Background: HELLP syndrome, a severe pregnancy complication characterized by hemolysis, elevated liver enzymes, and low platelet count, occurs in 0.5 to 0.9% of all pregnancies and in 10–20% of severe preeclampsia cases. It poses significant risks to both mother and fetus, presenting diagnostic and therapeutic challenges. Patients often experience epigastric or right upper quadrant pain, hypertension, proteinuria, fatigue, nausea, vomiting, sudden weight gain, and headaches. HELLP syndrome typically occurs in the second and third trimesters (27-37 weeks) and 15–30% of cases present postpartum. The exact causes remain unclear but may involve placental origins, autoimmune factors, gene mutations, or fatty acid oxidation disorders. Aims and Objectives: To analyze the clinical profile of HELLP syndrome cases and to assess maternal and perinatal outcomes, including morbidity and mortality. Material and Methods: This prospective cross-sectional study was conducted in the Obstetrics and Gynecology department at Pravara Rural Hospital, Loni, involving 45 patients with severe preeclampsia and eclampsia above 28 weeks of gestation diagnosed with HELLP syndrome. Patients were admitted to the ICU, and detailed histories and examinations were recorded. Patients were divided into two groups: those with HELLP syndrome (Group A) and those without (Group B). Results: Group A had a higher representation in the 20-22 age bracket, while Group B had more members aged 22-24. Cesarean sections were more common in Group A, whereas vaginal deliveries were more frequent in Group B. Blood pressure readings were higher in Group A. Maternal complications, such as abruption placentae, DIC, hepatic infarction, acute renal failure, and ascites, were more frequent in Group A, as were neonatal complications like IUGR, preterm delivery, neonatal thrombocytopenia, and RDS. Conclusion: The study reveals significant differences between patients with and without HELLP syndrome. Group A included younger patients, more first-time mothers, and a higher incidence of complications and mortality. These findings highlight the need for tailored management strategies for severe preeclampsia/eclampsia, especially in those with HELLP syndrome, to improve maternal and neonatal outcomes.

Background: PCOS is the most common endocrine disorder in women that can lead to a variety of ailments associated with chronic anovulation and hyperandrogenism, it is also still a common cause of infertility in women. It is the most frequent endocrine and metabolic disorder among reproductive-aged women. PCOS (polycystic ovarian syndrome) is the most frequent cause of anovulatory infertility, accounting for more than 75% of all cases. This widespread problem affects around one in every six marriages and has a variety of causes across countries and social groups. Aims and Objective: The objective of this study was to evaluate the treatment strategies for infertile patients with diagnosed Polycystic Ovary Syndrome (PCOS). Material and Methods: This study looked at 80 cases of infertility caused by polycystic ovarian syndrome. From August 2021 to July 2022, this study evaluated 80 cases of infertility with PCOS at a tertiary medical college. The diagnosis was made using a hormone assay, ultrasound, and laparoscopy. Treatment options included clomiphene citrate, letrozole, and laparoscopic ovarian drilling. Results: In our study, the majority (50%) were between the ages of 26 and 30 years old, and 100% of patients complained of infertility, with 66.25% being of the primary type. Menstrual abnormalities affected 73.75% of women. The LH: FSH ratio was greater than 1.6 in approximately 85% of responders, and 77.5% of women had enlarged polycystic ovaries. Clomiphene citrate had a conception rate of 24%, Letrozole 31% had a rate of 20%, and laparoscopic ovarian drilling followed by Letrozole had a rate of 60%. Conclusion: Polycystic ovarian syndrome is a complex illness that necessitates a variety of treatment techniques based on the reason a patient seeks treatment. Aside from diet and fitness improvements, most patients with good conception rates require lifestyle modification treatment such as C/C and laparoscopic ovarian drilling.

Introduction: Placenta previa (PP) is a significant cause of maternal and fetal morbidity and mortality worldwide. However, there is limited data from developing countries on the maternal and fetal outcomes and complications associated with placenta previa. Aim of the study: The aim of this study was to evaluate maternal and perinatal outcome in preterm placenta praevia. Methods: This prospective observational study was conducted in the Department of Gynae and Obstetrics of Dhaka Medical College Hospital, Dhaka, Bangladesh during the period from March 2010 to August 1010. Result: Total 66 patients were diagnosed with placenta previa. We found, the majority (42%) of participants were aged between 26-30 years and with lower socio-economic status significantly associated with higher prevalence due to lack of regular antenatal care. The majority were admitted at 35-37 weeks gestation, with the highest perinatal loss occurring before 30 weeks. Initial bleeding was generally small, and many presented with labor pain and anemia. Ultrasonography diagnosed 55% of cases, with cesarean sections frequently used, leading to better outcomes compared to vaginal deliveries. Severe postpartum complications like hemorrhage and urinary tract infections were common in more severe cases. Conclusion: Placenta previa is a major cause of maternal and perinatal morbidity and mortality. Early registration, regular antenatal care, early detection of high-risk cases, and timely referral to higher centers with good NICU services and blood bank facilities can help prevent these adverse outcomes.

