SHORT COMMUNICATION | Aug. 3, 2022
Virtual Reality Complementary Therapy and Breast Cancer Recovery: A Brief Update
Dr. A. M. Tacon
Page no 137-139
This update reviewed the effects of VR complementary therapy in breast cancer patients regarding physical symptoms such as the common triad of pain, lymphedema and upper limb impairment following treatment. The results revealed weak but consistently positive, significant effect in physical symptoms. Findings, however, were limited by poor methodological quality, small sample sizes and low statistical power in studies. Future recommendations include better designed studies with large sample sizes and acceptable power to investigate the effects of VR interventions in women with breast cancer, during and after cancer treatment.
ORIGINAL RESEARCH ARTICLE | Aug. 11, 2022
Toxicological Profile of the Stem Bark Extract of Cylicodiscus gabunensis Harms (Fabaceae)
Ngoule Christian, Essome Henri, Ngene Jean Pierre, Ladoh-Yemeda Christelle Flora, Ngongodi Bagnak Anne Syntyche, Etame-Loe Gisèle, Mpondo Mpondo Emmanuel
Page no 140-146
This study aimed at evaluating the toxicity of the methanolic extract of Cylicodiscus gabunensis stem bark, a plant traditionally used against female fertility problems. Acute toxicity was evaluated in rats by sequential administration of a single dose of 2000 mg/kg and 5000 mg/kg of body weight of extract according to the method described by protocol 425 of the Organization for Cooperation and economic development. Subacute toxicity was assessed by daily administration of the extract at 100, 200 and 400 mg/kg for 28 days. The weight evolution and the signs of toxicity were observed, the biochemical and haematological parameters of the blood of the animals were collected and analysed. The administration of the extract at 2000 and 5000 mg/kg caused no death and no toxic signs. The weight evolution, the biochemical and haematological parameters of the surviving rats were analysed and compared with those of the controls. Acute oral toxicity data determined that the LD50 of the extract is greater than 5000 mg/kg. Repeated dose administration did not cause any deaths or significant changes in haematological parameters. Some signs of intoxication were however noted and certain biochemical parameters analysed in the rats showed statistically significant differences compared to the controls. A decrease in creatinine was observed on the renal level, an increase in transaminases and a decrease in alkaline phosphatase on the hepatic level. An increase in total proteins at 100 and 200 mg/kg and triglycerides at 100 mg/kg were observed and also a significant drop in LDL-cholesterol at 100, 200 and 400 mg/kg. This study shows that the stem barks of C. gabunensis would be moderately toxic in repeated oral administration, additional studies should be carried out to determine the effect of the extract on the tissues of the different organs.
ORIGINAL RESEARCH ARTICLE | Aug. 13, 2022
Prognostic Value of Inflammatory Biomarkers in COVID-19
Kouam Tasnim, Abdelkhaled Ilias, Ammor Abdesselam, Khalki Hanane
Page no 147-151
Background: Coronavirus disease 2019 (COVID-19) is characterized by a variable clinical picture ranging from asymptomatic to severe or even critical forms that can be life-threatening. The biological assessment can also be within the limits of normality, even little disturbed or outright witness of an excessive inflammatory response or a real cytokine storm which would follow the virological phase of the disease. The objective of our study is to evaluate the contribution of inflammatory biomarkers: LDH, procalcitonin (PCT), ferritin, C-reactive protein (CRP) and the level of lymphocytes, in the prediction of mortality in COVID-19 patients. Methods: We collected 79 patients diagnosed with COVID-19 on the basis of a set of clinical, radiological and / or biological arguments, which we divided into two groups: Survivors (N = 45) and deceased (N = 34). All these patients had all the biomarkers measured upon admission. Results: In our study, we found that the levels of the four inflammatory biomarkers studied in our series were elevated in both groups of patients (survivors and decedents), however, the decedents did not have significantly higher levels than the survivors (P >0.05).
REVIEW ARTICLE | Aug. 29, 2022
Mechanistic Insights an Anthelmintic Potential of Cleome viscose Seeds: “Molecular Docking”
Rizwan Ahmad, Jitender K Malik
Page no 152-158
Herbal remedies used traditionally to cure different types of human disease. The research in herbal drugs, to discover single compound used a lead for developing new therapeutically active products. Cleome viscosa Linn. (wild or dog mustard), belongs to family(Capparaceae). Cleome viscosa well known plant for their antimicrobial, anti-diarrheal, hepatoprotective, analgesic and anti-fibrolytic potential. In living beings, infection caused by helminths (helminthiasis) is a severe problem to health that results in hardship and stunted growth. In the developing world, helminthiasis (in human intestine) is the most common infectious disease. The seed contained salicylic acid and Lupeol. This study has been carried out to evaluate anthelmintic potential of Cleome viscose seed by molecular docking via drug-tubulin interaction. The molecular docking result revealed that salicylic acid and Lupeol showed encouraging docking score. The docking score found to be -1.98 and -3.82 kcal mol–1 respectively.