A series of novel substituted 2-((3-chloro-2-methylphenyl) ((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)amino) benzoic acid (5a-l) derivatives were synthesized using a multi-step synthetic route involving the click chemistry approach. The structures of the synthesized compounds were confirmed using various spectroscopic techniques, including NMR, IR, Mass and elemental analysis. The antibacterial and antifungal activities of the synthesized compounds were evaluated against a panel of bacterial strains (including B. Subtilis, B. Sphaericus, and S. Aureus, P. Aeruginosa, K. Aerogenes and C. violaceum) and fungal species (such as C. albicans, A. Fumigatus, T. Rubrum and T. mentagrophytes). The results revealed significant inhibitory effects, with some derivatives showing superior activity compared to standard drugs. Additionally, the cytotoxicity of these compounds was assessed against human cancer cell lines (MCF-7, PC-3, and HeLa) using MTT assays. Several derivatives exhibited potent cytotoxic effects, indicating their potential as anticancer agents. Molecular docking studies of newly synthesized derivatives 5a-l, along with Doxorubicin and Tamoxifen, against enoyl reductase (PDB ID: 1QSG) indicate potential inhibitors for lipid biosynthesis in cancer therapy.

Coronaviruses are a large family of viruses that cause a variety of illnesses, from the common cold to severe acute respiratory syndrome. The SARS–COV–2 outbreak was first reported by the World Health Organization in China and has now become an epidemic, reflecting the extremely high transmissibility of the virus, which has caused great concern and stress among people around the world. Research suggests that prevention, risk education, and promotion of self–care behaviors can slow the spread of the disease in communities, and identifying sources of transmission can be effective in controlling it. The mortality rate of this virus is significantly higher in the elderly and people with underlying diseases compared to healthy people. Coronavirus is a challenging disease and can be easily transmitted in public places, and the number of people infected with this virus is increasing exponentially across all ages and groups. Therefore, increasing public awareness of this disease and providing positive psychological programs and teaching prevention methods in the media can reduce mental problems in society, in addition to reducing mortality and the number of patients.