for multiple myeloma cases and lymphoproliferative syndrome compared to other studies.
Original Research Article
Oct. 29, 2020
Study of Effect of Nutrition and Sunlight Exposure on Bone Mineral Density in and Around Kanchipuram District
Gopalakrishnan, Sivakumar J, K.Ponnazhagan
Page Numbers : 221-225
DOI : 10.36348/sijb.2020.v03i10.004
Objectives: The aim of the present study was to investigate the relationship between nutrition and sunlight exposure on BMD levels in different age group between 30 to 75 years old subjects and to assess the relationship between age, sex and BMD in general population. Design: An observational cross sectional study of randomly selected in kanchipuram district aged from 30–75 years. Materials and methods: The study was conducted in the department of biochemistry, Meenakshi Medical College Hospital and Research Institute, Kanchipuram .Under this cross-sectional comparative study. 80 subjects of both sexes were subjected to the study. And subjects are divided into group 1(Age Group between 30-45), group 2 (Age Group between 46-60), and group 3 (Age Group between 61-75). Nutrition status and exposure to sunlight was collected by questionaries. Results: 80 adults between 30 to 75 years of both sexes were subjected to this study. People in the age group of 30-45 years were found to be more osteopenic particularly very high in females (males -0.97±1.2 and females -1.3±1.45) and people in the age group 61 to 75 years, were found to be osteoporotic (males -1.43±1.3 and females -2.08±0.95). Based on nutrition, 15 people of both sexes were selected who are vegetarian (-0.96 ± 0.6), 22 people were selected who take non-veg three times in a week (1.29 ± 0.92), and 28 people were selected who take non veg more than 3 times in a week (1.3 ± 0.77) and 15 people were selected who take both veg and non-veg in a week (1.38 ± 0.77). The results indicate that vegetarian taking people were got low BMD levels when compared to other groups. BMD level significantly increased in people exposed to sunlight for more than 10 minutes when compared to less exposed to sunlight. Conclusion: This study confirms that people of younger age group (30-45 years) are found to be more osteopenic when compared to the older age group (46-60 years) due to of less exposure in sunlight and low intake of vitamin D and calcium diets. Highlight of this study is “Osteopenia is more prevalent in the younger age group which necessitates earlier intervention”
Oct. 21, 2020
Biochemistry of Water Soluble Vitamins, Sources, Biochemical Functions and Toxicity
Hamza Rafeeq, Irha Basit, Rizwana Jabeen, Iqra Shehzadi, Kanwal Shafique, Sobia Tariq, Qurat ul Ain Naseer, Hafiza Mariyem Raheem
Page Numbers : 215-220
DOI : 10.36348/sijb.2020.v03i10.003
There are thirteen vitamins in humans: four fat soluble (A, D, E, and K) and nine water soluble (vitamin B complex and vitamin C). Water-soluble vitamins dissolve rapidly in water and are usually easily excreted by the body. Because they are not processed too soon, a steady intake is important. B vitamin supplements available for each vitamin: B1: thiamine, B2: riboflavin, B3: niacin, etc. Niacin, pantothenic acid, biotin and folate are recognized by name rather than by quantity. B vitamins are usually used in energy drinks and many are advertised with high levels of B vitamins boasting that they can 'go through the day and do not feel nervous or anxious. B vitamins are primarily absorbed in foods such as pork, fish and liver. Healthy vitamin B sources include vegetables (pulses or beans), whole grains, rice, bananas, chilli pepper, tempeh, brewer's yeast and molasses. While beverage yeast has been used to produce beer, its bioavailability varies from low to adverse, as drinking ethanol hinders the absorption of thiamine (B1), riboflavin (B2), niacin (B3), biotin (B7) and folic acid (B9). Vitamin C is needed for tissue growth and repair in all areas of the body. It is used as an essential protein for the development, repair and maintenance of cartilage, bones and teeth and assists in the absorption of iron.
Oct. 18, 2020
Green Tea Treats and Prevents Infectious Diseases
Dr. Anil Batta
Page Numbers : 211-214
DOI : 10.36348/sijb.2020.v03i10.002
Green tea is one of the most popular drinks consumed worldwide. Produced mainly in Asian countries from the leaves of the Camellia sinensis plant, the potential health benefits have been widely studied. Recently, researchers have studied the ability of green tea to eradicate infectious agents and the ability to actually prevent infections. The important components in green tea that show antimicrobial properties are the catechins. The four main catechins that occur in green tea are (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG). Of these catechins, EGCG and EGC are found in the highest amounts in green tea and has been the subject of most of the studies. These catechins have been shown to demonstrate a variety of antimicrobial properties, both to organisms affected and in mechanisms used. Consumption of green tea has been shown to distribute these compounds and/or their metabolites throughout the body, which allows for not only the possibility of treatment of infections but also the prevention of infections.
