ORIGINAL RESEARCH ARTICLE | Aug. 6, 2020
To Compare the Efficacy of Labetalol and Methyldopa in Treatment of Pregnancy Induced Hypertension
Dr. Neha Sharma, Dr. Alka Batar
Page no 178-181
Background: The present study is undertaken with limited available facilities to find out the efficacy of two oral antihypertensive drugs namely labetalol and methyldopa in management of pregnancy induced hypertension. Methods: The study consisted of 150 patients with pregnancy induced hypertension attending outpatient department and admitted in ANW, or who directly came to labour room. These patients were randomly selected on lottery basis after they fulfilled the inclusion criteria. Total 150 patients were taken for the study and divided into 2 groups of 75 patients in each group. Results: The mean SBP before treatment in methyldopa group was161.33 ± 8.97 mmHg and 160.03 ± 8.23 mmHg in labetalol group which showed a fall to 138.61 ± 6.67 mmHg (methyldopa group) and 138.08 ± 5.37 mmHg (labetalol groups) after treatment. Fall of SBP was significant in both the groups. But inter group difference was not significant (p > 0.05). The mean DBP before treatment was 106.85 ± 4.33 mmHg in methyldopa group and 105.63 ± 5.23 mmHg in labetalol group which decreased to 89.31 ± 6.51 mmHg and 89.68 ± 5.26 mmHg respectively after treatment. Fall of DBP was significant in both the groups. But inter group difference was not significant (p > 0.05). Fall of MAP was significant in Group A and Group B. But inter group difference was not significant (p > 0.05). Conclusion: Labetalol and methyldopa are equally efficacious in controlling blood pressure in new onset hypertension in pregnancy.
CASE REPORT | Aug. 6, 2020
Factor V Leiden and Repeated Early Miscarriages
Fatima Zahra Gounain, Nisrine Mamouni, Sanae Errharay, Chahrazed Bouchikhi, Abdelazez Banani
Page no 182-186
During pregnancy there is a physiological hypercoagulability which may be increased by genetic risk factors and / or acquired thrombosis. This increases the risk of thromboembolism and the risk of thrombosis in placental vessels and thus termination of pregnancy. Among genetic risk factors for thrombosis, factor V Leiden and mutated factor II are responsible for spontaneous miscarriages, which are essentially late. The rare deficits in antithrombin, protein C and protein S are also involved. Factor V Leiden is a thrombophilic condition that can lead to serious thromboembolic events and in pregnant women recurrent miscarriages. We report the case of a 36-year-old woman who presented 6 miscarriages that led to the diagnosis of thrombophilia by resistance to activated protein C and whose last 4 pregnancies were well followed by anticoagulant treatment with low molecular weight heparin aspirin.
REVIEW ARTICLE | Aug. 11, 2020
Laparoscopic Pectopexy Vs Sacrohysteropexy/Sacrocolpopexy in Management of Pelvic Organ Prolapse: A Review of Literature
Dr. Nidhi Jain, Dr. Jyotsna Kamra, Dr. Shruthi Srinivas
Page no 187-191
Pelvic organ prolapse (POP) is a common disorder characterized by downward displacement of pelvic organs through vaginal wall. Women of advance age, multiparous, with history of previous gynaecological surgeries are at risk of developing POP. Various clinical features associated with POP are something coming of vagina, altered bladder habits or defecation problems. These features affects the quality of life of a women, thus timely management of POP is essential. It can be managed conservatively or surgically. Surgical approaches are hysterectomy, sacrohysteropexy, sacrocolpopexy and pectopexy. Sacrohysteropexy/ sacrocolpopexy are considered as the gold standard procedure of management of POP. However, recently, another procedure i.e. laparoscopic pectopexy is described as a new alternative procedure, which is equally effective and associated with lesser complications. Thus, authors hereby review the literature to compare laparoscopic pectopexy over Sacrohysteropexy/ sacrocolpopexy.