The ACE2 (Angiotensin I Converting Enzyme 2) receptor has been considered to be the major receptor of 2019-nCOV, the causative pathogen of the world wide prevailing COVID-19. Since, ACE2 is widely expressed across a variety of organs and moderately expressed in lungs, it raises a confusion about what makes the lung tissue the most infected in the Corona Virus Disease. Thus we hypothesized that there could be certain other genes playing key roles in the entry of 2019-nCOV into the human cells. Here, we found that PRCP (prolyl-carboxypeptidase) which is highly expressed in lungs than ACE2, has interactions with Bradykinin and has been proved as a potential target for obesity, could be a possible gene playing important role in the Corona Virus entry. In this study we have tried to dock the PCRP protein with two ligands [Epigallocatechin and Theaflavin] which could possibly reduce the effect of this protein.

Fibroadenoma is a benign breast tumor common in young women, affecting their daily life. Modern medicine often recommends surgical intervention, which can have physical and emotional consequences. The study explores alternative treatments through Ayurveda, which offers non-invasive and cost-effective options. This study investigates the comparative efficacy of Kanchnar Guggulu and Cystogrit Diamond in the management of Stanagranthi (Fibroadenoma breast). Sixty patients were randomly divided into two groups: Group A (treated with Kanchnar Guggulu) and Group B (treated with Cystogrit Diamond). The study assessed subjective (pain, consistency) and objective (size, number of lumps) parameters before and after a 90-day treatment period. The study aims to provide a safe, effective alternative to surgery for managing fibroadenoma, with Ayurveda offering promising non-invasive treatments. Results showed a significant reduction in pain for both groups, with Group B demonstrating a 93.24% improvement compared to Group A's 83.93%. In terms of lump size reduction, Group B also outperformed Group A, with a 42.86% decrease versus 29.85%, respectively. The average effect on consistency was higher in Group B (31.58%) compared to Group A (25%). The findings suggest that Cystogrit Diamond is more effective than Kanchnar Guggulu in managing Stanagranthi, providing a potential non-invasive, cost-effective alternative to surgery for fibroadenoma patients.