Introduction: Psychosocial factors, such as stress, adversity, socioeconomic status, depression, and anxiety, are associated with overall health and with cardiovascular health in particular. Psychosocial risk factors have been frequently studied in relation to coronary heart disease. In observational studies, high levels of depression and anxiety have consistently been associated with incident coronary heart disease, whereas associations with hostility and social support have been mixed. However, psychosocial factors have been examined less often in HF. Among patients with HF, depression is the most commonly researched psychosocial risk factor. Aim of the study: The aim of this study was to determine the psychosocial antecedents to precipitation of congestive heart failure in cardiac patients. Methods: This was a prospective study and was conducted in the Department of Cardiology of Lugansk State Medical University (LSMU), Hospital No-01, Lugansk, Ukraine during the period from November, 2008 to September 2009. We included 120 patients with heart disease in our study. The patients were randomly divided into two groups – HF group (Patients who hadn’t any heart failure, n=60) and No-HF group (Patients who had heart failure, n=60) Result: In total 120 patients from both the groups completed the study. In our study we found majority (35.83%) of our patients were aged 61-70 years and most of our patients were female (62%) compared to male (38%). We found the mean age was 49.73 ± 8.9 years. Among all patients 76.67% were smoker, 70% had DM, 80% had history of hypertension, 31.67% had asthma, 59.17% had previous history of CVD and the mean duration of CVD was 3.29±2.41 years. The mean BMI was 27.67±4.24 kg/m2. TC, HDL & LDL was higher in no-HF group which indicates a lower risk of heart disease while Tg was higher in HF group indicating a great risk of heart disease. We also found CRP , albumin & fibrinogen was higher in HF group that indicates a greater risk of heart disease. Among all psychosocial factors, anger, anxiety, depressive symptoms, hostility and self-reported health were found higher in HF group compared to no-HF group. Conclusion: In our study, we found statistically significant relationships between psychosocial factors and incident HF. However, adverse levels of psychosocial factors played a role to be an indicator of HF development among cardiac patients. We found psychosocial risk factors such as anger, anxiety, depressive symptoms, hostility and self-reported health as an indicator of congestive heart failure among our cardiac patients.

Background: Plate fixation is the mainstay of care for distal forearm shaft fractures in adults. By and large, volar or dorsal plating is used for radial shaft fractures. The radius's lateral surface offers an equal and constantly curved region for inserting a plate. The radial bow may be readily evaluated and restored after surgery. A prospective investigation was performed to examine the result of lateral plating of radius shaft fractures. Objective: In this study our main goal is to evaluate the treatment outcome of fixation of fracture shaft of radius ulna. Method: The research was conducted at tertiary medical hospital and district general hospital, Dinajpur included 100 patients. Several of them had broken both of their forearm bones, while others had broken only the radial shaft. Within 36 hours of damage, all patients were fixed with a 3.5 mm restricted contact dynamic compression plate or locking compression plate on the lateral surface of the radius. Typical procedure was used to repair the ulna. Results: During the study, majority were belong to 32-40 years age group, 36%. Followed by 20% were belong to 41-50 years age group, 11% belong to 20-31 years age group. In addition to that, 80% were male. 75% had fractured both of their forearm bones. Followed by 70% had closed fractured type, 35% had motor vehicle accident and lastly 85% had middle third radial shaft. Union was assessed by gradual disappearance of the fracture line and/or development of bridging callus at the fracture site. After getting treatment, 89% patients had excellent results, 8% had satisfactory and 1% had unsatisfactory result. There was 1% failure (nonunion). Conclusion: As compared to conventional methods, radial lateral plating holds promise as a viable option. Longitudinal studies with larger patient groups and study criteria are needed to confirm the potential advantages and validate our results.

