Background: Pre-eclampsia affects up to 10% pregnancies worldwide and is one of the foremost causes of poor maternal and foetal outcome. The situation in India is even grave with high rate of maternal mortality due to pre-eclampsia. Though multiple risk factors are associated with pre-eclampsia, it is known that first pregnancy itself is a significant pre-eclamptic risk factor. Therefore, in this study we intent to gauge the effects of low dose Acetyl salicylic acid (Aspirin) among pregnant women in prevention of pre-eclampsia. Materials and Methods: This randomized controlled study was conducted in Department of Obstetrics and Gynaecology of Mamata Medical College and General Hospital. Total 100 patients were enrolled in this study. Pregnant women with and without any other pre-eclamptic risk factor consulting before the 16th week of amenorrhea were selected in the study. One group i.e. Treatment group (n=50) was given 75mg/day aspirin orally after breakfast to one week before estimated date of delivery while the other group received no aspirin. Both groups were followed for regular antenatal check-up. Results: The treatment group who received acetyl salicylic acid (aspirin), the age ranged from 20-35 years with a mean age of 24.81±3.12 years. Maximum number of cases belonged wot age group of 26-30 years. The treatment group who received acetyl salicylic acid (aspirin), the age ranged from 20-35 years with a mean age of 25.21±4.29 years. Moreover, we found pre-eclampsia in aspirin group was of lesser severity as compared to those in control group. Further, proportion wise the risk of pregnancy induced hypertension and eclampsia were also reduced with aspirin, however, these were not found statistically significant. Conclusion: Our study highlights the beneficial effect of low-dose acetyl salicylic acid in decreasing hypertension and proteinuria. This study also confirms the efficacy of acetyl salicylic acid in decreasing caesarean section, maternal mortality and morbidity.