Objective: In this study our main goal is to evaluate the clinical and laboratory profile of patients with ovarian tumor. Method: This cross-sectional observational study was done at different tertiary hospitals from 2018 to 2020. Total 100 post-menopausal women with ovarian cysts aged 50-65 years were enrolled for this study. In each case, information about the patient was collected in a prescribed questionnaire after getting written consent from the patients in a preformed consent form. Results: During the study, (50%) of the patients belong to 54-57 years age group. 18% had family history of cancer, followed by 33.3% were nulliparas, 20.4% used barrier contraceptive method. According to histopathology report of the patients 27.9% cases mucinous cyst abdenomia were found followed by 18.7% cases endometrioma, in 17.5% cases serous cyst adenoma, 5.1% cases mucinous adenocarcinomas 5.6% cases papillary adenocarcinoma, 2.5% cases paraovarian cysts and benign cystic lesion and area of hemorrhagic infract were reported. Rt. Ovarian cyst about (10x6.6)cm cases were found 23.2% cases, followed by Rt. Adenexal mass about (12x9)cm found in 21.1% cases,11.6% cases Large complex mass about (13.9X12.8)cm were found, 6.3% cases cystic mass about (13x10)cm in the Lt. abdenexa were found, 5.3% cases Malignant ovarian tumor and complex pelvic mass about (9.3X7)cm were found. 26.6% cases mucinous cyst abdenomia were found followed by 17.7% cases endometrioma, in 16.5% cases serous cyst adenoma, 5.1% cases Mucinous adenocarcinoma and Papillary adenocarcinoma, 2.5% cases Peravarian cyst and Benign cystic lesion and area of hemorrhagic infract were reported. 32.4% cases were benign tumor and 16.2% cases were malignant.

Background: Metabolic syndrome is common in women with polycystic ovary syndrome. Some studies have suggested that vitamin D deficiency may play role in metabolic disturbance and vitamin D supplementation improves metabolic profile of these patients. Objective: To evaluate the effect of vitamin D supplementation on the metabolic profile in the polycystic ovary syndrome patients. Methods: Seventy seven diagnosed cases of vitamin D deficient polycystic ovary syndrome patient with metabolic syndrome, age range 18-45 years were administered standard therapy of oral vitamin D (OH)2 40000 IU weekly for seven weeks followed by maintenance therapy of oral vitamin D2 2000 IU daily. Follow up vitamin D was done 3 months after initiation of vitamin D supplementation. The changes in features of metabolic syndrome namely, waist circumference, blood pressure, fasting plasma glucose, fasting serum triglyceride and high density lipoprotein levels were recorded. Paired‘t’ test was done to see if the changes were significant. Result: Mean serum vitamin D was significantly increased (11.5±4.0 ng/ml vs. 36.8±10.7 ng/ml) after the vitamin D supplementation (p<0.05). Triglycerides level decreased (180.7±62.3 vs 148.1±46.2 mg/dl) and HDL level increased (38.2±11.3 vs 47.1±10.3 mg/dl) which were statistically significant (p<0.05). But the changes were not significant for the waist circumference (93.9±8.6 vs. 93.4±8.2), blood pressure (SBP-117.6±12.4 vs 117.5±11.9 mm Hg; DBP- 80.9±7.6 vs 80.8±7.8 mmHg), fasting glucose (5.77±1.02 mmol/L vs. 5.74±0.99 mmol/L). Conclusion: Vitamin D supplementation have favorable effects on features of metabolic syndrome.

Background: Preeclampsia is a life-threatening condition, which carries adverse effects for women and fetus. Lifestyle modification can modify the preeclampsia and improve its outcomes. Educational programs are an effective method to modify the lifestyle among pregnant women with mild preeclampsia. Methods: Aim of the current study was to evaluate the effect of an educational program on modifying lifestyle among pregnant women with mild preeclampsia. A pre and post research design was utilized on a purposive sample of 40 pregnant women at 20 – 24 weeks of gestation with mild preeclampsia at the antenatal outpatient unit, Port Said Maternity Hospital, Egypt; they get information regarding the proper lifestyle for mild preeclampsia and the lifestyle dimensions were assessed at the pre- program and post-program phases. Two tools were used for data collection: Interviewing Questionnaire Sheet and Lifestyle Questionnaire. Results: The findings showed a statistically significant improvement in the lifestyle after conducting the educational session. Conclusion: Educational programs about the proper lifestyle for mild preeclampsia through a PowerPoint presentation and distribution of the booklet are an effective method to modify the lifestyle among pregnant women with mild preeclampsia.

