Coronary heart disease, non-communicable disease has become epidemic and increasing in world crisis. There is escalation in developing countries and known to be the death cause in developed countries. Due to the absence of proper guidance and preventive measures its risk factors are increasing day by day. 30-40% of deaths in Pakistan are due to cardiovascular disease. Study of C-reactive protein relationship with cardiovascular disease risk factors is essential for heart disease patients. C-reactive protein is an inflammatory marker it’s helpful tool for the recognition of risks in developing heart disease. C-reactive protein assessed by Enzyme Linked- Immunosorbent assay method is more effective in comparison with other risk factors of cardiovascular disease such as obesity, blood pressure, diabetes mellitus, cholesterol, Triglycerides, LDL cholesterol and HDL cholesterol. Written consent filled by the patients was studied to understand the relative relation of C-reactive protein with other parameters. Systolic and diastolic blood pressure mmHg was measured at 5 minutes of interval for the average analysis. By statistical analysis on Graph Pad Prism we have found the prevalence of C- reactive protein in heart patients in reference to their physical activity, smoking status and stress. Statistical means of h heart patients and control were compared to each other and there see mainly increase in level of CRP, LDL cholesterol, Triglycerides, diabetes mellitus and total cholesterol. High density lipoprotein cholesterol was low in patients and higher in control because this is the good cholesterol. Total number of heart patients is 50, and 15controls. C-reactive protein in heart patients is (4.594±0.2099***) at a 95% of confidence interval whereas in control it was 1.42±0.1776. Statistical value of total cholesterol is 246.1±7.081*** in heart patients and in control (173.7±7.909). There was significant association of all parameters with coronary heart disease.

Background: When it concerns to lumbar spine surgery, patients have the option of either general or regional anesthetic. General anesthesia is the most often used anesthetic method (GA). These patients had spinal anesthesia (SA) and general anesthesia (GA) to see which had better intraoperative and postoperative results. Methods: Multicenter non-randomized quasi-experimental prospective study has been conducted in Rajshahi Medical College Hospital and tertiary care Hospital Rajshahi, Bangladesh. From June 2019 until December 2020. The research involved a total of 72 patients. There were 37 patients in the GA Group and 35 in the SA Group who were randomly assigned to the two groups. They also kept track of the patient's heart rate, systolic and diastolic blood pressure, blood loss, satisfaction with the operating circumstances, and the intensity of postoperative discomfort assessed using a visual analogue scale (VAS). Results: This study found that the SA group suffered from considerably less blood loss than the GA group. The SA Group saw substantially less changes in intraoperative maximal blood pressure and heart rate (p=0.05). This group was substantially satisfied with their surgeons' work (p=0.05). There were substantially fewer patients in the SA group who required postoperative analgesics and postoperative mean VAS than in the GA group. (p < 0.05 for both). Conclusions: While maintaining improved perioperative hemodynamic stability without increasing undesirable side effects, our research demonstrated that SA was superior to GA in delivering surgical analgesia and reducing blood loss.