Corona virus (COVID-19) is an enveloped RNA virus that is diversely initiates in humans and wildlife. A total of 6 species have been identified to cause disease in humans. Viral infections play a critical role in human diseases, and recent outbreaks is the influx worldwide in form of novel corona .The SS-RNA virus from the enveloped corona virus family caused SARS (Severe acute respiratory syndrome) which is life threatening viral infection. The spreading of infection is quick in many countries of the world. The World Health Organization (WHO) called COVID-19 a pandemic on March 11, 2020. There are numerous drug trials going on with some positive results. Though, since no vaccine is available, the best way to fight the virus is by preventive measures. In the present research an attempt had been made to find new COVID-19 main protease inhibitor by molecular docking approach. The present study reveals that rifampicin has good binding affinity with COVID-19 protease and thus can be used as prophylaxis and therapeutic treatment for corona patient.

Self-Medication is an important phenomenon worldwide. In addition to its advantages, it is associated with some risk when medicines are misused or abused. Students may not have the sufficient knowledge about medications that is why the resultant side effects can be very serious. The study mainly aims to evaluate the knowledge and attitudes of high school and university female students (Taif City, KSA) towards the use of medicines during Exams. A self-administered as well as an electronic questionnaire was used to collect responses from the students in March 2017. Total of 363 students were randomly selected and from the university and four high schools and recruited in the study. Respondents recruited with face-to-face questionnaires were 241 (66.4%), compared to 122 (33.6%) included electronically. The statistical package for Social Science (SPSS) version 22 was used to analyze the study data. The study showed that about 48.5% of the female students agreed that exams affect their health status and food habits to a large extent and about 56% suffer from anxiety during exams. The most prominent health problem during exams was headache (44.3%) followed by stomach pain (27.8%) and respiratory problems (15.9%). Few students (15%) agreed that using medicines would improve their performance, while (31.4%) answered that side effects of medication negatively affected their academic performance. The most common drugs used by students during exams period were antihistamine (49%), followed by painkillers (8%), and antibiotics and medicines for chest illness (6.3%). There is a high prevalence of irresponsible self-medication among high school and university students, with observed side effects. There is a need to raise the students’ awareness about medicines at school, university and homes.

Non communicable diseases like Cancer is a leading cause of death group worldwide. The reason for every sixth death in the world is cancer, making it the second leading cause of death. Curing cancer is certainly one of the biggest challenges of the 21st century. In the last two decades, our knowledge of cancer and its treatment has greatly improved. This has revealed the huge variability that can be found between not only different types of cancer, but also between patients with the same type of cancer. It seems increasingly evident that there won’t be a single method to ‘cure’ rather, each patient will be treated accordingly to their specific needs. But for individualized medicine to become a reality, we need a range of therapies wide enough to cover the broad spectrum of cancer. It has been found that cancer in one person doesn’t always behave the same way in another person. Thanks to the innovative research that has fueled the newer treatment options available for cancer treatment that increases the individuals’ survival rate. New approaches to cultivate the immune system in the fight against cancer are getting us closer to a future where cancer becomes a curable disease. Targeted therapies, personalized vaccines, gene therapy, microbiome treatments and stem cell transplantation are some of the technologies that will change the way of cancer treatment.

Background: Skin diseases are very much prevalent in the developing countries. It is generally agreed that pattern of skin & venereal diseases differ in different countries and within various regions of a country depending upon social, economic, racial & environmental factor. The morbidity associated with skin and venereal diseases makes them an important public health problem. Very scanty literature is found on the problem which is either disease based, community based or specified population group based. Objective: To assess the pattern of skin and venereal diseases in patients attending OPD of department of Dermatology & Venereology Of Rangpur Medical College Hospital, Rangpur, Bangladesh. Materials and Methods: It is a descriptive study conducted at Dermatology and Venereology OPD in Rangpur Medical College Hospital, Rangpur, Bangladesh for the period from 1st January, 2019 to 31st December 2019. Six thousand and two hundred and three patients were enrolled during the study period. The study population comprised of newly diagnosed cases as well as relapsing cases presenting in the outpatient irrespective of gender and age. Diagnosis was made on clinical basis. Lab investigations were restricted to the cases where it carried diagnostic importance. Then they were processed with the help of software SPSS (Statistical Package for Social Sciences) version 19.0 and analyzed. Results: Study was conducted on 6203 patients comprising 3373 (54.38%) males and 2830 (45.62%) females, who attended skin and VD OPD of Rangpur medical College hospital, Rangpur, Bangladesh during the period of one year. Males were found to be most commonly affected. Male female ratio is 1.2: 1. Age group between 15 to 29 years carried maximum incidence (43.79%). All disorders were broadly classified into noninfective (63.5%), infective (20.2%) and miscellaneous dermatoses (16.2%). Eczema 1721 (27.7%) and fungal infections 694 (11.2%) came out to be the two top most common cause for OPD attendances. Conclusion: Our study found a higher prevalence of non-infective dermatoses than infective dermatoses. Eczema and fungal infections formed the largest group in their respective categories.

