With the growing population of cancer survivors, the concept of quality of life (QOL) has become important. Chemotherapy-induced peripheral neuropathy (CIPN) is one such common, ailing chronic condition characterized by tingling senstaion, pain and sometimes decreased function of hands and foot, which hampers the QOL of patients post chemotherapy treatment. A PubMed search for ‘chemotherapy-induced peripheral neuropathy’ was done. Despite the volume of recent publications, there are limited preventive or therapeutic strategies for CIPN supported by high-level evidence. Recently the effect of alternative non-pharmacological therapeutic approaches and predictive biomarkers have been explored.As CIPN still affects a mojrity of patients’, there is a need for critical analysis of the literature. The present study aimed to review the literature on chemotherapy-induced peripheral neuropathy and its treatment or other possible interventions.

Lophira lanceolata is a plant is commonly used in traditional medicine for the treatment of dermatosis, toothache, muscular tiredness and menstruel pain. This research was aimed at evaluating the in-vitro antifungal potential of different extracts and fractions of Lophira lanceolata stem-bark. The stem bark of the plant was collected, air-dried, powdered and extracted with methanol, ethanol and aqueous solvents using maceration method. The crude methanol extract (CME) was fractionated into n-hexane (HF), ethyl acetate (EF), n-Butanol (BF) and aqueous (AF) portions and were tested against pathogenic fungus strains namely; Aspergillus Niger, Candida albican, Trichophyton mentagrophyte and Trichophyton rubrum. The agar well – diffusion methods were used to determine the diameter of the zones of inhibition using 96 wells micro titer plates. The minimum inhibitory concentration and minimum fungicidal concentration were also determined. The methanol extract was found to be more effective against fungi tested, ethanol and aqueous extract which showed moderate effect against the test organisms. The methanol extract was found to be inhibitorier compared to ethanol and aqueous extracts. The results obtained revealed that, stem bark of Lophira lanceolta may contain phytochemicals that possesses antifungal activity

Keywords: Takotsubo syndrome, cardiomyopathy, mitochondrial, statins, acquired.

The aim of current study was to develop simple and convenient dosage form for delivery of naratriptan hydrochloride. Mouth dissolving tablets of Naratriptan HCl were prepared using superdisintegrants Croscarmellose sodium, sodium starch glycolate, crospovidone, using sublimation methods. Camphor was used as a sublimating agent. The prepared tablets were evaluated for thickness, uniformity of weight, content uniformity, hardness, friability, wetting time, water absorption ratio, in vitro disintegration time and in vitro drug release. The tablet disintegrate in vitro within 12-14 sec. Almost 95% of drug were released from all formulations within 10 min. The formulations containing camphor, crospovidone was found to give the best results. The tablets prepared by this method exhibited higher rate of release

Vertebral hydatid cysts are found in <1% of all cases of hydatidosis. This localization has an infiltrative malignant nature, affecting the vertebral body with possible extension in the epidural space. Primary extradural hydatid cyst of the spine without any other systemic involvement is extremely rare entity. We report a case in young a man and we review different aspect of this pathology.

Objective: To evaluate medication adherence and analyse the prescribing pattern of cardiovascular disease patients in tertiary care hospital using a newly developed medication adherence scale. Methods: It is a multi centered retro prospective observational study, conducted for a period of 6 months involving around 300 cardiac patients. The level of adherence is measured using newly developed medication adherence scale and prescribing patterns in cardiovascular patients is assessed through case reports. Analysis of data was done. Results: Among 300 cardiovascular patients, 58% were male and 42% were female. Most commonly diagnosed diseases are ST segment elevated myocardial infraction (28.3%) and left ventricular dysfunction (14%). Drugs used for the treatments are aspirin (95%) and clopidogrel (85.6%). Major risk factor is alcohol (11.6%) consumption, Hypertension and Diabetes Mellitus (9.6%). Major indication of cardiac patients is chest pain (42%), nausea (41%).The diagnosis was performed using Echocardiogram (89%), 2D-Echo (52%). The maximum adherence is seen in the age group of 31-40 female and male. Age group of 51-60 are more non adherent compared to other groups in males, whereas in females age group of 61-70 are more non adherent. Overall study show that Females (62%) are more non adherent compared to males (58.6%). The major reason for reduction of medication adherence is long duration regimens, lack of clinical communication between patients and health care professionals, forgetfulness etc. Conclusion: According to the study there is a suboptimal adherence is seen in cardiac patients and requires clinical interventions, which include affordable medications, easy-to-use medication regimens with fewer daily doses, communication between patients and healthcare providers

Congenital diaphragmatic hernia is exceptional in children. It is defined by the presence of an abnormal diaphragmatic defect causing the abdominal cavity and the thoracic cavity to communicate. It usually manifests itself at birth through respiratory distress, or sometimes through sepsis requiring urgent treatment. We report the rare case a girl with cholestatic jaundice secondary to a left antero diaphragmatic hernia with visceral content (hail and colon).

