Aim of current study is to perform and investigate the renoprotective effect of nintedanib on diabetic nephropathy in albino wistar rat. Diabetic nephropathy was induced in overnight fasted rats by a single intraperitoneal injection of Streptozotocin (STZ) (45 mg/kg) prepared freshly in ice chilled 0.1 M citrate buffer (Ph-4.5) and after 15 minutes Nicotinamide (110 mg/kg)in in 0.9% normal saline was administered. The rat were divided into five grouping six animal in each group Each group underwent a different treatment protocol Treatment with nintedanib at 30 mg/kg and 50 mg/kg was evaluated using invivo studies such as physiological evaluation, serum and urine biochemical parameters like creatinine, albumin, BUN, uric acid and urine albumin level and histological studies of diabetic nephropathy induced rat's kidney. The present study demonstrated that the treatment of nintedanib exerts its renoprotective potential against the progression of diabetic nephropathy. The results showed significant improvements in renal function parameters and reduced histological changes when compared to the disease control group. Thereby, nintedanib at 50 mg/kg has demonstrated better effectiveness than nintedanib at 30 mg/kg. Our finding suggests that nintedanib holds potential as a novel therapeutic agent in the management of diabetic nephropathy by inhibiting TGF-L. vascular endothelial growth factors, and their signaling pathways in the progression of diabetic nephropathy. Further research is needed to elucidate its long-term safety and efficacy in clinical treatments.

The paper examined the fact that all over the world, countries develop in accordance with the quality of education. That is the quality education in any country depended largely on the extent to which its challenges were addressed. The paper explored some of the possible challenges impending the realization of quality education in Nigeria such as quality teachers, learners and environment, arguing that access to quality education definitely would ensure societal balance, promote accountability, stability and prevent resorting to anarchy. In this paper concept like quality education and national development were conceptualized. By way of recommendations, the paper took the position among others that quality teachers in terms of training and re-training as well as adequate unavoidability infrastructural facilities should be provided for the development of the individual and society.

The rate of hunger in oil rich African States specifically Nigeria is becoming so alarming despite the huge wealth generated over the years. There seemed to be a mismatch between government policies, rising population and food security. The prices of food items have been rising since 2000, triples in 2008 and reached unbearable limit in 2023 and 2024. Food scarcity is a significant problem to the masses whose capacity to buy food is hindered by poor wages and food marketing cartels that control the force of food demand and supply. On the other hand, peasant farmers have lost interest in farming because of unfavourable conditions like high cost of farm input, human invaders, microbial invaders as well as pest. The issue of hunger has attracted palliative from federal government, private donors and international agencies. Policy analysts are dissatisfied with the notion of palliative-hunger alleviation strategy being that it acts as a first aid treatment rather than a cure. The study adopted both primary and secondary data primarily using CBN bulletin, online materials and interview. Key informant interview was carried out using officials from NIMETS, Ministry of Agriculture, Ministry of Power and Energy, Ministry of Finance, Ministry of Environment, Ministry of Humanitarian Affairs. Sixty (60) interviewees were purposively selected and the criteria was based on their depth of knowledge in their various fields of endeavour. The study delves into understanding how hunger became a chronic ailment in an oil rich Sub-Saharan African giant. In the study, historical framework of hunger was established, the reasons for persistent hunger despite intervention as well as key hunger alleviation programmes were discussed. It was revealed that several factors are responsible for hunger ranging from climate, environmental hazard, unsuitable policies, high electricity tariff and petrol prices, exchange rate fluctuation, global oil price shock, insecurity, poor social welfare structure, low motivation to farming, over-riding number of consumers than producers and government commitment to food production and value-added services. In the study, food crises in Nigeria began from the 21st century precisely year 2000 when the price of petrol, exchange rate and global oil price rose uncontrollable and peaked between 2023 and 2024 resulting to series of hunger protest and strike across different labour unions in the country. Given this, it was recommended that holistic, people-centred and multi-sectorial approach to hunger reduction be employed against the conventional methods characterised by imposition of failing policies for the masses.

