Triple-negative breast cancer (estrogen receptor negative, progesterone receptor negative and HER2 negative) is a particularly high-risk breast cancer which does not receive specific therapy targeting these proteins. We report the case of a 23-year-old patient diagnosed with triple-negative breast cancer of the left breast with a family history of breast cancer and carrying a BRCA1 mutation. The classification of breast cancer based on genomic data is required to allow us to optimize therapies and improve the management of breast cancer patients.

Introduction: Advanced maternal age which is defined as the age of the mother as 35 years or more at the time of delivery has become increasingly common in the last two to three decades. This study aimed to evaluate obstetric and perinatal outcomes in women with advanced maternal age in comparison to that of younger women. Methods: This cross-sectional study was conducted at the Department of Obstetrics and Gynaecology in Rangpur Medical College Hospital, Rangpur, from November 2015 to April 2016. A total of 100 patients were selected as study subjects by simple random sampling. Patients aged younger than 35 years primi/ multigravida and advanced maternal age 35 years and older primi/ multigravida were considered as group I and group II respectively. Data cleaning, validation, and analysis were performed using the SPSS software version 16.0. Different statistical methods were adopted for this study. Result: Concerning the obstetric outcomes, malpresentation was found in 05(10.0%) and 12(24.0%) in group I and group II respectively. PROM was 2(4.0%) in group I but not found in group II. Gestational hypertension was 2(4.0%) in group I and 1(2.0%) in group II. Abruptio placentae were 1(2.0%) in group I and 1(2.0%) in group II. PPH was not found in both groups. Regarding fetal outcomes, NICU admission patients were found 2 (4.0%) in group I and 16 (32%) in group II respectively. Meconium aspiration was 6(12.0%) and 7(14.0%) in group I and group II respectively. The congenital anomaly was 1(2.0%) in group I and 2(4.0%) in group II. The perinatal loss was 1(2.0%) and 2(2.0%) in group I and group II respectively. APGAR score at 1 minute <7 was found 2(4.0%) in group I and 19(38.0%) in group II respectively. Conclusion: Advancing maternal age appears to be associated with pre-eclampsia, cesarean section, gestational diabetes in primigravida and preterm labor, low birth weight, and placenta previa more common in multigravida women in this age group. NICU admission, malpresentation, APGAR score <7 compared to young age.

Background: Cervical cancer poses a significant public health challenge globally, especially in regions like Bangladesh where access to effective screening programs is limited. Early detection and management of cervical intraepithelial neoplasia (CIN) play crucial roles in preventing the progression to cervical cancer. This study investigates the diagnostic accuracy of colposcopy, compared with histopathological findings, in detecting various grades of CIN and cervical cancer. Methods: This retrospective observational study reviewed hospital records of 200 VIA-positive cases from January 2021 to December 2023 at the Obstetrics and Gynecology Department of Holy Family Red Crescent Medical College Hospital Dhaka, Bangladesh. Colposcopic examinations were conducted, followed by histopathological evaluations of biopsied tissues to confirm the presence and grade of CIN. Data on demographic characteristics, clinical findings, and outcomes were analyzed using descriptive statistics. Result: Of the participants, 44% had normal colposcopic findings, while the prevalence of CIN I, CIN II, CIN III, and cervical cancer was 22.5%, 17%, 11%, and 4%, respectively. Histopathological correlation confirmed 46% as normal, with discrepancies noted in higher-grade lesion diagnosis. The study highlighted the high sensitivity but variable specificity of colposcopy in detecting and grading cervical lesions. Conclusion: Colposcopy serves as a valuable diagnostic tool in the early detection of cervical abnormalities. However, discrepancies in lesion grading underscore the need for integrating colposcopy with histopathological evaluations to enhance diagnostic accuracy and optimize patient management.

Background: Perinatal and maternal morbidity and mortality is decreasing in most countries with effective antenatal care and safe child delivery facilities, but it is rising in underdeveloped nations with low resources and dangerous home birth practices. The present study sought to determine the factors that influence home birth in western Sudan. Methodology: This is a descriptive longitudinal study that took place at the Obstetrics and Gynecology teaching hospital in Al-Obeid, North Kordofan State, Sudan, from January to December of 2023. This study has enrolled around 224 individuals. Results: Financial problems were the most common reason for choosing home birth (23.6%). The majority of cases (22.3%) occurred among individuals under the age of 20. The majority of cases were from rural areas, accounting for 62.1%. The majority of the study population (29.9%) were illiterates. The majority of the patients (22.7%) were from Shikan, while the remaining were from other war-affected locations. Conclusion: The preference for home childbirth is growing in western Sudan states, particularly among illiterates, rural residents, teenagers, and low-income patients. The most apparent factors include financial and community beliefs.