Infertility is an important and growing health problem affecting nearly 15% of couples worldwide. It is estimated that male factors contribute to 20-70% of cases depending on the latitude. Male reproductive system is highly sensitive to many factors such as environmental, lifestyle as well as numerous physical and chemical factors which leads to infertility. In 40 to 50 % of cases, a semen analysis can rule out the cause of the infertility. Many drugs in the market are available but they might produce various side effects that cannot be ignored. Vajikarana is one among the eight branches of Ayurveda. In Ayurveda, there are various herbal and herbomineral formulations that take place in Vajikarana chikitsa owing to their aphrodisiac property. Gokshuradi Churna is one of such versatile formulation that possesses Vajikarana properties and is used in male infertility. This formulation consists of five herbal ingredients i.e. Gokshura (Tribulus terrestris Linn.), Ikshura (Asteracantha longifolia Nees.), Mash (Phaseolus Mungo Linn.), Atmagupta (Mucuna prurita Hook.) & Shatavari (Asparagus racemosus Wild.). It is a polyherbal formulation illustrated in the classical text of Ashtanga Hridaya. Many formulations are available in various texts under the same name Gokshuradi Churna with different contents and different Rogadhikara (indications). This article compiles probable mode of action and Spermatogenesis activity of each ingredient of Gokshuradi Churna.

Darvyadi Ghrita is a polyherbal formulation and is mainly indicated for the diarrhoea. It is mentioned in Charak Samhita by Acharya Charak. Preparation of oleaginous dosage form is described as Sneha Kalpana performed by subjecting Ghrita or oil to a particular pattern of heat treated with Kalka (Paste) of Kutaja, Daruharidra, Pippali, Shunthi, Katuka, Draksha and Kwath (Decoction) of same ingredients. Murchana is a pre procedure to Sneha Kalpana in which Ghrita is treated with few drugs. The main ingredients of Darvyadi Ghrita is Kutaja (Holarrhena Antidysentrica Wall.), Daruharidra (Berberis Aristata DC.), Pippali (Piper Longum Linn.), Shunthi (Zingiber Officinale Rosc.), Katuka (Picrorhiza kurroa Royle ex.Benth), Draksha (Vitis Vinifera Linn.) and Go-Ghrita. In Ayurvedic therapeutics the Pharmacokinetics and Pharmacodynamics of the drug entirely depends upon Rasa, Virya, Vipaka, Prabhava and balance of Tridosha in the body. The ingredients of Darvyadi Ghrita with their Rasapanchaka, are very much competent to exhibit anti-bacterial and anti-diarrheal property from Ayurvedic perspective.