RESEARCH ARTICLE | Sept. 30, 2016
In Vitro α-Amylase and α-Glucosidase Inhibitory Activity of Methanol Extract of Tolypiocladia glomerulata (C. Agardh) F. Schmitz
Mohanapriya N, Murugesan S, Sivamurugan V
Page no 59-63 |
10.21276/sjbr.2016.1.3.1
The present study is to evaluate the inhibitory activity of α-amylase and α-glucosidase enzymes in the
methanol extracts of marine red alga Tolypiocladia glomerulata. The methanol extract of red alga T. glomerulata showed
concentration dependent α-glucosidase inhibitory and with achieved maximum activity of 87.08 ± 0.01% at a
concentration of 900 µg/mL in a manner IC50 = 608 µg/mL. Similarly the dose dependent effect was observed against α-
amylase enzyme with 81.25 ± 0.02% of inhibition at 900 µg/mL (IC50 = 543 µg/mL). The above results were compared
with that of the standard drug Acarbose. It can be concluded that the methanol extracts of red alga T. glomerulata exert
an effective antidiabetic activity and considered as a potential candidate for the management of diabetes mellitus.
RESEARCH ARTICLE | Sept. 30, 2016
Iron deficiency and iron deficiency anaemia in children of school canteens in Abidjan, Côte d’Ivoire
Baudouin Angoua Kokoré, Mathieu Nahounou Bléyéré, Soualio Kamagaté, Paul Angoué Yapo
Page no 64-71 |
10.21276/sjbr.2016.1.3.2
In Côte d'Ivoire very few studies have been devoted to the exploration of iron status among school-age
children. This study aims to evaluate iron status in children aged 5 to 11 years in good health in three canteens of three
municipalities in of Abidjan (Côte d'Ivoire). A total of 103 students, including 42 girls and 61 boys were selected for this
study. Blood samples were taken in each of these children in order to investigate some parameters of blood count and
determine some biochemical parameters of iron status. The mean values of various biological parameters of iron status
were normal in accordance to physiological reference values from the literature with the exception of hemoglobin in boys
which is below normal rate. All parameters did not indicate significant differences between girls and boys (p > 0.05). Our
study indicated that in children about two out of three have abnormal iron status. Abnormal iron status is composed
respectively by 3.9% of iron deficiency, 8.7% iron deficiency anaemia, 22.3% of simple inflammatory anemia and 23.3%
of inflammatory anaemia associated to deficiency martial. Iron deficiency anemia was the only type of nutritional
anaemia noted in this work. In addition, we observed two types of anaemia of inflammatory origin.
CASE REPORT | Nov. 30, 2016
An Oral Ulcer- Unraveling the Mystery
N. Rajesh, D Ayesha Thabusum, R. Sudhakarareddy, M. Ravikanth, U. Shivaji Raju
Page no 72-75 |
10.21276/sjbr.2016.1.3.3
Tuberculosis is a chronic infectious disease affecting humans of all ages in all parts of the world. The primary
site of infection commonly involves lungs, although it can affect any part of the body, including oral cavity. Although
oral manifestations of tuberculosis are very rare, the disease can present itself in a variety of clinical appearances which
may mimic malignancy clinically. Thus the oral physician plays a pivotal role in the identification and control of this
condition by early recognition of lesions that may precede the detection of pulmonary form. Tuberculous involvement of
oral cavity is a very rare finding even in areas and countries where Tuberculosis is endemic. We present one such case of
36 year old female who presented with non-healing ulcer in the right lateral surface of the tongue and floor of the mouth.
This paper deals with the case of tuberculosis diagnosed on the basis of oral manifestations, there by emphasizing the
importance of the oral physician in diagnosis of multisystem disorder.
ORIGINAL RESEARCH ARTICLE | Nov. 30, 2016
Assessment of Erythrocyte Superoxide Dismutase as Biomarker of Oxidative Stress in Sudanese: Male Smokers in Khartoum State
Noon Babiker Mohammed, Hind Haider Adam Ahmed
Page no 76-78 |
10.21276/sjbr.2016.1.3.4
Oxidative stress plays an important role in the pathogenesis of some diseases. Smoking may enhance oxidative
stress not only through the production of reactive oxygen radicals in smoke but also through weakening of the
antioxidant defense systems. Study done To assess the erythrocyte superoxide dismutase activity in cigarette smokers.
This is case control study. The study was conducted from February to May 2015, sixty samples from non smokers chosen
randomly as control and sixty sample from smoker as test group. All samples were tested for superoxide dismutase
activity using fortress diagnostic reagent by spectrophotometer analyzer, and results were analyzed using statistical of
package social science. The study result showed that the level of superoxide dismutase activity was significantly decrease
(P = 0.00) in smokers. Mean ± SD cases versus controls (907±134.47 versus 1159±93.44). There are a significant
moderate negative correlation with the number of cigarettes per day (P = 0.00) also weak negative correlation with
duration of smoking (P = 0.048).From this study, concluded that superoxide dismutase level was significantly decreased
in smokers and correlated negatively with number of cigarettes and duration.