ORIGINAL RESEARCH ARTICLE | Dec. 30, 2018
Evaluation of the Antifungal Properties of Cassia alata Based Herbal Ointments Formulated in Different Ointment Bases
Alalor CA
Page no 38-42 |
10.36348/sijtcm
Superficial fungal infections are generally more prevalent in tropical
environments because of the enhancement of their growth by the high temperatures
and high humidity conditions prevalent in these regions. The aim of this study is to
investigate the antifungal potency of herbal ointments formulated with aqueous
extract of Cassia alata. The in vitro antifungal activity of crude extract of leaves of
Cassia alata as well as herbal ointments were determined against Candida albicans,
Trichophyton mentagrophyte, Aspergillus niger and Penicillium using the Agar cup
plate method. Herbal ointments were prepared by incorporating the crude extract of
Cassia alata (10 % w/w) into ointment bases and evaluated for their in vitro
antifungal efficacy. The crude extract showed moderate antifungal activity against
Candida albicans, Trichophyton mentagrophyte and Aspergillus niger with zones of
inhibition of 23 mm, 21 mm and 19 mm respectively at 200 mg/ml but no activity
against Penicillium. The antifungal activity was retained in the herbal ointments with
higher zones of inhibition for corresponding concentrations. The formulation
containing Cassia alata extract in aqueous cream showed comparatively better
antifungal activity. The herbal ointment also compared favourably with a commercial
brand of Miconazole cream used as standard. This study shows that Cassia alata
possesses antifungal activity and also has high potential as antifungal agent when
formulated as ointment for topical use and could therefore explain the successes
claimed in the folk use of the plant in the treatment of common skin conditions, hence
the need to have herbal topical dosage forms.