The present study was aimed to look for the effect of a natural compound i.e. Crocin on the viability of mature adipocytes and on inhibition of adipocyte differentiation. The 3T3-L1 cell line is one of the most well-characterized and reliable models for studying the conversion of pre-adipocytes into adipocytes. 3T3- L1 pre-adipocytic cell line was used and differentiated into mature adipocytes using standard adipogenic media. The MTT assay was used for the assessment of cell viability whereas effect on adipocyte differentiation was visualised by Oil Red O staining. The changes in relative lipid content were monitored spectrophotometrically at 510nm. Mature adipocytes when treated with Crocin decreased cell viability in a dose dependent manner. It also showed an enhanced inhibition of adipocyte differentiation as monitored by Oil Red O Staining. The western blot analysis revealed significant increase in the expression levels of AMP activated protein Kinase which is a key regulator of energy homeostasis. Thus, the crocin seems to affect multi-potent anti-obesity parameters and may have promising benefits for the treatment and prevention of obesity.

Marine macroalgae produce a great variety of biological active compounds which cannot be scientifically characterized with in other organism’s biomass. These marine habitats have been scientifically reported for modern medicinal uses although rheteoratically associated to coastal communities’ healthy eating and folk medicine practice. In tandem to this, these marine macroalgae have highly potentiate themselves as a tangible source of functional ingredients that is industrial applicable. Globally various division of geochemical marine macroalgae flora taxa (Chlorophyta, Phaeophyta, and Rhodophyta) flourish. However, despite substantial optimised yield and empirical evidence of their health potential benefits, these macroalgae remained largely pharmaceutical and medical related industries innovative unexploited. Of these leads compounds, sulfated polysaccharides offer a wide range of physiological and chemical-biological activities that include antioxidative, anticoagulant, antiviral, antitumor, anti-inflammatory, antihyperlipidemic and antihepatotoxic activities. Per se, the optimization of sulfated polysaccharides as functional food and Vis a Vis, as therapeutic agents is this millennium important research agenda. As such, this review extrapolates the bioprospect of sulfated polysaccharides (Sulfated galactans, Fucans, and Ulvans) from geochemical signature macroalgae potential context as functional food and as tangible source for drug discovery.

Obesity, a pathologic state characterised by excess fat reserves, is a serious health problem that increases the risk of numerous medical complications and mortality. The disease arises as a direct consequence of alterations in regulating energy balance in the body. The recent global rise in the prevalence of Obesity and unavailability of effective anti-obesity drugs has created an urgent need to understand and identify the important aspects related to the disease. In this review, we provide a perspective on the factors influencing Obesity, Obesity-associated disorders, pharmacological interventions and several other important concepts related to the disease.

Weed infestation is one of the major threats to crop growth and yield.Weed control is the method of limiting weed infestation so that crops can be grown profitably. Metsulfuron methyl + Chlorimuron ethyl is a new post-emergence herbicide in Bangladesh. Field trials were conducted at Bangladesh Rice Research Institute (BRRI), Gazipur during Aman, 2014 and Boro, 2014-15 to evaluate the efficacy of Metsulfuron methyl 10% + Chlorimuron ethyl 2% WP on weed suppression and performance of transplanted rice. Metsulfuron methyl 10% + Chlorimuron ethyl 2% WP @ 15, 20 and 25 g ha-1 were applied and Pyrazosulfuran ethyl @ 125 g ha-1, weed free and unweeded control were used for comparison. Visual observation indicated that this herbicide possesses high selectivity and not toxic to rice plants. The results revealed that the major weed flora associated with the transplanted rice was mainly comprised of two grasses, two sedges and three broadleaves in Aman, 2014 and two grasses, two sedge and two broad leaves in Boro, 2014-15. The most dominant weeds were Cyperus difformis, Echinochloa crus-galli, Scirpus maritimus and Monochoria vaginalis in both the growing seasons. Application of Metsulfuron methyl 10% + Chlorimuron ethyl 2% WP @ 20 g ha-1 was most effective to suppress weed density and dry masses in both the seasons resulting increased grain yield more than 30% as compared to unweeded control. Therefore, Metsulfuron methyl 10% + Chlorimuron ethyl 2% WP @ 20 g ha-1 should apply at one to two leaf stage of weed may be recommended for effectively control weed in transplanted rice.