Intestinal worm infestation is the commonest form of helminth infections in human, which affect a great proportion of the world’s population and children are the most vulnerable population among them. Intestinal worm infestation is the major risk to community health which adversely contributes to the prevalence of malnourishment in developing countries. The World Health Organization estimates that over two billion people are affected with helminthiasis. Unani physicians described intestinal worms as Deedan e Ama’a and they are of opinion that the excessive putrefied phlegm is the cause for the formation of intestinal helminthiasis and the presence of worms always depends on mal-temperament or imbalance of phlegmatic temperament and unhealthy living conditions. Exploration for further alternative therapeutic agents for the treatment and control of helminthic infections has become crucial at present. Various single and compound drugs have been described in Unani literature for the treatment of different types of worm infestations and Unani physicians prescribed them since antiquity. It has been observed in routine practice that the compound formulations are more effective compared to the single drug. This systematic study was focused to assess the scope of herbal medicine in the treatment of worm infection.