Introduction: Eclampsia, a major neurological complication of pre-eclampsia, is defined by a convulsive manifestation and /or consciousness disorder occurring in a preeclampsia context and cannot be attributed to a pre-existing neurological problem. Pre eclampsia is a leading cause of maternal morbidity and mortality. Substandard care is often present and many deaths are preventable. The severity of this pathology is correlated with visceral neurological, renal, hepatic and / or hematological involvement. Objective: To study the peculiarities of anesthesia-resuscitation and the prognostic factors of morbidity and mortality of eclampsia in the intensive care unit of the Anaesthesiology Dept. Cumilla Medical College, Cumilla, Bangladesh. Materials and Methods: All patients admitted to resuscitation for management of eclampsia from 1 January to 31 December 2018 were included. We studied the clinical, therapeutic, evolutionary and prognostic factors of morbidity and mortality. Results: We collected 51 cases of eclampsia for 5000 deliveries in the study (incidence of 1%). The average age of the patients was 22.23 years. Primiparity was found in 28 patients (54.9%). Antenatal consultations were effective in 4 patients (7.8%). Consciousness was clear at admission in 42 patients (82.36%) and for one patient a Glasgow score < 8 was reported (1.96%). Severe hypertension was observed in 27.4% of cases. A ventilation intubation of 03 days was required in one patient in 1.9% of cases. Caesarean was the mode of delivery in 56.8% of cases and vaginal delivery was performed in 43% of cases. General anesthesia was doing in 20 patients (68.9%) and spinal anesthesia was performed in 9 patients (31%). Maternal complications were represented by: Postpartum acute renal failure (13.7%), Hellp syndrome (11.7%), and coagulopathy (15.6%). Prematurity was found in 14 neonates (13.7%), perinatal mortality was 9.8% and the maternal mortality rate was 5.8%. Conclusion: Eclampsia is still responsible for high maternal and infant mortality. The association of two or even more serious factors is very important in this mortality.

This study has investigated the antidiabetic potential of the extracts of Diodia sarmentosa (Rubiaceae) leaves on alloxan induced diabetic Wistar rats. The leaves are used to treat diabetes and various other disease conditions in traditional medicine. In this study, the leaves were air-dried and pulverized. A 1kg of the powdered leaves was extracted by maceration with n-hexane, chloroform and 70% methanol successively for three consecutive days, respectively. Phytochemical screening was conducted on the leaves using standard methods. Acute toxicity test was conducted on the rats by the Lorke’s method. Diabetes was induced by the intraperitoneal injection of 120mg/kg body weight of alloxan monohydrate to the rats. Results of the phytochemical screening showed the presence of cardiac glycosides, saponins, tannins, triterpenoids and carbohydrates. The acute toxicity test indicated the plant to be safe since no fatality was recorded on the rats even at the dose of 5000mg/kg body weight. The n-hexane extract produced a peak significant (p<0.05) reduction of 75.3% in the blood glucose levels of the rats at day 7, comparable to 82.38% reduction by the control drug, glibenclamide. The chloroform and aqueous methanol extracts did not exhibit significant reductions in blood glucose levels. This study suggests that the n-hexane extract of D. sarmentosa leaves possesses significant (p<0.05) antidiabetic activity. This tends to justify its use in ethnomedicine for the management of diabetes and its related conditions.

Objective: The present study is aimed to evaluate an antidiabetic herbal tablet containing Oryza sativa L. var Joha Rice, Dillenia indica and Syzygium cumini Lam. of Assam. Material & Methods: The plants materials were obtained from local area and authenticated by botanist and extracted using solvent ethanol using soxlet apparatus. The poly herbal tablet is prepared using plant extracts with excipients by granulation method. The anti diabetic study of the herbal tablets were done in streptozotocin induced diabetic rats. Results: In our study we found that best two herbal tablet formulations in doses (250mg/kg, 500 mg/kg) significantly lowered the fasting blood glucose levels in rats compared to control group. Moreover, the effect continued to sustain after withdrawal of drug treatment. Similarly, these tablet formulations found to improve lipid profiles (TG, HDL, LDS, VLDL, TC) and serum creatinine level and body weight. Conclusion: It can be concluded that the prepared formulation of poly herbal antidiabetic tablets showed very good antidiabetic activity in animal studies. By further, clinical studies, we can prepare a cost effective herbal formulation for diabetes.