Expression and Function of FGF5 Isoform in Hair Growth
Seong Kyeong Jo, Sooil Kim, Young Ho Lee
Page Numbers : 1-5
DOI : 10.36348/sijap.2021.v04i01.001
In mammals, hair cycle occurs continuously in three cycles: anagen, catagen, telogen. One of the fibroblast growth factor (FGF) family, FGF5, have been known to act as an inhibitor of hair growth in the transition from anagen to catagen. The FGF5 gene is composed of a long form (FGF5) and a short form (FGF5s). We examined the effect of FGF5 isoform on hair growth in the cultured keratinocytes. To analyze the effect of FGF5 isoform the keratinocytes, we overexpressed FGF5 isoform and gene expression change was observed with RT-PCR. Expression of hepatic growth factor (HGF) gene was increased when FGF5s was overexpressed by adenovirus (Ad) in keratinocytes. BMP6 tend to be decreased in the group transfected with Ad/FGF5 virus than in the control group. Taken together, FGF5s might activate HGF in hair growth and FGF5 may inhibit BMP6 expression in hair growth suppression.
Review Article
Jan. 30, 2021
Current Update on Nanoemulsion: A Review
Himesh Soni, Sarvesh Sharma
Page Numbers : 6-13
DOI : 10.36348/sijap.2021.v04i01.002
In this review, the formation, characterization, properties and applications of nano-emulsions are reviewed and summarized. Nanoemulsions are submicron sized emulsions that are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Nanoemulsions are the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase by means of an appropriate surfactants. Due to their small droplet size nano-emulsions possess stability against sedimentation or creaming with Ostwald ripening forming the main mechanism of nanoemulsion breakdown. Nanoemulsion droplet sizes fall typically in the range of 20-200nm. Diameter and surface properties of droplets of nanoemulsion plays an important role in the biological behavior of the formulation. Nanoemulsion show great promise for the future of cosmetics, diagnostics, drug therapies, and biotechnologies. The main application of nanoemulsions is the preparation of nanoparticles using a polymerizable monomer as the disperse phase (the so-called miniemulsion polymerization method) where nanoemulsion droplets act as nanoreactors. Another interesting application which is experiencing an active development is the use of nanoemulsions as formulations, namely for controlled drug delivery and targeting.
Original Research Article
Nov. 30, 2020
Knowledge Attitude and Practice of Body Donation in Medical Students: A descriptive Study
Dr. Ajay N, Dr. Asharani SK, Dr. Tejaswi HL
Page Numbers : 99-102
DOI : 10.36348/sijap.2020.v03i11.002
The aim of the study was to ascertain the knowledge attitude and practices of Indian medical students towards post mortem body donation. An online questionnaire was sent to 150 students who have witnessed and performed human cadaver dissection. Even though most of the respondents are aware of the existence of the practice of body donation (98% aware) and are direct beneficiaries of it, a substantial number of them lack an understanding of the laws governing body donation (only 32.7% are aware of the Indian Anatomy Act, 1948 and 26.5% of the Karnataka Anatomy Act, 1957?) and a majority are hesitant to donate their own body for medical research and learning (46.9% are willing to donate). The reason for unwillingness to donate their body could be stemming from hesitation to be the first one in their peer/family circle to pledge to donate (87.8% have no one close to them who has donated), an apprehension that their body will be ill-treated (26.5%), opposition from family/friends (61.2%) and religious beliefs (53.1%).
Review Article
Nov. 19, 2020
"Magic Rock" Modern Applications: A Review
Himesh Soni, Sarvesh Sharma
Page Numbers : 95-98
DOI : 10.36348/sijap.2020.v03i11.001
“Magic Rock” Zeolites are microporous crystalline aluminosilicates resulting from the reaction of volcanic rocks, ash layers and an alkaline groundwater. Zeolites are incorporated the group contain natural silica similarly diatomaceous earth. Zeolites situate apart among the many families of porous materials. They have a number of significant practical properties such as a high adsorption capacity and the ability to cation exchange because of their structure. The present reviews focus on the application of natural zeolites as they were naturally available and abundant, low cost and stable.