Although preeclampsia claims the lives of 70,000 mothers and 500,000 newborns each year worldwide, its origin is still elusive and a number of risk factors such as environmental pollution are not yet addressed properly. In this study, exposures due to the extents of air, water and noise pollution as well as mental stress on preeclamptic patients have been investigated. Using a cross-sectional longitudinal design, 90 women hospitalized with preeclampsia in 7 hospitals of Rajshahi, Bangladesh were considered, of which Rajshahi Medical College Hospital is a tertiary referral hospital. The data were collected by interviewing the patients, physical examinations and merging the patients’ data with British Geological Survey’s groundwater data-sets (n=3,540). For statistical analyses, SPSS software was employed. It was found that most of the patients’ living rooms were within 15 feet from kitchen. Only 10% patients had good room ventilation, while the remaining 90% patients had either moderate or poor room ventilation. Combination of these facts reveals that the preeclamptic patients were subject to moderate CO2 exposure. Since 79% of the preeclamptic patients’ living rooms were below 50 ft from the nearest roads and 84% for 100 ft distance, they would experience noise pollution. Combination of traffic conditions and potential sources of noise pollution revealed that 60% of the preeclamptic patients experienced moderate to intense noise pollution. Groundwater arsenic, calcium, magnesium, iron and sodium concentrations in the patients’ drinking water were higher than WHO guideline values that should favour constipation and mild hypertension. While 70% patients were under high mental stress and 24% under very high mental stress, only 6% patients had moderate mental stress. It is concluded that air, water and noise pollution, and mental stress are potential risk factors of preeclampsia.

Sirenomelia, also known as mermaid syndrome, is a rare congenital malformation in which the lower limbs fuse together, giving the appearance of a mermaid's tail. It is frequently combined with severe urogenital and gastrointestinal anomalies. We report the case of a 30-year-old pregnant woman. During this pregnancy, sirenomelia was first diagnosed during a routine 2nd-trimester ultrasound examination, which showed fusion of the lower limbs. Neither she or any member of her family had a history of diabetes. As for other risk factors, she had no history of exposure to teratogenic agents during her pregnancy. Moreover, her marriage was not consanguineous. Sirenomelia is a rare malformative sequence that should be diagnosed as early as possible. Bilateral renal agenesis, confirmed by color Doppler, makes it a lethal condition.

Background: Late pregnancies are a hot topic for both women and health professionals, due to their increasing increase and their prone to more complications, both during pregnancy and for the unborn child. The objective was to assess the rate of obstetric pathologies according to age group, in order to determine whether pregnancies at an advanced age require special monitoring. Material and Methods: this was a retrospective case-control analytical study over a period of eighteen months, taking place from January 1, 2023 to June 30, 2024 in the obstetrics and gynecology department of the Mali Hospital in Bamako. The study population was divided into two groups: cases, represented by patients 35 years of age or older in early pregnancy, and controls, patients under 35 years of age in early pregnancy. The inclusion criteria were all patients followed in antenatal consultations and presenting with a singleton pregnancy at our department during the study period. The criteria for non-inclusion were multiple pregnancies and those resulting from medically assisted reproduction (ART). Data entry and statistical analysis were performed by SPSS software. The Pearson chi-2 test as well as the Fisher exact test with a significance threshold of 5% (p ˂ 0.05) were used for the interpretation of the data. Results: The out-of-school population was the most represented (54%, (n = 281/515) with 43% (n = 223/515) and 11% n = 58/515) respectively among those under 35 years of age and among those 35 years of age or older. Pre-existing conditions such as diabetes and chronic hypertension were significantly associated with age groups with a higher percentage in those aged 35 or over than in those under 30 years of age with respectively (4% versus 3% diabetic) and (5% versus 2% chronic hypertensive). Obstetric complications were most common among women aged 35 years and older. hypertensive disorders of pregnancy (gestational hypertension, preeclampsia) were significantly more frequent in women from the age of 35. The pregnancy hypertension rate was 5.6% to 3.4%) respectively in those aged 35 or over versus under 35 years. As for gestational diabetes, the rate was 10% versus 2% respectively in those over 35 and over versus those under 35. Conclusion: Our study shows that maternal age of thirty-five years or more plays a role in maternal complications.