In order to effectively deliver drug molecules to their intended targets in the body, different dosage forms are utilized. Adapting dosage forms to the specific needs of the modern era and the condition of the disease can enhance the provision of healthcare to those in need, particularly through the use of herbal and traditional (Unani and Ayurvedic) products. Ayurveda employs various classifications of dosage forms, such as Aushadha kalpana and Ahara kalpana. Aushadha kalpana can be further categorized into Primary kalpana (Panchavidha kashaya Kalpana) and Secondary kalpana. These classifications are based on the origin of the ingredients, including plant, animal, and mineral sources. Dosage forms can also be classified based on their physical state, such as liquid, semi-solid, and solid forms. Furthermore, dosage forms can be categorized according to their intended usage, including Bahya kalpana (external application) and Abhyantara kalpana (internal administration). The importance of employing various dosage forms in Ayurveda lies in making them compatible and palatable to patients, as well as increasing their shelf life. One significant classification within Ayurveda is the topical dosage form (Bahya Kalpana), which encompasses formulations like lepa Kalpana, Malhara Kalpana, and Upnaha Kalpana. This article focuses specifically on exploring the topical dosage forms in Ayurveda.

Background: The decline in kidney function experienced by people with type 1 and type 2 diabetes who are chronically ill is known as diabetic nephropathy (DN) or diabetic kidney disease. The condition is known to progress in a number of stages and is related to blood pressure and glycemic management. Nevertheless, despite strict blood sugar management, the prevalence of chronic kidney disease (CKD) in diabetic patients has not decreased over the past 20 years, which has led to the discovery of new risk factors for the illness's development. The medical characteristics of the Paper Flower, Bougainvillea spectabilis, include anti-inflammatory, anti-hepatotoxic, anti-inflammtory, anti-hyperlipidemic, antibacterial, antioxidant, and antiulcer capabilities. Alkaloids, flavonoids, glycosides, phenolics, phytobannins, quinones, saponins, tannins, and terpenoids are examples of phytoconstituents that have been claimed to have medicinal characteristics. Method: In the current study, a molecular docking technique was used to try and identify mTORC1protein inhibitors. A grid-based docking strategy was used to determine the binding using the Auto Dock software. Merck Molecular Force Field was used to build the 2D structures of compounds, convert them to 3D, and then energetically reduce them up to arms gradient of 0.01. (MMFF). Result: The molecular docking of Ferulic acid & Gallic acid with mTORC1 protein showed binding energy (Kcal/mol) -5.37 & -4.56 respectively. Conclusion: Theoretically, all the ligand molecules have shown encouraging docking score. The docking result of ferulic acid revealed that their docking scores was -5.37 kcal mol–1, and it can be predicted as good inhibitor of mTORC1 protein and thereby prevents dysregulation of intracellular protein synthesis and the metabolic balance along with decreasing oxidative stress on the kidney.

In the present era, the cases of renal diseases are speedily growing and relapses of these diseases are also very frequent. Diuretics in contemporary science, play a major role in the treatment of renal anomalies, but they have side effects too. So, to combat the situation, Ayurvedic Mutral drugs are gaining wide acceptance as they are safe and effective. In Ayurveda, great importance has been given to Mutra and Mutravaha srotas in maintaining the health of an individual. This can be illustrated by the fact that to deal with urinary disorders, Acharya Charak has specifically mentioned the Mutravirechaniya Mahakashaya and Acharya Sushruta and Acharya Vagbhata have mentioned Veertarvadigana and Trinapanchmoolagana. The herbs of the above-mentioned Kashaya and Gana are used to treat various renal ailments like burning micturition, scanty urine, calculi, etc. Apart from this, they also help to re-establish the normal physiological function of the affected renal tissues and organs. Hence, due to these attributes, they are the components of a wide number of Ayurvedic Mutral formulations. The current review is undertaken for screening the therapeutic action on the renal system of a total twelve herbs, taken from Mutravirechaniya Mahakashaya, Veertarvadigana and Trinapanchmoola gana. Various research studies concerning property of increasing urinary output (Mutral) of such plants are compiled here. These drugs are mostly sheet virya and snigdha guna, so increase the watery content of urine, thereby increasing its amount and flow.