Sapropel being a unique natural organic product, which due to multicomponent composition, has a wide range of pharmacological activity. The resources of sapropel in Ukraine comprise approximately 74.5 million tonnes. Taking into consideration significant natural resources of sapropel in Ukraine as a promising raw material for preparing effective medicines products, sapropel was used as an active ingredient for the development of the cream composition. The anti-inflammatory activity of creams with sapropel extracts on the model of acute photodynamic skin inflammation in animals (UV erythema) was investigated. It is established that the creams with sapropel extracts have expressed anti-inflammatory properties, reduce the intensity of acute photodynamic inflammation and cut down the treatment duration. The anti-inflammatory activity of the studied medicinal products largely depends on the concentration of the active substance

One of the most notable congenital malformations in the head and neck include cleft lip, palate & alveolus. It may manifest as unilateral or bilateral and complete or incomplete. Reconstruction of the alveolar cleft is challenging and has ever remained controversial with regard to timing, graft materials, surgical techniques, and methods of evaluation. The primary goal of alveolar cleft reconstruction in is to provide a bony bridge at the cleft site that allows maxillary arch continuity, oronasal fistula repair, eruption of the permanent dentition into the newly formed bone, enhances nasal symmetry through providing alar base support, orthodontic movement and placement of osseointegrated implants when indicated. In addition to these it also enhances speech, periodontal conditions, establishes better oral hygiene, and limits growth disturbances. In order to rehabilitate oral function in patients with cleft lip and or palate, alveolar bone grafting is necessary. Secondary bone grafting is the most widely accepted method for treating alveolar clefts. Literature shows that autogenous bone graft is the primary source for reconstructing alveolar cleft defects and is currently the preferred grafting material. However, it is believed that the use of a membrane in conjunction with an autogenous bone graft for alveolar ridge augmentation provides superior results. Hence, this paper reviews the role of collagen membrane in alveolar bone grafting.

Technological advances in three-dimensional (3D) imaging, computer-assisted surgical planning and simulation in the field of medicine are now regularly being used for analysis of craniofacial structures. It also gained ingress in prediction of surgical outcomes in orthognathic surgery. A variety of patient-specific surgical guides and devices have been designed and manufactured using 3D printing technology, which rapidly gained widespread popularity to improve the outcomes. The article presents an overview of 3D printing technology and its applications in orthognathic surgery with emphasis on treatment feasibility and patient outcome.

Background: This study was undertaken in a tertiary care teaching hospital in Kolkata to comparatively analyse the non-pharmacological supportive care interventions for reducing stress and pain in preterm and term newborns. Methodology: A prospective observational study conducted on 100 newborns of gestational age 34 weeks and above who weighed more than 1.5kg admitted in NICU at the Department of Paediatrics, of Dr B C Roy Post Graduate Institute of Paediatric Sciences, Kolkata, India from January 2018- December 2018. All the patients experienced moderately painful heel lance procedure and comparative analysis of four non-pharmacological supportive care interventions namely swaddling, facilitative tucking, kangaroo mother care (KMC) and non-nutritional sucking (NNS) for reducing stress and pain were studied using Premature Infant Pain Profile (PIPP)scales. Results: Present study had 52% female newborns. 69% were term babies with a mean weight of 2.59kg. Non-pharmacological supportive care interventions significantly (p-value < 0.001) reduce stress and pain in preterm and term newborns. Mean PIPP score was statistically significantly lower with each intervention; swaddling (4.27), facilitative tucking (3.43), KMC (1.84) and NNS (0.78) as compared with control (7.21). Non-nutritional sucking followed by Kangaroo mother care, facilitative tucking and swaddling were effective in reducing pain and stress in that order. Conclusion: Non-nutritive sucking, a non-pharmacological supportive care intervention is significantly effective and the best intervention in reducing stress and pain in preterm and term newborns