The increasing incidence of mortality due to benign prostatic hyperplasia (BPH) in ageing men globally is of serious concern and needed collective efforts to arrest it. The benign prostatic hyperplasia result from excessive growth of the prostate gland due to proliferating cells which impairs urethral functions by compressing it. This present study evaluated the effect of methanol extract of Allium sativa (MEAS) on lipid profile, renal and hepatic function biomarkers of testosterone induced benign prostate hyperplasia in male rats. The study was done using 25 adult male albino rats, divided into 5 groups, which comprises of normal control, negative control, positive control, and BPH induced rats treated with 200 and 400 mg/kg /day of MEAS respectively. Hepatic and renal biomarkers (ALT, AST, ALP, Urea, Creatinine) and lipid profile (HDL, LDL, TAG, CHOL were evaluated. The BPH induction caused significant (p<0.05) increases in lipid profile with exception HDL; hepatic and renal biomarkers of the negative control when compared with the normal control. The MEAS treated BPH-induced rats had significant (p>0.05) reduction in the biochemical biomarkers with significant (p<0.05) increase HDL. The findings of this study indicated that BPH impairs cellular functionality and treatment of BPH with methanol extract of Allium sativa showed to be effective. Therefore, extract of Allium sativa is a potential agent for the treatment of benign prostatic hyperplasia.

Diabetes mellitus is a chronic condition characterized by major derangements in glucose metabolism and abnormalities in fat and protein metabolism. Diabetes and infection are among the serious health challenges. This study evaluated the in vitro and hypoglycemic effect and antimicrobial properties of methanol extract of Ipomoea batatas leaf. The antimicrobial activity was done using agar disc diffusion methods and the in vitro hypoglycemic activity was done using Alpha-Glucosidase Inhibitory activities assay, Lipase activity assay, Glucose absorption Capacity assay, Glucose diffusion retardation Index. The result of the percentage alpha glucosidase inhibition ranged from 35.70 to 56.33%. The percentage alpha amylase inhibition ranged from 40.96 to 65.15%. The extract showed significant (p<0.05) dose dependent inhibition of alpha glucosidase and alpha amylase. The extract possess inhibition of lipase activity with percentage inhibition ranging from 72.35 to 81.57%. Though there was non-significant (p<0.05) difference in the various concentrations of the extract on inhibition of lipase activity. The result of the glucose absorption capacity (0.30 to 2.25) was observed to be dose dependent. The glucose diffusion retardation index was time dependent. The antimicrobial susceptibility screening of extracts showed a zone of inhibition that ranged from 2.70 to 15.73mm. The study showed that Ipomoea batatas leaf could be used in the treatment and management of diabetes and infections.

Background/Objectives: Diabetes is frequent among cancer patients. Diabetes and cancer co-occurrence may result in a worse prognosis and complications in cancer patients. This systematic review aims to investigate the impact of glycemic control in patients having both cancer and diabetes. Methods: PubMed, Web of Science, Science Direct, and Google Scholar were systematically searched to include the relevant literature. Rayyan QRCI was used throughout this systematic approach. Results/ Interpretation: A total of thirteen studies with 13550 patients were included in this review. The reported follow-up duration ranged from 2 to 12 months. Cancer patients with diabetes are more likely to get infections, be hospitalized, and require chemotherapy reductions or discontinuation. Having cancer with comorbid diabetes affects diabetes self-management and results in poor glycemic control. Applying clinical pharmaceutical programs to raise awareness about compliance with diabetic medication along with cancer treatment was found to have positive outcomes. Evidence-based practice recommendations or policies should be developed that advocate assessing diabetes patients' glycemic state at the time of cancer diagnosis.