This study was undertaken to comparatively investigate groundwater quality in Uyo capital city from private and public boreholes in order to ascertain if there are variations in quality. Four objectives were used in the study using both experimental and survey methodology. The flame atomic absorption spectrophotometry was used to analyze the level of chemical concentration in the borehole water samples. A total of fourteen (14) groundwater samples were collected from 7 commercial boreholes located at Nwaniba Road, Aka Road by Udo Udoma, Oron Road, Ikpa Road by CCC, Abak Road, Mbierebe Junction and Ikot Ambang and 7 private boreholes located at Water Board Itam, Water Board Oron Road, Nwaniba Road close to Water Fountain, Champion Brewery, Redeemed Church close to Dumpsite Uyo Village Road (Ikpa Road), Abak Road and Mbierebe Junction. The groundwater samples were analyzed in the laboratory for their chemical and microbiological characteristics. On comparing the results with standard values recommended by World Health Organization (WHO), it was discovered that some of the groundwater samples had parameters that were within the permissible limits with slight variation across the different locations. While also, there were parameters that did not meet up with the permissible limit set by the World Health Organization. For instance, the pH of the groundwater samples was not within the permissible limit of 6.50mg/l-8.50mg/l in six (6) different locations of the commercial boreholes which are Oron road, Nwaniba road, Aka road, Ikpa road, Abak road, Ikot Mbang with values of 5.3, 6.3, 4.5, 5.9, 5.1, 5, 7 respectively. While, the pH in the private boreholes was not within the permissible limit in five (5) different locations which are Water board Itam, Nwaniba road, Champion brewery, Ikpa road, Abak road with values of 4.31, 4.98, 6.1, 5.53, 6.21 respectively. Several other parameters also got slight differences. The study found out that the groundwater of the study area is not devoid of contaminants, be it from the private or commercial borehole and as such both requires treatment. The study recommends continuous monitoring of the groundwater supply to keep the quality in check.

Background: Targeted therapy refers to agents that block the growth of malignant cells by interfering with specific targeted molecules needed for carcinogenesis and growth of tumors rather than by simply interfering with all rapidly dividing cells. Haematological malignancies (HM) are clonal haemopoietic disorders that arise as a result of varied genetic damages to several key biochemical pathways in cellular differentiation, proliferation and maturation. These pathways have the focus of a new generation of targeted therapy that have revolutionized the management of haematological malignancies. Methodology: The study was a retrospective study carried out at Delta State University Teaching Hospital, Oghara. Participants were recruited consecutively as diagnosis were made. Data obtained were analysed using Statistical Package for the social sciences (SPSS) version 23. Results: A total of 132 patients with haematological malignancies participated in the study. Males were 71 (53.8%) females were 61 (46.2%). 108 (81.8%) of the patients did not use molecular targeted therapeutic agents while 24 (18.2%) used. and 56.8% of the patients with haematological malignancies were dead at the end of follow-up. Financial constraints accounted for the reason 66 patients, (61.1%) did not use molecular targeted therapies while unavailability of the specific therapy within the country accounted for the reason why 42 patients (38.89%) could not access them. Use of targeted therapy was found to have a significant relationship with treatment outcome (p = 0.035). Patients who used molecular targeted therapy were more likely to be alive at the end of follow-up. Conclusion: Molecular targeted therapies hold tremendous promise in the treatment of haematological malignancies, with associated improvements in patients quality of life and outcomes. However, challenges such as availability, accessibility and cost remain especially in a developing country such as ours.

Simultaneous bilateral quadriceps tendon rupture is a rare injury, particularly in individuals with underlying medical conditions such as renal failure. This paper presents the case of a renal failure patient 51 old year with 10 years history of haemodialysis treatment suffering from bilateral quadriceps tendon rupture.

Since the Belt and Road Initiative was put forward, it has continuously achieved fruitful results. China has increasingly close contacts with foreign countries. China is committed to increasing trade cooperation with other countries to benefit the people of all countries. So how to appropriately translate political, economic, and cultural languages with Chinese characteristics to tell Chinese stories well and spread the voice of China is becoming increasingly important in international communication. Based on the three principles of the Skopos theory, this paper analyzes some of the original and translated versions of Xi Jinping's speech on the tenth anniversary of the Belt and Road Initiative, aiming to explore the translation methods of documents with Chinese characteristics and enrich the research on document translation through the analysis of the content of the speech.