Oct. 16, 2020
A Novel Approach towards the Identification of plant genes, Bioinformatics Analysis and Role of EIN3 and EIL1 in plants
Syed Abu Bakr Haider Bukhari, Muhammad Waqas Akhtar, Shuja Ur Rehman, Waseem Akhtar, Hamza Rafeeq, Alyan Ashraf, Muhammad Zeeshan Talib, Naveed Aslam
Page Numbers : 206-210
DOI : 10.36348/sijb.2020.v03i10.001
One of the most important parameter in elongation of cotton fibre is the biosynthesis of ethylene. EIN3 and EIL1 (Ethylene Insensitive3/Ethylene Insensitive 3) are the main transcriptional factors that are specifically playing an important role in signal transduction in cotton. Expression analysis of the EIN3/EIL1 genes involved in development of cotton fibre investigated out through RT-qPCR. Further, STRINGTIE is a tool that is use for measuring the different levels of expression. ClustalW method is a method that is used to determine the sequences of amino acids of EIN3/EIL1 genes by aligning by using the sequences. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways of the EIN3/EIL1 genes is also bioinformatics tools that is functionally use for classification and characterization of genes at functional level with using the principles of functional enrichment analysis. Biological database such as STRING is designed for to construct the specific PPI networks of EIN3/EIL1 due to known PPIs and analysis to check interactions among protein. Bioinformatics tool such as BLASTP use for identification of transcription factors of EIN3/EIL1genes. Biological database such as Plant CARE is especially used to analyze the cis-elements in specific sequences of promoters of EIN3/EIL1 that are especially involved in transcription of genes.
Original Research Article
Sept. 26, 2020
Study of Vitamin D, hs-CRP and Lipid Profile Status in Newly Diagnosed Hypothyroid Patients in the Local Population of Kanchipuram District
Background: Thyroid dysfunction is relatively a common disease which affects people, irrespective of their age and gender. Hypothyroidism is a clinical syndrome resulting from deficiency of thyroid hormones, which in turn results in a generalized slowing down of the metabolic processes. Newly diagnosed hypothyroidism has been reported to be associated with inflammation, dyslipidemia which leads to CV risk. hs-CRP is a marker of subclinical inflammation and a predictor of CVD. Vitamin D deficiency is involved in autoimmune diseases, metabolic syndromes, cardiovascular disease, and cancers. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases. Objectives: The aim of the present study was to compare vitamin D, hs CRP levels and lipid profile with that of thyroid profile among newly diagnosed hypothyroid subjects. Materials and methods: A total of 70 subjects with the clinical features and investigative reports suggestive of hypothyroidism and newly diagnosed as hypothyroid patients in General Medicine department, Meenakshi medical college, kanchipuram, were compared with 70 healthy controls. Results: The levels of vitamin D were significantly reduced compared to controls and negatively correlate with TSH in hypothyroid cases. hs-CRP levels were significantly increased and positively correlate with TSH in hypothyroid patients. Total cholesterol and TGL levels were significantly higher compared to control group and positively correlate with TSH in hypothyroid cases but the level of HDL was significantly reduced compared to controls and negatively correlate with TSH in hypothyroid patients. Conclusion: Our results indicated that newly diagnosed hypothyroid patients become an important entity due to possible link between diagnosed hypothyroid patients and cardiovascular risk factors, especially lipid abnormalities and alteration of BMI levels. Patients with hypothyroidism suffered from hypovitaminosis D and also significant association between TSH and hs-CRP is an important finding in this study.
Original Research Article
Sept. 25, 2020
Study on Frequency of ABO Blood Grouping and Rhesus Phenotype Distribution in Tamil Nadu and Pondicherry of South India
R. Srikumar, R.Vijayakumar, E. Prabhakar Reddy, S. Ravichandran C, Naveen Kumar
Page Numbers : 199-200
DOI : 10.36348/sijb.2020.v03i09.002
Blood is a fluid which we have in our bodies that carries oxygen from the lungs to the rest of the body and also waste to be eliminated from the body. ABO and Rh blood group system is the most important system in transfusion and organ transplants. Though, many studies have been conducted in various parts of India to determine the local ABO and Rh distribution, no Indian study has so far been conducted to explore the South Indian especially Tamil Nadu and Pondicherry ABO and Rh distribution. The present study made an attempt to provide data on ABO and Rh blood group distribution across Tamil Nadu and Pondicherry. A total of 25,000 subjects of college students were included in this study and ABO and Rh (D) grouping was performed on all these samples. Data on the frequency of ABO and Rh(D) blood groups was expressed in simple numbers and percentages. The present study explored Among the ABO grouping system the highest frequency of blood group was found to be group O [10023(40.09%)], followed by group B [7447(29.79%)], and group A[6393(25.57%)]. The least common blood group was AB group [1137(4.55%)]. 94.69% Rh antigen was detected and the prevalence of Rh – ve was 5.13%. Of the 25000 individuals, the most common blood group was O followed by B and A and the least blood group was AB. The present study provides information about the relative distribution of various ABO blood grouping in the Tamil nadu and Pondicherry. This vital information may be helpful in planning for future health care blood transfusion services.