Background: Combined oral contraceptive pills are an effective and widely used method for contraception. Combined oral contraceptives have been shown to alter lipid profiles among various population groups with different patterns of dyslipidemia and cardiovascular risk. Objectives: The study aimed at determining the lipid profile pattern and cardiovascular risk among combined oral contraceptive users. Methods: This cross-sectional analytical study was conducted in the Department of Physiology, Rajshahi Medical College, from January 2018 to December. 2018. The study group was made of 100 women. (mean age 24.1 ± 5 years), who took combined oral contraceptive pills (30 mg ethinyl estradiol, 150 mg Levonorgestrel) for a period ranging from 1-60 months, while 100 age-matched women with regular mentruation with no history of hormonal use within the last six months before the investigation were used as controls. Fasting blood samples from all study subjects were collected and analyzed for lipid profile [ Total cholesterol (TC), High-Density Lipoprotein- cholesterol (HDL-c), Low-Density Lipoprotein- cholesterol (LDL-c) and Triglyceride (TG)] using standard calorimetric Techniques. Results: Combined oral contraceptive use was associated with increased levels of total cholesterol (p ≤ 0.001), Low-density lipoprotein cholesterol (p ≤ 0.001), triglyceride (p ≤ 0.001), as well as decreased high-density lipoprotein cholesterol (HDL-c) (p = .408) in comparison to controls. Conclusion: Combined oral contraceptive use is associated with alteration in lipid profile, particularly increases total cholesterol triglyceride, LDL and decreased HDL-c. These changes carry a potential risk in the development of cardiovascular disease. Evaluating the most effective and safest contraceptive methods is important to avoid the potential risk of developing cardiovascular disease.

Introduction: Intramedullary nailing is a commonly employed procedure for treating distal tibial fractures. The two primary approaches for this procedure include the suprapatellar and infrapatellar techniques. Despite their widespread use, there is ongoing debate about the relative merits and drawbacks of these two approaches. Aim of the Study: The aim of this study was to assess the comparison between suprapatellar and infrapatellar approaches for intramedullary nailing of distal tibial fractures. Methods: This cross-sectional study was conducted in Department of Orthopaedics Surgery, Brahmanbaria Medical College Hospital, Brahmanbaria, Bangladesh, during the period from December 2020 to December 2022. Total 120 patients with intramedullary nailing of distal tibial fractures were included in this study. All the patients were divided into two groups; Group A comprised of 60 patients treated by suprapatellar approach and Group B comprised of patients treated by infrapatellar approaches. Result: For age, the mean age in Group A is 42.3 years (SD± 9.8 years), and in Group B it is 44.7 years (SD±10.3 years). In terms of sex, male predominance was seen in both groups. Surgical characteristics like surgical time (68.5 vs 74.2 mins), blood loss (58.4 vs 63.7 ml), and fluoroscopy number (15.7 vs 18.9) were significantly less in Group A. Post-operatively, Group B reported more pain (VAS score: 27.1 vs 18.7), while Group A had better range of motion (18.3 vs 17.1) and knee functionality (Lysholm score: 84.6 vs 80.9). Group B showed better foot and ankle functionality (AOFAS score: 94.4 vs 91.3). Fracture healing time was similar (24.5 vs 24.7 months). Fewer patients in Group A experienced complications like fracture deformity, malalignment, and surgical site infections. Conclusion: The suprapatellar approach may be the preferred nailing technique for treating distal tibial fractures compared with infrapatellar approach.

Introduction: The development of APL is associated with a more severe prognosis of the disease, and with a significant alteration of the quality of life. For this reason, the advent of biological agents has allowed in a significant number of patients a healing of these APL. Through this work, we illustrate the evolution of these lesions by comparing patients before and after the beginning of biotherapy. Materials and Methods: A retrospective analytical study carried out in our department between January 2015 and January 2021 including all patients receiving biological treatment for CD with APL. Results: Among 355 patients with CD, 45 patients were on biological treatment which 32 (71%) had APL. Among these 32 patients, sex ratio (W/M) was 1.9, mean age was 37 +/- 9.3. The type of anal involvement was as follow: 20 patients (75%) had anal suppurations, 7 patients (20%) had ulcerations and 5 patients (5%) had anal stenosis. In 5% it was an isolated anal Crohn's disease, in 15% it was intestinal disease with APL, in 31% it was colonic disease with APL. 25 patients (78%) were under Infliximab and 7 (21.8%) under Adalumimab. The number of patients with APL before treatment has significantly decreased after treatment with a p=0.002, with an improvement of APL in 20 patients (60%) of under anti-TNF agent. Conclusion: Anti-TNF agents allowed a better management and a favorable evolution of APL in most of our CD patients. However, to overcome the failure of anti-TNF in some of our patients, the availability of other biological molecules on the Moroccan market remains more than desirable.