Background: Polycystic Ovarian Syndrome (PCOS) is a major endocrine disorder in reproductive age women. PCOS is associated with insulin resistance. Some of the PCOS women also have thyroid dysfunction. There are variable and controversial findings regarding the association of thyroid stimulating hormone with insulin resistance. The objective of our study was to analyze the relation between thyroid stimulation hormone with insulin resistance in patients with PCOS. Methods: The case control study was carried out on 216 reproductive age women with PCOS. Insulin resistance was measured by Homeostatic model assessment of insulin resistance (HOMA-IR) and those with HOMA-IR more than 1.9 were defined as having insulin resistance. PCOS women with insulin resistance were cases (n=108) and those without insulin resistance were controls (n=108). Thyroid stimulating hormone (TSH) levels was assessed in both groups.Association of thyroid stimulating hormone with insulin resistance was analyzed. Result: The mean serum TSH level was significantly more in insulin resistant PCOS women (3.87±3.44 mIU/L) than those without insulin resistance (2.29±1.66 mIU/L). Hypothyroidism (TSH >2.5 mIU/L) were present in 63.9% of insulin resistant PCOS women compared to 31.3% of those without insulin resistance. The odds of hypothyroidism (TSH level >2.5 mIU/L) was 4.19 times more in insulin resistant PCOS women. Conclusion: There is significant positive association of hypothyroidism with insulin resistance in PCOS.

Background: Mullerian agenesis also known as Mayer- Rokitansky- Kuster- Hauser Syndrome is a congenital disorder characterized by agenesis of the uterus and upper part of vagina. Vagina is created or lengthened by non-surgical vaginal dilatation or surgical vaginoplasty to allow sexual function.We have been doing non-surgical vaginal dilatation facilitated initially by saline injection and sustained digital pressure in women with Mullerian agenesis for a few years. This was a follow up study with the purpose to evaluate the sexual function of these women. Method: We practiced a novel approach to quicken non- surgical dilatation of vagina. We interviewed women who received this treatment over cell phone after two months to four years. Result: A total fifteen women who had nonsurgical vaginal dilatation in our department were called over cellphone. Total 10 women could be reached.The age range of women was between 16 and 35 years. The frequency of intercourse was 3 to 5 times per week in couples living together. All eight women admitted of the experience of full genital performance during sexual intercourse and said they could provide pleasure to their partners. When asked about the presence of stable relationships and a good communication with the partners only five out of eight agreed. The reason behind strained relationship with husband was not sexual dysfunction but inability to conceive. Conclusion: Short term procedure of saline injection and sustained digital pressure under supervision can augment vaginal dilatation with vaginal dilators and lead to adequate sexual activity.

Background: Vitamin D deficiency may be associated with endocrine disturbances including male infertility. Vitamin D receptor and metabolizing enzymes are found in the male reproductive system. Expression of Vitamin D inactivating enzyme in spermatozoa may be responsible for sperm motility and vitamin D responsiveness. Vitamin D supplementation may help in improvement of asthenozoospermic infertile males who are vitamin D deficient. Objective: To evaluate the impact of Vitamin D supplementation on sperm motility in vitamin D-deficient asthenozoospermic infertile males. Methods: A total of 110 infertile males who had asthenozoospermia and vitamin D- deficiency were included in this study. Vitamin D supplementation was given 40000 IU weekly for six weeks and 2000 IU daily for another six weeks and follow up semen analysis was done after 3 months to analyze the changes in sperm motility. Statistical analyses were carried out by paired t test. Result: The mean age was 33.19±5.81 years (range from 25 to 45 years).The mean vitamin D level was 16.19±3.19 ng/ml before and 32.93±7.74 ng/ml after supplementation, the increase being statistically significant (p<0.05). There was significant (p<0.05) increase in sperm motility (%), 23.58±9.51 before treatment versus 35.29±14.76 after treatment. The changes in progressive motility (18.20±8.15 % vs 28.94±13.06 %) and total motile count (17.10±16.78 % vs 28.52±25.89 %) were statistically significant (p<0.05). Conclusion: Supplementation of vitamin D improves sperm motility in infertile males with asthenozoospermia and vitamin D-deficiency.