ORIGINAL RESEARCH ARTICLE | May 20, 2016
Determination of Mineral Content, Cytotoxicity and Anthelmintic Activity of Syzygium guineense Fruits
Sheila Maregesi, Godeliver Kagashe, Charles W. Messo, Lucy Mugaya
Page no 95-99 |
10.36348/sjmps.2016.v02i05.001
Syzygium guineense Willd D.C. (Synonym Memecylon lopezianum. A. Chev) is a leafy forest tree of the family Myrtaceae found in many parts of Africa both wild and domesticated. Its fruits and leaves are edible and the fruits are used for treatment of dysentery. Ethanolic extract prepared from fresh seeds was used for cytotoxicity and antihelmintic testing using Artemia salina and Pherithema posthuma respectively. The dried pulp was analyzed for mineral contents using Delta-Portable X-Ray Fluorescence (DPXRF) with a sensitivity of 10 ppm. The ethanolic extract showed antihelmintic activity in a dose dependent manner giving shorter time of paralysis and death compared to the Albendazole tablets. Brine shrimps results gave the LC50 value 9 times higher than the standard drug suggesting absence of toxicity. The fruit pulp contains various amounts of macro elements and micro elements. To our understanding, this is the first study on S. guineense fruits on cytotoxicity and antihelmintic activities and mineral analysis. These preliminary findings indicate S. guineense fruits as a good source of micro and macronutrients as well as potential antihelmintic agent. The study is ongoing to capture various aspects of isolation and identification of bioactive compounds for drug development and establishment of safety
ORIGINAL RESEARCH ARTICLE | May 25, 2016
Studies on Prescribing Pattern in the Management of Diabetes Mellitus in Rural Teaching Hospital
V. Karthikeyan, S. Maadhusudhan, S. Selvamuthukumran
Page no 100-107 |
10.36348/sjmps.2016.v02i05.002
The aim of the study was to observe and analyze the prescribing pattern of anti diabetic drugs in medicine ward. This study was a descriptive cross sectional study/ prospective observation study. The study was conducted at Rajah Muthiah Medical College Hospital (RMMCH), Annamalai University, Chidambaram, a 1250 bedded multi specialty tertiary care University teaching hospital located in rural India. Analyze the prescription as per the WHO Prescribing Indicators. The following are the parameters: Prescribing indicator, Patient care indicator and Facility indicator. A prescribing practices measure the performance of health care providers in several key dimensions related to the appropriate use of drugs. The indicators are based on the practices observed in a sample of clinical encounters taking place at outpatient health facilities for the treatment of acute or chronic illness. A total of 1232 drug products were prescribed. Thus, the average number of drugs per prescription or mean was 4.83. The total number of drugs prescribed by generic name was 40.01% (493 drugs), 32.46% drugs prescribed with diabetic medication and 67.54% of drugs prescribed with the management of co morbidity diseases conditions, 17.04% of prescription containing injections that include insulin, antibiotics, GIT and some vitamins. Almost all drugs (58.76%) prescribed from Tamilnadu EDL, as well as RMMCH drug list. Drugs prescribed from an Essential Drug List (EDL) were 74.30%. Since Insulin can be administered only by subcutaneous route, % of injections (17.04%) comprise only of insulin injection. Among the 255 patients the average consultation time with prescribe was 8.40 minute and the average dispensing time in medical store was 7.2 minute. About 30.58% patients have good knowledge about the correct dosage of each tablet. Present study shows that the majority of diabetes patients were in the age group of 40 -60 years. Resulting in the development of diabetic related complications in most productive years of life, as compared to western studies were mean age is around 60 years, Prescription pattern analysis showed that most of the patients were on combination therapy 51.37% and followed by monotherapy 48.62%, Commonest drugs used in monotherapy were sulfonylureas, Insulin and metformin. The commonest two drug combinations were sulfonylureas with metfomin. There are no overall changes in prescription pattern by the physicians during the three year study period
Cardiac amyloidosis is underdiagnosed. Prevalence is increasing with age. Diagnosis can be elusive and challenging. High index of suspicion is required for recognition and prompt diagnosis. Cardiac amyloid diagnosis carries important therapeutic and prognostic implication. We outline the prevalence, types, clinical presentation, diagnosis, prognosis and treatment of cardiac amyloidosis
REVIEW ARTICLE | May 30, 2016
Pharmacognostic and Phytochemical Evaluation of Gynocardia odorata Leaves
Neelakshi Sharma, Sanjib Kumar Sarma, Dipankar Saha, Trishna Das, Barnali Hazarika, Dhrubajyoti Sarma
Page no 112-121 |
10.36348/sjmps.2016.v02i05.004
According to World Health Organization (WHO) medicinal plant is any plant which, in one or more of its organ, contains substance that can be used for therapeutic purpose or which is a precursor for synthesis of useful drugs. The plants that possess therapeutic properties or exert beneficial pharmacological effects on the animal body are generally designated as “Medicinal Plants”. It has now been established that the plants which naturally synthesis and accumulate some secondary metabolites, like alkaloids, glycosides, tannins, volatiles oils and contain minerals and vitamins, possess medicinal properties. In this section the results of various investigations carried out were compiled. All the pharmacognostic and phytochemical evaluations are performed in order to make an attempt to discuss these results, in order to provide convincing reasons for the studies performed. The TLC studies showed in naked eyes and under different wavelength the presence of some compound like, Flavonoid, Triterpinoids and their significant Rf values