Primary hyperparathyroidism is a relatively common endocrine disorder that can lead to hypercalcemia and, consequently, cause long-term renal and skeletal complications. Usually, the diagnosis of this disorder is made at an asymptomatic stage. We report three cases of primary hyperparathyroidism revealed by acute pancreatitis, which is an unusual initial manifestation. The three patients, aged 55, 61, and 78 years, experienced acute epigastric pain accompanied by vomiting. Laboratory tests showed hyperlipasemia, and the abdominal CT scan revealed acute necrotizing pancreatitis. After an investigation into the underlying causes, the diagnosis of primary hyperparathyroidism was confirmed, and imaging identified the presence of parathyroid adenoma in all three patients. Parathyroidectomy was performed and the anatomopathological examination confirmed the diagnosis of parathyroid adenoma.

Background: Acute myocarditis is an inflammatory disease of the heart muscle that manifests clinically with a spectrum of symptoms, ranging from mild chest pain to myocardial infarction. It can also be linked to viral or bacterial illnesses like pneumonia. Case summary: A 19-year-old male with no notable medical history reported to the Emergency Department with substernal chest pain radiating to the left arm, accompanied by nausea and profuse perspiration. His vital signs were stable and his physical examination was normal, with the exception of left lower chest crackles. The electrocardiogram revealed ST segment increase in inferior and lateral leads, along with ST depression in leads V1 through V3. A portable chest x-ray revealed a patchy opacity in the lower lobe of the left lung. Invasive coronary angiography revealed normal coronary arteries. Further evaluation with echocardiography and cardiac MRI revealed characteristics of acute myocarditis, including a minimally dilated LV and subtle hypokinesia in the midventricular inferior and lateral segments, as well as mild global hypokinesia in the LV and RV. Perimyocarditis was detected in the patient, and antiplatelet medication were terminated. Due to a low ejection fraction, Bisoprolol, Ramipril, and spironolactone were administered, and he was hospitalised until his intravenous treatments for pneumonia were completed. Further laboratory tests revealed a decrease in troponin T, white blood cell count, and C-reactive protein. He was discharged with medications including spironolactone, metoprolol, Ramipril, and colchicine. Unfortunately, he failed to comply with the directive. On the eighth day of hospitalisation, a discharge ECG revealed sinus rhythm with no ST-T alterations. Conclusion: When evaluating an acute cardiac event, healthcare practitioners should examine the possibility of uncommon bacterial myocarditis and keep in mind that Streptococcus pneumoniae infection might imitate acute MI in otherwise healthy young males. The timely diagnosis and administration of appropriate antibiotics are critical in the treatment of such conditions.

Background: Coronary artery disease (CAD) is the most common form of heart disease. It is the result of atheromatous changes in the vessels supplying the heart. CAD is used to describe a range of clinical disorders from asymptomatic atherosclerosis and stable angina to acute coronary syndrome (unstable angina, NSTEMI, STEMI). Objective: To assess the clinical status of patients with coronary artery disease (CAD). Methods: This prospective observational study was conducted in the Department of Cardiology, Dhaka Medical College Hospital, Dhaka, Bangladesh from July, 2017 to Dec, 2017. Total 110 confirmed coronary artery disease (CAD) patients were included as the study subjects for this study. A predesigned questionnaire was used in data collection. All data were collected, processed and analyzed by using MS Office and SPSS version 23 programs as per need. Results: In this study, among total 110 participants, 67.3% were male and the rest 32.7% were female. The mean (±SD) age and BMI of the participants were 47.28±11.87 years and 23.68± 2.44 Kg/m2 respective. The waist and hip circumferences of the participants were found 89.81±10.32 cm and 106.82±18.56 cm respectively. The mean (±SD) total cholesterol (mg/dl), S creatinine (mg/dl) and ESR (mm in 1st hour) of the participants were found as 177.69±31.55, 1.6±0.04 and 26.55±5.17 respectively. Conclusion: The frequency of coronary artery disease among male population is found as alarming. The abnormalities in waist or hip circumferences, total cholesterol (mg/dl), S creatinine (mg/dl) and ESR (mm in 1st hour) of patients may be considered as some potential indicator for coronary artery diseases.