Background: ACS is a major cause of mortality and morbidity in both developed and developing countries. HsCRP is an independent risk marker of cardiovascular disease. Objective: The aim of this study was to compare serum hsCRP levels and lipid profile and to correlate with angiographic findings. Materials and methods: This is a case control study, 70 patients with onset of chest pain and 70 sex matched controls were enrolled. Details of clinical examination, ECG, angiographic findings and laboratory findings like CK-MB, AST, LDH also collected. RESULTS: Among the cases, highest mean levels of hs-CRP, CK-MB and LDH were found in STEMI patients compared to other two groups. Among the 28 UA patients 21 were diabetic (75%), in the case of STEMI it was 79%, 19 out of 24, and in the case of NSTEMI 12 out 18 (67%). Patients with SVD, had hs-CRP levels <1-3 mg/L whereas most of the patients with TVD had elevated (>3 mg/L) hs-CRP level. Conclusion: The present study showed a positive correlation between hsCRP, dyslipidemia and angiographic findings in ACS. Hs-CRP seems to be a stronger predictor of cardio vascular events.

Background: Mercury is found in liquid form at room temperature, but it has a very high vapor pressure, which causes it to be more toxic that it would be otherwise. In its gaseous state, mercury, Hg (g), is highly toxic. Because it dissolves very easily in lipids, and is absorbed very easily by red blood cells and nerve cells. The study aimed to measure of serum mercury and renal function test among case study and control. Method: Blood (serum), Personal protection equipments (PPE) such as gloves were used. Blood was drawn directly from venous port .5 ml of whole blood was collected; Samples were centrifuged at 3000-4000 RPM for 5 minutes. Serum was collected in plain containers, and then stored at refrigerator between (2-8 C). Total of 70 participant age (20 -50 years 50 as workers mining gold and 20 as control .serum collected for each participants and mercury determined by DMA-80(direct mercury analyzer) and serum urea, creatinine, uric acid by biosystem analyzer A15. Result: Results statistically analysis mercury p. value (0.001). Urea P.value (0.571). Creatinine P. value (0.022). Uric acid P.value (˂0.001). Conclusion: This study established that there is a significant increase in the levels of serum mercury and, creatinine and uric acid levels between case and normal control groups (p<0.05).The new workers are more exposed to mercury than the older workers.

Objective: The aim of this research was to ascertain how often blood donors were VDRL seropositive and whether there was a connection between syphilis serological evidence and age as well as residency. Methods: A retrospective analysis of sequentially blood donor documents from January to December 2019 was performed out in North Darfur State, Western Sudan. The analytical descriptions wre computed using percentages. Chi-square was used to analyze trends and quantify p-values. Results: There were a total of 6100 enthusiastic blood donors, all of whom were males between the ages of 15 and 55; the average age was 29.5 years. VDRL screenings for syphilis indicated that 794 of them (13.0 %) had serological evidence of syphilis, and the remainder 50306 (78%) were negative. A strong association was found between residency and serological evidence of syphilis infection in the study (P = 0.000). Age was shown to be a strong predictor of the occurrence of transfusion transmissible infections (P = 0.002). When opposed towards the other age categories, the (21-25) and (26-30) year age ranges had a higher incidence. 239/1551 (15.4%), 140/1089(12.8%) were positive respectively. Conclusions: There seems to be an increasing proportion of sero-positive VDRL in blood donations in North Darfur State. An association between syphilis infection and residency was realized, as well as a high prevalence within a particular age demographic with a statistically meaningful correlation.

COVID-19 has become one of the worst infectious disease outbreaks of recent times, with over 6.3 million cases and 367000 deaths. Our study aims to analyze characteristics, biomarkers changes of patients with COVID-19 and their associations with severity and outcomes of the disease. Laboratory parameters included inflammatory markers such as procalcitonin (PCT), serum ferritin, C-reactive protein (CRP), lactate dehydrogenase (LDH) and interleukin-6 (IL-6). Fifty-two consecutive hospitalized patients in intensive care unit with confirmed COVID-19, in the university Hospital of Mohammed 6 of Marrakech were enrolled in this retrospective study between March 20, 2020, and May20, 2020. Demographics, underlying diseases and laboratory data were collected. 39 (75%) were man and 13 (25%) were woman; the mean age was 58 years, 76, 1% were up to 50 years old. Among all non-survivors, 81% were male. The median course of the disease was 9 days. The most common co morbidity was hypertension (13/52, 25 %) and diabetes (13/52, 25%). Respirator was used in 23 patients (23/52, 44.2%). 78.59% patients had received Hydroxychloroquine+Azythromycine and 15.8% patients had received antiviral medications: lopinavir/ritonavir. The fatality rate was 71.2 % in this population considered critical. On admission, regardless of the severity, majority of patients present an identical level of inflammation marker levels. Levels of serum ferritin (median 845 [IQR 102.5–4275]), CRP (median 174.15 [IQR 5.19–508.39]), PCT (median 0.68 [IQR 0.04– 45]), LDH (median 519.5 [90–1238]), IL6 concerning 7/52 (median 101[IQR 17– 201]. Dynamic changes of biochemical and immunologic biomarkers during progression of COVID-19 across on admission, mid-hospitalization and end-hospitalization. Measurement of inflammatory markers especially CRP, IL-6 and serum ferritin might assist clinicians to evaluate the severity of COVID-19 because the variations of these biomarkers could serve to predict recovery of fatal outcome.