Original Research Article
Oct. 18, 2020
Morphometry of Parietal Foramen in Skulls of Telangana Population
Dr. T. Sumalatha, Dr. V. Sailaja, Dr. S. Deepthi, Dr. Mounica Katukuri
Page Numbers : 90-94
DOI : 10.36348/sijap.2020.v03i10.001
Aims & Objectives: To study the prevalence, number, location and variations of parietal foramen in human skulls and correlate with the clinical significance if any. Material and Methods: A total of 45 skulls with 90 parietal bones were studied in the Department of Anatomy Govt medical college Mahabubnagar from osteology specimens in the academic year 2018-2019.Various parameters like unilateral or bilateral occurance or total absence of the parietal foramen, their location in relation to sagittal suture and lambda, their shape have been observed using appropriate tools and the findings have been tabulate. Observation & Conclusions: Out of total 45 skulls there were 64 parietal foramina in 90 parietal bones, with foramina only on right side in 10 skulls, only on left side in 7 skulls, bilaterally present in 23 skulls, total absence in 4 skulls and 1 foramen located in the sagittal suture. Right foramen is at a mean distance of 0.58+/-3.6mm from sagittal suture & left is at 0.54+/-3.7mm from sagittal suture. Only 1 foramen was more close to lambda, rest (63) are at the junction of anterior 2/3rd & posterior 1/3rd of sagittal suture. Shape of 18 foramina were Circular, 10 were Slit like and the rest 36 were Oval.
Original Research Article
Sept. 30, 2020
Aberrant Right Hepatic Artery: A Systematic Review
Dr. Chaudhari Gunwant, Dr. Sonawane Monali, Dr. Singel T.C, Dr. Chaudhari Heena
Page Numbers : 86-89
DOI : 10.36348/sijap.2020.v03i09.001
Abdominal arterial branching pattern have given attention to researchers because of their significance. The variations in branching pattern of hepatic artery, supplies liver are documented by many authors. But still there are much variations present which are not classified. The aim of present study was to aid the knowledge of variation in the hepatic artery for surgeons and radiologists. For this study, scientific literature from PubMed was carried out from year 2005 to 2020 for the articles having anatomical variations of the hepatic artery in all publications. The relevant articles were also studied. Out of 2173 cases, 1500 (69.02 %) showed type I normal pattern. 37 (1.70 %) cases displayed type II: a replaced LHA from left gastric artery. Type III: a replaced RHA from SMA was observed in 158 (7.27%) cases. Type IV: replaced RHA and LHA were observed in 4 (0.18 %) cases.136 (6.25%) cases displayed type V: an accessory LHA. 7(0.32 %) of the subjects were found to have type VI: an accessory RHA. Type VII: accessory RHA and LHA. Type VIII: a replaced RHA or LHA with other hepatic artery being an accessory one were not found. Type IX: the hepatic trunk as a branch of the SMA were 14 (0.64 %). 1(0.04%) was found in type X: the CHA from the left gastric artery. Variations in hepatic arterial pattern are useful for various surgical procedures like hepatobiliary, pancreatic, gastric surgery and radiological interventions. Accidental ligation or injury to these vessels may interrupt the blood supply.
Original Research Article
Aug. 30, 2020
Branching Patterns of Human Coronary Vasculature and its Clinical Importance – Cadaveric Study
Babu Rao Sake, G. GeethaVani, S. Lokanadham
Page Numbers : 83-85
DOI : 10.36348/sijap.2020.v03i08.005
Background: Coronary arteries and their variation in branching patterns have a significant role in cardiac deaths in recent years. Aim: To study the branching patterns of the human coronary arteries and their clinical importance. Materials and Methods: A total of 40 Human heart specimens were collected from the Department of anatomy, Santhiram Medical College, Nandyal to study the branching patterns of human coronary arteries and their clinical importance. The variations in branching patterns like Trifurcation, Quadrifurcation of the coronary arteries were noted in the present study. Results: The termination of left coronary artery showed a branching pattern as bifurcation in 29 (72.5%) specimens, Trifurcation in 6(15%), Quadrifurcation in 5(12.5%) out of 40 specimens in our study. We observed 28% of the variations in branching patterns of left coronary artery, whereas right coronary artery branching pattern was normal in the present study. Conclusion: Various branching patterns of coronary arteries should be acknowledged during the catheterization for coronary angiography.
