Backgrounds: Dengue viruses are transmitted to humans via mosquito bites from infected Aedes species (Aedesaegypti or Aedesalbopictus). Dengue fever affects over half of the world's population, or about 4 billion people. Dengue fever is a common cause of sickness in high-risk settings. Methods: In the current study two serotypes of Dengue viruses namely DENV1 and DENV2 taken for the study. Here two important compounds namely Ellagic acid and Ferric Carboxymaltose chosen for the targets to be inhibited. In silico docking approach performed to dock the two compounds against the DENV1 and DENV2 viruses of Dengue. Autodock 4.2 tool chosen for the docking purpose. Results: Dengue i.e., DENV-1 & 2 indicate excellent biding property with Ellagic Acid & Ferric Carboxymaltose of the order -6.02 kcal/mol& -6.9 kcal/mol, respectively. Either are hematinic; pregnancy safe; non-toxic; complete synergy between either vis-à-vis virus targets\binding sites; with supportive therapies; etc. Novel. It was found that, the Ellagic acid is more effective for DENV1 virus and Ferric kcal/mol, respectively. Conclusions: It can be stated that, these two drugs can be better approach for future study against the Dengue viruses and expected drug candidates.

The aim of this study is to determine the nutritional indices (Glucose, cholesterol, total protein and albumin) and body mass index of students attending public and private secondary schools in Igbanke. The study was conducted on 185 students comprising 95 students from public secondary schools (Igbanke mixed secondary and Igbanke grammar school) and 90 students from private secondary schools (Future hope secondary school and Wisdom comprehensive secondary school) in Igbanke. The research was designed to evaluate and compare the nutritional indices (Glucose, cholesterol, total protein and albumin) of students attending public and private secondary schools in Igbanke. The sample analysis was done at Diagnostic Laboratory, Department of Medical Laboratory Science, Ambrose Alli University, Ekpoma. This study was carried out within three (3) months. Our result shows that the mean values of body mass index (BMI) of students in public secondary school and private secondary school are 20.28±4.21kg/m2 and 21.74±4.14 kg/m2 respectively. There is no significant difference (p>0.05) in the values of BMI of students in public secondary school when compared with private secondary school. The mean levels of glucose (Glu) of students in public secondary school and private secondary school are 84.38±12.80mg/dl and 79.48±15.02mg/dl respectively. There was a significant increase (p<0.05) in the level of Glu of students in public secondary school when compared with private secondary school. The mean levels of total protein (TP) of students in public secondary school and private secondary school are 6.78±0.86mg/dl and 6.98±0.58mg/dl respectively. There was a significant decrease (p<0.05) in the level of TP of students in public secondary school when compared with private secondary school. The mean levels of albumin (Alb) of students in public secondary school and private secondary school are 3.73±0.61mg/dl and 4.01±0.48mg/dl respectively. There was a significant decrease (p<0.05) in the level of Alb of students in public secondary school when compared with private secondary school. The mean levels of cholesterol (Chol) of students in public secondary school and private secondary school are 154.62±30.94mg/dl and 168.30±14.88mg/dl respectively. There was significant increase (p<0.05) in the levels of cholesterol of students in private secondary school when compared with public secondary school. In conclusion, a poor diet can cause deficiency diseases such as blindness, anemia, scurvy, health-threatening conditions like obesity and metabolic syndrome and such common chronic systemic diseases as cardiovascular disease, diabetes and osteoporosis. The findings from this study have shown that there are differences in the nutritional indices of students in public secondary school and private secondary school with public secondary school having lower protein level and private secondary school high cholesterol level.

Introduction: Congenital anomalies are structural, behavioral, functional, or metabolic defects that occur before the birth of a baby, and their nature and type are highly dependent on the causative agent. It refers to changes in embryonic or fetal development caused by genetic, environmental, or unknown factors that result in physical and/or mental impairment. This study aims to evaluate the various types of abnormalities in newborns with congenital anomalies. Methods: This prospective observational study was conducted at the Pediatric Medicine and Pediatric Surgery departments of Dhaka Shishu Hospital, Dhaka, Bangladesh. Eighty (80) newborns were included in the study using a purposive sampling method. The study was conducted during the time from April 2012 to September 2012. The aim of the study was to evaluate the various types of abnormalities in newborns with congenital anomalies. A pre-designed questionnaire was completed for every neonate including H/O regular maternal antenatal care with the taking of TT and MMR vaccine, any maternal disease or fever with rash, taking any offending drug, use of abortifacient, exposure to radiation or industrial hazards, feeding habit including smoking or use of alcohol and clinical and anthropological examination. Results: Eighty neonates were presented with congenital anomalies. Male infants were 52(65.0%) and female infants were 28(35.0%). Among congenital heart diseases TGA found in 4(5.0%), TOF 2(2.5%), VSD 4(5.0%), PDA 5(6.3) cases. According to the patient’s abnormalities, hydrocephalus was found in 14(17.5%), encephalocele in 4(5.0%) & meningocele, myelomeningocele was found in 13(16.3%) cases. Club foot in 8(10.0%) syndactyly, polydactyly was in 6(7.5%) and cleft lip and palate were in 16(20.0%) cases. Anorectal malformations were observed in 11(13.8%) cases. Ambiguous genitalia were 11(13.8%) cases. Previous maternal history of abnormal delivery shows Encephalocele, meningocele, myelomeningocele, club foot was 9(11.4%), IUGR 3(3.8%), preterm birth 7(8.8%), stillbirth 3(3.8%) and infants death was 3(3.8%). Conclusion: Most frequent birth defect was cleft lip and/or palate followed by congenital heart diseases, hydrocephalus, myelomeningocele, ambiguous genitalia, and anorectal malformations. The study of birth defects in underdeveloped countries should continue.