Bioremediation is a process to remove or detoxify contaminant present in the environment by certain biomolecules or biomass to bind and concentrate selected ions or other molecules. Water pollution is an issue of great concern worldwide, and it can be broadly divided into three main categories, that is, contamination by organic compounds, inorganic compounds (e.g., heavy metals), and microorganisms. A wide range of microorganisms, including bacteria, fungi, yeasts, and algae, can act as biologically active methylators, which are able to at least modify toxic species. Microorganisms cannot destroy metals, they can alter their chemical properties via a surprising array of mechanisms. Different factors affect bioremediation include environmental factor biological factor, availability of nutrients, temperature, ph, and toxic compounds. Among organic pollutants, hydrocarbons may enter in water either directly by spills or effluents or indirectly from atmosphere. These metals are extremely sensitive at low concentrations and can be stored in food webs, posing a serious public health risk. Several microorganisms (natural/exotic/ engineered) having specific metabolic capability and various enzyme production ability which fall under six main divisions include Oxidoreductases, Transferases, Hydrolases, Lyases, Isomerases and Ligases (synthetases) are used during bioremediation process. The heavy metals associated with environmental contamination, for instance, lead (Pb), cadmium (Cd), and chromium (Cr), which are potentially hazardous to ecosystems. The types of microorganisms that are used in bioremediation processes due to their natural capacity to biosorb toxic heavy metal ions.

Nature has generously open life-saving remedies to mankind by offering evolutionarily optimized drug like bimolecular in the form of several natural products. These marvelous gifts of nature have been serving as most suitable candidates against the treatment of multiple disorders and particularly for cancer (2nd leading cause of death, cancer) due to their pleiotropic mode of action on target molecules. Current review intends to provide an update on the bioactivities of such gifts from nature, natural borneol, which is the major bioactive constituents of traditionally used medicines. Borneol is a monoterpenoid, isolated from different medicinal plants and have strong potential to be used against multiple disorders such as bacterial and inflammatory infections. Recently it is investigated that borneol has a great potential of inhibiting the growth of multiple neoplasms such as hepatocellular carcinoma, neuroblastoma, glioma, esophageal squamous cell carcinoma, ovarian and lung cancer. Moreover, by regulating the BBB junctions it also increases the drug concentration in cancer cells, this shows that its combine use with already practiced therapeutics may increase the efficacy of these therapeutics against cancer cells. In this review we will summarize all the studies on anticancer activity of borneol, our primary goal will be to discuss the combined use of borneol with other clinically used drugs to improve their efficacy against human cancers.